Myocardial recovery by mechanical unloading with left ventricular assist system

Circulation Journal

Volumn 73, Issue 8, 2009, Pages 1386-1392

  Matsumiya, Goro ^a   Saitoh, Shunsuke ^a   Sakata, Yasushi ^a   Sawa, Yoshiki ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cardiomyopathy; Heart failure; Left ventricular assist device; Reverse remodeling

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; ALDOSTERONE ANTAGONIST; ANGIOTENSIN II ANTAGONIST; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISOPROLOL; CARVEDILOL; CLENBUTEROL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LISINOPRIL; LOSARTAN; SPIRONOLACTONE;

CARDIOMYOPATHY; CONGESTIVE HEART FAILURE; CONVALESCENCE; DISEASE COURSE; DRUG EFFECT; DRUG SUBSTITUTION; EXPERIENCE; HEART ASSIST DEVICE; HEART FUNCTION; HEART LEFT VENTRICLE FUNCTION; HEART PERFORMANCE; HUMAN; LEFT VENTRICULAR ASSIST DEVICE; PREDICTION; REVIEW;

HEART FAILURE; HEART-ASSIST DEVICES; HUMANS; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT;

EID: 69049108988     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-09-0396     Document Type: Review

References (44)

1. Miura K, Matsumori A, Nasermoaddeli A, Soyama Y, Morikawa Y, Sakurai M, et al. Prognosis and prognostic factors in patients with idiopathic dilated cardiomyopadiy in Japan: Results from a nationwide study. Circ J 2008; 72: 343-348. (Pubitemid 351600624)
2. Matsuda H, Matsumiya G. Current status of left ventricular assist devices: The role in bridge to heart transplantation and future perspectives. J Artif Organs 2003; 6: 157-161. (Pubitemid 37229235)
3. Rose EA, Gelijns AC, Moskowitz AJ, Heitjan DF, Stevenson LW, Dembitsky W, et al, Randomized EVALUATION OF MECHANICAL ASSISTANCE for the Treatment of Congestive Heart Failure (REMATCH) Study Group: Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med 2001; 345: 1435-1443.
4. Müller J, Wallukat G, Weng YG, Dandel M, Spiegelsberger S, Semrau S, et al. Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy. Circulation 1997; 96: 542-549. (Pubitemid 27329431)
5. Frazier OH, Myers TJ. Left ventricular assist system as a bridge to myocardial recovery. Ann Thorac Surg 1999; 68: 734-741. (Pubitemid 29527024)
6. Matsumiya G, Monta O, Fukushima N, Sawa Y, Funatsu T, Toda K, et al. Who would be a candidate for bridge to recovery during prolonged mechanical left ventricular support in idiopathic dilated cardiomyopathy? J Thorac Cardiovasc Surg 2005; 130: 699-704. (Pubitemid 41265707)
7. Birks EJ, Tansley PD, Hardy J, George RS, Bowler CT, Burke M, et al. Left ventricular assist device and drug therapy for the reversal of heart failure. N Engl J Med 2006; 355: 1873-1884. (Pubitemid 44664645)
8. Burkhoff D, Klotz S, Mancini DM. LVAD-induced reverse remodeling: Basic and clinical implications for myocardial recovery. J Cardiac Fail 2006; 12: 227-239.
9. Drakos SG, Terrovitis JV, Anastasiou-Nana MI, Nanas JN. Reverse remodeling during long-term mechanical unloading of the left ventricle. J Mol Cell Cardiol 2007; 43: 231-242.
10. Dandel M, Weng Y, Siniawski H, Evgenij P, Drews T, Lehmkuhl HB, et al. Prediction of cardiac stability after weaning from left ventricular assist devices in patients with idiopathic dilated cardiomyopathy. Circulation 2008; 118(Suppl): S94-S105.
11. Maybaum S, Mancini D, Xydas S, Starling R, Aaronson K, Pagani FD, et al. Cardiac improvement during mechanical circulatory support: A prospective multicenter study of the LVAD working group. Circulation 2007; 115: 2497-2505. (Pubitemid 46763223)
12. Geroge RS, Yacoub MH, Tasca G, Webb C, Bowles CT, Tansley P, et al. Hemodynamic and echocardiographic responses to acute interruption of left ventricular assist device support: Relevance to assessment of myocardial recovery. J Heart Lung Transplant 2007; 26: 967-973. (Pubitemid 47500147)
13. Matsumiya G, Miyamoto Y, Monta O, Takano H, Sawa Y, Matsuda H. Left ventricular restoration for ischemic cardiomyopathy and simultaneous implantation of left ventricular assist system actively aiming at bridge to recovery. J Thorac Cardiovasc Surg 2005; 130: 219-220. (Pubitemid 40941699)
