메뉴 건너뛰기




Volumn 96, Issue 12, 2009, Pages 5122-5129

Stochastic simulation of signal transduction: Impact of the cellular architecture on diffusion

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL MOTILITY; CYTOARCHITECTURE; CYTOSKELETON; DIFFUSION; EXPERIMENT; IN VITRO SELECTION; IN VIVO STUDY; MACROMOLECULE; METHODOLOGY; REACTION ANALYSIS; SIGNAL TRANSDUCTION; SIMULATION; STOCHASTIC MODEL;

EID: 68949103682     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2009.03.049     Document Type: Article
Times cited : (31)

References (62)
  • 1
    • 33746889808 scopus 로고    scopus 로고
    • A comprehensive pathway map of epidermal growth factor receptor signaling
    • Oda, K., Y. Matsuoka, A. Funahashi, and H. Kitano. 2005. A comprehensive pathway map of epidermal growth factor receptor signaling. Mol. Syst. Biol. 1:1-17.
    • (2005) Mol. Syst. Biol , vol.1 , pp. 1-17
    • Oda, K.1    Matsuoka, Y.2    Funahashi, A.3    Kitano, H.4
  • 2
    • 0037672688 scopus 로고    scopus 로고
    • Trafficking of signaling modules by kinesin motors
    • Schnapp, B. J. 2003. Trafficking of signaling modules by kinesin motors. J. Cell Sci. 116:2125-2135.
    • (2003) J. Cell Sci , vol.116 , pp. 2125-2135
    • Schnapp, B.J.1
  • 4
    • 33846250352 scopus 로고    scopus 로고
    • Mass fluctuation kinetics: Capturing stochastic effects in systems of chemical reactions through coupled mean-variance computations
    • Gómez-Uribe, C. A., and G. C. Verghese. 2007. Mass fluctuation kinetics: capturing stochastic effects in systems of chemical reactions through coupled mean-variance computations. J. Chem. Phys. 126:024109.
    • (2007) J. Chem. Phys , vol.126 , pp. 024109
    • Gómez-Uribe, C.A.1    Verghese, G.C.2
  • 5
    • 3142577523 scopus 로고    scopus 로고
    • Stochastic approaches for modeling in vivo reactions
    • Turner, T. E., S. Schnell, and K. Burrage. 2004. Stochastic approaches for modeling in vivo reactions. Comput. Biol. Chem. 28:165-178.
    • (2004) Comput. Biol. Chem , vol.28 , pp. 165-178
    • Turner, T.E.1    Schnell, S.2    Burrage, K.3
  • 6
    • 0017030517 scopus 로고
    • A general method for numerically simulating the stochastic time evolution of coupled chemical reactions
    • Gillespie, D. 1976. A general method for numerically simulating the stochastic time evolution of coupled chemical reactions. J. Comput. Phys. 22:403-434.
    • (1976) J. Comput. Phys , vol.22 , pp. 403-434
    • Gillespie, D.1
  • 7
    • 14844321288 scopus 로고    scopus 로고
    • Space in systems biology of signaling pathways towards intracellular molecular crowding in silico
    • Takahashi, K., S. Arjunan, and M. Tomita. 2005. Space in systems biology of signaling pathways towards intracellular molecular crowding in silico. FEBS Lett. 579:1783-1788.
    • (2005) FEBS Lett , vol.579 , pp. 1783-1788
    • Takahashi, K.1    Arjunan, S.2    Tomita, M.3
  • 8
    • 33748972985 scopus 로고    scopus 로고
    • Accommodating space, time and randomness in network simulation
    • Ridgway, D., G. Broderick, and M. J. Ellison. 2006. Accommodating space, time and randomness in network simulation. Curr. Opin. Biotechnol. 17:493-498.
    • (2006) Curr. Opin. Biotechnol , vol.17 , pp. 493-498
    • Ridgway, D.1    Broderick, G.2    Ellison, M.J.3
  • 9
