Population pharmacokinetic-pharmacodynamic modelling of the anti-hyperalgesic effect of 5′ deoxy-N6-cylopentyladenosine in the mononeuropathic rat

European Journal of Pharmacology

Volumn 504, Issue 1-2, 2004, Pages 7-15

  Schaddelee, Marloes P ^a   DeJongh, Joost ^a   Collins, Sue D ^b   De Boer, Albertus G ^a   Ijzerman, Adriaan P ^a   Danhof, Meindert ^a,c  

^a LEIDEN UNIVERSITY   (Netherlands)

^b GLAXOSMITHKLINE   (United Kingdom)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Anti hyperalgesic effect; Anti nociceptive effect; Chronic constriction injury model; Neuropathic pain; Pharmacokinetic pharmacodynamic modelling; Sparse data analysis

Indexed keywords

5' DEOXY 6 N CYCLOPENTYLADENOSINE; ANALGESIC AGENT; ANTINOCICEPTIVE AGENT; UNCLASSIFIED DRUG;

ACCURACY; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; MALE; MATHEMATICAL MODEL; MECHANICAL STIMULATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL MODEL; WITHDRAWAL REFLEX;

EID: 6944253616     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.09.029     Document Type: Article

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