Preparation of suspensions of phospholipid-coated microbubbles by coaxial electrohydrodynamic atomization

Journal of the Royal Society Interface

Volumn 6, Issue 32, 2009, Pages 271-277

  Farook, U ^a   Stride, E ^a   Edirisinghe, M J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Coaxial electrohydrodynamic atomization; Microbubbles; Phospholipid

Indexed keywords

AIR; ATOMIZATION; ELECTRIC FIELDS; ELECTROHYDRODYNAMICS; FLOW RATE; FLUID DYNAMICS; JETS; MEDICAL APPLICATIONS; POLYDISPERSITY; SIZE DISTRIBUTION; STANDARDIZATION; SUSPENSIONS (FLUIDS);

AIR FLOW; AIR FLOW-RATE; AMBIENT TEMPERATURES; APPLIED ELECTRIC FIELD; BUBBLE DIAMETER; COAXIAL ELECTROHYDRODYNAMIC ATOMIZATION; ELECTROHYDRODYNAMIC ATOMIZATION; HIGHER TEMPERATURES; HUMAN BODY TEMPERATURE; MEAN DIAMETER; MECHANICAL AGITATION; MICROBUBBLE SUSPENSION; MICROBUBBLES; NARROW SIZE DISTRIBUTIONS; POLYDISPERSE; PREPARATION METHOD; SCALING EQUATIONS; SIZE AND SIZE DISTRIBUTIONS; STANDARD DEVIATION; SUSPENSION FLOWS;

PHOSPHOLIPIDS;

PHOSPHOLIPID; CONTRAST MEDIUM; PHOSPHATIDYLCHOLINE;

AIRFLOW; ARTICLE; BODY TEMPERATURE; COAXIAL ELECTROHYDRODYNAMIC ATOMIZATION; ENVIRONMENTAL TEMPERATURE; FLOW RATE; MICROBUBBLE; NEBULIZATION; PARTICLE SIZE; SUSPENSION; CHEMISTRY; ELECTRIC CONDUCTIVITY; SURFACE TENSION; SYNTHESIS; VISCOSITY;

CONTRAST MEDIA; ELECTRIC CONDUCTIVITY; MICROBUBBLES; PHOSPHATIDYLCHOLINES; SURFACE TENSION; VISCOSITY;

EID: 64549098216     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2008.0225     Document Type: Article

References (26)

