Novel preparation techniques for controlling microbubble uniformity: A comparison

Medical and Biological Engineering and Computing

Volumn 47, Issue 8, 2009, Pages 883-892

  Stride, Eleanor ^a   Edirisinghe, Mohan ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Coaxial electrohydrodynamic; Contrast agents; Drug delivery; Microbubbles; Microfluidic; T junction; Ultrasound

Indexed keywords

COAXIAL ELECTROHYDRODYNAMIC; CONTRAST AGENTS; MICROBUBBLES; T-JUNCTION; ULTRASOUND;

ACOUSTIC WAVES; DRUG DELIVERY; ELECTROHYDRODYNAMICS; FLUID DYNAMICS; IMAGING TECHNIQUES; ULTRASONIC APPLICATIONS; ULTRASONIC IMAGING; ULTRASONICS;

MICROFLUIDICS;

ECHO CONTRAST MEDIUM;

ACCURACY; ACOUSTICS; ARTICLE; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; ECHOGRAPHY; HYDRODYNAMICS; MATHEMATICAL ANALYSIS; MICROBUBBLE; MICROFLUIDIC ANALYSIS; NEBULIZATION; PARTICLE SIZE; QUANTITATIVE ANALYSIS; SIGNAL PROCESSING; TECHNOLOGY; TISSUE PERFUSION; ULTRASOUND;

ACOUSTICS; CONTRAST MEDIA; DRUG DELIVERY SYSTEMS; HUMANS; MICROBUBBLES; MICROFLUIDICS; MODELS, THEORETICAL; PARTICLE SIZE; SONICATION;

EID: 69049093765     PISSN: 01400118     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11517-009-0490-8     Document Type: Article

References (50)

