S-allylcysteine attenuates renal injury by altering the expressions of iNOS and matrix metallo proteinase-2 during cyclosporine-induced nephrotoxicity in Wistar rats

Journal of Applied Toxicology

Volumn 29, Issue 6, 2009, Pages 522-530

  Magendiramani, Vinayagam ^b   Umesalma, Syed ^b   Kalayarasan, Srinivasan ^b   Nagendraprabhu, Ponnuraj ^b   Arunkumar, Jagadeesan ^b   Sudhandiran, Ganapasam ^a  

^a UNIVERSITY OF MADRAS   (India)

^b NONE

Author keywords

Cyclosporine; iNOS; Kidney; Lipid peroxidation; MMP2; Nephrotoxicity; NF B; Oxidative stress; Reactive oxygen species; S allyl cysteine

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CATALASE; CREATININE; CYCLOSPORIN A; ENZYME; GELATINASE A; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; S ALLYLCYSTEINE; SUPEROXIDE DISMUTASE; UREA; URIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFICACY; HISTOPATHOLOGY; KIDNEY FUNCTION; KIDNEY INJURY; LIPID PEROXIDATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; SERUM; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL;

ANIMALS; CYCLOSPORINE; CYSTEINE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; MALE; MATRIX METALLOPROTEINASE 2; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR;

RATTUS; RATTUS NORVEGICUS;

EID: 68949108144     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1437     Document Type: Article

References (64)

