Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5643-5650

  Lazo, John S ^a,b   Nunes, Ruth ^a   Skoko, John J ^a,b   de Oliveira, Pierre E Queiroz ^a,b   Vogt, Andreas ^a,b   Wipf, Peter ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Enzyme inhibition; Mitogenic signaling; Protein tyrosine phosphatases; Structure activity relationship

Indexed keywords

2 [2 (5 CARBAMIMIDOYLBENZOFURAN 2 YL)VINYL] 1H INDOLE 6 CARBOXIMIDAMIDE BIS(HYDROGEN CHLORIDE); 2 [2 (5 CYANOBENZOFURAN 2 YL)ETHYL] 1H INDOLE 6 CARBONITRILE; 2 [2 (5 CYANOBENZOFURAN 2 YL)VINYL] 1H INDOLE 6 CARBONITRILE; 2 [2 [5 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)BENZOFURAN 2 YL]VINYL] 6 (1H IMIDAZOL 2 YL) 1H INDOLE; 2 [4 (4 CARBAMIMIDOYLPHENOXY)PHENYL] 1H INDOLE 6 CARBOXIMIDAMIDE BIS(HYDROGEN FORMATE); 2 [[2 (5 METHYLENEAMINOGUANIDYL)BENZOFURAN 2 YL]VINYL] 1H INDOLE 6 METHYLENEAMINOGUANIDINE BIS(DIHYDROGEN CARBONATE); 4 [4 (6 ISOCYANO 1H INDOL 2 YL)PHENOXY]BENZONITRILE; 6 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 2 [2 [5 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)BENZOFURAN 2 YL]VINYL] 1H INDOL 3 YLAMINE; BENZOFURAN DERIVATIVE; ESTERASE INHIBITOR; METHYL 3 (6 CYANO 1H INDOL 2 YL)ACRYLATE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; NSC 357756; NU 126; NU 135; NU 145; NU 154; NU 176; NU 2 157; NU 2 168; PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; IC 50; OXIDATION REDUCTION REACTION;

BENZOFURANS; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHORYLATION; PROTEIN-TYROSINE-PHOSPHATASE; SUBSTRATE SPECIFICITY;

EID: 33745610883     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.036     Document Type: Article

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