Low p38 MAPK and JNK activation in cultured hepatocytes of DRH rats; a strain highly resistant to hepatocarcinogenesis

Molecular Carcinogenesis

Volumn 46, Issue 9, 2007, Pages 758-765

  Honmo, Satoshi ^a   Ozaki, Atsuko ^a   Yamamoto, Masahiro ^a   Hashimoto, Norikazu ^a   Miyakoshi, Masaaki ^a   Tanaka, Hiroki ^a   Yoshie, Masumi ^a   Tamakawa, Susumu ^a   Tokusashi, Yoshihiko ^a   Yaginuma, Yuji ^a   Kasai, Shinichi ^a   Ogawa, Katsuhiro ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

ASK1; DRH rats; Hepatocarcinogenesis; JNK; p38

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; COMPLEMENTARY DNA; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SCATTER FACTOR; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL LYSATE; CELL PROLIFERATION; CELL STRESS; CONTROLLED STUDY; DNA DAMAGE; DONRYU STRAIN; DRH RAT; ENZYME ACTIVATION; ENZYME INHIBITION; HISTOPATHOLOGY; LIVER CARCINOGENESIS; LIVER CELL CULTURE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; STRAIN DIFFERENCE;

2-ACETYLAMINOFLUORENE; ANIMALS; CARCINOGENS; CELLS, CULTURED; ENZYME ACTIVATION; GENETIC PREDISPOSITION TO DISEASE; HEPATOCYTES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MAP KINASE KINASE KINASE 5; MODELS, BIOLOGICAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, INBRED STRAINS;

RATTUS;

EID: 34548781877     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20304     Document Type: Article

References (36)

1. Higashi T, Fukui R, Sekiyama M, Yoshimoto F, Tateishi N, Sakamoto Y. Decreased induction of γ-glutamyltransferase activity by 3′-methyl-4-dimethylaminoazobenzene in the liver of rats given carcinogen-containing diet for several generations. Jpn J Cancer Res 1986;77:139-144.
2. Denda A, Kitayama W, Konishi Y, et al. Genetic properties for the suppression of development of putative preneoplastic glutathione S-transferase placental form-positive foci in the liver of carcinogen-resistant DRH strain rats. Cancer Lett 1999;140:59-67.
3. Zeng ZZ, Higashi S, Kitayama W, et al. Genetic resistance to chemical carcinogen-induced preneoplastic hepatic lesions in DRH strain rats. Cancer Res 2000;60:2876-2881.
4. Yan Y, Higashi K, Yamamura K, et al. Different responses other than the formation of DNA-adducts between the livers of carcinogen-resistant rats (DRH) and carcinogen-sensitive
5. rats (Donryu) to 3′-methyl-4-dimethylaminoazobenzene administration. Jpn J Cancer Res 1998;89:806-813.
6. Mathon NF, Lloyd AC. Cell senescence and cancer. Nat Rev Cancer 2001;1:203-213.
7. Fausto N, Laird AD, Webber EM. Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration. FASEB J 1995;9:1527-1536.
8. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997;276:60-66.
9. Kapahi P, Boulton ME, Kirkwood TB. Positive correlation between mammalian life span and cellular resistance to stress. Free Radic Biol Med 1999;26:495-500.
10. Caraceni P, De Maria N, Ryu HS, et al. Proteins but not nucleic acids are molecular targets for the free radical attack during reoxygenation of rat hepatocytes. Free Radic Biol Med 1997; 23:339-344.
11. Ferraris M, Radice S, Catalani P, Francolini M, Marabini L, Chiesara E. Early oxidative damage in primary cultured trout hepatocytes: A time course study. Aquat Toxicol 2002;59: 283-296.
12. Talarmin H, Rescan C, Cariou S, et al. The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes. Mol Cell Biol 1999;19:6003-6011.
13. Auer KL, Contessa J, Brenz-Verca S, et al. The Ras/Rac1/ Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Mol Biol Cell 1998;9:561-573.
14. Spector MS, Auer KL, Jarvis WD, et al. Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes. Mol Cell Biol 1997;17: 3556-3565.
15. Takeda K, Matsuzawa A, Nishitoh H, Ichijo H. Roles of MAPKKK ASK1 in stress-induced cell death. Cell Struct Funct 2003;28:23-29.
16. Gilot D, Loyer P, Corlu A, et al. Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation. J Biol Chem 2002;277:49220-49229.
17. Ichijo H, Nishida E, Irie K, et al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 1997;275:90-94.
18. Evelson P, Travacio M, Repetto M, Escobar J, Llesuy S, Lissi EA. Evaluation of total reactive antioxidant potential (TRAP) of tissue homogenates and their cytosols. Arch Biochem Biophys 2001;388:261-266.
19. Kadohama T, Tsuji K, Ogawa K. Indistinct cell cycle checkpoint after u.v. damage in H-ras-transformed mouse liver cells despite normal p53 gene expression. Oncogene 1994;9:2845-2852.
20. Worner W, Schrenk D. Influence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofluorene, ultraviolet light, or transforming growth factor β1. Cancer Res 1996;56:1272-1278.
21. Watanabe T, Nakagawa K, Ohata S, et al. SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-κB-induced anti-apoptosis. Dev Biol 2002;250:332-347.
22. Hilberg F, Aguzzi A, Howells N, Wagner EF. c-jun is essential for normal mouse development and hepatogenesis. Nature 1993;365:179-181.
23. Behrens A, Sibilia M, David JP, et al. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBOJ 2002;21:1782-1790.
24. Adams RH, Porras A, Alonso G, et al. Essential role of p38α MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 2000;6:109-116.
25. Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M. Requirement for p38α in erythropoietin expression: A role for stress kinases in erythropoiesis. Cell 2000;102: 221-231.
26. Yoo J, Ghiassi M, Jirmanova L, et al. Transforming growth factor-β-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation. J Biol Chem 2003;278:43001-43007.
27. Iwasa H, Han J, Ishikawa F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 2003;8:131-144.
28. Wang W, Chen JX, Liao R, et al. Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol 2002; 22:3389-3403.
29. Saitoh M, Nishitoh H, Fujii M, et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 1998;17:2596-2606.
30. Cho SG, Lee YH, Park HS, et al. Glutathione S-transferase μ modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1. J Biol Chem 2001; 276:12749-12755.
31. Park HS, Cho SG, Kim CK, et al. Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. Mol Cell Biol 2002;22:7721-7730.
32. Masters SC, Subramanian RR, Truong A, et al. Survival-promoting functions of 14-3-3 proteins. Biochem Soc Trans 2002;30:360-365.
33. Yuan ZQ, Feldman RI, Sussman GE, Coppola D, Nicosia SV, Cheng JQ. AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: Implication of AKT2 in chemoresistance. J Biol Chem 2003;278:23432-23440.
34. Cho SG, Kim JW, Lee YH, et al. Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities. J Cell Biol 2003;163:71-81.
35. Nishitoh H, Saitoh M, Mochida Y, et al. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell 1998,2:389-395.
36. Zhang R, He X, Liu W, Lu M, Hsieh JT, Min W. AIP1 mediates TNF-α-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3. J Clin Invest 2003;111:1933-1943.