Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU)

International Journal of Hyperthermia

Volumn 23, Issue 2, 2007, Pages 105-120

  Coussios, C C ^a   Farny, C H ^b   ter Haar, G ^c   Roy, R A ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Department of Aerospace and Mechanical Engineering ^*  (United States)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Control; Heating; Hyperecho; Inertial; Stable

Indexed keywords

ACCELERATION; ACOUSTICS; ARTICLE; B SCAN; HEALTH CARE DELIVERY; HEATING; HIGH INTENSITY FOCUSED ULTRASOUND; IMAGE ANALYSIS; MALIGNANT NEOPLASTIC DISEASE; PATIENT MONITORING; ULTRASOUND TRANSDUCER;

ACOUSTICS; HUMANS; MICROBUBBLES; NEOPLASMS; TREATMENT OUTCOME; ULTRASONIC THERAPY; ULTRASONOGRAPHY;

EID: 33947117433     PISSN: 02656736     EISSN: 14645157     Source Type: Journal    
DOI: 10.1080/02656730701194131     Document Type: Article

References (173)

1. Church, CC (2002) Spontaneous homogeneous nucleation, inertial cavitation and the safety of diagnostic ultrasound. Ultrasound Med Biol, 28, pp. 1349-1364.
2. Miller, MW, Everbach, EC, Miller, WM and Battaglia, LF (2003) Biological and environmental factors affecting ultrasound-induced hemolysis in vitro: 2. Medium dissolved gas (pO(2)) content. Ultrasound Med Biol, 29, pp. 93-102.
3. Apfel, RE (1984) Acoustic cavitation series. 4. Acoustic cavitation inception. Ultrasonics, 22, pp. 167-173.
4. Neppiras, EA (1980) Acoustic cavitation. Phys Rep, 61, pp. 159-251.
5. Apfel, RE (1981) Acoustic cavitation. Methods of experimental physics, 19, pp. 355-411. Academic
6. Apfel, RE (1981) Acoustic cavitation prediction. J Acoust Soc Am, 69, p. 1624.
7. Crum, LA and Fowlkes, JB (1986) Acoustic cavitation generated by microsecond pulses of ultrasound. Nature, 319, pp. 52-54.
8. Holland, CK and Apfel, RE (1990) Thresholds for transient cavitation produced by pulsed ultrasound in a controlled nuclei environment. J Acoust Soc Am, 88, pp. 2059-2069.
9. Miller, DL (1984) Acoustic cavitation series. 6. Gas body activation. Ultrasonics, 22, pp. 261-269.
10. Miller, DL (1987) A review of the ultrasonic bioeffects of microsonation, gas-body activation, and related cavitation-like phenomena. Ultrasound Med Biol, 13, pp. 443-470.
11. Miller, DL (1991) Update on safety of diagnostic ultrasonography. J Clin Ultrasound, 19, pp. 531-540.
12. Cardinale, A., Lagalla, R., Giambanco, V. and Aragona, F. (1991) Bioeffects of ultrasound: An experimental study on human embryos. Ultrasonics, 29, pp. 261-263.
13. Holland, CK, Deng, CX, Apfel, RE, Alderman, JL, Fernandez, LA and Taylor, KJW (1996) Direct evidence of cavitation in vivo from diagnostic ultrasound. Ultrasound Med Biol, 22, pp. 917-925.
14. Miller, MW, Miller, DL and Brayman, AA (1996) A review of in vitro bioeffects of inertial ultrasonic cavitation from a mechanistic perspective. Ultrasound Med Biol, 22, pp. 1131-1154.
15. Barnett, SB, Haar, GR Ter, Ziskin, MC, Rott, HD, Duck, FA and Maeda, K. (2000) International recommendations and guidelines for the safe use of diagnostic ultrasound in medicine. Ultrasound Med Biol, 26, pp. 355-366.
16. Fowlkes, JB and Holland, CK (2000) Mechanical bioeffects from diagnostic ultrasound: AIUM consensus statements - Introduction. J Ultrasound Med, 19, pp. 69-72.
17. Holland, CK, Roy, RA, Biddinger, PW, Disimile, CJ and Cawood, C. (2001) Cavitation mediated rat lung bioeffects from diagnostic ultrasound. J Acoust Soc Am, 109, p. 2433.
18. Church, CC (2003) A theoretical study of acoustic cavitation produced by "positive-only" and "negative-only" pressure waves in relation to in vivo studies. Ultrasound in Medicine and Biology, 29, pp. 319-330.
