The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse

Genes and Development

Volumn 21, Issue 2, 2007, Pages 143-147

  Bauer, Hermann ^a   Véron, Nathalie ^a   Willert, Jürgen ^a   Herrmann, Bernhard G ^a,b  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

G proteins; Mouse; Rho; Sperm motility; Testis; Transmission ratio distortion

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN FGD2; PROTEIN T COMPLEX DISTORTER 1; PROTEIN T COMPLEX DISTORTER 2; PROTEIN T COMPLEX DISTORTER 3; PROTEIN T COMPLEX DISTORTER 4; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RNA; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENE MAPPING; GENE TARGETING; GENETIC TRANSDUCTION; HAPLOTYPE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SPERMATOGENESIS; TESTIS;

ALLELES; ANIMALS; CROSSES, GENETIC; FEMALE; GENE TARGETING; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HAPLOTYPES; MALE; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, GENETIC; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION; SPERM MOTILITY; SPERMATOZOA; TESTIS;

EID: 33846468275     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.414807     Document Type: Article

References (21)

1. Bauer, H., Willert, J., Koschorz, B., and Herrmann, B.G. 2005. The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice. Nat. Genet. 37: 969-973.
2. Brent, A.E., Schweitzer, R., and Tabin, C.J. 2003. A somitic compartment of tendon progenitors. Cell 113: 235-248.
3. Eddy, E.M., Toshimori, K., and O'Brien, D.A. 2003. Fibrous sheath of mammalian spermatozoa. Microsc. Res. Tech. 61: 103-115.
4. Gummere, G.R., McCormick, P.J., and Bennett, D. 1986. The influence of genetic background and the homologous chromosome 17 on thaplotype transmission ratio distortion in mice. Genetics 114: 235-245.
5. Herrmann, B.G., Koschorz, B., Wertz, K., McLaughlin, K.J., and Kispert, A. 1999. A protein kinase encoded by the t complex responder gene causes non-Mendelian inheritance. Nature 402: 141-146.
6. Hinsch, K.D., Habermann, B., Just, I., Hinsch, E., Pfisterer, S., Schill, W.B., and Aktories, K. 1993. ADP-ribosylation of Rho proteins inhibits sperm motility. FEBS Lett. 334: 32-36.
7. Katz, D.F., Erickson, R.P., and Nathanson, M. 1979. Beat frequency is bimodally distributed in spermatozoa from T/t12 mice. J. Exp. Zool. 210: 529-535.
8. Lyon, M.F. 1984. Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37: 621-628.
9. Lyon, M.F. 1986. Male sterility of the mouse t-complex is due to homozygosity of the distorter genes. Cell 44: 357-363.
10. Lyon, M.F. 1992. Deletion of mouse t-complex distorter-1 produces an effect like that of the t-form of the distorter. Genet. Res. 59: 27-33.
11. Lyon, M.F. 2003. Transmission ratio distortion in mice. Annu. Rev. Genet. 37: 393-408.
12. Olds-Clarke, P. and Johnson, L.R. 1993. t haplotypes in the mouse compromise sperm flagellar function. Dev. Biol. 155: 14-25.
13. Olson, M.F., Pasteris, N.G., Gorski, J.L., and Hall, A. 1996. Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases. Curr. Biol. 6: 1628-1633.
14. Pasteris, N.G. and Gorski, J.L. 1999. Isolation, characterization, andmapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues. Genomics 60: 57-66.
15. Ramirez-Solis, R., Davis, A.C., and Bradley, A. 1993. Gene targeting in embryonic stem cells. Methods Enzymol. 225: 855-878.
16. Rossman, K.L., Der, C.J., and Sondek, J. 2005. GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell Biol. 6: 167-180.
17. Schimenti, J. 2000. Segregation distortion of mouse t haplotypes the molecular basis emerges. Trends Genet. 16: 240-243.
18. Schmidt, A. and Hall, A. 2002. Guanine nucleotide exchange factors for Rho GTPases: Turning on the switch. Genes & Dev. 16: 1587-1609.
19. Silver, L.M. and Remis, D. 1987. Five of the nine genetically defined regions of mouse t haplotypes are involved in transmission ratio distortion. Genet. Res. 49: 51-56.
20. Whitehead, I.P., Abe, K., Gorski, J.L., and Der, C.J. 1998. CDC42 and FGD1 cause distinct signaling and transforming activities. Mol. Cell. Biol. 18: 4689-4697.
21. Willison, K. and Ashworth, A. 1987. Mammalian spermatogenic gene expression. Trends Genet. 3: 351-355.