메뉴 건너뛰기




Volumn 158, Issue 1, 2009, Pages 198-208

The signal transduction cascade regulating the expression of the gap junction protein connexin43 by β-adrenoceptors

Author keywords

Beta adrenoceptor; Cardiomyocytes; Congestive heart failure; Cx43; Human cardiac biopsy; Hypertrophic cardiomyopathy; Isoprenaline; MAPK

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BETA ADRENERGIC RECEPTOR; CONNEXIN 43; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOSPORIN A; ISOPRENALINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROPRANOLOL; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

EID: 69249230889     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00344.x     Document Type: Article
Times cited : (60)

References (38)
  • 1
    • 33747080587 scopus 로고    scopus 로고
    • 2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells
    • 2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells. Cell Signal 18 : 1801 1812.
    • (2006) Cell Signal , vol.18 , pp. 1801-1812
    • Aggeli, I.K.S.1    Gaitanaki, C.2    Beis, I.3
  • 2
    • 0036284602 scopus 로고    scopus 로고
    • Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2) isoforms in the human myometrium during pregnancy and labor: Identification of a novel ATF2 species with potent transactivation properties
    • Bailey J, Phillips RJ, Pollard AJ, Gilmore K, Robson SC, Europe-Finner GN (2002). Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2) isoforms in the human myometrium during pregnancy and labor: identification of a novel ATF2 species with potent transactivation properties. J Clin Endocrinol Metab 87 : 1717 1728.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1717-1728
    • Bailey, J.1    Phillips, R.J.2    Pollard, A.J.3    Gilmore, K.4    Robson, S.C.5    Europe-Finner, G.N.6
  • 3
    • 0028981213 scopus 로고
    • 2+ -responsive elements in cerebellar granular neurons
    • 2+ -responsive elements in cerebellar granular neurons. J Neurochem 64 : 41 51.
    • (1995) J Neurochem , vol.64 , pp. 41-51
    • Barthel, F.1    Loeffler, J.P.2
  • 5
    • 34249658490 scopus 로고    scopus 로고
    • Beta-, not alpha-adrenergic stimulation enhances conduction velocity in cultures of neonatal cardiomyocytes
    • de Boer TP, van Rijen HV, Van der Heyden MA, Kok B, Opthof T, Vos MA et al. (2007). Beta-, not alpha-adrenergic stimulation enhances conduction velocity in cultures of neonatal cardiomyocytes. Circ J 71 : 973 981.
    • (2007) Circ J , vol.71 , pp. 973-981
    • De Boer, T.P.1    Van Rijen, H.V.2    Van Der Heyden, M.A.3    Kok, B.4    Opthof, T.5    Vos, M.A.6
  • 6
    • 0027076014 scopus 로고
    • Adrenergic stimulation of cFOS via protein kinase A is mediated by cAMP regulatory element binding protein (CREB)-dependent and tissue-specific CREB-independent mechanisms in corticotrope cells
    • Boutillier AL, Barthel F, Robertsll JL, Loeffler JP (1992 adrenergic stimulation of cFOS via protein kinase A is mediated by cAMP regulatory element binding protein (CREB)-dependent and tissue-specific CREB-independent mechanisms in corticotrope cells. J Biol Chem 267 : 23520 23526.
    • (1992) J Biol Chem , vol.267 , pp. 23520-23526
    • Boutillier, A.L.1    Barthel, F.2    Robertsll, J.L.3    Loeffler, J.P.4
  • 7
    • 0030017422 scopus 로고    scopus 로고
    • Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes
    • Darrow BJ, Fast VG, Kléber AG, Beyer EC, Saffitz JE (1996). Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes. Circ Res 79 : 174 183.
    • (1996) Circ Res , vol.79 , pp. 174-183
    • Darrow, B.J.1    Fast, V.G.2    Kléber, A.G.3    Beyer, E.C.4    Saffitz, J.E.5
  • 9
    • 0032769955 scopus 로고    scopus 로고
    • Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene
    • Echetebu CO, Ali M, Izban MG, MacKay L, Garfield RE (1999). Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene. Mol Hum Reprod 5 : 757 766.