1. Ahmad Z, Zhang H, Farook U, Edirisinghe M, Stride E, Colombo P (2008) Generation of multi-layered structures for biomedical applications using a novel tri-needle co-axial device and electrohydrodynamic flow. J R Soc Interface 5:1255-1261
2. Albrecht T, Blomley MJK, Heckemann RA, Cosgrove DO, Jayaram V, Butler-Barnes J, Eckersley RJ, Hoffmann CW, Bauer A (2000) Stimulated acoustic emission with the ultrasound contrast agent levovist: A clinically useful contrast effect with liver-specific properties. Rofo-Fortschritte Auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren 172:61-67
3. Al-Mansour HA, Mulvagh SL, Pumper GM, Klarich KW, Foley DA (2000) Usefulness of harmonic imaging for left ventricular opacification and endocardial border delineation by Optison. Am J Cardiol 85:795-799
4. Anna SL, Bontoux N, Stone HA (2003) Formation of dispersions using "flow focusing" in microchannels. Appl Phys Lett 82:364-366
5. Borden MA, Longo ML (2002) Dissolution behavior of lipid monolayer-coated, air-filled microbubbles: Effect of lipid hydrophobic chain length. Langmuir 18:9225-9233
6. Bull JL (2007) The application of microbubbles for targeted drug delivery. Expert Opin Drug Deliv 4:475-493
7. Christiansen C, Kryvi H, Sontum PC, Skotland T (1994) Physical and biochemical-characterization of Albunex(Tm), a new ultrasound contrast agent consisting of air-filled albumin microspheres suspended in a solution of human albumin. Biotechnol Appl Biochem 19:307-320
8. Church CC (1995) The effects of an elastic solid-surface layer on the radial pulsations of gas-bubbles. J Acoust Soc Am 97:1510-1521
9. Cosgrove D (2006) Ultrasound contrast agents: An overview. Eur J Radiol 60:324-330
10. Coussios CC, Farny CH, Ter Haar G, Roy RA (2007) Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU). Int J Hyperthermia 23:105-120
11. de Jong N, Hoff L, Skotland T, Bom N (1992) Absorption and scatter of encapsulated gas filled microspheres - theoretical considerations and some measurements. Ultrasonics 30:95-103
12. Dollet B, van Hoeve W, Raven JP, Marmottant P, Versluis M (2008) Role of the channel geometry on the bubble pinch-off in flow-focusing devices. Phys Rev Lett 1:034504-1-034504-4
13. Epstein PS, Plesset MS (1950) On the stability of gas bubbles in liquid-gas solutions. J Chem Phys 18:1505-1509
14. Farook U, Zhang HB, Edirisinghe MJ, Stride E, Saffari N (2007) Preparation of microbubble suspensions by co-axial electrohydrodynamic atomization. Med Eng Phys 29:749-754
15. Farook U, Stride E, Edirisinghe MJ, Moaleji R (2007) Microbubbling by co-axial electrohydrodynamic atomization. Med Biol Eng Comput 45:781-789
16. Farook U, Stride E, Edirisinghe M (2009) Preparation of suspensions of phospholipid-coated microbubbles by coaxial electrohydrodynamic atomisation. J R Soc Interface 6:271-277
17. Farook U, Stride E, Edirisinghe MJ (2009) Stability of microbubbles prepared by co-axial electrohydrodynamic atomisation. Eur Biophys J. doi: 10.1007/s00249-008-0391-z
18. Feshitan JA, Chen CC, Kwan JJ, Borden MA (2009) Microbubble size isolation by differential centrifugation. J Colloid Interface Sci 329:316-324
19. Garstecki P, Gitlin I, DiLuzio W, Whitesides GM, Kumacheva E, Stone HA (2004) Formation of monodisperse bubbles in a microfluidic flow-focusing device. Appl Phys Lett 85:2649-2651
20. Grinstaff MW, Suslick KS (1991) Air-filled proteinaceous microbubbles: synthesis of an Echo-contrast agent. Proc Natl Acad Sci USA 88:7708-7710
21. Heppner P, Lindner JR (2005) Contrast ultrasound assessment of angiogenesis by perfusion and molecular imaging. Expert Rev Mol Diagn 5:447-455
22. Hettiarachchi K, Talu E, Longo ML, Dayton PA, Lee AP (2007) On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging. Lab Chip 7:463-468
23. Hilgenfeldt S, Lohse D, Zomack M (2000) Sound scattering and localized heat deposition of pulse-driven microbubbles. J Acoust Soc Am 107:3530-3539
24. Hill CR, Bamber J, Ter Haar G (2004) Physical principles of medical ultrasound, Chap 3, 2nd edn. Wiley/Blackwell, Chichester, UK
25. Hoff L, Sontum PC, Hovem JM (2000) Oscillations of polymeric microbubbles: Effect of the encapsulating shell. J Acoust Soc Am 107:2272-2280
