Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: Induction of oxidative stress versus reactivation efficacy

Journal of Applied Toxicology

Volumn 29, Issue 6, 2009, Pages 483-488

  Pohanka, Miroslav ^a,b   Karasova, Jana Zdarova ^b   Musilek, Kamil ^b   Kuca, Kamil ^a,b   Kassa, Jiri ^b  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Antioxidant; Cholinesterase; Organophosphate; Oxidative stress; Oxime reactivator

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 BENZYL 2 HYDROXYIMINOMETHYLPYRIDINIUM SALT; 4 CARBAMOYL 4' HYDROXYIMINOMETHYL 1,1' (1,3 PHENYLENEDIMETHYL) BISPYRIDINIUM DIBROMIDE; ACETYLCHOLINESTERASE; ATROPINE; CHOLINESTERASE; CHOLINESTERASE REACTIVATOR; K 347; K 628; OBIDOXIME; TABUN; TRIMEDOXIME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CHEMICAL PARAMETERS; CHOLINESTERASE BLOOD LEVEL; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; DISEASE SIMULATION; DRUG EFFICACY; DRUG INTOXICATION; DRUG PENETRATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME REACTIVATION; ERYTHROCYTE; LD 50; MALE; MOLECULAR WEIGHT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROBABILITY; RAT;

ACETYLCHOLINESTERASE; ACUTE TOXICITY TESTS; ANIMALS; ANTIDOTES; ATROPINE; BRAIN; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DRUG THERAPY, COMBINATION; INJECTIONS, INTRAMUSCULAR; LETHAL DOSE 50; MALE; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; OBIDOXIME CHLORIDE; OXIDATIVE STRESS; PHOSPHORIC ACID ESTERS; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR; TRIMEDOXIME;

RATTUS;

EID: 68949112011     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1432     Document Type: Article

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