Assessment of transmission distortion on chromosome 6p in healthy individuals using tagSNPs

European Journal of Human Genetics

Volumn 17, Issue 9, 2009, Pages 1182-1189

  Santos, Pablo Sandro Carvalho ^a   Höhne, Johannes ^a   Schlattmann, Peter ^a   König, Inke R ^b   Ziegler, Andreas ^a,b   Uchanska Ziegler, Barbara ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SUPT3H; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME 6P; CONTROLLED STUDY; ETHNICITY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PHYLOGENY; PLESIOMORPHY; PRIORITY JOURNAL; SEGREGATION DISTORTION; SINGLE NUCLEOTIDE POLYMORPHISM;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 6; COMPUTATIONAL BIOLOGY; FEMALE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; NUCLEAR FAMILY; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 69249216655     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2009.16     Document Type: Article

References (49)

1. de Villena FPM, de la Casa-Esperón E, Sapienza C: Natural selection and the function of genome imprinting: Beyond the silenced minority. Trends Genet 2000; 16: 573-579.
2. de Villena FPM, Sapienza C: NonrTndom segregation during meiosis: the unfairness of females. Mamm Genome 2001; 12: 331-339.
3. Lyttle TW: Cheaters soDetimes prosper: distortion of mendelian segregation by meiotic drive. Trends Genet 1993; 9: 205-210.
4. Lyon MF: Transmission ratio distortion in mice. Annu Rev Genet 2003; 37: 393-408.
5. Carroll LS, Meagher S, Morrison L et al: Fitness effects of a selfish gene (the Mus t complex) are revealed in an ecological context. Evolution 2004; 58: 1318-1328.
6. Ardlie KG, Silver LM: Low frequency of mouse t haplotypes in wild populations is not explained by modifiers of meiotic drive. Genetics 1996; 144: 1787-1797.
7. Bauer H, Véron N, Willert J et al: The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse. Genes Dev 2007; 21: 143-147.
8. Naumova AK, Leppert M, Barker DF et al: Parental origin-dependent, male offspring-specific transmission-ratio distortion at loci on the human X chromosome. Am J Hum Genet 1998; 62: 1493-1499.
9. Eaves IA, Bennett ST, Forster P et al: Transmission ratio distortion at the INS-IGF2 VNTR. Nat Genet 1999; 22: 324-325.
10. Naumova AK, Greenwood CMT, Morgan K: Imprinting and deviation from Mendelian transmission ratios. Genome 2001; 44: 311-320.
11. Lemire M, Roslin NM, Laprise C et al: Transmission-ratio distortion and allele sharing in affected sib pairs: A new linkage statistic with reduced bias, with application to chromosome 6q25.3. Am J Hum Genet 2004; 75: 571-586.
12. Hanchard N, Rockett K, Udalova I et al: An investigation of transmission ratio distortion in the central region of the human MHC. Genes Immun 2006; 7: 51-58.
13. Dean NL, Loredo-Osti JC, Fujiwara TM et al: Transmission ratio distortion in the myotonic dystrophy locus in human preimplantation embryos. Eur J Hum Genet 2006; 14: 299-306.
14. Alias L, Barceló MJ, Gich I et al: Evidence of a segregation ratio distortion of SMN1 alleles in spinal muscular atrophy. Eur J Hum Genet 2007; 15: 1090-1093.
15. Ermakov S, Malkin I, Keter M et al: Family-based association study of polymorphisms in the RUNX2 locus with hand bone length and hand BMD. Ann Hum Genet 2008; 72: 510-518.
16. Sull JW, Liang KY, Hetmanski JB et al: Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations. Genet Epidemiol 2008; 32: 505-512.
17. Greenwood CM, Morgan K: The impact of transmission-ratio distortion on allele sharing in affected sibling pairs. Am J Hum Genet 2000; 66: 2001-2004.
18. Paterson AD, Sun L, Liu XQ et al: Transmission ratio distortion in families from the Framingham Heart Study. BMC Genet 2003; 4: S48.
19. International HapMap Consortium: The International HapMap Project. Nature 2003; 426: 789-796.
20. International HapMap Consortium: A haplotype map of the human genome. Nature 2005; 437: 1299-1320.