14. Nishimura M, Ogiwara M, Ishikawa M, Imanaka K, Okamura N, Kato M, et al. Successful bridge to resynchronization therapy with a left ventricular assist system in a patient with idiopathic dilated cardiomyopadiy. J Artif Organs 2005; 8: 210-213. (Pubitemid 41464680)
15. Nasseri BA, Kukucka M, Dandel M, Knosalla C, Potapov E, Lehmkuhl HB, et al. Intramyocardial delivery of bone marrow mononuclear cells and mechanical assist device implantation in patients with end-stage cardiomyopathy. Cell Transplant 2007; 16: 941-949.
16. Miyagawa S, Matsumiya G, Funatsu T, Yoshitatsu M, Sekiya N, Fukui S, et al. Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopadiy with left ventricular assist system implantation: Report of a case. Surg Today 2009; 39: 133-136.
17. Nakatani S, McCarthy PM, Kottke-Marchant K, Harasaki H, James KB, Savage RM, et al. Left ventricular echocardiographic and histologic changes: Impact of chronic unloading by an implantable ventricular assist device. J Am Coll Cardiol 1996; 27: 894-901. (Pubitemid 26104871)
18. James KB, McCarthy PM, Thomas JD, Vargo R, Hobbs RE, Sapp S, et al. Effect of the implantable left ventricular assist device on neuroendocrine activation in heart failure. Circulation 1995; 92(Suppl II): II-191-II-195.
19. Mancini DM, Beniaminovitz A, Levin H, Catanese K, Flannery M, DiTullio M, et al. Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure. Circulation 1998; 98: 2383-2389. (Pubitemid 28549781)
20. Simon MA, Kormos RL, Murali S, Nair P, Heffeman M, Gorcsan J, et al. Myocardial recovery using ventricular assist devices: Prevalence, clinical characteristics, and outcomes. Circulation 2005; 112(Suppl): I-32-I-36. (Pubitemid 41266650)
21. Sodian R, Loebe M, Schmitt C, Potapov EV, Siniawski H, Müller J, et al. Decreased plasma concentration of brain natriuretic peptide as a potential indicator of cardiac recovery in patients supported by mechanical circulatory assist systems. J Am Coll Cardiol 2001; 38: 1942-1949. (Pubitemid 33116568)
22. Kinoshita M, Takano H, Takaichi S, Taenaka Y, Nakatani T. Influence of prolonged ventricular assistance on myocardial histopathology in intact heart. Ann Thorac Surg 1996; 61: 640-645. (Pubitemid 26060894)
23. Thohan V, Stetson SJ, Nagueh SF, Rivas-Gotz C, Koerner MM, Lafuente JA, et al. Cellular and hemodynamics responses of failing myocardium to continuous flow mechanical circulatory support using the DeBakey-Noon left ventricular assist device: A comparative analysis with pulsatile-type devices. J Heart Lung Transplant 2005; 24: 566-575. (Pubitemid 40693879)
24. Zefeiridis A, Jeevanandam V, Houser SR, Margulies KB. Regression ofcellular hypertrophy after left ventricular assist device support. Circulation 1998; 98: 656-662. (Pubitemid 28387492)
25. Barbone A, Holmes JW, Heerdt PM, The' AH, Naka Y, Joshi N, et al. Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure: A primary role of mechanical unloading underlying reverse remodeling. Circulation 2001; 104: 670-675. (Pubitemid 32738521)
26. De Jonge N, van Wichen DF, Schipper MEI, Lahpor JR, Gmelig-Meyting FHJ, Robles de Medina EO, et al. Left ventricular assist device in end-stage heart failure: Persistence of structural myocyte damage after unloading: An immunohistochemical analysis of the contractile myofilaments. J Am Coll Cardiol 2002; 39: 963-969. (Pubitemid 34234117)
27. Vatta M, Stetson SJ, Perez-Verdia A, Entman ML, Noon GP, Torre-Amione G, et al. Molecular remodeling of dystrophin in patients with end-stage cardiomyopathies and reversal in patients on assistance-device therapy. Lancet 2002; 359: 936-941. (Pubitemid 34246384)
28. Bruckner BA, Stetson SJ, Perez-Verdia A, Youker KA, Radovancevic B, Connelly JH, et al. Regression of fibrosis and hypertrophy in failing myocardium following mechanical circulatory support. J Heart Lung Transplant 2001; 20: 457-464. (Pubitemid 32297756)
