Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)

Journal of Neurochemistry

Volumn 86, Issue 2, 2003, Pages 344-350

  Lew, Rebecca A ^a   Mustafa, Tomris ^b   Ye, Siying ^b   McDowall, Sharon G ^b   Chai, Siew Yeen ^b   Albiston, Anthony L ^b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Ang IV; AT4 receptor; Enzyme kinetics; Hemorphin

Indexed keywords

AMINO ACID DERIVATIVE; AMINOPEPTIDASE; ANGIOTENSIN 4 [1 NORLEUCINE]; ANGIOTENSIN DERIVATIVE; ANGIOTENSIN II [3-8]; ANGIOTENSIN RECEPTOR; ARYL ACYLAMIDASE; DIVALINAL ANGIOTENSIN 4; INSULIN REGULATED AMINOPEPTIDASE; LEUCYLLEUCYLVALINE; LIGAND; METENKEPHALIN; NEUROPEPTIDE; OXYTOCIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VASOPRESSIN; ANGIOTENSIN II; ANGIOTENSIN II, DES ASP(1) DES ARG(2) ILE(5); ANGIOTENSIN II, DES-ASP(1)-DES-ARG(2)-ILE(5)-; AT4 RECEPTOR; CYSTYL AMINOPEPTIDASE; DIVALINAL ANGIOTENSIN IV; DIVALINAL-ANGIOTENSIN IV; DRUG DERIVATIVE; ENZYME INHIBITOR; HEMOGLOBIN; LEUCINE; LEUCINE-BETA-NAPHTHYLAMIDE; LEUCYL 2 NAPHTHYLAMIDE; LEUCYL CYSTINYL AMINOPEPTIDASE; LEUCYL-CYSTINYL AMINOPEPTIDASE; LVV HEMORPHIN 7; LVV-HEMORPHIN-7; NLE(1) ANGIV; NLE(1)-ANGIV; OLIGOPEPTIDE; PEPTIDE; PEPTIDE FRAGMENT;

ARTICLE; ASSAY; BINDING SITE; CATALYSIS; CELL LINE; CELL MEMBRANE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; MEMORY; PRIORITY JOURNAL; PROTEIN DEGRADATION; BINDING COMPETITION; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; ENZYME ACTIVATION; ENZYME SPECIFICITY; KIDNEY; METABOLISM; PHYSIOLOGY;

AMINOPEPTIDASES; ANGIOTENSIN II; BINDING, COMPETITIVE; CELL LINE; CYSTINYL AMINOPEPTIDASE; ENZYME ACTIVATION; ENZYME INHIBITORS; HEMOGLOBINS; HUMANS; KIDNEY; LEUCINE; LIGANDS; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PEPTIDES; RECEPTORS, ANGIOTENSIN; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0037817386     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01852.x     Document Type: Article

References (29)