    • (1999) Mol Hum Reprod , vol.5 , pp. 757-766
    • Echetebu, C.O.1    Ali, M.2    Izban, M.G.3    MacKay, L.4    Garfield, R.E.5
  • 10
    • 0029860018 scopus 로고    scopus 로고
    • Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl preotein kinase inhibitors H7, H8, and H89. Structural implications for selectivity
    • Engh RA, Girod A, Kintel V, Hubert R, Bossemeyer D (1996). Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl preotein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J Biol Chem 271 : 26157 26164.
    • (1996) J Biol Chem , vol.271 , pp. 26157-26164
    • Engh, R.A.1    Girod, A.2    Kintel, V.3    Hubert, R.4    Bossemeyer, D.5
  • 11
    • 33751320355 scopus 로고    scopus 로고
    • Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1
    • Fan GC, Yuan Q, Song G, Wang Y, Chen G, Qian J et al. (2006). Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Circ Res 99 : 1233 1242.
    • (2006) Circ Res , vol.99 , pp. 1233-1242
    • Fan, G.C.1    Yuan, Q.2    Song, G.3    Wang, Y.4    Chen, G.5    Qian, J.6
  • 12
    • 0040175067 scopus 로고    scopus 로고
    • Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction
    • Frödin M, Gammeltoft S (1999). Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol Cell Endocrinol 151 : 65 77.
    • (1999) Mol Cell Endocrinol , vol.151 , pp. 65-77
    • Frödin, M.1    Gammeltoft, S.2
  • 13
    • 0742304427 scopus 로고    scopus 로고
    • Low dose ionizing radiation-induced activation of connexin 43 expression
    • Glover D, Little JB, Lavin MF, Gueven N (2003). Low dose ionizing radiation-induced activation of connexin 43 expression. Int J Radiat Biol 79 : 955 964.
    • (2003) Int J Radiat Biol , vol.79 , pp. 955-964
    • Glover, D.1    Little, J.B.2    Lavin, M.F.3    Gueven, N.4
  • 14
    • 0033569905 scopus 로고    scopus 로고
    • P38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons
    • Goh KC, Haque SJ, Williams BRG (1999). p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. EMBO J 18 : 5601 5608.
    • (1999) EMBO J , vol.18 , pp. 5601-5608
    • Goh, K.C.1    Haque, S.J.2    Williams, B.R.G.3
  • 15
    • 0029790453 scopus 로고    scopus 로고
    • Physiological role of phosphorylation of the cyclic AMP response element binding protein in rat cardiac nuclei
    • Goldspink PH, Russell B (1996). Physiological role of phosphorylation of the cyclic AMP response element binding protein in rat cardiac nuclei. Cell Tissue Res 285 : 379 385.
    • (1996) Cell Tissue Res , vol.285 , pp. 379-385
    • Goldspink, P.H.1    Russell, B.2
  • 16
    • 0032562150 scopus 로고    scopus 로고
    • Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle
    • Kaprielian RR, Gunning M, Dupont E, Sheppard MN, Rothery SM, Underwood R et al. (1998). Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle. Circulation 97 : 651 660.
    • (1998) Circulation , vol.97 , pp. 651-660
    • Kaprielian, R.R.1    Gunning, M.2    Dupont, E.3    Sheppard, M.N.4    Rothery, S.M.5    Underwood, R.6
  • 17
    • 1942534677 scopus 로고    scopus 로고
    • Connexin 43 expression and distribution in compensated and decompensated cardiac hypertrophy in patients with aortic stenosis
    • Kostin S, Dammer S, Hein S, Klövekorn WP, Bauer EP, Schaper J (2004). Connexin 43 expression and distribution in compensated and decompensated cardiac hypertrophy in patients with aortic stenosis. Cardiovasc Res 62 : 426 436.
    • (2004) Cardiovasc Res , vol.62 , pp. 426-436
    • Kostin, S.1    Dammer, S.2    Hein, S.3    Klövekorn, W.P.4    Bauer, E.P.5    Schaper, J.6
  • 18
    • 0037286470 scopus 로고    scopus 로고
    • Gap junction remodeling and altered connexin43 expression in the failing human heart
    • Kostin S, Rieger M, Dammer S, Hein S, Richter M, Klövekorn WP et al. (2003). Gap junction remodeling and altered connexin43 expression in the failing human heart. Mol Cell Biochem 242 : 135 144.