21. International HapMap Consortium: A second generation human haplotype map of over 3.1 million SNPs. Nature 2007; 449: 851-861.
22. Horton R, Wilming L, Rand V et al: Gene map of the extended human MHC. Nat Rev Genet 2004; 5: 889-899.
23. Ober C, Hyslop T, Elias S et al: Human leukocyte antigen matching and fetal loss: Results of a 10 year prospective study. Hum Reprod 1998; 13: 33-38.
24. Kruse C, Steffensen R, Varming K et al: A study of HLA-DR and - DQ alleles in 588 patients and 562 controls confirms that HLADRB1*03 is associated with recurrent miscarriage. Hum Reprod 2004; 19: 1215-1221.
25. Ziegler A, Kentenich H, Uchanska-Ziegler B: Female choice and the MHC. Trends Immunol 2005; 26: 496-502.
26. Ilmonen P, Penn DJ, Damjanovich K et al: Major histocompatibility complex heterozygosity reduces fitness in experimentally infected mice. Genetics 2007; 176: 2501-2508.
27. Zöllner S, Wen X, Hanchard NA et al: Evidence for extensive transmission distortion in the human genome. Am J Hum Genet 2004; 74: 62-72.
28. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52: 506-516.
29. Ziegler A, König IR: A Statistical Approach to Genetic Epidemiology: Concepts and Applications. Weinheim: Wiley-VCH, 361p.
30. de Bakker PIW, Yelensky R, Pe'er I et al: Efficiency and power in genetic association studies. Nat Genet 2005; 37: 1217-1223.
31. BarreAt JC, Fry B, Maller J et al: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21 263-265.
32. McIntyre LM, Martin ER, Simonsen KL et al: Circumventing multiple testing: A multilocus Monte Carlo approach to testing for association. Genet Epidemiol 2000; 19: 18-29.
33. Shi M, Umbach DM, Weinberg CR: Identification of risk-related haplotypes with the use of multiple SNPs from nuclear families. Am J Hum Genet 2007; 81: 53-66.
34. Becker T, Knapp M: A powerful strategy to account for multiple testing in the context of haplotype analysis. Am J Hum Genet 2004; 75 561-570.
35. Graves JAM, Wakefield MJ, Peters J et al: Report of the committee on comparative gene mapping; in: Human Gene Mapping. Johns Hopkins Press: Baltimore, 1996, pp 1351-1408.
36. Cummins JM, He Y, Leary RJ et al: The colorectal microRNAome. Proc Natl Acad Sci USA 2006; 103: 3687-3692.
37. Nagy Z, Tora L: Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Oncogene 2007; 26: 5341-5357.
38. Martinez E, Palhan VB, Tjernberg A et al: Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol Cell Biol 2001; 21: 6782-6795.
39. Aberg T, Wang XP, Kim JH et al: Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 2004; 270: 76-93.
40. Stein GS, Lian JB, van Wijnen AJ et al: Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene 2004; 23: 4315-4329.
41. de Bruijn MFTR, Speck NA: Core-binding factors in hematopoiesis and immune function. Oncogene 2004; 23: 4238-4248.
42. Okumura AJ, Peterson LF, Lo MC et al: Expression of AML/Runx and ETO/MTG family members during hematopoietic differentiation of embryonic stem cells. Exp Hematol 2007; 35: 978-988.
43. Young DW, Hassan MQ, Pratap J et al: Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature 2007; 445: 442-446.
44. Young DW, Hassan MQ, Yang XQ et al: Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2. Proc Natl Acad Sci USA 2007; 104: 3189-3194.
45. Jeong JH, Jin JS, Kim HN et al: Expression of Runx2 transcription factor in non-skeletal tissues, sperm and brain. J Cell Physiol 2008; 217: 511-517.
46. Stock M, Otto F: Control of RUNT2 isoform expression: the role of promoters and enhancers. J Cell Biochem 2005; 95: 506-517.
47. Styrkarsdottir U, Halldorsson BV, Gretarsdottir S et al: Multiple genetic loci for bone mineral density and fractures. N Engl J Med 2008; 358: 2355-2365.
48. Evans DM, Morris AP, Cardon LR et al: A note on the power to detect transmission distortion in parent-child trios via the transmission disequilibrium test. Behav Genet 2006; 36: 947-950.
49. Baker AEM: Mendelian inheritance of t haplotypes in house mouse (Mus musculus domesticus) field populations. Genet Res 2008; 90 331-339.