Cyclooxygenase-1 overexpression decreases basal airway responsiveness but not allergic inflammation

Journal of Immunology

Volumn 177, Issue 7, 2006, Pages 4785-4793

  Card, Jeffrey W ^a   Carey, Michelle A ^a   Bradbury, J Alyce ^a   Graves, Joan P ^a   Lih, Fred B ^a   Moorman, Michael P ^a   Morgan, Daniel L ^a   DeGraff, Laura M ^a   Zhao, Yun ^a   Foley, Julie F ^a   Zeldin, Darryl C ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOKINE; ICOSANOID; METHACHOLINE; OVALBUMIN; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DISEASE EXACERBATION; EOSINOPHIL; GENE DISRUPTION; GENE OVEREXPRESSION; GENOTYPE; INFLAMMATION; LUNG FUNCTION; LUNG LAVAGE; LUNG MECHANICS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; STIMULUS RESPONSE; TRANSGENE; TRANSGENIC MOUSE; WILD TYPE;

EID: 33749123726     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.7.4785     Document Type: Article

References (30)

1. Zeldin, D. C., C. Wohlford-Lenane, P. Chulada, J. A. Bradbury, P. E. Scarborough, V. Roggli, R. Langenbach, and D. A. Schwartz. 2001. Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. Am. J. Respir. Cell Mol. Biol. 25: 457-465.
2. Gavett, S. H., S. L. Madison, P. C. Chulada, P. E. Scarborough, W. Qu, J. E. Boyle, H. F. Tiano, C. A. Lee, R. Langenbach, V. L. Roggli, and D. C. Zeldin. 1999. Allergic lung responses are increased in prostaglandin H synthase-deficient mice. J. Clin. Invest. 104: 721-732.
3. Bonner, J. C., A. B. Rice, J. L. Ingram, C. R. Moomaw, A. Nyska, A. Bradbury, A. R. Sessoms, P. C. Chulada, D. L. Morgan, D. C. Zeldin, and R. Langenbach. 2002. Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis. Am. J. Pathol. 161: 459-470.
4. Ermert, L., C. Dierkes, and M. Ermert. 2003. Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. Clin. Cancer Res. 9: 1604-1610.
5. Hardy, C. C., P. Bradding, C. Robinson, and S. T. Holgate. 1988. Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma. J. Appl. Physiol. 64: 1567-1574.
6. 2 on airway conductance in healthy subjects and asthmatic patients. Am. Rev. Respir. Dis. 111: 313-320.
7. 2 in normal and asthmatic men. N. Engl. J. Med. 311: 209-213.
8. 2 on allergen-induced airway responses and airway inflammation. Am. J. Respir. Crit. Care Med. 159: 31-36.
9. 2 on allergen-induced asthma. Am. Rev. Respir. Dis. 148: 87-90.
10. 2 on exercise-induced bronchoconstriction in asthmatic subjects. Am. J. Respir. Crit. Care Med. 149: 1138-1141.
11. 4 excretion in aspirin-sensitive asthma. Am. J. Respir. Crit. Care Med. 153: 572-575.
12. Carey, M. A., D. R. Germolec, R. Langenbach, and D. C. Zeldin. 2003. Cyclooxygenase enzymes in allergic inflammation and asthma. Prostaglandins Leukotrienes Essent. Fatty Acids 69: 157-162.
13. Peebles, R. S., Jr., K. Hashimoto, J. D. Morrow, R. Dworski, R. D. Collins, Y. Hashimoto, J. W. Christman, K. H. Kang, K. Jarzecka, J. Furlong, et al. 2002. Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hypenesponsiveness in mice. Am. J. Respir. Crit. Care Med. 165: 1154-1160.
14. Card, J. W., M. A. Carey, J. A. Bradbury, L. M. Degraff, D. L. Morgan, M. P. Moorman, G. P. Flake, and D. C. Zeldin. 2006. Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation. J. Immunol. 177: 621-630.
15. -/- mice. Am. J. Respir. Crit. Care Med. 167: 1509-1515.
16. Hayashi, T., Y. Adachi, K. Hasegawa, and M. Morimoto. 2003. Less sensitivity for late airway inflammation in males than females in BALB/c mice. Scand. J. Immunol. 57: 562-567.
17. Melgert, B. N., D. S. Postma, I. Kuipers, M. Geerlings, M. A. Luinge, B. W. van der Strate, H. A. Kerstjens, W. Timens, and M. N. Hylkema. 2005. Female mice are more susceptible to the development of allergic airway inflammation than male mice. Clin. Exp. Allergy 35: 1496-1503.
18. Morham, S. G., R. Langenbach, C. D. Loftin, H. F. Tiano, N. Vouloumanos, J. C. Jennette, J. F. Mahler, K. D. Kluckman, A. Ledford, C. A. Lee, and O. Smithies. 1995. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 83: 473-482.
19. Goncalves de Moraes, V. L., B. Boris Vargaftig, J. Lefort, A. Meager, and M. Chignard. 1996. Effect of cyclo-oxygenase inhibitors and modulators of cyclic AMP formation on lipopolysaccharide-induced neutrophil infiltration in mouse lung. Br. J. Pharmacol. 117: 1792-1796.
20. 2 in mice. J. Appl. Physiol. 88: 2214-2218.
21. 2 on airway tone. Am. J. Physiol. 284: L599-L606.
22. 2 protects lower airways against bronchoconstriction. Am. J. Physiol. 290: L105-L113.
23. Vichai, V., C. Suyamsesthakorn, D. Pittayakhajonwut, K. Sriklung, and K. Kirtikara. 2005. Positive feedback regulation of COX-2 expression by prostaglandin metabolites. Inflamm. Res. 54: 163-172.
24. 2 production and alters the gastric prostanoid profile. J. Biol. Chem. 279: 23229-23237.
25. MacNab, M. W., E. L. Foltz, B. S. Graves, R. K. Rinehart, S. L. Tripp, N. R. Feliciano, and S. Sen. 1984. The effects of a new thromboxane synthetase inhibitor, CGS-13080, in man. J. Clin. Pharmacol. 24: 76-83.
26. Rocca, B., L. M. Spain, E. Pure, R. Langenbach, C. Patrono, and G. A. FitzGerald. 1999. Distinct roles of prostaglandin H synthases 1 and 2 in T cell development. J. Clin. Invest. 103: 1469-1477.
27. 2. Trends Immunol. 25: 40-46.
28. 4 receptor agonist inhibits airways hyperreactivity and inflammation in murine models of asthma. Proc. Am. Thor. Soc. 3: A290.
29. 2 production is not sufficient for lung tumorigenesis in mice. Carcinogenesis 26: 209-217.
30. Geraci, M. W., B. Gao, D. C. Shepherd, M. D. Moore, J. Y. Westcott, K. A. Fagan, L. A. Alger, R. M. Tuder, and N. F. Voelkel. 1999. Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension. J. Clin. Invest. 103: 1509-1515.