    • (2003) Mol Cell Biochem , vol.242 , pp. 135-144
    • Kostin, S.1    Rieger, M.2    Dammer, S.3    Hein, S.4    Richter, M.5    Klövekorn, W.P.6
  • 19
    • 34047232485 scopus 로고    scopus 로고
    • Beta1 integrins modulate beta-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling
    • Krishnamurthy P, Subramanian V, Singh M, Singh K (2007). Beta1 integrins modulate beta-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling. Hypertension 49 : 865 872.
    • (2007) Hypertension , vol.49 , pp. 865-872
    • Krishnamurthy, P.1    Subramanian, V.2    Singh, M.3    Singh, K.4
  • 21
    • 7444264191 scopus 로고    scopus 로고
    • Phenylephrine induces activation of CREB in adult rat cardiac myocytes through MSK1 and PKA signaling pathways
    • Markou T, Hadzopoulou-Cladaras M, Lazou A (2004). Phenylephrine induces activation of CREB in adult rat cardiac myocytes through MSK1 and PKA signaling pathways. J Mol Cell Cardiol 37 : 1001 1011.
    • (2004) J Mol Cell Cardiol , vol.37 , pp. 1001-1011
    • Markou, T.1    Hadzopoulou-Cladaras, M.2    Lazou, A.3
  • 22
    • 0034850908 scopus 로고    scopus 로고
    • Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes
    • Müller FU, Boknik P, Knapp J, Linck B, Lüss H, Neumann J et al. (2001). Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes. Cardiovasc Res 52 : 95 102.
    • (2001) Cardiovasc Res , vol.52 , pp. 95-102
    • Müller, F.U.1    Boknik, P.2    Knapp, J.3    Linck, B.4    Lüss, H.5    Neumann, J.6
  • 23
    • 0032589774 scopus 로고    scopus 로고
    • Gq/11-coupled receptors and protein synthesis in rat cardiomyocytes: Role of Gi proteins and protein kinase C-isoenzymes
    • Pönicke K, Heinroth-Hoffmann I, Becker K, Osten B, Brodde OE (1999). Gq/11-coupled receptors and protein synthesis in rat cardiomyocytes: role of Gi proteins and protein kinase C-isoenzymes. Naunyn Schmiedebergs Arch Pharmacol 360 : 301 308.
    • (1999) Naunyn Schmiedebergs Arch Pharmacol , vol.360 , pp. 301-308
    • Pönicke, K.1    Heinroth-Hoffmann, I.2    Becker, K.3    Osten, B.4    Brodde, O.E.5
  • 24
    • 0036127637 scopus 로고    scopus 로고
    • Differential effects of bucindolol and carvedilol on noradenaline-induced hypertrophic response in ventricular cardiomyocytes of adult rats
    • Pönicke K, Heinroth-Hoffmann I, Brodde OE (2002). Differential effects of bucindolol and carvedilol on noradenaline-induced hypertrophic response in ventricular cardiomyocytes of adult rats. J Pharmacol Exp Ther 301 : 71 76.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 71-76
    • Pönicke, K.1    Heinroth-Hoffmann, I.2    Brodde, O.E.3
  • 26
    • 36049035882 scopus 로고    scopus 로고
    • Enhanced transmural fiber rotation and connexin 43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy
    • Ripplinger CM, Li W, Hadley J, Chen J, Rothenberg F, Lombardi R et al. (2007). Enhanced transmural fiber rotation and connexin 43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circ Res 101 : 1049 1057.
    • (2007) Circ Res , vol.101 , pp. 1049-1057
    • Ripplinger, C.M.1    Li, W.2    Hadley, J.3    Chen, J.4    Rothenberg, F.5    Lombardi, R.6
  • 27
    • 28944437893 scopus 로고    scopus 로고
    • Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer?
    • Salameh A, Dhein S (2005). Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer? Biochim Biophys Acta 1719 : 36 58.
    • (2005) Biochim Biophys Acta , vol.1719 , pp. 36-58
    • Salameh, A.1    Dhein, S.2
  • 28
    • 33644915279 scopus 로고    scopus 로고
    • Subchronic alpha- and beta-adrenergic regulation of cardiac gap junction protein expression
    • Salameh A, Frenzel C, Boldt A, Rassler B, Glawe I, Schulte J et al. (2006). Subchronic alpha- and beta-adrenergic regulation of cardiac gap junction protein expression. FASEB J 20 : 365 367.
    • (2006) FASEB J , vol.20 , pp. 365-367
    • Salameh, A.1    Frenzel, C.2    Boldt, A.3    Rassler, B.4    Glawe, I.5    Schulte, J.6
