Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13)

Blood

Volumn 94, Issue 5, 1999, Pages 1820-1824

  Cools, Jan ^b   Bilhou Nabera, Chrystèle ^b   Wlodarska, Iwona ^b   Cabrol, Christine ^b   Talmant, Pascaline ^b   Bernard, Philippe ^b   Hagemeijer, Anne ^b   Marynen, Peter ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HELIX LOOP HELIX PROTEIN; HYBRID PROTEIN; TRANSCRIPTION FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CASE REPORT; CHIMERA; CHROMOSOME 12P; CHROMOSOME TRANSLOCATION 4; FEMALE; GENE FUSION; GENE REARRANGEMENT; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY;

EID: 0033199749     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.5.1820.417k09_1820_1824     Document Type: Article

References (15)

1. Golub TR, Barker GF, Lovett M, Gilliland DG: Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307, 1994
2. O'Connor HE, Butler TA, Clark R, Swanton S, Harrison CJ, Seeker-Walker LM, Foroni L: Abnormalities of the ETV6 gene occur in the majority of patients with aberrations of the short arm of chromosome 12: A combined PCR and Southern blotting analysis. Leukemia 12:1099, 1998
3. Papadopoulos P, Ridge SA, Boucher CA, Stocking C, Wiedemann LM: The novel activation of ABL by fusion to an ets-related gene, TEL. Cancer Res 55:34, 1995
4. Peeters P, Raynaud S, Cools J, Wlodarska I, Grosgeorge J, Philip P, Monpoux F, Van Rompaey L, Baens M, Van Den Berghe H, Marynen P: Fusion of TEL, the Ets-variant gene 6 (ETV6) to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 90:2535, 1997
5. Romana SP, Mauchauffe M, Le Coniat M, Chumakov I, Le Paslier D, Berger R, Bernard OA: The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 85:3662, 1995
6. Peeters P, Wlodarska I, Baens M, Criel A, Selleslag D, Hagemeijer A, Van Den Berghe H, Marynen P: Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders. Cancer Res 57:564, 1997
7. Chase A, Reiter A, Burci L, Cazzaniga G, Biondi A, Pickard J, Roberts IAG, Goldman JM, Cross NCP: Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12). Blood 93:1025, 1999
8. Buijs A, Sherr S, Van Baal S, Van Bezouw S, Van der Plas D, Van Kessel AG, Riegman P, Lekanne-Deprez RL, Zwarthoff E, Hagemeijer A, Grosveld G: Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene 10:1511, 1995
9. Harada H, Harada Y, Eguchi M, Dohy H, Kamada N: Characterization of acute leukemia with t(4;12). Leuk Lymphoma 25:47, 1997
10. + myeloid/natural killer cell precursor acute leukemia: A distinct hematolymphoid disease entity. Blood 90:2417, 1997
11. Wlodarska I, Mecucci C, Marynen P, Guo C, Franckx D, La Starza R, Aventin A, Bosly A, Martelli MF, Cassiman J-J, Van Den Berghe H: TEL gene is involved in myelodysplastic syndromes with either the typical t(5;12)(q33;p13) translocation or its variant t(10; 12)(q24;p13). Blood 85:2848, 1995
12. Baens M, Peeters P, Guo C, Aerssens J, Marynen P: Genomic organisation of TEL: The human ETS-variant gene 6 (ETV6). Genome Res 6:404, 1996
13. Baens M, Wlodarska I, Corveleyn A, Hoornaert I, Hagemeijer A, Marynen P: A physical, transcript, and deletion map of chromosome region 12p12.3 flanked by ETV6 and CDKN1B: Hypermethylation of the LRP6 CpG island in two leukemia patients with hemizygous del(12p). Genomics 56:40, 1999
14. Andreasson P, Johansson B, Billström R, Oarwicz S, Mitelman F, Höglund M: Fluorescence in situ hybridization analyses of hematologic malignacies reveal frequent cytogenetically unrecognized 12p rearrangements. Leukemia 12:390, 1998
15. Birg F, Marynen P, Hagemeijer A: The ETV6/TEL gene in haematological malignancies. Leukemia 10:1998, 1996 (abstr)