19. Holland, CK and Apfel, RE (1989) An improved theory for the prediction of microcavitation thresholds. IEEE Trans Ultrason Ferroelectr Freq Control, 36, pp. 204-208.
20. Apfel, RE and Holland, CK (1991) Gauging the likelihood of cavitation from short-pulse, low-duty cycle diagnostic ultrasound. Ultrasound Med Biol, 17, pp. 179-185.
21. Church, CC (2005) Frequency, pulse length, and the mechanical index. Acoust Res Lett Online-Arlo, 6, pp. 162-168.
22. Haar, GR Ter (2002) Ultrasonic contrast agents: Safety considerations reviewed. European Journal of Radiology, 41, pp. 217-221.
23. Vaezy, S., Martin, R., Schmiedl, U., Caps, M., Taylor, S., Beach, K., Carter, S., Kaczkowski, P., Keilman, G. and Helton, S. (1997) Liver hemostasis using high-intensity focused ultrasound. Ultrasound Med Biol, 23, pp. 1413-1420.
24. Vaezy, S., Martin, R., Yaziji, H., Kaczkowski, P., Keilman, G., Carter, S., Caps, M., Chi, EY, Bailey, M. and Crum, L. (1998) Hemostasis of punctured blood vessels using high-intensity focused ultrasound. Ultrasound Med Biol, 24, pp. 903-910.
25. Martin, RW, Vaezy, S., Kaczkowski, P., Keilman, G., Carter, S., Caps, M., Beach, K., Plettt, M. and Crum, L. (1999) Hemostasis of punctured vessels using Doppler-guided high-intensity ultrasound. Ultrasound Med Biol, 25, pp. 985-990.
26. Vaezy, S., Martin, R., Kaczkowski, P., Keilman, G., Goldman, B., Yaziji, H., Carter, S., Caps, M. and Crum, L. (1999) Use of high-intensity focused ultrasound to control bleeding. J Vasc Surg, 29, pp. 533-542.
27. Poliachik, SL, Chandler, WL, Mourad, PD, Ollos, RJ and Crum, LA (2001) Activation, aggregation and adhesion of platelets exposed to high-intensity focused ultrasound. Ultrasound Med Biol, 27, pp. 1567-1576.
28. Vaezy, S., Martin, R. and Crum, L. (2001) High intensity focused ultrasound: A method of hemostasis. Echocardiography, 18, pp. 309-315.
29. Hwang, JH, Vaezy, S., Martin, RW, Cho, MY, Noble, ML, Crum, LA and Kimmey, MB (2003) High-intensity focused US: A potential new treatment for GI bleeding. Gastrointestinal Endoscopy, 58, pp. 111-115.
30. Vaezy, S., Noble, ML, Keshavarzi, A., Paun, M., Prokop, AF, Cornejo, C., Sharar, S.,Chi, EY, Crum, LA and Martin, RW (2004) Liver hemostasis with high-intensity ultrasound - Repair and healing. J Ultrasound Med, 23, pp. 217-225.
31. Vaezy, S., Vaezy, S., Starr, F., Chi, E., Cornejo, C., Crum, L. and Martin, RW (2005) Intra-operative acoustic hemostasis of liver: Production of a homogenate for effective treatment. Ultrasonics, 43, pp. 265-269.
32. Zderic, V., Keshavarzi, A., Noble, ML, Paun, M., Sharar, SR, Crum, LA and Martin, RW (2006) Hemorrhage control in arteries using high-intensity focused ultrasound: A survival study. Ultrasonics, 44, pp. 46-53.
33. Rivens, IH, Rowland, I., Denbow, M., Fisk, NM, Leach, MO and Haar, GR Ter (2003) Focused ultrasound surgery-induced vascular occlusion in fetal medicine. Proceedings of SPIE, 3249, p. 260.
34. Denbow, ML, Rivens, IH, Rowland, IJ, Leach, MO, Fisk, NM and Haar, GR Ter (2000) Preclinical development of noninvasive vascular occlusion with focused ultrasonic surgery for fetal therapy. Am J Obstet Gynecol, 182, pp. 387-392.
35. Trubestein, G., Engel, C., Etzel, F., Sobbe, A., Cremer, H. and Stumpff, U. (1976) Thrombolysis by ultrasound. Clin Sci Mol Med Suppl, 3, pp. 697s-698s.
36. Lauer, CG, Burge, R., Tang, DB, Bass, BG, Gomez, ER and Alving, BM (1992) Effect of ultrasound on tissue-type plasminogen activator-induced thrombolysis. Circulation, 86, pp. 1257-1264.
