Aminopeptidase N/CD13 is directly linked to signal transduction pathways in monocytes

Cellular Immunology

Volumn 201, Issue 1, 2000, Pages 22-32

  Santos, Alexander Navarrete ^a   Langner, Juergen ^a   Herrmann, Manfred ^a   Riemann, Dagmar ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Aminopeptidase N; CD13; Competitive RT PCR; Intracellular free calcium; Mitogen activated protein; Monocytes; Tyrosine kinase inhibitors

Indexed keywords

CALCIUM; MICROSOMAL AMINOPEPTIDASE;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 0034630350     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1006/cimm.2000.1629     Document Type: Article

References (45)

1. Kenny A. J., Stephenson L. S., Turner A. J. Mammalian Ectoenzymes. 1987;Elsevier Science, Amsterdam.
2. Shipp M. A., Look A. T. Hematopoietic differentiation antigens that are membrane-associated enzymes: Cutting is the key! Blood. 82:1993;1052-1070.
3. Riemann D., Kehlen A., Langner J. CD13 - Not just a marker in leukemia typing. Immunol. Today. 20:1999;83-88.
4. Drexler H. G. Classification of acute myeloid leukemias - A comparison of FAB and immunophenotyping. Leukemia. 1:1987;697-705.
5. Look A. T., Ashmun R. A., Shapiro L. H., Peiper S. C. Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N. J. Clin. Invest. 83:1989;1299-1307.
6. Hooper N. M. Families of zinc metalloproteases. FEBS Lett. 354:1994;1-6.
7. Olsen J., Cowell G. M., Konigshofer E., Danielsen E. M., Moller J., Laustsen L., Hansen O. C., Welinder K. G., Engberg J., Hunziker W., Spies M., Sjöström H., Noren O. Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA. FEBS Lett. 238:1988;307-314.
8. Van Hal P. T. W., Hopstaken-Broos J. P. M., Prins A., Favaloro E. J., Huijbens R. J., Hilvering C., Figdor C. G., Hoogsteden H. C. Potential indirect anti-inflammatory effects of IL-4: Stimulation of human monocytes, macrophages, and endothelial cells by IL-4 increases aminopeptidase-N activity (CD13; EC 3.4.11.2). J. Immunol. 153:1994;2718-2728.
9. Löhn M., Mueller C., Thiele K., Kähne T., Riemann D., Langner J. Aminopeptidase N-mediated signal transduction and inhibition of proliferation of human myeloid cells. Adv. Exp. Med. Biol. 421:1997;85-91.
10. Wex T., Lendeckel U., Reinhold D., Kähne T., Arndt M., Frank K., Ansorge S. Antisense-mediated inhibition of aminopeptidase N (CD13) markedly decreases growth rates of hematopoietic tumour cells. Adv. Exp. Med. Biol. 421:1997;67-73.
11. Larsen S. L., Pedersen L. O., Buus S., Stryhn A. T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides. J. Exp. Med. 184:1996;183-189.
12. McIntyre E. A., Jones H. M., Roberts P. J., Tidman N., Linch D. C. Leucocyte Typing III: White Cell Differentiation Antigens. 1987;Oxford Univ. Press, Oxford.
13. Ziegler-Heitbrook H. W. L., Thiel E., Fuetterer A., Herzog V., Wirtz A., Riethmueller G. Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes. Int. J. Cancer. 41:1988;456-461.
14. Riemann D., Wollert H. G., Menschikowski J., Mittenzwei J., Langner J. Immunophenotype of lymphocytes in pericardial fluid from patients with different forms of heart disease. J. Int. Arch. Allergy Immunol. 104:1994;48-56.
15. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:1985;3440-3450.
16. Navarrete Santos A., Riemann D., Thiele K., Kehlen A., Navarrete Santos A., Langner J. Constitutive expression of HLA class II mRNA in synovial fibroblast-like cells from patients with rheumatoid arthritis. Immunol. Lett. 58:1997;53-58.
17. Favaloro E. J. CD-13 ('gp150′; aminopeptidase-N): Co-expression on endothelial and haemopoietic cells with conservation of functional activity. Immunol. Cell. Biol. 69:1991;253-260.
18. Razak K., Collins P. W., Kelsey S. M., Newland A. C. Binding of antibodies to different CD13 epitopes on human myeloid leukaemic cells. Int. J. Oncol. 3:1993;749-754.
19. Lytton J., Westlin M., Hanley M. R. Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J. Biol. Chem. 266:1991;17067-17071.
20. 2+-release channels. Trends Pharmacol. Sci. 15:1994;145-149.
