Antiretroviral protease inhibitors potentiate chloroquine antimalarial activity in malaria parasites by regulating intracellular glutathione metabolism

Experimental Parasitology

Volumn 123, Issue 2, 2009, Pages 122-127

  He, Zhengxiang ^a   Chen, Lili ^a   You, Jianlan ^a   Qin, Li ^a   Chen, Xiaoping ^a  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

Author keywords

CQ resistance; Glutathione; P. chabaudi; P. falciparum; Protease inhibitors

Indexed keywords

ANTIRETROVIRUS AGENT; CHLOROQUINE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; NELFINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALARIA; NONHUMAN; PLASMODIUM; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANIMALS; ANTI-RETROVIRAL AGENTS; ANTIMALARIALS; CHLOROQUINE; DRUG RESISTANCE; DRUG SYNERGISM; FEMALE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HIV PROTEASE INHIBITORS; INHIBITORY CONCENTRATION 50; MALARIA; MICE; NELFINAVIR; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; RITONAVIR; SAQUINAVIR;

APIS; PLASMODIUM FALCIPARUM;

EID: 68949167759     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2009.06.008     Document Type: Article

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