Inhibitory effect of tea polyphenals on transforming growth factor-β1 expression in rat with cyclosporine A-induced chronic nephrotoxicity

Acta Pharmacologica Sinica

Volumn 25, Issue 1, 2004, Pages 98-103

  Shi, Shao Hua ^a   Zheng, Shu Sen ^a   Jia, Chang Ku ^a   Zhu, You Fa ^a   Xie, Hai Yang ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Cyclosporine A; Immunohistochemistry; Kidney; Polymerase chain reaction; Tea; Transforming growth factor ; Western blotting

Indexed keywords

CYCLOSPORIN A; MESSENGER RNA; POLYPHENOL DERIVATIVE; TEA POLYPHENOL DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; CREATININE CLEARANCE; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; KIDNEY FIBROSIS; KIDNEY FUNCTION; MALE; NEPHROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEA; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; CYCLOSPORINE; FLAVONOIDS; GENE EXPRESSION; KIDNEY; KIDNEY DISEASES; MALE; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TEA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0345763107     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Shihab FS. Cyclosporine nephropathy: pathophysiology and clinical impact. Semin Nephrol 1996; 16: 536-47.
2. Campistol JM, Sacks SH. Mechanisms of nephrotoxicity. Transplantation 2000; 69: S5-10.
3. Wayne-Flye M. Principles of organ transplantation. In: Shaw BW, Starzl TE, Zwatsuki S, et al. An overview of orthotopic transplantation of the liver. Saunders WB Company; 1989. p 347-363.
4. Wang C, Salahudeen AK, McClain M, Whitehead J. Lipid peroxidation accompanies cyclosporine nephrotoxicity: effects of vitamin E. Kidney Int 1995; 47: 927-34.
5. Zhong Z, Connor HD, Yin M, Wheeler MD, Mason RP, Thurman RG. Viral delivery of superoxide dismutase gene reduces cyclosporine A-induced nephrotoxicity. Kidney Int 2001; 59: 1397-404.
6. Zhao BL, Liu SL, Chen YS, Xin WJ. Scavenging effect of catechin on free radicals studied by molecular orbital calculation. Acta Pharmacol Sin 1992; 13: 9-13.
7. Shi SH, Zheng SS, Xie HY. Tea polyphenols protect against cyclosporine-induced acute nephrotoxicity in rats. Chin J Organ Transplant 2001; 22: 271-3.
8. Shihab FS, Andoh TE, Tanner AM, Noble NA, Border WA, Franceschini N, et al. Role of transforming growth factor-beta1 in experimental chronic cyclosporine nephropathy. Kidney Int 1996; 49: 1141-51.
9. Pankewycz OG, Miao L, Isaacs R, Guan J, Pruett T, Haussman G, et al. Increased renal tubular expression of transforming growth factor beta in human allografts correlates with cyclosporine toxicity. Kidney Int 1996; 50: 1634-40.
10. Wolf G, Thaiss F, Stahl RA. Cyclosporine stimulates expression of transforming growth factor-beta in renal cells. Possible mechanism of cyclosporine antiproliferative effects. Transplantation 1995; 60: 237-41.
11. Khanna AK, Cairns VR, Becker CG, Hosenpud JD. Transforming growth factor (TGF)-beta mimics and anti-TGF-beta antibody abrogates the in vivo effects of cyclosporine: demonstration of a direct role of TGF-beta in immunosuppression and nephrotoxicity of cyclosporine. Transplantation 1999; 67: 882-9.
12. Jernigan S, Wing D, Schnaper HW. Effects of chronic blockade with soluble TGF-β II receptor in rats with overload proteinuria. J Am Soc Nephrol 1999; 10: 537A (abstract).
13. Wolin MS. Interactions of oxidants with vascular signaling systems. Arterioscler Thromb Vasc Biol 2000; 20: 1430-42.
14. Shihab FS, Yi H, Bennett WM, Andoh TF. Effect of nitric oxide modulation on TGF-beta1 and matrix proteins in chronic cyclosporine nephrotoxicity. Kidney Int 2000; 58: 1174-85.
15. Parra T, de Arriba G, Conejo JR, Cantero M, Arribas I, Rodriguez-Puyol D, et al. Cyclosporine increases local glomerular synthesis of reactive oxygen species in rats: effect of vitamin E on cyclosporine nephrotoxicity. Transplantation 1998; 66: 1325-29.
16. Jenkins JK, Huang H, Ndebele K, Salahudeen AK. Vitamin E inhibits renal mRNA expression of COX II, HO I, TGFbeta,- and osteopontin in the rat model of cyclosporine nephrotoxicity. Transplantation 2001; 71: 331-4.
17. Takahashi K, Nammour TM, Fukunaga M, Ebert J, Morrow JD, Roberts LT, et al. Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors. J Clin Invest 1992; 90: 136-41.
18. Butterly DW, Spurney RF, Ruiz P, Griffiths R, Albrightson C, Coffman TM. A role for leukotrienes in cyclosporine nephrotoxicity. Kidney Int 2000; 57: 2586-93.
19. Perico N, Rossini M, Imberti O, Malanchini B, Cornejo RP, Gaspari F, et al. Thromboxane receptor blockade attenuates chronic cyclosporine nephrotoxicity and improves survival in rats with renal isograft. J Am Soc Nephrol 1992; 2: 1398-404.
20. Giachelli CM, Pichler R, Lombardi D, Denhardt DT, Alpers CE, Schwartz SM, et al. Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis. Kidney Int 1994; 45: 515-24.
21. del Moral RG, Andujar M, Ramirez C, Gomez-Morales M, Masseroli M, Aguilar M, et al. Chronic cyclosporin A nephrotoxicity, P-glycoprotein overexpression, and relationships with intrarenal angiotensin II deposits. Am J Pathol 1997; 151: 1705-14.
22. Noble NA, Border WA. Angiotensin II in renal fibrosis: should TGF-beta rather than blood pressure be the therapeutic target? Semin Nephrol 1997; 17: 455-66.