1. Albiston A. L., McDowall S. G., Matsacos D., Sim P., Clune E., Mustafa T., Lee J., Mendelsohn F. A., Simpson R. J., Connolly L. M. and Chai S. Y. (2001) Evidence that the angiotensin IV (AT4) receptor is the enzyme insulin regulated aminopeptidase. J. Biol. Chem. 276, 48263-48266.
2. Braszko J. J., Kupryszewski G., Witczuk B. and Wisniewski K. (1988) Angiotensin II-(3-8)-hexapeptide affects motor activity, performance of passive avoidance and a conditioned avoidance response in rats. Neuroscience 27, 777-783.
3. Chai S. Y., Lee J. H., Matscos D., McDowall S. G., Mendelsohn F. A. O. M., Robel P. and Albiston A. L. (2001) Angiotensin AT4 receptor distribution in mouse brain and its possible role in facilitation of spatial memory. J. Neurochem. 78, 15.
4. Handa R. K. (2001) Characterization and signaling of the AT(4) receptor in human proximal tubule epithelial (HK-2) cells. J. Am. Soc. Nephrol. 12, 440-449.
5. Handa R. K., Harding J. W. and Simasko S. M. (1999) Characterization and function of the bovine kidney epithelial angiotensin receptor subtype 4 using angiotensin IV and divalinal angiotensin IV as receptor ligands. J. Pharmacol. Exp. Ther 291, 1242-1249.
6. Herbst J. J., Ross S. A., Scott H. M., Bobin S. A., Morris N. J., Lienhard G. E. and Keller S. R. (1997) Insulin stimulates cell surface amino-peptidase activity toward vasopressin in adipocytes. Am. J. Physiol. 272, E600-E606.
7. Keller S. R., Scott H. M., Mastick C. C., Aebersold R. and Lienhard G. E. (1995) Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles. J. Biol. Chem 270, 23612-23618.
8. Kovacs G. L. and De Wied D. (1994) Peptidergic modulation of learning and memory processes. Pharmacol. Rev. 46, 269-291.
9. Krebs L. T., Kramar E. A., Hanesworth J. M., Sardinia M. F., Ball A. E., Wright J. W. and Harding J. W. (1996) Characterization of the binding properties and physiological action of divalinal-angiotensin IV, a putative AT4 receptor antagonist. Regul. Pept. 67, 123-130.
10. Lee J., Allen A. M., Mendelsohn F. A. O., Ping S., Barrett G. L., Murphy M. and Chai S. Y. (2001a) 21st Scientific Meeting of the Hong Kong Society of Neurosciences, December 2001, Abstract 79. Hong Kong Society of Neuroscience, Hong Kong.
11. Lee J., Chai S. Y., Mendelsohn F. A., Morris M. J. and Allen A. M. (2001b) Potentiation of cholinergic transmission in the rat hippocampus by angiotensin IV and LVV-hemorphin-7. Neuropharmacology. 40, 618-623.
12. Matsumoto H., Rogi T., Yamashiro K., Kodama S., Tsuruoka N., Hattori A., Takio K., Mizutani S. and Tsujimoto M. (2000) Characterization of a recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells. Eur. J. Biochem. 267, 46-52.
13. Matsumoto H., Nagasaka T., Hattori A., Rogi T., Tsuruoka N., Mizutani S. and Tsujimoto M. (2001) Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides. Eur. J. Biochem. 268, 3259-3266.
14. Moeller I., Lew R. A., Mendelsohn F. A., Smith A. I., Brennan M. E., Tetaz T. J. and Chai S. Y. (1997) The globin fragment LVV-hemorphin-7 is an endogenous ligand for the AT4 receptor in the brain. J. Neurochem. 68, 2530-2537.
15. Moeller I., Chai S. Y., Smith I., Lew R. and Mendelsohn F. A. (1998) Haemorphin peptides may be endogenous ligands for brain angiotensin AT4 receptors. Clin. Exp. Pharmacol. Physiol. Suppl. 25, S68-S71.
16. Mustafa T., Chai S. Y., Mendelsohn F. A., Moeller I. and Albiston A. L. (2001a) Characterization of the AT(4) receptor in a human neuroblastoma cell line (SK-N-MC). J. Neurochem. 76, 1679-1687.
17. Mustafa T., Lee J. H., Chai S. Y., Albiston A. L., McDowall S. G. and Mendelsohn F. A. O. (2001b) Bioactive Angiotensin Peptides: Focus on Angiotensin IV. J. Renin Angiotensin Aldosterone Syst 2, 205-210.
18. Nikolova J. G., Getova D. P. and Nikolov F. P. (2000) Effects of ACE-inhibitors on learning and memory processes in rats. Folia Med. 42, 47-51.
19. Odya C. E., Wilgis F. P., Vavrek R. J. and Stewart J. M. (1983) Interactions of kinins with angiotensin I converting enzyme (kininase II). Biochem. Pharmacol. 32, 3839-3847.
20. Pederson E. S., Harding J. W. and Wright J. W. (1998) Attenuation of scopolamine-induced spatial learning impairments by an angiotensin IV analog. Regul. Pept. 74, 97-103.
21. Raghavendra V., Chopra K. and Kulkami S. K. (2001) Comparative studies on the memory-enhancing actions of captopril and losartan in mice using inhibitory shock avoidance paradigm. Neuropeptides 35, 65-69.
22. Riva L. and Galzin A. M. (1996) Pharmacological characterization of a specific binding site for angiotensin IV in cultured porcine aortic endothelial cells. Eur. J. Pharmacol. 305, 193-199.
23. Rogi T., Tsujimoto M., Nakazato H., Mizutani S. and Tomoda Y. (1996) Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family. J. Biol. Chem. 271, 56-61.
24. Sardinia M. F., Hanesworth J. M., Krishnan F. and Harding J. W. (1994) AT4 receptor structure-binding relationship: N-terminal-modified angiotensin IV analogues. Peptides 15, 1399-1406.
25. Shinoda M., Miyazaki A. and Toide K. (1999) Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the nucleus basalis magnocellularis. Behav Brain Res. 99, 17-25.
26. Toide K., Shinoda M., Iwamoto Y., Fujiwara T., Okamiya K. and Uemura A. (1997) A novel prolyl endopeptidase inhibitor, JTP-4819, with potential for treating Alzheimer's disease. Behav Brain Res. 83, 147-151.
27. Wayner M. J., Armstrong D. L., Phelix C. F., Wright J. W. and Harding J. W. (2001) Angiotensin IV enhances LTP in rat dentate gyrus in vivo. Peptides 22, 1403-1414.
28. Wright J. W., Miller-Wing A. V., Shaffer M. J., Higginson C., Wright D. E., Hanesworth J. M. and Harding J. W. (1993) Angiotensin II (3-8) (ANG IV) hippocampal binding: potential role in the facilitation of memory. Brain Res. Bull. 32, 497-502.
29. Wright J. W., Stubley L., Pederson E. S., Kramar E. A., Hanesworth J. M. and Harding J. W. (1999) Contributions of the brain angiotensin IV-AT4 receptor subtype system to spatial learning. J. Neurosci. 19, 3952-3961.