21. Parker I., Ivorra I. Caffeine inhibits inositol trisphosphate-mediated liberation of intracellular calcium in xenopus oocytes. J. Physiol. 433:1991;229-240.
22. Hanke J. H., Gardner J. P., Dow R. L., Changelian P. S., Brisette W. H., Weringer E. J., Pollok B. A., Connelly P. A. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor: Study of Lck- and Fyn- T-dependent T cell activation. J. Biol. Chem. 271:1996;695-701.
23. Vlahos C. J., Matter W. F., Hui K. Y., Brown R. F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269:1994;5241-5248.
24. Nakanishi S., Yano H., Matsuda Y. Novel functions of phosphatidylinositol 3-kinase in terminally differentiated cells. Cell Signal. 7:1995;545-557.
25. Seger R., Krebs E. G. The MAPK signaling cascade. FASEB J. 9:1995;726-735.
26. Dudley D. T., Pang L., Decker S. J., Bridges A. J., Saltiel A. R. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA. 92:1995;7686-7689.
27. Cuenda A., Rouse J., Doza Y. N., Meier R., Cohen P., Gallagher T. F., Young P. R., Lee J. C. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364:1995;229-233.
28. 2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils. Nature. 377:1995;75-79.
29. 2+ inhibition. Proc. Natl. Acad. Sci. USA. 95:1998;15821-15825.
30. Jayaraman T., Ondrias K., Ondriasova E., Marks A. R. Regulation of the inositol 1,4,5-trisphosphate receptor by tyrosine phosphorylation. Science. 272:1992;1492-1494.
31. 2+ elevation and mobilization in T cells. J. Biol. Chem. 267:1992;7154-7159.
32. 2+ entry by tyrosine kinase inhibitors. J. Biol. Chem. 268:1993;9945-9948.
33. Jackson J. R., Bolognese B., Hillegass L., Kassis S., Adams J., Griswold D. E., Winkler J. D. Pharmacological effects of SB220025, a selective inhibitor of p38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models. J. Pharmacol. Exp. Ther. 284:1998;687-692.
34. Falasca M., Logan S. K., Lehto V. P., Baccante G., Lemmon M. A., Schlessinger J. Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J. 17:1998;414-422.
35. Ansorge S., Bühling F., Kähne T., Lendeckel U., Reinhold D., Taeger M., Wrenger S. CD26/dipeptidyl peptidase IV in lymphocyte growth regulation. Adv. Exp. Med. Biol. 421:1997;127-140.
36. Mittruecker H. W., Steeg C., Malissen B., Fleischer B. The cytoplasmic tail of the T cell receptor zeta chain is required for signaling via CD26. Eur. J. Immunol. 25:1995;295-297.
37. Hegen M., Kameoka J., Dong R. P., Schlossman S. F., Morimoto C. Cross-linking of CD26 by antibody induces tyrosine phosphorylation and activation of mitogen-activated protein kinase. Immunology. 90:1997;257-264.
38. Gaetaniello L., Fiore M., De Filippo S., Pozzi N., Tamasi S., Pignata C. Occupancy of dipeptidyl peptidase IV activates an associated tyrosine kinase and triggers an apoptotic signal in human hepatocarcinoma cells. Hepatology. 25:1998;934-942.
39. 2+ signalling through leukocyte CD11b/CD18 integrin. Biochem. J. 288:1992;465-473.
40. Beekhuizen H., Blokland I., van Furth R. Cross-linking of CD14 molecules on monocytes results in a CD11/CD18- and ICAM-1-dependent adherence to cytokine-stimulated human endothelial cells. J. Immunol. 150:1993;950-959.
41. Simons K., Ikonen E. Functional rafts in cell membranes. Nature. 387:1997;569-572.
42. Danielsen E. M. Localization and biosynthesis of aminopeptidase N in pig fetal small intestine. Biochemistry. 34:1995;1596-1605.
43. Poulsen L. K., Jacobsen N., Sorensen B. B., Bergenhem N. C., Kelly J. D., Foster D. C., Thastrup O., Ezban M., Petersen L. C. Signal transduction via the mitogen-activated protein kinase pathway induced by binding of coagulation factor VIIa to tissue factor. J. Biol. Chem. 273:1998;6228-6232.
44. Emmrich F., Gebauer F., Weseloh G., Glückert K., Kinne R. Phenotype analysis of "inflammatory" macrophages in rheumatoid arthritis by two-colour cytofluorometry and immunohistology. Agents Actions. 29:1990;95-97.
45. 2+ mobilization in response to ligation of macrophage HLA-DP. Interferon Cytokine Res. 17:1997;671-679.