37. Luo, H., Steffen, W., Cercek, B., Arunasalam, S., Maurer, G. and Siegel, RJ (1993) Enhancement of thrombolysis by external ultrasound. Am Heart J, 125, pp. 1564-1569.
38. Sehgal, CM, Leveen, RF and Shlansky-Goldberg, RD (1993) Ultrasound-assisted thrombolysis. Invest Radiol, 28, pp. 939-943.
39. Olsson, SB, Johansson, B., Nilsson, AM, Olsson, C. and Roijer, A. (1994) Enhancement of thrombolysis by ultrasound. Ultrasound Med Biol, 20, pp. 375-382.
40. Kornowski, R., Meltzer, RS, Chernine, A., Vered, Z. and Battler, A. (1994) Does external ultrasound accelerate thrombolysis? Results from a rabbit model. Circulation, 89, pp. 339-344.
41. Shlansky-Goldberg, RD, Cines, DB and Sehgal, CM (1996) Catheter-delivered ultrasound potentiates in vitro thrombolysis. J Vascular and Interventional Radiology, 7, pp. 313-320.
42. Hamm, CW, Steffen, W., Terres, W., De Scheerder, I., Reimers, J., Cumberland, D., Siegel, RJ and Meinertz, T. (1997) Intravascular therapeutic ultrasound thrombolysis in acute myocardial infarctions. Am J Cardiol, 80, pp. 200-204.
43. Tachibana, K. (1997) Prototype therapeutic ultrasound emitting catheter for accelerating thrombolysis. Am Inst Ultrasound Med, 16, pp. 529-535.
44. Porter, TR, Kricsfeld, D., Lof, J., Everbach, EC and Xie, F. (2001) Effectiveness of transcranial and transthoracic ultrasound and microbubbles in dissolving intravascular thrombi. J Ultrasound Med, 20, pp. 1313-1325.
45. Shaw, GJ, Meunier, JM, Cheng, JY and Holland, CK (2005) Duty cycle dependence of ultrasound enhanced thrombolysis in an in-vitro human clot model. Ann Emerg Med, 46, p. S27.
46. Parikh, DS, Tiukinhoy-Laing, S., Huang, SL, Holland, CK, MacDonald, RC, McPherson, DD and Klegerman, ME (2006) Targeting of tissue plasminogen activator-loaded echogenic liposomes for site-specific thrombolysis. Arterioscler Thromb Vasc Biol, 26, p. E102.
47. Tata, DB, Biglow, J., Tritton, TR and Dunn, F. (1996) Ultrasound-enhanced hydroxyl radical production from two clinically employed anti-cancer drugs, adriamycin and mitomycin C. Ultrason Sonochem, 3, pp. 39-45.
48. Umemura, SI, Yumita, N., Nishigaki, R. and Umemura, K. (1989) Sonochemical activation of hematoporphyrin: A potential modality for cancer treatment. Ultrason Symp 1989 Proc, IEEE 1989, pp. 955-960.
49. Jeffers, J., Feng, RQ, Fowlkes, JB, Brenner, DE and Cain, CA (1991) Sonodynamic therapy: Activation of anticancer agents with ultrasound. Ultrason Symp 1991 Proc, IEEE 1991, pp. 1367-1370.
50. Miyoshi, N., Misik, V., Fukuda, M. and Riesz, P. (1995) Effect of gallium-porphyrin analogue ATX-70 on nitroxide formation from a cyclic secondary amine by ultrasound: On the mechanism of sonodynamic activation. Radiat Res, 143, pp. 194-202.
51. Hynynen, K., McDannold, N., Vykhodtseva, N. and Jolesz, FA (2001) Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology, 220, pp. 640-646.
52. Mesiwala, AH, Farrell, L., Wenzel, HJ, Silbergeld, DL, Crum, LA, Winn, HR and Mourad, PD (2002) High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo. Ultrasound Med Biol, 28, pp. 389-400.
53. Hynynen, K., McDannold, N., Martin, H., Jolesz, FA and Vykhodtseva, N. (2003) The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison (R)). Ultrasound Med Biol, 29, pp. 473-481.
54. McDannold, N., Vykhodtseva, N., Jolesz, FA and Hynynen, K. (2004) MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain. Magn Reson Med, 51, pp. 913-923.
55. Sheikov, N., McDannold, N., Vykhodtseva, N., Jolesz, F. and Hynynen, K. (2004) Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound Med Biol, 30, pp. 979-989.
56. Hynynen, K., McDannold, N., Sheikov, NA, Jolesz, FA and Vykhodtseva, N. (2005) Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. Neuroimage, 24, pp. 12-20.
