Dissociation of airway inflammation and hyperresponsiveness by cyclooxygenase inhibition in allergen challenged mice

European Respiratory Journal

Volumn 34, Issue 1, 2009, Pages 200-208

  Swedin, L ^a   Neimert Andersson, T ^a   Hjoberg, J ^b   Jonasson, S ^b   Van Hage, M ^a   Adner, M ^a   Ryrfeldt, A ^a   Dahlen S E ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Airway hyperresponsiveness; Allergic mouse model; Cyclooxygenase inhibition; Eosinophilic allergic reaction; Prostaglandins

Indexed keywords

ALLERGEN; CYCLOOXYGENASE 1 INHIBITOR; DICLOFENAC; FR 122047; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; LUMIRACOXIB; METHACHOLINE; OVALBUMIN; PROSTAGLANDIN SYNTHASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE MODEL; ENZYME ACTIVITY; ENZYME INHIBITION; EOSINOPHIL; FEMALE; INFLAMMATORY CELL; LUNG LAVAGE; LUNG RESISTANCE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROVOCATION TEST; RESPIRATORY TRACT INFLAMMATION;

ALLERGENS; ANIMALS; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; FEMALE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INFLAMMATION; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C;

EID: 69249153835     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00030908     Document Type: Article

References (32)

1. Peebles RS Jr, Hashimoto K, Morrow JD, et al. Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice. Am J Respir Crit Care Med 2002; 165: 1154-1160.
2. Peebles RS Jr, Dworski R, Collins RD, et al. Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice. Am J Respir Crit Care Med 2000; 162: 676-681.
3. -/- mice. Am J Respir Crit Care Med 2003; 167: 1509-1515.
4. Gavett SH, Madison SL, Chulada PC, et al. Allergic lung responses are increased in prostaglandin H synthase-deficient mice. J Clin Invest 1999; 104: 721-732.
5. FitzGerald GA. COX-2 and beyond: approaches to prostaglandin inhibition in human disease. Nat Rev Drug Discov 2003; 2: 879-890.
6. Epstein MM. Do mouse models of allergic asthma mimic clinical disease? Int Arch Allergy Immunol 2004; 133: 84-100.
7. Mitchell JA, Akarasereenont P, Thiemermann C, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 1993; 90: 11693-11697.
8. Esser R, Berry C, Du Z, et al. Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. Br J Pharmacol 2005; 144: 538-550.
9. Ochi T, Motoyama Y, Goto T. The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models. Eur J Pharmacol 2000; 391: 49-54.
10. Barnas GM, Ho G, Green MD, et al. Effects of analysis method and forcing waveform on measurement of respiratory mechanics. Respir Physiol 1992; 89: 273-285.
11. Tomioka S, Bates JH, Irvin CG. Airway and tissue mechanics in a murine model of asthma: alveolar capsule vs forced oscillations. J Appl Physiol 2002; 93: 263-270.
12. Hjoberg J, Shore S, Kobzik L, et al. Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness. J Appl Physiol 2004; 97: 249-259.
13. Neimert-Andersson T, Thunberg S, Swedin L, et al. Carbohydrate-based particles reduce allergic inflammation in a mouse model for cat allergy. Allergy 2008; 63: 518-526.
14. Grootendorst DC, Rabe KF. Mechanisms of bronchial hyperreactivity in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 2004; 1: 77-87.
15. Hakonarson H, Halapi E, Whelan R, et al. Association between IL-1β/TNFα-induced glucocorticoid-sensitive changes in multiple gene expression and altered responsiveness in airway smooth muscle. Am J Respir Cell Mol Biol 2001; 25: 761-771.
16. Slats AM, Janssen K, van Schadewijk A, et al. Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma. J Allergy Clin Immunol 2008; 121: 1196-1202.
17. Card JW, Carey MA, Bradbury JA, et al. Cyclooxygenase-1 overexpression decreases basal airway responsiveness but not allergic inflammation. J Immunol 2006; 177: 4785-4793.
18. 2 as a mediator of allergic asthma. Science 2000; 287: 2013-2017.
19. Richter M, Sirois P. Effects of eicosanoids, neuromediators and bioactive peptides on murine airways. Eur J Pharmacol 2000; 389: 225-234.
20. 2 on airway tone. Am J Physiol Lung Cell Mol Physiol 2003; 284: L599-L606.
21. Penning TD, Talley JJ, Bertenshaw SR, et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H- pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J Med Chem 1997; 40: 1347-1365.
22. Gyles SL, Xue L, Townsend ER, et al. A dominant role for chemoattractant receptor-homologous molecule expressed on Thelper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants. Immunology 2006; 119: 362-368.
23. 3. Nat Immunol 2005; 6: 524-531.
24. 2 on allergen-induced airway responses and airway inflammation. Am J Respir Crit Care Med 1999; 159: 31-36.
25. 2 on allergen-induced asthma. Am Rev Respir Dis 1993; 148: 87-90.
26. 2 in airways of subjects with asthma. Am J Respir Crit Care Med 2000; 162: 637-640.
27. Wedmore CV, Williams TJ. Control of vascular permeability by polymorphonuclear leukocytes in inflammation. Nature 1981; 289: 646-650.
28. Williams TJ. Interactions between prostaglandins, leukotrienes and other mediators of inflammation. Br Med Bull 1983; 39: 239-242.
29. 2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. Nat Rev Drug Discov 2007; 6: 313-325.
30. Tomkinson A, Duez C, Cieslewicz G, et al. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J Immunol 2001; 166: 5792-5800.
31. Eum SY, Maghni K, Hamid Q, et al. Inhibition of allergic airways inflammation and airway hyperresponsiveness in mice by dexamethasone: role of eosinophils, IL-5, eotaxin, and IL-13. J Allergy Clin Immunol 2003; 111: 1049-1061.
32. Wardlaw AJ, Brightling CE, Green R, et al. New insights into the relationship between airway inflammation and asthma. Clin Sci (Lond) 2002; 103: 201-211.