Post-resuscitation NOS inhibition does not improve hemodynamic recovery of hypoxic newborn pigs

Intensive Care Medicine

Volumn 35, Issue 9, 2009, Pages 1628-1635

  Lee, Tze Fun ^a   Tymafichuk, Corinne N ^a   Schulz, Richard ^a   Cheung, Po Yin ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Antioxidant; Heart; Newborn; Nitric oxide; Swine

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE; LIPID HYDROPEROXIDE; N(G) METHYLARGININE; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; CONVALESCENCE; ENZYME INHIBITION; HEART RATE; HYPOXIA; LOW DRUG DOSE; NEWBORN; NEWBORN CARE; NONHUMAN; OXIDATIVE STRESS; PIGLET; PULMONARY HYPERTENSION; REOXYGENATION; RESUSCITATION;

ACETYLCYSTEINE; ALBERTA; ANIMALS; ANOXIA; ANTIOXIDANTS; BLOOD GAS ANALYSIS; HEMODYNAMICS; NITRIC OXIDE; RANDOM ALLOCATION; RESUSCITATION; STROKE VOLUME; SWINE;

EID: 68949218820     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-009-1553-x     Document Type: Article

References (36)

1. A Martín-Ancel A García-Alix F Gayá F Cabañas M Burgueros J Quero 1995 Multiple organ involvement in perinatal asphyxia J Pediatr 127 786 793
2. J Liu J Li M Gu 2007 The correlation between myocardial function and cerebral hemodynamics in term infants with hypoxic-ischemic encephalopathy J Trop Pediatr 53 44 48
3. J Sochman 2002 N-acetylcysteine in acute cardiology: 10 years later: what do we know and what would we like to know? J Am Coll Cardiol 39 1422 1428
4. K Ihnken 2000 Myocardial protection in hypoxic immature hearts Thorac Cardiovasc Surg 48 46 54
5. 2, at the onset of reperfusion improves myocardial recovery Resuscitation 74 508 515
6. AM Prasan HC McCarron Y Zhang RW Jeremy 2007 Myocardial release of nitric oxide during ischaemia and reperfusion: effects of l-arginine and hypercholesterolaemia Heart Lung Circ 16 274 281
7. K Morita MP Sherman GD Buckberg K Ihnken G Matheis HH Young LJ Ignarro 1995 Studies of hypoxemic/reoxygenation injury: without aortic clamping. V. Role of the l-arginine-nitric oxide pathway: the nitric oxide paradox J Thorac Cardiovasc Surg 110 1200 1211
8. G Cotter E Kaluski A Blatt O Milovanov Y Moshkovitz R Zaidenstein A Salah D Alon Y Michovitz M Metzger Z Vered A Golik 2000 L-NMMA (a nitric oxide synthase inhibitor) is effective in the treatment of cardiogenic shock Circulation 101 1358 1361
9. PE Parrino VE Laubach JR Gaughen Jr KS Shockey TA Wattsman RC King CG Tribble IL Kron 1998 Inhibition of inducible nitric oxide synthase after myocardial ischemia increases coronary flow Ann Thorac Surg 66 733 739
10. Y Zhang KA Boddicker BJ Rhee LR Davies RE Kerber 2005 Effect of nitric oxide synthase modulation on resuscitation success in a swine ventricular fibrillation cardiac arrest model Resuscitation 67 127 134
11. ST Johnson DL Bigam M Emara L Obaid G Slack G Korbutt LD Jewell J Van Aerde PY Cheung 2007 N-acetylcysteine improves the hemodynamics and oxidative stress in hypoxic newborn pigs reoxygenated with 100% oxygen Shock 28 484 490
12. TF Lee LL Jantzie KG Todd PY Cheung 2008 Post-resuscitation N-acetylcysteine treatment reduces cerebral hydrogen peroxide in the hypoxic piglet brain Intensive Care Med 34 190 197
13. DD Rees RM Palmer R Schulz HF Hodson S Moncada 1990 Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo Br J Pharmacol 101 746 752
14. C Li RM Jackson 2002 Reactive species mechanisms of cellular hypoxia-reoxygenation injury Am J Physiol Cell Physiol 282 C227 C241
15. ZQ Zhao 2004 Oxidative stress-elicited myocardial apoptosis during reperfusion Curr Opin Pharmacol 4 159 165
16. J Brunet MJ Boily S Cordeau C Des Rosiers 1995 Effects of N-acetylcysteine in the rat heart reperfused after low-flow ischemia: evidence for a direct scavenging of hydroxyl radicals and a nitric oxide-dependent increase in coronary flow Free Radic Biol Med 19 627 638