    • 33846027696 scopus 로고    scopus 로고
    • Particle-based stochastic simulation in systems biology
    • Tolle, D., and N. Le Novre. 2006. Particle-based stochastic simulation in systems biology. Curr. Bioinformat. 1:315-320.
    • (2006) Curr. Bioinformat , vol.1 , pp. 315-320
    • Tolle, D.1    Le Novre, N.2
  • 10
    • 14844328879 scopus 로고    scopus 로고
    • SmartCell, a framework to simulate cellular processes that combines stochastic approximation with diffusion and localization: Analysis of simple networks
    • Ander, M., P. Beltrao, B. Di Ventura, J. Ferkinghoff-Borg, M. Foglierini, et al. 2004. SmartCell, a framework to simulate cellular processes that combines stochastic approximation with diffusion and localization: analysis of simple networks. Syst. Biol. 1:129-138.
    • (2004) Syst. Biol , vol.1 , pp. 129-138
    • Ander, M.1    Beltrao, P.2    Di Ventura, B.3    Ferkinghoff-Borg, J.4    Foglierini, M.5
  • 11
    • 0038608273 scopus 로고    scopus 로고
    • Four-dimensional organization of protein kinase signaling cascades: The roles of diffusion, endocytosis and molecular motors
    • Kholodenko, B. N. 2003. Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors. J. Exp. Biol. 206:2073-2082.
    • (2003) J. Exp. Biol , vol.206 , pp. 2073-2082
    • Kholodenko, B.N.1
  • 12
    • 0035253217 scopus 로고    scopus 로고
    • Macromolecular crowding: An important but neglected aspect of the intracellular environment
    • Ellis, R. 2001. Macromolecular crowding: an important but neglected aspect of the intracellular environment. Curr. Opin. Struct. Biol. 11:114-119.
    • (2001) Curr. Opin. Struct. Biol , vol.11 , pp. 114-119
    • Ellis, R.1
  • 13
    • 34249876893 scopus 로고    scopus 로고
    • A mesoscopic simulation approach for modeling intracellular reactions
    • Grima, R., and S. Schnell. 2007. A mesoscopic simulation approach for modeling intracellular reactions. J. Stat. Phys. 128:139-164.
    • (2007) J. Stat. Phys , vol.128 , pp. 139-164
    • Grima, R.1    Schnell, S.2
  • 14
    • 0013312518 scopus 로고
    • The translational mobility of substances within the cytoplasmic matrix
    • Jacobson, K., and J. Wojcieszyn. 1984. The translational mobility of substances within the cytoplasmic matrix. Proc. Natl. Acad. Sci. USA. 81:6747-6751.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 6747-6751
    • Jacobson, K.1    Wojcieszyn, J.2
  • 15
    • 0024758362 scopus 로고
    • Effect of cytoskeletal geometry on intracellular diffusion
    • Blum, J. J., G. Lawler, M. Reed, and I. Shin. 1989. Effect of cytoskeletal geometry on intracellular diffusion. Biophys. J. 56:995-1005.
    • (1989) Biophys. J , vol.56 , pp. 995-1005
    • Blum, J.J.1    Lawler, G.2    Reed, M.3    Shin, I.4
  • 16
    • 0031968609 scopus 로고    scopus 로고
    • Monte Carlo analysis of obstructed diffusion in three dimensions: Application to molecular diffusion in organelles
    • Ölveczky, B. P., and A. S. Verkman. 1998. Monte Carlo analysis of obstructed diffusion in three dimensions: application to molecular diffusion in organelles. Biophys. J. 74:2722-2730.
    • (1998) Biophys. J , vol.74 , pp. 2722-2730
    • Ölveczky, B.P.1    Verkman, A.S.2
  • 17
    • 11144264728 scopus 로고    scopus 로고
    • Simulated diffusion of phosphorylated CheY through the cytoplasm of