1. Abuja PM, Albertini R. 2001. Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins. Clin. Chim. Acta 306: 1-17. (Pubitemid 32244320)
2. Amagase H, Petesch BL, Matsuura H, Kasuga S, Itakura Y. 2001. Intake of garlic and its bioactive components. J. Nutr. 131: 955S-962S. (Pubitemid 32194988)
3. Amore A, Gianoglio B, Ghigo D, Peruzzi L, Porcellini MG, Bussolino ?, Costamagna C, Cacace G, Picciotto G, Mazzucco G. 1995. A possible role for nitric oxide in modulating the functional cyclosporine toxicity by arginine. Kidney Int. 47: 1507-1514.
4. Anjaneyulu M, Tirkey N, Chopra K. 2003. Attenuation of cyclosporine-induced renal dysfunction by catechin: possible antioxidant mechanism. Ren. Fail. 25: 691-707. (Pubitemid 37187664)
5. Banerjee SK, Mukherjee PK, Maulik SK. 2003. Garlic as an antioxidant: the good, the bad and the ugly. Phytother. Res. 17: 97-106. (Pubitemid 36262255)
6. Barany P, Stenvinkel P, Ottosson-Seeberger A. Alvestrand A, Morrow J, Roberts JJ, Salahudeen AK. 2001. Effects of 6 weeks of vitamin E administration on renal haemodynamic alterations following a single dose of neoral in healthy volunteers. Nephrol. Dial. Transplant. 16: 580-584. (Pubitemid 32229293)
7. Bianchi R, Rodella L, Rezzani R. 2003. Cyclosporine A up-regulates expression of matrix matalloproteinase 2 and vascular endotelial growth factor in rat heart. Int. Immunopharmacol. 3: 427-433. (Pubitemid 36293971)
8. Buffoli B, Pechanova O, Kojsova S, Andriantsitohaina R, Giugno L, Bianchi R, Rezzani R. 2005. Provinol prevents CsA-induced nephrotoxicity by reducing reactive oxygen species, iNOS, and NF-κB expression. J. Histochem. Cytochem. 53: 1459-1468. (Pubitemid 41720685)
9. Burdmann EA, Andoh TF, Yu L, Bennett WM. 2003. Cyclosporine nephrotoxicity. Semin. Nephrol. 23: 465-476.
10. Caraway WT. 1963. Uric acid. In Standard Methods of Clinical Chemistry, Seligson D (ed.). Academic Press: New York; 239-247.
11. Chander V, Tirkey N, Chopra K. 2005. Resveratrol, a polyphenolic Phytoalexin protects against cyclosporine-induced nephrotoxicity through nitric oxide dependent mechanism. Toxicology 210: 55-64. (Pubitemid 40459642)
12. Cheng S, Pollock AS, Mahimkar R, Olson JL, Lovett DH. 2006. Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury. FASEB J. 20: 1898-1900. (Pubitemid 44933772)
13. Cohen DJ, Loertscher R, Rubin MF, Tilney NL, Carpenter CB, Strom TB. 1984. Cyclosporine: a new immunosuppressive agent for organ transplantation. Ann Intern Med. 101: 667-682. (Pubitemid 15223313)
14. Deman A, Ceyssens B, Pauwels M, Zhang J, Houte KV, Verbeelen D, Van den Branden C. 2001. Altered antioxidant defense in a mouse adriamycin model of glomerulosclerosis. Nephrol Dial Transplant. 16: 147-150. (Pubitemid 32051489)
15. Desai I. 1984. Vitamin E analysis methods for animal tissues. Meth. Enzymol. 105: 138-147. (Pubitemid 14165381)
16. Doller A, Akool E, Muller R, Gutwein P, Kurowski C, Pfeilschifter, Eberhardt W. 2007. Molecular mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 in glomerular mesangial Cells. J. Am. Soc. Nephrol. 18: 581-592. (Pubitemid 46193323)
17. Durkan AM, Hodson EM, Willis NS, Craig JC. 2001. Immunosuppressive agents in childhood nephrotic syndrome: a meta-analysis of randomized controlled trials. Kidney Int. 59: 1919-1927.
18. Edwards BD, Chalmers RJ, O'Driscoll JB, Mitchell DM, Smith RJ, Lawson RS, Testa HJ, Ballardie FW. 1994. Angiotensin II as a risk factor for cyclosporine nephrotoxicity in patients with psoriasis. Clin. Nephrol. 41: 350-356.
19. Ellman GL. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82: 70-77.
20. Ide N, Lau BH. 1999. Aged garlic extract attenuates intracellular oxidative stress. Phytomedicine 6: 125-131. (Pubitemid 129634471)
21. Ide N, Lau BH. 2001. Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-kappa b activation. J. Nutr. 131: 1020S-1026S. (Pubitemid 32195001)
22. Julien J, Farge D, Kreft-Jais C, Guyene TT, Plouin PF, Houssin D, Carpentier A, Corvol P. 1993. Cyclosporine-induced stimulation of the renin- angiotensin system after liver and heart transplantation. Transplantation 56: 885-891. (Pubitemid 23321524)
23. Kahan BD. 1989. Cyclosporine. New Engl. J. Med. 321: 1725-1738.
24. Kalayarasan, Sriram N, Sudhandiran G. 2008. Diallyl sulfide attenuates bleomycin-induced pulmonary fibrosis: Critical role of iNOS, NF-κB, TNF-α and IL-1β. Life Sci. 82: 1142-1153.
25. Kim KM, Chun SB, Koo MS, Choi WJ, Kim TW, Kwon YG, Chung HT, Billiar TR, Kim YM. 2001. Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine. Free Radic. Biol. Med. 30: 747-756.
26. King J. 1965a. The transferase-alanine and aspartate transaminase. In Practical Clinical Enzymology, King J (ed.). London: Nostrand; 121-138.
27. King J. 1965b. The dehydrogenases or oxidoreductases-lactate dehydrogenase. In Practical Clinical Enzymology, Van D (ed.). London: Nostrand; 83-93.
28. King J. 1965c. The phosphohydrolases-acid and alkaline phosphatases. In Practical Clinical Enzymology, Van D (ed.). London: Nostrand; 191-208.
29. Koch HP, Lawson LD. 1996. The composition and chemistry of garlic cloves and processed garlic. In The Science and Therapeutic Application of Allium sativum L. and Related Species. Baltimore, MD: Williams and Wilkins; 37-107.
30. Longoni BM, Giovannini L, Migliori M, Bertelli AA, Bertelli A. 1999. Cyclosporine- induced lipid peroxidation and propionyl carnitine protective effect. Int. J. Tissue React. 21: 7-11. (Pubitemid 29386086)
31. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with folin-phenol reagent. J. Biol. Chem. 193: 265-275.