17. NS Dhalla AB Elmoselhi T Hata N Makino 2000 Status of myocardial antioxidants in ischemia-reperfusion injury Cardiovasc Res 47 446 456
18. LF Carbonell J Diaz I Hernandez S Cuevas F Valero T Quesada F Fenoy MG Salom 2007 N-acetylcysteine exerts protective effects and prevents lung redox imbalance and peroxynitrite generation in endotoxemic rats Med Chem 3 29 34
19. EL Conesa F Valero JC Nadal FJ Fenoy B López B Arregui MG Salom 2001 N-acetyl-L-cysteine improves renal medullary hypoperfusion in acute renal failure Am J Physiol 281 R730 R737
20. PM Harrison JA Wendon AE Gimson GJ Alexander R Williams 1991 Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure New Eng J Med 324 1852 1857
21. W Yasmin KD Strynadka R Schulz 1997 Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts Cardiovasc Res 33 422 432
22. H Han R Kaiser K Hu M Laser G Ertl J Bauersachs 2003 Selective modulation of endogenous nitric oxide formation in ischemia/reperfusion injury in isolated rat hearts-effects on regional myocardial flow and enzyme release Basic Res Cardiol 98 165 174
23. F Ichinose R Hataishi JC Wu N Kawai AC Rodrigues C Mallari JM Post JF Parkinson MH Picard KD Bloch WM Zapol 2003 A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice Am J Physiol Heart Circ Physiol 285 H2524 H2530
24. D Wu J Bassuk J Arias P Kurlansky H Lozano G Lamas JA Adams 2007 Different roles of nitric oxide synthase isoforms in cardiopulmonary resuscitation in pigs Resuscitation 73 144 153
25. AD Stewart SC Millasseau MT Kearney JM Ritter PJ Chowienczyk 2003 Effects of inhibition of basal nitric oxide synthesis on carotid-femoral pulse wave velocity and augmentation index in humans Hypertension 42 915 918
26. J Sugawara S Maeda T Otsuki T Tanabe R Ajisaka M Matsuda 2004 Effects of nitric oxide synthase inhibitor on decrease in peripheral arterial stiffness with acute low-intensity aerobic exercise Am J Physiol Heart Circ Physiol 287 H2666 H2669
27. M Kobara T Tatsumi M Takeda A Mano S Yamanaka J Shiraishi N Keira S Matoba J Asayama M Nakagawa 2003 The dual effects of nitric oxide synthase inhibitors on ischemia-reperfusion injury in rat hearts Basic Res Cardiol 98 319 328
28. C Depré JL Vanoverschelde JF Goudemant I Mottet L Hue 1995 Protection against ischemic injury by nonvasoactive concentrations of nitric oxide synthase inhibitors in the perfused rabbit heart Circulation 92 1911 1918
29. D Nordhaug T Steensrud E Aghajani C Korvald T Myrmel 2004 Nitric oxide synthase inhibition impairs myocardial efficiency and ventriculo-arterial matching in acute ischemic heart failure Eur J Heart Fail 6 705 713
30. G-monomethyl-l-arginine after resuscitation worsened hemodynamic recovery despite reducing oxidative state (Abstract) Arch Dis Child 93 97
31. TD Le Cras IF McMurtry 2001 Nitric oxide production in the hypoxic lung Am J Physiol Lung Cell Mol Physiol 280 L575 L582
32. PJ Offner H Ogura BS Jordan BA Pruitt Jr WG Cioffi 1996 Cardiopulmonary effects of combined nitric oxide inhibition and inhaled nitric oxide in porcine endotoxic shock J Trauma 41 641 646
33. RF Wideman ME Chapman 2004 N(omega)-nitro-l-arginine methyl ester (L-NAME) amplifies the pulmonary hypertensive response to endotoxin in broilers Poult Sci 83 485 494
34. JA Avontuur M Biewenga SL Buijk KJ Kanhai HA Bruining 1998 Pulmonary hypertension and reduced cardiac output during inhibition of nitric oxide synthesis in human septic shock Shock 9 451 454
35. A Azad SB Lall S Mittra 2001 Effect of N-acetylcysteine and L-NAME on aluminium phosphide induced cardiovascular toxicity in rats Acta Pharmacol Sin 22 298 304
36. E Haase DL Bigam QB Nakonechny D Rayner G Korbutt PY Cheung 2005 Cardiac function, myocardial glutathione, and matrix metalloproteinase-2 levels in hypoxic newborn pigs reoxygenated by 21%, 50%, or 100% oxygen Shock 23 383 389