57. McDannold, N., Vykhodtseva, N., Raymond, S., Jolesz, FA and Hynynen, K. (2005) MRI-guided targeted blood-brain barrier disruption with focused ultrasound: Histological findings in rabbits. Ultrasound Med Biol, 31, pp. 1527-1537.
58. Hynynen, K., McDannold, N., Vykhodtseva, N., Raymond, S., Weissleder, R., Jolesz, FA and Sheikov, N. (2006) Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: A method for molecular imaging and targeted drug delivery. J Neurosurg, 105, pp. 445-454.
59. Kinoshita, M., McDannold, N., Jolesz, FA and Hynynen, K. (2006) Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci USA, 103, pp. 11719-11723.
60. Kinoshita, M., McDannold, N., Jolesz, FA and Hynynen, K. (2006) Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound. Biochem Biophys Res Commun, 340, pp. 1085-1090.
61. McDannold, N., Vykhodtseva, N. and Hynynen, K. (2006) Targeted disruption of the blood-brain barrier with focused ultrasound: Association with cavitation activity. Phys Med Biol, 51, pp. 793-807.
62. Bao, SP, Thrall, BD and Miller, DL (1997) Transfection of a reporter plasmid into cultured cells by sonoporation in vitro. Ultrasound Med Biol, 23, pp. 953-959.
63. Miller, DL, Bao, SP, Gies, RA and Thrall, BD (1999) Ultrasonic enhancement of gene transfection in murine melanoma tumors. Ultrasound Med Biol, 25, pp. 1425-1430.
64. Miller, DL, Dou, CY and Song, JM (2003) DNA transfer and cell killing in epidermoid cells by diagnostic ultrasound activation of contrast agent gas bodies in vitro. Ultrasound Med Biol, 29, pp. 601-607.
65. Everbach, EC and Francis, CW (2000) Cavitational mechanisms in ultrasound-accelerated thrombolysis at 1 MHz. Ultrasound Med Biol, 26, pp. 1153-1160.
66. Datta, S., Coussios, CC, McAdory, LE, Tan, J., Porter, T., De Courten-Myers, G. and Holland, CK (2006) Correlation of cavitation with ultrasound enhancement of thrombolysis. Ultrasound Med Biol, 32, pp. 1257-1267.
67. Miller, DL, Pislaru, SV and Greenleaf, JF (2002) Sonoporation: Mechanical DNA delivery by ultrasonic cavitation. Som Cell Mol Genet, 27, pp. 115-134.
68. Ohl, CD, Arora, M., Ikink, R., De Jong, N., Versluis, M., Delius, M. and Lohse, D. (2006) Sonoporation from jetting cavitation bubbles. Biophys J, 91, pp. 4285-4295.
69. Ross, JP and Chui, JF (2002) Repairable sonoporation generated by microstreaming. The Journal of the Acoustical Society of America, 111, pp. 1460-1464.
70. Fry, WJ and Fry, RB (1953) Temperature changes produced in tissue during ultrasonic irradiation. J Acoust Soc Am, 25, pp. 6-11.
71. Barnard, JW, Fry, WJ, Fry, FJ and Krumins, RF (1955) Effects of high intensity ultrasound on the central nervous system of the cat. J Comp Neurol, 103, pp. 459-484.
72. Fry, WJ, Mosberg Jr, WH, Barnard, JW and Fry, FJ (1954) Production of focal destructive lesions in the central nervous system with ultrasound. J Neurosurg, 11, pp. 471-478.
73. Kennedy, JE (2005) High-intensity focused ultrasound in the treatment of solid tumours. Nat Rev Cancer, 5, pp. 321-327.
74. Rooney, JA, Gammell, PM, Hestenes, JD, Chin, HP and Blankenhorn, DH (1982) Velocity and attenuation of sound in arterial tissues. J Acoust Soc Am, 71, pp. 462-466.
75. Parker, KJ (1983) Ultrasonic attenuation and absorption in liver tissue. Ultrasound Med Biol, 9, pp. 363-369.
76. Hill, CR, Bamber, JC and Haar, GR (2004) Physical principles of medical ultrasonics, John Wiley &Sons
77. Chivers, RC and Hill, CR (1975) Ultrasonic attenuation in human tissue. Ultrasound Med Biol, 2, pp. 25-29.
78. Hynynen, K., Watmough, DJ and Mallard, JR (1981) Design of ultrasonic transducers for local hyperthermia. Ultrasound Med Biol, 7, pp. 397-402.
79. Hill, CR (1994) Optimum acoustic frequency for focused ultrasound surgery. Ultrasound Med Biol, 20, pp. 271-277.
80. Hynynen, K. (1991) The threshold for thermally significant cavitation in dog thigh muscle in vivo. Ultrasound Med Biol, 17, pp. 157-169.