29. Klotz S, Foronjy RF, Dickstein ML, Gu A, Garrelds IM, Danser J, et al. Mechanical unloading during left ventricular assist device support increases left ventricular collagen cross-linking and myocardial stiffness. Circulation 2005; 112: 364-374.
30. Bruggink AH, va Oosterhout MFM, de Jonge N, Ivangh B, van Kuik J, Voorbij AM, et al. Reverse remodeling of the myocardial extracellular matrix after prolonged left ventricular assist device support follows a biphasic pattern. J Heart Lung Transplant 2006; 25: 1091-1098.
31. Torre-Amione G, Frazier OH, Starling R, Miller L, Aaronson K, Murali S, et al. Cellular regression of fibrosis and hypertrophy following chronic LVAD support does not translate into sustained improvements in contractile function: Results from the LVAD Working Group. J Card Fail 2003; 9: S10.
32. Francis GS, Anwar F, Bank AJ, Kubo SH, Jessurun J. Apoptosis, Bcl-2, and proliferating cell nuclear antigen in the failing human heart: Observations made after implantation of left ventricular assist device. J Card Fail 1999; 5: 308-315. (Pubitemid 30033672)
33. Baba HA, Stypmann J, Grabellus F, Kirchhof P, Sokoll A, Schafers M, et al. Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: Myocardial mechanotransduction-sensitivity as a possible molecular mechanism. Cardiovasc Res 2003; 59: 390-399. (Pubitemid 37272033)
34. Bartling B, Milting H, Schumann H, Darmer D, Arusoglu L, Koemer MM, et al. Myocardial gene expression of regulators of myocyte apoptosis and myocyte calcium homeostasis during hemodynamic unloading by ventricular assist devices in patients with end-stage heart failure. Circulation 1999; 100(Suppl II): II-216-II-223. (Pubitemid 29523538)
35. Grabellus F, Levkau B, Sokoll A, Welp H, Schmid C, Deng MC, et al. Reversible activation of nuclear factor-kappaB in human end-stage heart failure after left ventricular mechanical support. Cardiovasc Res 2002; 53: 124-130. (Pubitemid 34020772)
36. Ogletree-Hughes ML, Stull LB, Sweet WE, Smedira NG, McCarthy PM, Movarec CS. Mechanical unloading restores β-adrenergic responsiveness and reverses receptor downregulation in the failing human heart. Circulation 2001; 104: 881-886.
37. Terracciano CM, Harding SE, Adamson D, Koban M, Tansley P, Birks EJ, et al. Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy. Eur Heart J 2003; 24: 1329-1339. (Pubitemid 36917704)
38. Bruckner BA, Razeghi P, Stetson S, Thompson L, Lafuente J, Entman M, et al. Degree of cardiac fibrosis and hypertrophy at time of implantation predicts myocardial improvement during left ventricular assist device support. J Heart Lung Transplant 2004; 23: 36-42. (Pubitemid 38084828)
39. Takeda K, Matsumiya G, Sakaguchi T, Matsue H, Masai T, Otake S, et al. Long-term results of left ventricular reconstructive surgery in patients with ischemic dilated cardiomyopadiy: A multicenter study. Circ J 2008; 72: 1730-1736.
40. Fowler MB. Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Trial: Carvedilol in severe heart failure. Am J Cardiol 2004; 93(Suppl 1): 35-39.
41. Klotz S, Danser AH, Foronjy RF, Oz MC, Wang J, Mancini D, et al. The impact of angiotensin-converting enzyme inhibitor therapy on the extracellular collagen matrix during left ventricular assist device support in patients with end-stage heart failure. J Am Coll Cardiol 2007; 49: 1166-1174. (Pubitemid 46400328)
42. Tevaearai HT, Eckhart AD, Walton GB, Keys JR, Wilson K, Koch WJ. Myocardial gene transfer and overexpression of β2 adrenergic receptors potentiates the functional recovery of unloaded failing hearts. Circulation 2002; 106: 124-129. (Pubitemid 34747452)
43. Barton PJR, Felkin LE, Birks EJ, Cullen ME, Banner NR, Grindle S, et al. Myocardial insulin-like growth factor I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy. Circulation 2005; 112(Suppl I): I-46-I-50. (Pubitemid 41266652)
44. Kamalakkannan G, Petrilli CM, George I, LaManca J, McLaughlin BT, Shane E, et al. Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure. J Heart Lung Transplant 2008; 27: 457-461.