  • 30
    • 7444225800 scopus 로고    scopus 로고
    • Chronic regulation of the expression of gap junction proteins connexin40, connexin43, and connexin 45 in neonatal rat cardiomyocytes
    • Salameh A, Schneider P, Mühlberg K, Hagendorff A, Dhein S, Pfeiffer D (2004). Chronic regulation of the expression of gap junction proteins connexin40, connexin43, and connexin 45 in neonatal rat cardiomyocytes. Eur J Pharmacol 503 : 9 16.
    • (2004) Eur J Pharmacol , vol.503 , pp. 9-16
    • Salameh, A.1    Schneider, P.2    Mühlberg, K.3    Hagendorff, A.4    Dhein, S.5    Pfeiffer, D.6
  • 31
    • 0035170002 scopus 로고    scopus 로고
    • Beta-adrenoceptor stimulation attenuates the hypertrophic effect of alpha-adrenoceptor stimulation in adult rat ventricular cardiomyocytes
    • Schäfer M, Pönicke K, Heinroth-Hoffmann I, Brodde OE, Piper HM, Schlüter KD (2001). Beta-adrenoceptor stimulation attenuates the hypertrophic effect of alpha-adrenoceptor stimulation in adult rat ventricular cardiomyocytes. J Am Coll Cardiol 37 : 300 307.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 300-307
    • Schäfer, M.1    Pönicke, K.2    Heinroth-Hoffmann, I.3    Brodde, O.E.4    Piper, H.M.5    Schlüter, K.D.6
  • 32
    • 0029801693 scopus 로고    scopus 로고
    • Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathy
    • Sepp R, Severs NJ, Gourdie RG (1996). Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathy. Heart 76 : 412 417.
    • (1996) Heart , vol.76 , pp. 412-417
    • Sepp, R.1    Severs, N.J.2    Gourdie, R.G.3
  • 33
    • 2542481786 scopus 로고    scopus 로고
    • Transcription activator protein 1 mediates alpha- but not beta-adrenergic hypertrophic growth responses in adult cardiomyocytes
    • Taimor G, Schlüter KD, Best P, Helmig S, Piper HM (2004). Transcription activator protein 1 mediates alpha- but not beta-adrenergic hypertrophic growth responses in adult cardiomyocytes. Am J Physiol Heart Circ Physiol 286 : H2369 H2375.
    • (2004) Am J Physiol Heart Circ Physiol , vol.286
    • Taimor, G.1    Schlüter, K.D.2    Best, P.3    Helmig, S.4    Piper, H.M.5
  • 34
    • 0032700847 scopus 로고    scopus 로고
    • Increased JNK, AP-1 and NF-κB DNA binding activities in isoproterenol-induced cardiac remodeling
    • Takemoto Y, Yoshiyama M, Takeuchi K, Omura T, Komatsu R, Izumi Y et al. (1999). Increased JNK, AP-1 and NF-κB DNA binding activities in isoproterenol-induced cardiac remodeling. J Mol Cell Cardiol 31 : 2017 2030.
    • (1999) J Mol Cell Cardiol , vol.31 , pp. 2017-2030
    • Takemoto, Y.1    Yoshiyama, M.2    Takeuchi, K.3    Omura, T.4    Komatsu, R.5    Izumi, Y.6
  • 35
    • 0032502785 scopus 로고    scopus 로고
    • Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase
    • Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF (1998). Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase. J Biol Chem 273 : 9188 9196.
    • (1998) J Biol Chem , vol.273 , pp. 9188-9196
    • Warn-Cramer, B.J.1    Cottrell, G.T.2    Burt, J.M.3    Lau, A.F.4
  • 37
    • 0034704157 scopus 로고    scopus 로고
    • Beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes
    • Zheng M, Zhang SJ, Zhu WZ, Ziman B, Kobilka BK, Xiao RP (2000). Beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes. J Biol Chem 275 : 40635 40640.
    • (2000) J Biol Chem , vol.275 , pp. 40635-40640
    • Zheng, M.1    Zhang, S.J.2    Zhu, W.Z.3    Ziman, B.4    Kobilka, B.K.5    Xiao, R.P.6
  • 38
    • 0033515118 scopus 로고    scopus 로고
    • Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy
    • Zou Y, Komuro I, Yamazaki T, Kudoh S, Uozumi H, Kadowaki T et al. (1999). Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy. J Biol Chem 274 : 9760 9770.
    • (1999) J Biol Chem , vol.274 , pp. 9760-9770
    • Zou, Y.1    Komuro, I.2    Yamazaki, T.3    Kudoh, S.4    Uozumi, H.5    Kadowaki, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.