Lovastatin enhances the genotoxicity of doxorubicin in Chinese hamster V79 cells via noncovalent DNA binding

Drug and Chemical Toxicology

Volumn 32, Issue 1, 2009, Pages 17-20

  Snyder, Ronald D ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Bldg S12 2 ^*  (United States)

Author keywords

Bleomycin; DNA intercalation; Doxorubicin; Lovastatin

Indexed keywords

DOXORUBICIN; MEVINOLIN; ANTINEOPLASTIC ANTIBIOTIC; DNA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MUTAGENIC AGENT;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DNA BINDING; DRUG DNA INTERACTION; DRUG EFFECT; GENOTOXICITY; NONHUMAN; ANIMAL; CELL LINE; CRICETULUS; DRUG POTENTIATION; HAMSTER; METABOLISM; MICRONUCLEUS TEST;

CRICETULUS GRISEUS;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE; CRICETINAE; CRICETULUS; DNA; DOXORUBICIN; DRUG SYNERGISM; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MICRONUCLEUS TESTS; MUTAGENS;

EID: 69449089119     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540802433948     Document Type: Article

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