Is reversal of chloroquine resistance ready for the clinic?

Lancet

Volumn 357, Issue 9260, 2001, Pages 904-

  Ward, S A ^a   Bray, P G ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; CEPHARANTHINE; CHLOROQUINE; CITALOPRAM; FANSIDAR; NOMIFENSINE; OXAPROTILINE; VERAPAMIL;

ANTIBIOTIC RESISTANCE; CANCER CELL; CHEMOSENSITIVITY; DRUG BIOAVAILABILITY; DRUG CHOICE; DRUG EFFICACY; DRUG UPTAKE; HUMAN; MALARIA; MULTIDRUG RESISTANCE; NOTE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

EID: 0035941953     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(00)04232-X     Document Type: Note

References (10)

1. Chemotherapy for falciparum malaria: The armoury, the problems and the prospects
2. Chloroquine uptake by Plasmodium falciparum-infected human erythrocytes during in vitro culture and its relationship to chloroquine resistance
3. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
4. Reversal of chloroquine resistance in Plasmodium falciparum by verapamil
5. A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum
6. Role of the neurotransmitter reuptake-blocking activity of antidepressants in reversing chloroquine resistance In vitro in Plasmodium falciparum
7. Potent enhancement of the sensitivity of Plasmodium falciparum to chloroquine by the bisbenzylisoquinoline alkaloid cepharanthin
8. The potential of desipramine to reverse chloroquine resistance of Plasmodium falciparum is reduced by its binding to plasma protein
9. Lack of effect of desipramine on the response to chloroquine of patients with chloroquine-resistant falciparum malaria
10. Comparative efficacy of chloroquine plus chlorpheniramine and pyrimethamine/sulfadoxine in acute uncomplicated falciparum malaria in Nigerian children