Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum

American Journal of Veterinary Research

Volumn 70, Issue 8, 2009, Pages 992-1000

  Cook, Vanessa L ^a,b   Meyer, Colleen T ^a   Campbell, Nigel B ^a   Blikslager, Anthony T ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FIROCOXIB; FLUNIXIN MEGLUMINE; LIPOPOLYSACCHARIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; THROMBOXANE B2; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CONVALESCENCE; HORSE; INTESTINE INJURY; ISCHEMIA; JEJUNUM INJURY; JEJUNUM MUCOSA; MORPHOMETRICS; NONHUMAN; PAIN ASSESSMENT; PLASMA CONCENTRATION-TIME CURVE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

4-BUTYROLACTONE; ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOTTING, WESTERN; CLONIXIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; EICOSANOIDS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HORSE DISEASES; HORSES; ISCHEMIA; JEJUNAL DISEASES; SULFONES; THROMBOXANE B2;

ANIMALIA; EQUIDAE;

EID: 69249092286     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.70.8.992     Document Type: Article

References (46)

1. Wineland N. Part 1: baseline reference of 1998 equine health and management. In: National animal health monitoring system. Fort Collins, Colo: USDA, APHIS, Veterinary Services, Centers for Epidemiology and Animal Health, 1998;42-46.
2. Tinker MK, White NA, Lessard P, et al. Prospective study of equine colic incidence and mortality. Equine Vet J 1997;29:448-453. (Pubitemid 127519431)
3. Dabareiner RM, White NA, Donaldson LL. Effects of intraluminal distention and decompression on microvascular permeability and hemodynamics of the equine jejunum. Am J Vet Res 2001;62:225-236.
4. Little D, Tomlinson JE, Blikslager AT. Post operative neutrophilic inflammation in equine small intestine after manipulation and ischaemia. Equine Vet J 2005;37:329-335. (Pubitemid 40977428)
5. Tomlinson JE, Wilder BO, Young KM, et al. Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia. Am J Vet Res 2004;65:761-769.
6. Baskett A, Barton MH, Norton N, et al. Effect of pentoxifylline, flunixin meglumine, and their combination on a model of endotoxemia in horses. Am J Vet Res 1997;58:1291-1299. (Pubitemid 27479322)
7. Shuster R, Traub-Dargatz J, Baxter G. Survey of diplomates of the American College of Veterinary Internal Medicine and the American College of Veterinary Surgeons regarding clinical aspects and treatment of endotoxemia in horses. J Am Vet Med Assoc 1997;210:87-92. (Pubitemid 27037496)
8. Khanapure SP, Garvey DS, Janero DR, et al. Eicosanoids in inflammation: biosynthesis, pharmacology, and therapeutic frontiers. Curr Top Med Chem 2007;7:311-340.
9. MacAllister CG, Morgan SJ, Borne AT, et al. Comparison of adverse effects of phenylbutazone, flunixin meglumine, and ketoprofen in horses. J Am Vet Med Assoc 1993;202:71-77.
10. Read WK. Renal medullary crest necrosis associated with phenylbutazone therapy in horses. Vet Pathol 1983;20:662-669.
11. Reed SK, Messer NT, Tessman RK, et al. Effects of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses. Am J Vet Res 2006;67:398-402.
12. Campbell NB, Blikslager AT. The role of cyclooxygenase inhibitors in repair of ischaemic-injured jejunal mucosa in the horse. Equine Vet J Suppl 2000;32:59-64.
13. Blikslager AT, Roberts MC, Rhoads JM, et al. Prostaglandins 12 and E2 have a synergistic role in rescuing epithelial barrier function in porcine ileum. J Clin Invest 1997;100:1928-1933.
14. Hersh EV, Lally ET, Moore PA. Update on cyclooxygenase inhibitors: has a third COX isoform entered the fray? Curr Med Res Opin 2005;21:1217-1226.
15. Little D, Brown SA, Campbell NB, et al. Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum. Am J Vet Res 2007;68:614-624. (Pubitemid 47054509)
16. McCann ME, Andersen DR, Zhang D, et al. In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis. Am J Vet Res 2004;65:503-512.
17. McCann ME, Rickes EL, Hora DF, et al. In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in cats with lipopolysaccharide- induced pyrexia. Am J Vet Res 2005;66:1278-1284.
18. Doucet MY, Bertone AL, Hendrickson D, et al. Comparison of efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis. J Am Vet Med Assoc 2008;232:91-97.
19. Pritchett LC, Ulibarri C, Roberts MC, et al. Identification of potential physiological and behavioral indicators of postoperative pain in horses after exploratory celiotomy for colic. Appl Anim Behav Sci 2003;80:31-43. (Pubitemid 36035068)
20. Kvaternick V, Malinski T, Wortmann J, et al. Quantitative HPLC-UV method for the determination of firocoxib from horse and dog plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2007;854:313-319. (Pubitemid 46970743)