81. Holt, RG and Roy, RA (2001) Measurements of bubble-enhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material. Ultrasound Med Biol, 27, pp. 1399-1412.
82. Miller, DL and Gies, RA (1998) The interaction of ultrasonic heating and cavitation in vascular bioeffects on mouse intestine. Ultrasound Med Biol, 24, pp. 123-128.
83. Chen, WS, Lafon, C., Matula, TJ, Vaezy, S. and Crum, LA (2003) Mechanisms of lesion formation in high intensity focused ultrasound therapy. Acoust Res Lett Online, 4, pp. 41-46.
84. Farny, CH (2006) Identifying and monitoring the roles of cavitation in heating from high intensity focussed ultrasound. Boston University, Boston
85. Leighton, TG (1994) The acoustic bubble, Academic Press, London
86. Mellen, RH (1954) Ultrasonic spectrum of cavitation noise in water. J Acoust Soc Am, 26, pp. 356-360.
87. Holt, RG and Crum, LA (1992) Acoustically forced-oscillations of air bubbles in water - Experimental results. J Acoust Soc Am, 91, pp. 1924-1932.
88. Hynynen, K. (1991) The role of nonlinear ultrasound propagation during hyperthermia treatments. Med Phys, 18, pp. 1156-1163.
89. Yang, X. and Church, CC (2005) A model for the dynamics of gas bubbles in soft tissue. J Acoust Soc Am, 118, pp. 3595-3606.
90. Rabkin, BA, Zderic, V. and Vaezy, S. (2005) Hyperecho in ultrasound images of HIFU therapy: Involvement of cavitation. Ultrasound Med Biol, 31, pp. 947-956.
91. Damianou, C. and Hynynen, K. (1994) The effect of various physical parameters on the size and shape of necrosed tissue volume during ultrasound surgery. J Acoust Soc Am, 95, pp. 1641-1649.
92. Damianou, CA, Hynynen, K. and Fan, XB (1995) Evaluation of accuracy of a theoretical-model for predicting the necrosed tissue volume during focused ultrasound surgery. IEEE Trans Ultrason Ferroelectr Freq Control, 42, pp. 182-187.
93. Meaney, PM, Cahill, MD and Haar, GR Ter (2000) The intensity dependence of lesion position shift durig focused ultrasound surgery. Ultrasound Med Biol, 26, pp. 441-450.
94. Bailey, MR, Couret, LN, Sapozhnikov, OA, Khokhlova, VA, Haar, G ter, Vaezy, S., Shi, XG, Martin, R. and Crum, LA (2001) Use of overpressure to assess the role of bubbles in focused ultrasound lesion shape in vitro. Ultrasound Med Biol, 27, pp. 695-708.
95. Khokhlova, VA, Bailey, MR, Reed, JA, Cunitz, BW, Kaczkowski, PJ and Crum, LA (2006) Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom. J Acoust Soc Am, 119, pp. 1834-1848.
96. Prosperetti, A. (1977) Thermal effects and damping mechanisms in forced radial oscillations of gas-bubbles in liquids. J Acoust Soc Am, 61, pp. 17-27.
97. Prosperetti, A. (1984) Acoustic cavitation series. 2. Bubble phenomena in sound fields 1. Ultrasonics, 22, pp. 69-78.
98. Minnaert, M. (1933) On musical air bubbles and the sounds of running water. Philos Mag, 16, pp. 235-248.
99. Holt, RG and Roy, RA (2005) Bubble dynamics in therapeutic ultrasound. Bubble and particle dynamics in acoustic fields: Modern trends and applications, pp. 108-229. Transworld Research Network, Kerala
100. Prosperetti, A. (1984) Acoustic cavitation series 3. Bubble phenomena in sound fields 2. Ultrasonics, 22, pp. 115-124.
101. Apfel, RE (1981) Acoustic cavitation. Methods Exp Phys (ed PD Edmonds), 19, pp. 355-411.
102. Yang, XM and Church, CC (2006) A simple viscoelastic model for soft tissues in the frequency range 6-20 MHz. IEEE Trans Ultrason Ferroelectr Freq Control, 53, pp. 1404-1411.
103. Keller, JB and Miksis, M. (1980) Bubble oscillations of large amplitude. J Acoust Soc Am, 68, pp. 628-633.
104. Prosperetti, A. and Lezzi, A. (1986) Bubble dynamics in a compressible liquid 1. 1st-order theory. J Fluid Mech, 168, pp. 457-478.