26. Kaneko Y, Maruyama T, Takegami K, Watanabe T, Mitsui H, Hanajiri K, Nagawa HA, Matsumoto Y (2005) Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue. Eur Radiol 15:1415-1420
27. Klibanov AL (2006) Microbubble contrast agents - targeted ultrasound imaging and ultrasound-assisted drug-delivery applications. Invest Radiol 41:354-362
28. Leen E, Ceccotti P, Kalogeropoulou C, Angerson WJ, Moug SJ, Horgan PG (2006) Prospective multicenter trial evaluating a novel method of characterizing focal liver lesions using contrast-enhanced sonography. Am J Roentgenol 186:1551-1559
29. Lepper W, Belcik T, Wei K, Lindner JR, Sklenar J, Kaul S (2004) Myocardial contrast echocardiography. Circulation 109:3132-3135
30. Loscertales IG, Barrero A, Guerrero I et al (2002) Micro/nano encapsulation via electrified coaxial liquid jets. Science 295:1695-1698
31. Marmottant P, Hilgenfeldt S (2003) Controlled vesicle deformation and lysis by single oscillating bubbles. Nature 423:153-156
32. Marmottant P, van der Meer S, Emmer M, Versluis M, de Jong N, Hilgenfeldt S, Lohse D (2005) A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture. J Acoust Soc Am 118:3499-3505
33. McDonald DM, Choyke PL (2003) Imaging of angiogenesis: From microscope to clinic. Nat Med 9:713-725
34. Mor-Avi V, Bednarz J, Weinert L, Sugeng L, Lang RM (2000) Power Doppler imaging as a basis for automated endocardial border detection during left ventricular contrast enhancement. Echocardiogr A J Cardiovasc Ultrasound Allied Tech 17:529-537
35. Nyborg W (2007) WFUMB safety symposium on echo-contrast agents: mechanisms for the interaction of ultrasound. Ultrasound Med Biol 33:224-232
36. Pancholi K, Stride E, Edirisinghe M (2008) Dynamics of bubble formation in highly viscous liquids. Langmuir 24:4388-4393
37. Pancholi KP, Farook U, Moaleji R, Stride E, Edirisinghe MJ (2008) Novel methods for preparing phospholipid coated microbubbles. Eur Biophys J Biophys Lett 37:515-520
38. Pancholi K, Stride E, Edirisinghe M (2008) Generation of microbubbles for diagnostic and therapeutic applications using a novel device. J Drug Target 16:494-501
39. Postema M, van Wamel A, Lancee CT, de Jong N (2004) Ultrasound-induced encapsulated microbubble phenomena. Ultrasound Med Biol 30:827-840
40. Schneider M (2008) Molecular imaging and ultrasound-assisted drug delivery. J Endourol 22:795-801
41. Stride E (2008) The influence of surface adsorption on microbubble dynamics. Philos Transact R Soc A Math Phys Eng Sci 366:2103-2115
42. Stride E, Edirisinghe M (2008) Novel microbubble preparation technologies. Soft Matter 4:2350-2359
43. Stride E, Tang M, Eckersley RJ (2008) Physical phenomena affecting quantitative imaging of ultrasound contrast agents. Appl Acoust doi: 10.1016/j.apacoust.2008.10.003
44. Suslick KS, Didenko Y, Fang MM, Hyeon T, Kolbeck KJ, McNamara WB, Mdleleni MM, Wong M (1999) Acoustic cavitation and its chemical consequences. Philos Trans R Soc Lond Ser A Math Phys Eng Sci 357:335-353
45. Talu E, Hettiarachchi K, Zhao S, Powell RL, Lee AP, Longo ML, Dayton PA (2007) Tailoring the size distribution of ultrasound contrast agents: Possible method for improving sensitivity in molecular imaging. Mol Imaging 6:384-392
46. Talu E, Hettiarachchi K, Powell RL, Lee AP, Dayton PA, Longo ML (2008) Maintaining monodispersity in a microbubble population formed by flow-focusing. Langmuir 24:1745-1749
47. Unger EC, McCreery TP, Sweitzer RH, Caldwell VE, Wu YQ (1998) Acoustically active lipospheres containing paclitaxel: A new therapeutic ultrasound contrast agent. Invest Radiol 33:886-892
48. Wang WH, Moser CC, Wheatley MA (1996) Langmuir trough study of surfactant mixtures used in the production of a new ultrasound contrast agent consisting of stabilized microbubbles. J Phys Chem 100:13815-13821
49. Xu S, Nie Z, Seo M, Lewis P, Kumacheva E, Stone HA, Garstecki P, Weibel DB, Gitlin I, Whitesides GM (2005) Generation of monodisperse particles by using microfluidics: Control over size, shape, and composition (vol 44, pg 724, 2005). Angew Chem Int Ed 44:3799
50. Zhao YZ, Liang HD, Mei XG, Halliwell M (2005) Preparation, characterization and in vivo observation of phospholipid-based gas-filled microbubbles containing hirudin. Ultrasound Med Biol 31:1237-1243