21. Cook VL, Jones Shults J, McDowell M, et al. Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine. Equine Vet J 2008;40:353-357. (Pubitemid 351881583)
22. Sellon DC, Roberts MC, Blikslager AT, et al. Effects of continuous rate intravenous infusion of butorphanol on physiologic and outcome variables in horses after celiotomy. J Vet Intern Med 2004;18:555-563.
23. Blikslager AT, Moeser AJ, Gookin JL, et al. Restoration of barrier function in injured intestinal mucosa. Physiol Rev 2007;87:545-564.
24. Gookin JL, Galanko JA, Blikslager AT, et al. PG-mediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum. Am J Physiol Gastrointest Liver Physiol 2003;285:G967-G979.
25. Collett A, Walker D, Sims E, et al. Influence of morphometric factors on quantitation of paracellular permeability of intestinal epithelia in vitro. Pharm Res 1997;14:767-773. (Pubitemid 27281672)
26. Marcial MA, Carlson SL, Madara JL Partitioning of paracellular conductance along the ileal crypt-villus axis: a hypothesis based on structural analysis with detailed consideration of tight junction structure-function relationships. J Membr Biol 1984;80:59-70.
27. Clark ES, Moore JN. The effects of slow infusion of a low dosage of endotoxin in healthy horses. Equine Vet J Suppl 1989;7:33-37.
28. Blikslager AT, Roberts MC. Mechanisms of intestinal mucosal repair. J Am Vet Med Assoc 1997;211:1437-1441.
29. Moeser AJ, Haskell MM, Shifflett DE, et al. ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum. Gastroenterology 2004;127:802-815.
30. Blikslager AT, Roberts MC, Argenzio RA. Prostaglandin-induced recovery of barrier function in porcine ileum is triggered by chloride secretion. Am J Physiol 1999;276:G28-G36.
31. Moeser AJ, Nighot PK, Ryan KA, et al. Prostaglandin-mediated inhibition of Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine. Am J Physiol Gastrointest Liver Physiol 2006;291:G885-G894.
32. Moeser AJ, Nighot PK, Engelke KJ, et al. Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone. Am J Physiol Gastrointest Liver Physiol 2007;292: G647-G656.
33. Argenzio RA, Liacos JA. Endogenous prostanoids control ion transport across neonatal porcine ileum in vitro. Am J Vet Res 1990;51:747-751.
34. Patrignani P, Sciulli MG, Manarini S, et al. COX-2 is not involved in thromboxane biosynthesis by activated human platelets. J Physiol Pharmacol 1999;50:661-667. (Pubitemid 30022144)
35. Gray PA, Warner TD, Vojnovic I, et al. Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors. Br J Pharmacol 2002;137:1031-1038. (Pubitemid 35440743)
36. Warner TD, Giuliano F, Vojnovic I, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A 1999;96:7563-7568. (Pubitemid 29299702)
37. Kudo I, Murakami M. Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis. J Biochem Mol Biol 2005;38:633-638. (Pubitemid 43240966)
38. Murakami M, Kudo I. Prostaglandin E synthase: a novel drug target for inflammation and cancer. Curr Pharm Des 2006; 12:943-954.
39. Tomimoto H, Shibata M, Ihara M, et al. A comparative study on the expression of cyclooxygenase and 5-lipoxygenase during cerebral ischemia in humans. Acta Neuropathol 2002;104:601-607. (Pubitemid 36075425)
40. Little D, Jones SL, Blikslager AT. Cyclooxygenase (COX) inhibitors and the intestine. J Vet Intern Med 2007;21:367-377. (Pubitemid 46814181)
41. Sato N, Kozar RA, Zou L, et al. Peroxisome proliferator-activated receptor gamma mediates protection against cyclooxygenase-2-induced gut dysfunction in a rodent model of mesenteric ischemia/reperfusion. Shock 2005;24:462-469. (Pubitemid 41567359)
42. Liu YT, Kardosh A, Cooc J, et al. Potential misidentification of cyclooxygenase-2 by Western blot analysis and prevention through the inclusion of appropriate controls. Mol Biotechnol 2006;34:329-335. (Pubitemid 46220192)
43. Blikslager AT, Yin C, Cochran AM, et al. Cyclooxygenase expression in the early stages of equine laminitis: a cytologic study. J Vet Intern Med 2006;20:1191-1196. (Pubitemid 44621050)
44. Ward DS, Fessier JF, Bottoms GD, et al. Equine endotoxemia: cardiovascular, eicosanoid, hematologic, blood chemical, and plasma enzyme alterations. Am J Vet Res 1987;48:1150-1156.
45. Parry BW, Anderson GA, Gay CC. Prognosis in equine colic: a comparative study of variables used to assess individual cases. Equine Vet J 1983;15:211-215.
46. Tudor RA, Papich MG, Redding WR. Drug disposition and dosage determination of once daily administration of gentamicin sulfate in horses after abdominal surgery. J Am Vet Med Assoc 1999;215:503-506.