105. Crum, LA and Hansen, GM (1982) Generalized equations for rectified diffusion. J Acoust Soc Am, 72, pp. 1586-1592.
106. Church, CC (1988) Prediction of rectified diffusion during nonlinear bubble pulsations at biomedical frequencies. J Acoust Soc Am, 83, pp. 2210-2217.
107. Elder, SA (1959) Cavitation microstreaming. J Acoust Soc Am, 31, pp. 54-64.
108. Nyborg, WLM (1965) Acoustic streaming. Physical Acoustics, pp. 265-331. Academic Press, New York
109. Miller, DL (1988) Particle gathering and microstreaming near ultrasonically activated gas-filled micropores. J Acoust Soc Am, 84, pp. 1378-1387.
110. (1997) Streaming generated by a bubble in an ultrasound field. J Acoust Soc Am, 101, pp. 1899-1907.
111. Rooney, JA (1970) Acoustic streaming as a mechanism in treatment of suspensions. J Acoust Soc Am, 48, pp. 114-117.
112. Rooney, JA (1970) Hemolysis near an ultrasonically pulsating gas bubble. Science, 169, pp. 869-871.
113. Williams, AR (1972) Disorganization and disruption of mammalian and amoeboid cells by acoustic microstreaming. J Acoust Soc Am, 52, pp. 688-693.
114. Harvey, EN (1939) Sonoluminescence and sonic chemiluminescence. J Am Chem Soc, 61, pp. 2392-2398.
115. Suslick, KS (1990) Sonochemistry. Science, 247, pp. 1439-1445.
116. Roy, RA (1994) Physical aspects of sonoluminescence from acoustic cavitation. Ultrason Sonochem, 1, pp. S5-S8.
117. Hilgenfeldt, S. and Lohse, D. (2000) The acoustics of diagnostic microbubbles: Dissipative effects and heat deposition. Ultrasonics, 38, pp. 99-104.
118. Allen, JS, Roy, RA and Church, CC (1997) On the role of shear viscosity in mediating inertial cavitation from short-pulse, megahertz-frequency ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control, 44, pp. 743-751.
119. Atchley, AA and Prosperetti, A. (1989) The crevice model of bubble nucleation. J Acoust Soc Am, 86, pp. 1065-1084.
120. Wang, G., Bai, J. and Wang, Z. (2004) A microbubble agent improves the therapeutic efficiency of high intensity focused ultrasound: A rabbit kidney study. Urol Res, 32, pp. 14-19.
121. Umemura, S., Kawabata, K. and Sasaki, K. (2005) In vivo acceleration of ultrasonic tissue heating by microbubble agent. IEEE Trans Ultrason Ferroelectr Freq Control, 52, pp. 1690-1698.
122. Kaneko, Y., Maruyama, T., Takegami, K., Watanabe, T., Mitsui, H., Hanajiri, K., Nagawa, H. and Matsumoto, Y. (2005) Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue. Eur Radiol, 15, pp. 1415-1420.
123. McDannold, NJ, Vykhodtseva, NI and Hynynen, K. (2006) Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits. Radiology, 241, pp. 95-106.
124. Apfel, RE (1971) Vapor nucleation at a liquid-liquid interface. J Chem Phys, 54, pp. 62-63.
125. Miller, DL and Thomas, RM (1995) Ultrasound contrast agents nucleate inertial cavitation in-vitro. Ultrasound Med Biol, 21, pp. 1059-1065.
126. Ophir, J. and Parker, KJ (1989) Contrast agents in diagnostic ultrasound. Ultrasound Med Biol, 15, pp. 319-333.
127. De Jong, N., Cate, FJ Ten, Lancee, CT, Roelandt, JR and Bom, N. (1991) Principles and recent developments in ultrasound contrast agents. Ultrasonics, 29, pp. 324-330.
128. Church, CC (1995) The effects of an elastic solid-surface layer on the radial pulsations of gas-bubbles. J Acoust Soc Am, 97, pp. 1510-1521.
129. Allen, JS, May, DJ and Ferrara, KW (2002) Dynamics of therapeutic ultrasound contrast agents. Ultrasound Med Biol, 28, pp. 805-816.
130. Stride, E. and Saffari, N. (2004) Theoretical and experimental investigation of the behaviour of ultrasound contrast agent particles in whole blood. Ultrasound Med Biol, 30, pp. 1495-1509.
131. Poliachik, SL, Chandler, WL, Mourad, PD, Bailey, MR, Bloch, S., Cleveland, RO, Kaczkowski, P., Keilman, G., Porter, T. and Crum, LA (1999) Effect of high-intensity focused ultrasound on whole blood with and without microbubble contrast agent. Ultrasound Med Biol, 25, pp. 991-998.
