Evidence for Extensive Transmission Distortion in the Human Genome

American Journal of Human Genetics

Volumn 74, Issue 1, 2004, Pages 62-72

  Zöllner, Sebastian ^a   Wen, Xiaoquan ^a   Hanchard, Neil A ^b   Herbert, Mark A ^b   Ober, Carole ^a   Pritchard, Jonathan K ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTOSOME; CALCULATION; DNA POLYMORPHISM; FERTILITY; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC SELECTION; GENOME; GENOTYPE; HUMAN; LINKAGE ANALYSIS; MOLECULAR EVOLUTION; PHENOTYPE; PRIORITY JOURNAL; SCREENING; SIBLING;

MAMMALIA;

EID: 17444448466     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/381131     Document Type: Article

References (33)

1. Abecasis GR, Cherny SS, Cookson WO, Cardon LR (2002) Merlin - rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30:97-101
2. Broman KW, Murray JC, Sheffield VC, White RL, Weber JL (1998) Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet 63:861-869
3. Chakraborty R, Stivers DN, Deka R, Yu LM, Shriver MD, Ferrell RE (1996) Segregation distortion of the CTG repeats at the myotonic dystrophy locus. Am J Hum Genet 59:109-118
4. Crow JF (1991) Why is Mendelian segregation so exact? Bioessays 13:305-312
5. Daw EW, Thompson EA, Wijsman EM (2000) Bias in multipoint linkage analysis arising from map misspecification. Genet Epidemiol 19:366-380
6. Eaves IA, Bennett ST, Forster P, Ferber KM, Ehrmann D, Wilson AJ, Bhattacharyya S, Ziegler AG, Brinkmann B, Todd JA (1999) Transmission ratio distortion at the INS-IGF2 VNTR. Nat Genet 22:324-325
7. Edmonds DK, Lindsay KS, Miller JF, Williamson E, Wood PJ (1982) Early embryonic mortality in women. Fertil Steril 38: 447-453
8. Edwards JH (2003) Sib-pairs in multifactorial disorders: the sib-similarity problem. Clin Genet 63:1-9
9. Evans K, Fryer A, Inglehearn C, Duvall-Young J, Whittaker JL, Gregory CY, Butler R, Ebenezer N, Hunt DM, Bhattacharya S (1994) Genetic linkage of cone-rod retinal dystrophy to chromosome 19q and evidence for segregation distortion. Nat Genet 6:210-213
10. Girardet A, McPeek MS, Leeflang EP, Munier F, Arnheim N, Claustres M, Pellestor F (2000) Meiotic segregation analysis of RB1 alleles in retinoblastoma pedigrees by use of single-sperm typing. Am J Hum Genet 66:167-175
11. Greenwood CM, Morgan K (2000) The impact of transmission-ratio distortion on allele sharing in affected sibling pairs. Am J Hum Genet 66:2001-2004
12. Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallbeck B, Masson G, Shlien A, Palsson ST, Frigge ML, Thorgeirsson TE, Gulcher JR, Stefansson K (2002) A high-resolution recombination map of the human genome. Nat Genet 31:241-247
13. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363
14. LeMaire-Adkins R, Hunt PA (2000) Nonrandom segregation of the mouse univalent X chromosome: evidence of spindle-mediated meiotic drive. Genetics 156:775-783
15. Lyttle TW (1993) Cheaters sometimes prosper: distortion of Mendelian segregation by meiotic drive. Trends Genet 9: 205-210
16. Macklon NS, Geraedts JPM, Fauser BCJM (2002) Conception to ongoing pregnancy: the "black box" of early pregnancy loss. Hum Reprod Update 8:333-343
17. Naumova AK, Greenwood CM, Morgan K (2001) Imprinting and deviation from Mendelian transmission ratios. Genome 44:311-320
18. Naumova AK, Leppert M, Barker DF, Morgan K, Sapienza C (1998) Parental origin-dependent, male offspring-specific transmission-ratio distortion at loci on the human X chromosome. Am J Hum Genet 62:1493-1499
19. Newman DL, Abney M, Dytch H, Parry R, McPeek MS, Ober C (2003) Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree. Hum Mol Genet 12:137-144
20. Ober C (1998) HLA and pregnancy: the paradox of the fetal allograft. Am J Hum Genet 62:1-5
21. Ober C, Hyslop T, Hauck WW (1999) Inbreeding effects on fertility in humans: evidence for reproductive compensation. Am J Hum Genet 64:225-231
22. Ober C, Tsalenko A, Parry R, Cox NJ (2000) A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet 67:1154-1162
23. O'Connell JR, Weeks DE (1998) PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63:259-266
24. Pardo-Manuel de Villena F, de la Casa-Esperón E, Sapienza C (2000) Natural selection and the function of genome im printing: beyond the silenced minority. Trends Genet 16: 573-579
25. Pardo-Manuel de Villena F, Sapienza C (2001) Nonrandom segregation during meiosis: the unfairness of females. Mamm Genome 12:331-339
26. Polanski A, Chakraborty R, Kimmel M, Deka R (1998) Dynamic balance of segregation distortion and selection maintains normal allele sizes at the myotonic dystrophy locus. Math Biosci 147:93-112
27. Regan L, Rai R (2000) Epidemiology and the medical causes of miscarriage. Baillieres Best Pract Res Clin Obstet Gynaecol 14:839-854
28. Risch N, deLeon D, Ozelius L, Kramer P, Almasy L, Singer B, Fahn S, Breakefield X, Bressman S (1995) Genetic analysis of idiopathic torsion dystonia in Ashkenazi Jews and their recent descent from a small founder population. Nat Genet 9:152-159
29. Risch N, Spiker D, Lotspeich L, Nouri N, Hinds D, Hallmayer J, Kalaydjieva L, et al (1999) A genomic screen of autism: evidence for a multilocus etiology. Am J Hum Genet 65: 493-507
30. Roberts CJ, Lowe CR (1975) Where have all the conceptions gone? Lancet 7907:498-499
31. Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-513
32. Weber JL, Broman KW (2001) Genotyping for human whole-genome scans: past, present, and future. In: Rao DC, Province MA (eds) Advances in genetics, volume 42. Academic Press, San Diego, pp 77-96
33. Westendorp RG, vanDunne FM, Kirkwood TB, Helmerhorst FM, Huizinga TW (2001) Optimizing human fertility and survival. Nat Med 7:873