1. Borden, M. A. & Longo, M. L. 2002 Dissolution behaviour of lipid monolayer-coated, air-filled microbubbles: effect of lipid hydrophobic chain length. Langmuir 18, 9225-9233. (doi:10.1021/la026082h)
2. Borden, M. A., Dayton, P., Zhao, S. & Ferrara, K. W. 2004a Physico-chemical properties of the microbubble lipid shell. In 2004 IEEE Int. Ultrasonics, Ferroelectrics, and Frequency Control Joint 50th Anniversary Conference, pp. 20-23.
3. Borden, M. A., Pu, G., Runner, G. J. & Longo, M. L. 2004b Surface phase behaviour and microstructure of lipid/PEGemulsifier monolayer-coated microbubbles. Colloids Surf. B: Biointerfaces 35, 209-223. (doi:10.1016/j. colsurfb.2004.03.007)
4. Borden, M. A., Kruse, D. E., Caskey, C. F., Zhao, S. K., Dayton, P. & Ferrara, K. W. 2005 Influence of lipid shell physiochemical properties on ultrasound-induced microbubble destruction. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 52, 1992-2002. (doi:10.1109/TUFFC.2005.1561668)
5. Borden, M. A., Caskey, C. F., Little, E., Gillies, R. J. & Ferrara, K. W. 2007 DNA and polylysine adsorption and multilayer construction onto cationic lipid-coated microbubbles. Langmuir 23, 9401-9408. (doi:10.1021/ la7009034) (Pubitemid 47383531)
6. Farook, U., Zhang, H. B., Edirisinghe, M. J., Stride, E. & Saffari, N. 2007a Preparation of microbubble suspensions by co-axial electrohydrodynamic atomization. Med. Eng. Phys. 29, 749-754. (doi:10.1016/j.medengphy.2006.08.009)
7. Farook, U., Stride, E., Edirisinghe, M. J. & Moaleji, R. 2007b Microbubbling by co-axial electrohydrodynamic atomization. Med. Biol. Eng. Comput. 45, 781-789. (doi:10.1007/s11517-007-0210-1)
8. Farook, U., Edirisinghe, M. J., Stride, E. & Colombo, P. 2008 Novel co-axial electrohydrodynamic in-situ preparation of liquid-filled polymer-shelled microspheres for biomedical applications. J. Microencapsul. 25, 241-247 (doi:10.1080/02652040801896666)
9. Ganan-Calvo, A. M. 2004 Perfectly monodisperse microbubbling by capillary flow focusing: an alternate physical description and universal scaling. Phys. Rev. E 69, 027 301-027 303. (doi:10.1103/PhysRevE.69.027301)
10. Garstecki, P., Ganan-Cavo, A. M. & Whitesides, G. M. 2005 Formation of bubbles and droplets in microfluidic systems. Bull. Pol. Acad. Tech. 53, 361-372.
11. Hettiarachchi, K., Talu, E., Longo, M. L., Dayton, P. A. & Lee, A. P. 2007 On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging. Lab Chip 7, 463-468. (doi:10.1039/b701481n) (Pubitemid 46496557)
12. Jayasinghe, S. N. & Edirisinghe, M. J. 2002 Effect of viscosity on the size of relics produced by electrostatic atomization. J. Aerosol Sci. 33, 1379-1388. (doi:10.1016/S0021-8502(02)00088-5)
13. Klibanov, A. L., Hughes, M. S., Wojdyla, J. K., Wible, J. H. & Brandenburger, G. H. 2002 Destruction of contrast agent microbubbles in the ultrasound field: the fate of the microbubble shell and the importance of the bubble gas content. Acad. Radiol. 9, S41-S45. (doi:10.1016/S1076-6332(03)80393- 8)
14. Krasovitski, B. & Kimmel, E. 2006 Stability of an encapsulated bubble shell. Ultrasonics 44, 216-220. (doi:10.1016/j.ultras.2005.11.003) (Pubitemid 43199482)
15. Ku, B. K. & Kim, S. S. 2002 Electrospray characteristics of highly viscous liquids. J. Aerosol Sci. 33, 1361-1378. (doi:10.1016/S0021-8502(02) 00075-7)
16. Lopez-Herrera, J. M., Barrero, A., Lopez, A., Loscertales, I. G. & Marquez, M. 2003 Coaxial jets generated from electrified Taylor cones. Scaling laws. J. Aerosol Sci. 34, 535-552. (doi:10.1016/S0021-8502(03)00021-1)
17. Loscertales, I. G., Barrero, A., Guerrero, I., Cortijo, R., Marquez, M. & Ganan-Calvo, A. M. 2002 Micro/nano encapsulation via electrified coaxial liquid jets. Science 295, 1695-1698. (doi:10.1126/science.1067595) (Pubitemid 34202901)
18. Pancholi, K., Stride, E. & Edirisinghe, M. J. 2008 Dynamics of bubble formation in highly viscous liquids. Langmuir 24, 4388-4393. (doi:10.1021/la703849x) (Pubitemid 351569056)
19. Raisinghani, A. & DeMaria, A. N. 2002 Physical principles of microbubble ultrasound contrast agents. Am. J. Cardiol. 90, 3J-7J. (doi:10.1016/S0002-9149(02)02858-8)
20. Soetanto, K. & Chan, M. 2000 Study on the lifetime and attenuation properties of microbubbles coated with carboxylic acid salts. Ultrasonics 38, 969-977. (doi:10.1016/S0041-624X(00)00027-5) (Pubitemid 32033647)
21. Stride, E. & Saffari, N. 2003 Microbubble ultrasound contrast agents: a review. Proc. Inst. Mech. Eng. Part H: J. Eng. Med. 217, 429-447. (doi:10.1243/09544110360729072)
22. Stride, E. & Saffari, N. 2005 Investigating the significance of multiple scattering in ultrasound contrast agent particle populations. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 52, 2332-2345. (doi:10.1109/TUFFC. 2005.1563278)
23. Stride, E., Pancholi, K., Edirisinghe, M. J. & Samarasinghe, S. 2008 Increasing the nonlinear character of microbubble oscillations at low acoustic pressures. J. R. Soc. Interface 5, 807-811. (doi:10.1098/rsif.2008.0005)
24. Talu, E., Lozano, M. M., Powell, R. L., Dayton, P. A. & Longo, M. L. 2006 Long-term stability by lipid coating monodisperse microbubbles formed by a flow-focusing device. Langmuir 22, 9487-9490. (doi:10.1021/la062095+) (Pubitemid 44826352)
25. Unger, E. C., Porter, T., Culp, W., Labell, R., Matsunaga, T. & Zutshi, R. 2004 Therapeutic applications of lipid-coated microbubbles. Adv. Drug Deliv. Rev. 56, 1291-1314. (doi:10.1016/j.addr.2003.12.006)
26. Wang, W. H., Moser, C. C. & Weatley, M. A. 1996 Langmuir trough study of surfactant mixtures used in the production of a new ultrasound contrast agent consisting of stabilized microbubbles. J. Phys. Chem. 100, 13 815-13 821. (doi:10.1021/jp9613549)