132. Coussios, CC, Holland, CK, Jakubowska, L., Huang, SL, MacDonald, RC, Nagaraj, A. and McPherson, DD (2004) In vitro characterization of liposomes and Optison (R) by acoustic scattering at 3.5 MHz. Ultrasound Med Biol, 30, pp. 181-190.
133. Miller, DL and Williams, AR (1992) Nucleation and evolution of ultrasonic cavitation in a rotating exposure chamber. J Ultrasound Med, 11, pp. 407-412.
134. Farny, CH, Wu, TM, Holt, RG, Murray, TW and Roy, RA (2005) Nucleating cavitation from laser-illuminated nano-particles. Acoust Res Lett Online, 6, pp. 138-143.
135. Miller, DL, Kripfgans, OD, Fowlkes, JB and Carson, PL (2000) Cavitation nucleation agents for nonthermal ultrasound therapy. J Acoust Soc Am, 107, pp. 3480-3486.
136. Fowlkes, JB and Cain, CA (2006) A new strategy to enhance cavitational tissue erosion using a high-intensity, initiating sequence. IEEE Trans Ultrason Ferroelectr Freq Control, 53, pp. 1412-1424.
137. Holt, RG, Roy, RA, Edson, PE and Yang, XM (2003) Bubbles and HIFU: The good, the bad and the ugly. International Symposium of Therapeutic Ultrasound 2003, pp. 120-131. American Institute of Physics, Seattle
138. Hilgenfeldt, S., Lohse, D. and Zomack, M. (2000) Sound scattering and localized heat deposition of pulse-driven microbubbles. J Acoust Soc Am, 107, pp. 3530-3539.
139. Edson, PL (2001) The role of acoustic cavitation in enhanced ultrasound-induced heating in a tissue-mimicking phantom. Boston University, Boston
140. Yang, XM, Roy, RA and Holt, RG (2004) Bubble dynamics and size distributions during focused ultrasound insonation. J Acoust Soc Am, 116, pp. 3423-3431.
141. Eller, A. and Flynn, HG (1965) Rectified diffusion during nonlinear pulsations of cavitation bubbles. J Acoust Soc Am, 37, pp. 493-503.
142. Eller, AI (1969) Growth of bubbles by rectified diffusion. J Acoust Soc Am, 46, pp. 1246-1250.
143. Crum, LA and Hansen, GM (1982) Growth of air bubbles in tissue by rectified diffusion. Phys Med Biol, 27, pp. 413-417.
144. Yang, XM (2003) Investigation of bubble dynamics and heating during focused ultrasound insonation in tissue-mimicking materials. Boston University, Boston
145. Miller, DL and Thomas, RM (1995) Thresholds for hemorrhages in mouse skin and intestine induced by lithotripter shock-waves. Ultrasound Med Biol, 21, pp. 249-257.
146. Miller, DL, Creim, JA and Gies, RA (1999) Heating vs. cavitation in the induction of mouse hindlimb paralysis by ultrasound. Ultrasound Med Biol, 25, pp. 1145-1150.
147. Sokka, SD, King, R. and Hynynen, K. (2003) MRI-guided gas bubble enhanced ultrasound heating in in vivo rabbit thigh. Phys Med Biol, 48, pp. 223-241.
148. Sokka, SD, Vykhodtseva, N. and Hynynen, K. (2006) Cavitation-enhanced ultrasound heating in vivo: Therapy protocols, mechanisms, and acoustic and MRI monitoring. J Acoust Soc Am, 119, p. 3227.
149. Huang, J., Holt, RG, Cleveland, RO and Roy, RA (2004) Experimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantoms. J Acoust Soc Am, 116, pp. 2451-2458.
150. Lafon, C., Zderic, V., Noble, ML, Yuen, JC, Kaczkowski, PJ, Sapozhnikov, OA, Chavrier, F., Crum, LA and Vaezy, S. (2005) Gel phantom for use in high-intensity focused ultrasound dosimetry. Ultrasound Med Biol, 31, pp. 1383-1389.
151. Jiang, P., Everbach, EC and Apfel, RE (1991) Applications of mixture laws for predicting the compositions of tissue phantoms. Ultrasound Med Biol, 17, pp. 829-838.
