Evidence for and role of the dimethylamino group in tamoxifen DNA intercalation in intact Chinese hamster V79 cells

Drug and Chemical Toxicology

Volumn 25, Issue 4, 2002, Pages 473-479

  Snyder, Ronald D ^a   Brown, John E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bleomycin amplification; DNA intercalation; Tamoxifen

Indexed keywords

4 HYDROXYTAMOXIFEN; ALPHA HYDROXYTAMOXIFEN; BLEOMYCIN; DIMETHYLAMINO GROUP; FUNCTIONAL GROUP; IMIPRAMINE; IX 076; IX 077; PROFLAVINE; TAMOXIFEN; TAMOXIFEN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; CELL ASSAY; CHO CELL; CONFERENCE PAPER; DNA ADDUCT; GENOTOXICITY; INTERCALATION COMPLEX; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BLEOMYCIN; CATTLE; CELL LINE; CRICETINAE; CRICETULUS; DNA; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ESTROGEN ANTAGONISTS; ETHIDIUM; INTERCALATING AGENTS; MICRONUCLEUS TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; TAMOXIFEN;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0036384072     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.1081/DCT-120014797     Document Type: Conference Paper

References (8)

1. Phillips, D.H. Understanding the Genotoxicity of Tamoxifen? Carcinogenesis 2001, 22, 839-849.
2. Hellmann-Blumberg, U.; Cartner, M.G.; Wurz, G.T.; DeGregorio, M.W. Intrinsic Reactivity of Tamoxifen and Toremifene Metabolites with DNA. Breast Cancer Res. Treat. 1998, 50, 135-141.
3. Snyder, R.D.; Strekowski, L. Enhancement of Bleomycin-Induced Micronucleus Formation in V79 Cells as a Rapid and Sensitive Screen for Non-covalent DNA-Binding Compounds. Mutat. Res. 1999, 444, 181-192.
4. Snyder, R.D. A Review and Investigation Into the Mechanistic Basis of the Genotoxicity of Antihistamines. Mutat. Res. 1998, 411, 235-248.
5. Snyder, R.D.; Diehl, M.S. The Bleomycin Amplification Assay in V79 Cells Predicts Frameshift Mutagenicity of Intercalative Agents. Mutagenesis 2000, 15, 203-205.
6. Edwards, M.L.; Snyder, R.D.; Stemerick, D.M. Synthesis and DNA Binding Properties of Polyamine Analogs. J. Med. Chem. 1991, 34, 2414-2420.
7. Styles, J.A.; Davies, A.; Davies, R.; White, I.H.N.; Smith, L.L. Clastogenic and Aneugenic Effects of Tamoxifen and Some of its Analogs in Hepatocytes from Dosed Rats and in Human Lymphoblastoid Cells Transfected with Human P450 cDNAs (MCL-5 cells). Carcinogenesis 1997, 18, 303-313.
8. Snyder, R.D.; Arnone, M.R. Putative Identification of Functional Interactions Between DNA Intercalating Agents and Topoisomerase II Using the V79 In Vitro Micronucleus Assay. Mutat. Res. In Press.