Putative identification of functional interactions between DNA intercalating agents and topoisomerase II using the V79 in vitro micronucleus assay

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 503, Issue 1-2, 2002, Pages 21-35

  Snyder, Ronald D ^a,b   Arnone, Marc R ^a  

^a DUPONT COMPANY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Auramine O; Bleomycin amplification; Curcumin; Intercalation; Proflavine; Topoisomerase

Indexed keywords

2 AMINOANTHRACENE; AMINOACRIDINE; CHLOROQUINE; CLASTOGEN; CURCUMIN; DIBENZAZEPINE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; ETHIDIUM BROMIDE; GYRASE INHIBITOR; IMIPRAMINE; INTERCALATING AGENT; MEPACRINE; POLYCYCLIC HYDROCARBON; PROFLAVINE; PROMETHAZINE; STILBENE DERIVATIVE; TACRINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; COVALENT BOND; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DRUG DNA INTERACTION; ENZYME INHIBITION; IN VITRO STUDY; INTERCALATION COMPLEX; MICRONUCLEUS TEST; NONHUMAN; PRIORITY JOURNAL; VALIDATION PROCESS;

ANIMALS; ANTHRACENES; CATALYSIS; CELL LINE; CRICETINAE; CRICETULUS; DNA TOPOISOMERASES, TYPE II; IMIPRAMINE; INTERCALATING AGENTS; MICRONUCLEUS TESTS; MUTAGENS; QUINACRINE;

MAMMALIA;

EID: 0037134763     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00028-3     Document Type: Article

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