152. (1899) Mellive, NY Standards Secretariat, Acoustical Society of America, Standards Secretariat, Acoustical Society of America
153. Leighton, TG (1997) A strategy for the development and standardisation of measurement methods for high power/cavitating ultrasonic fields: Review of cavitation monitoring techniques., University of Southampton-Institute of Sound and Vibration Research
154. Pennes, HH (1948) Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol, 1, pp. 93-122.
155. Hynynen, K. (1987) Demonstration of enhanced temperature elevation due to nonlinear propagation of focused ultrasound in dogs thigh in vivo. Ultrasound Med Biol, 13, pp. 85-91.
156. Clarke, RL, Bush, NL and Haar, GR Ter (2003) The changes in acoustic attenuation due to in vitro heating. Ultrasound Med Biol, 29, pp. 127-135.
157. Zderic, V., Keshavarzi, A., Andrew, MA, Vaezy, S. and Martin, RW (2004) Attenuation of porcine tissues in vivo after high-intensity ultrasound treatment. Ultrasound Med Biol, 30, pp. 61-66.
158. Hao, Y. and Prosperetti, A. (1999) The dynamics of vapor bubbles in acoustic pressure fields. Phys Fluid, 11, pp. 2008-2019.
159. Prosperetti, A. and Hao, Y. (2002) Vapor bubbles in flow and acoustic fields. Microgravity transport processes in fluid, thermal, biological, and materials sciences, pp. 328-347. New York Academy of Sciences, New York
160. Konofagou, EE, Thierman, J., Karjalainen, T. and Hynynen, K. (2002) The temperature dependence of ultrasound-stimulated acoustic emission. Ultrasound Med Biol, 28, pp. 331-338.
161. Vaezy, S., Shi, XG, Martin, RW, Chi, E., Nelson, PI, Bailey, MR and Crum, LA (2001) Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging. Ultrasound Med Biol, 27, pp. 33-42.
162. Chan, AH, Fujimoto, VY, Moore, DE, Martin, RW and Vaezy, S. (2002) An image-guided high intensity focused ultrasound device for uterine fibroids treatment. Med Phys, 29, pp. 2611-2620.
163. Seo, J., Tran, BC, Hall, TL, Fowlkes, JB, Abrams, GD, O'Donnell, M. and Cain, CA (2005) Evaluation of ultrasound tissue damage based on changes in image echogenicity in canine kidney. IEEE Trans Ultrason Ferroelectr Freq Control, 52, pp. 1111-1120.
164. Held, RT, Zderic, V., Nguyen, TN and Vaezy, S. (2006) Annular phased-array high-intensity focused ultrasound device for image-guided therapy of uterine fibroids. IEEE Trans Ultrason Ferroelectr Freq Control, 53, pp. 335-348.
165. Coussios, CC, Farny, CH, Thomas, CR, Cleveland, RO, Holt, RG and Roy, RA (2004) Cavitation detection during and following HIFU exposure in vitro. J Acoust Soc Am, 115, p. 2448.
166. Rabkin, BA, Zderic, V., Crum, LA and Vaezy, S. (2006) Biological and physical mechanisms of HIFU-induced hyperecho in ultrasound images. Ultrasound Med Biol, 32, pp. 1721-1729.
167. Thomas, CR, Farny, CH, Coussios, CC, Roy, RA and Holt, RG (2005) Dynamics and control of cavitation during high-intensity focused ultrasound application. Acoust Res Lett Online, 6, pp. 182-187.
168. Chapelon, JY, Dupenloup, F., Cohen, H. and Lenz, P. (1996) Reduction of cavitation using pseudorandom signals [therapeutic US]. IEEE Trans Ultrason Ferroelectr Freq Control, 43, pp. 623-625.
169. Ludomirsky, A., Eun, LY, Hall, TL, Tran, BC, Fowlkes, JB and Cain, CA (2004) Controlled ultrasound tissue erosion. IEEE Trans Ultrason Ferroelectr Freq Control, 51, pp. 726-736.
170. Sokka, SD, Gauthier, TP and Hynynen, K. (2005) Theoretical and experimental validation of a dual-frequency excitation method for spatial control of cavitation. Phys Med Biol, 50, pp. 2167-2179.
171. Fowlkes, JB, Rothman, ED, Levin, AM and Cain, CA (2005) Controlled ultrasound tissue erosion: The role of dynamic interaction between insonation and microbubble activity. J Acoust Soc Am, 117, pp. 424-435.
172. Lo, AH,; Kripfgans, OD, Carson, PL and Fowlkes, JB (2006) Spatial control of gas bubbles and their effects on acoustic fields. Ultrasound Med Biol, 32, pp. 95-106.
173. Roberts, WW, Hall, TL, Ives, K., Wolf, JS, Fowlkes, JB and Cain, CA (2006) Pulsed cavitational ultrasound: A noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney. J Urol, 175, pp. 734-738.