32. Maldonado PD, Barrera D, Rivero I, Mata R, Medina-Campos ON, Hernández- Pando R, Pedraza-Chaverri J. 2003. Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage. Free Radic. Biol. Med. 35: 317-324. (Pubitemid 37288932)
33. Maruhn D, Paar D, Bomhard E. 1983. Diagnostic sensitivity or urinary enzymes in experimental kidney damage in the rat. In Biologic Prospective: Comptes Rendus Da 5e Collogue' International Do Pont-A-Mousson, Galteau MM, Siest G, Henny J (eds). Masson, Paris; 943-994.
34. Mathieson PW. 2000. Cyclosporin: nephro-protective as well as nephrotoxic? Clin. Exp. Immunol. 121: 179-180.
35. Misra HP, Fridovich I. 1972. The role of superoxide anion in the auto oxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247: 3170-3175.
36. Moriguchi T, Matsura H, Kodera Y, Itakura Y, Katsuki H, Saito H, Nishiyama N. 1997. Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons. Neurochem. Res. 2: 1449-1452. (Pubitemid 27461120)
37. Morihara N, Sumioka I, Moriguchi T, Uda N, Kyo E. 2002. Aged garlic extract enhances production of nitric oxide. Life Sci. 71: 509-517. (Pubitemid 34607642)
38. Naesens M, Kuypers DR, Sarwal M. 2009. Calcineurin inhibitor nephrotoxicity. Clin. J. Am. Soc. Nephrol. 4: 481-508.
39. Natelson S, Scott ML, Beffa C. 1951. A rapid method for the estimation of urea in biologic fluids. Am. J. Clin. Pathol. 21: 275-281.
40. Nordberg J, Arner ES. 2001. Reactive oxygen species, antioxidants and the mammalian thioredoxin system. Free Radic. Biol. Med. 31: 1287-1312. (Pubitemid 33145299)
41. Numagami Y, Ohnishi ST. 2001. S-Allylcysteine inhibits free radical production, lipid peroxidation and neuronal damage in rat brain ischemia. J. Nutr. 131: 1100S-1105S. (Pubitemid 32195016)
42. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 195: 351-358. (Pubitemid 9194347)
43. Omaye ST, Tumball JD, Sauberlich HE. 1979. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Meth. Enzymol. 62: 1-11.
44. Owen JA, Iggo B, Scandrett FJ, Stewart CP. 1954. The determination of creatinine in plasma or serum, and in urine; a critical examination. Biochem. J. 58: 426-437.
45. Padi SS, Chopra K. 2002. Salvage of cyclosporine A-induced oxidative stress and renal dysfunction by carvedilol. Nephron 92: 685-692.
46. Parra Cid T, Conejo Garcia JR, Carballo Alvarez F, de Arriba G. 2003. Antioxidant nutrients protect against cyclosporine A nephrotoxicity. Toxicology 189: 99-111. (Pubitemid 36725026)
47. Rao AV, Shaha C. 2001. Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane. FEBS Lett. 507: 174-180. (Pubitemid 33001537)
48. Redondo-Horcajo M, Lamas S. 2005. Oxidative and nitrosative stress in kidney disease: a case for cyclosporine A. J. Nephrol. 18: 453-457. (Pubitemid 41700113)
49. Rezzani R. 2006. Exploring cyclosporineA-side effects and the protective role-played by antioxidants: the morphological and immunohistochemical studies. Histo Histopathol. 1: 301-316. (Pubitemid 43033739)
50. Rezzani R, Rodella L, Bianchi R. 1999. Early metabolic changes in peripheral blood cells of renal transplant recipients treated with cyclosporine A. Int. J. Immunopharmacol. 21: 455-462. (Pubitemid 29306927)
51. Rezzani R, Rodella LF, Tengattini S, Bonomini F, Pechánová O, Kojsová S, Andriantsitohaina R, Bianchi R. 2006. Protective role of polyphenols in cyclosporine A-induced nephrotoxicity during rat pregnancy. J. Histochem. Cytochem. 54: 923-932. (Pubitemid 44106870)
52. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. 1973. Selenium: biochemical role as a component of glutathione peroxidase. Science 79: 588-590.
53. Satyanarayana PS, Singh D, Chopra K. 2001. Quercetin, a bioflavonoid, protects against oxidative stress-related renal dysfunction by cyclosporine in rats. Meth. Find. Exp. Clin. Pharmacol. 3: 175-181. (Pubitemid 32916733)
54. Shi SH, Zheng SS, Jia CK, Zhu YF, Xie HY. 2004. Inhibitory effect of tea polyphenols on transforming growth factor-beta1 expression in rat with cyclosporine A-induced chronic nephrotoxicity. Acta Pharmacol. Sin. 5: 98-103.
55. Siwik DA, Colucci WS. 2004. Regulation of matrix metalloproteinases by cytokines and reactive oxygen/nitrogen species in the myocardium. Heart Fail. Res. 9: 43-51. (Pubitemid 38196076)
56. Staal GE, Visser J, Veeger C. 1969. Purification and properties of glutathione reductase of human erythrocytes. Biochim. Biophys. Acta. 185: 39-48.
57. Sung H, Nah J, Chun S, Park H, Yang SE, Min WK. 2000. In vivo antioxidant effect of green tea. Eur. J. Clin. Nutr. 54: 527-529. (Pubitemid 30447317)
58. Szabo C. 2003. Multiple pathways of peroxynitrite cytotoxicity. Toxicol. Lett. 140-141: 105-112.
59. Takahara S, Hamilton BH, Neell JV, Kobra TY, Ogura Y, Nishimura ET. 1960. Hypocatalasemia: a new genetic carrier state. J. Clin. Invest. 29: 10-619.
60. Thrailkill KM, Bunn CR, Fowlkes JL. 2009. Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy. Endocrine 35: 1-10.
61. Virag L, Szabo E, Gergely P, Szabo C. 2003. Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicol. Lett. 140: 113-124. (Pubitemid 36378929)
62. Walker RJ, Lazzaro VA, Duggin GG, Horvath JS, Tiller DJ. 1990. Evidence that alterations in renal metabolism and lipid peroxidation may contribute to cyclosporine nephrotoxicity. Transplantation 50: 487-492.
63. Welch C, Wuarin L, Sidell N. 1992. Antiproliferative effect of the garlic compound S-allylcysteine on human neuroblastoma cell in vitro. Cancer Lett. 63: 211-219.
64. Yilmaz S, Atessahin A, Sahna E, Karahan I, Ozer S. 2006. Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity. Toxicology 218: 164-171. (Pubitemid 41821347)