    • Lipkow, K., S. S. Andrews, and D. Bray. 2005. Simulated diffusion of phosphorylated CheY through the cytoplasm of. Escherichia coli. J. Bacteriol. 187:45-53.
    • (2005) Escherichia coli. J. Bacteriol , vol.187 , pp. 45-53
    • Lipkow, K.1    Andrews, S.S.2    Bray, D.3
  • 18
    • 85031352193 scopus 로고    scopus 로고
    • Stiles, J., and T. Bart. 2001. Monte Carlo methods for simulating realistic synaptic microphysiology using MCell. In Computational Neuroscience - Realistic Modeling for Experimentalists. Erik De Schutter, editor. CRC Press, Boca Raton, FL.
    • Stiles, J., and T. Bart. 2001. Monte Carlo methods for simulating realistic synaptic microphysiology using MCell. In Computational Neuroscience - Realistic Modeling for Experimentalists. Erik De Schutter, editor. CRC Press, Boca Raton, FL.
  • 19
    • 48649097820 scopus 로고    scopus 로고
    • Introducing spatial information into predictive NF-κB modeling - an agent-based approach
    • Pogson, M., M. Holcombe, R. Smallwood, and E. Qwarnstrom. 2008. Introducing spatial information into predictive NF-κB modeling - an agent-based approach. PLoS ONE. 3:e2367.
    • (2008) PLoS ONE , vol.3
    • Pogson, M.1    Holcombe, M.2    Smallwood, R.3    Qwarnstrom, E.4
  • 20
    • 67650526152 scopus 로고    scopus 로고
    • Stochastic simulations of 4D-spatial temporal dynamics of signal transduction processes
    • Stuttgart, Germany
    • Lapin, A., M. Klann, and M. Reuss. 2007. Stochastic simulations of 4D-spatial temporal dynamics of signal transduction processes. In Proceedings of the FOSBE 2007, Stuttgart, Germany.
    • (2007) Proceedings of the FOSBE
    • Lapin, A.1    Klann, M.2    Reuss, M.3
  • 22
    • 0036164351 scopus 로고    scopus 로고
    • Solute and macromolecule diffusion in cellular aqueous compartments
    • Verkman, A. S. 2002. Solute and macromolecule diffusion in cellular aqueous compartments. Trends Biochem. Sci. 27:27-33.
    • (2002) Trends Biochem. Sci , vol.27 , pp. 27-33
    • Verkman, A.S.1
  • 23
    • 0033991590 scopus 로고    scopus 로고
    • Cytoarchitecture and physical properties of cytoplasm: Volume, viscosity, diffusion, intracellular surface area
    • Luby-Phelps, K. 2000. Cytoarchitecture and physical properties of cytoplasm: volume, viscosity, diffusion, intracellular surface area. Int. Rev. Cytol. 192:189-221.
    • (2000) Int. Rev. Cytol , vol.192 , pp. 189-221
    • Luby-Phelps, K.1
  • 24
    • 0030742748 scopus 로고    scopus 로고
    • Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus
    • Seksek, O., J. Biwersi, and A. S. Verkman. 1997. Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus. J. Cell Biol. 138:131-142.
    • (1997) J. Cell Biol , vol.138 , pp. 131-142
    • Seksek, O.1    Biwersi, J.2    Verkman, A.S.3
  • 25
    • 0027529545 scopus 로고
    • Determinants of the translational mobility of a small solute in cell cytoplasm
    • Kao, H. P., J. R. Abney, and A. S. Verkman. 1993. Determinants of the translational mobility of a small solute in cell cytoplasm. J. Cell Biol. 120:175-184.
    • (1993) J. Cell Biol , vol.120 , pp. 175-184
    • Kao, H.P.1    Abney, J.R.2    Verkman, A.S.3
  • 26
    • 0037763871 scopus 로고    scopus 로고
    • Anomalous protein diffusion in living cells as seen by fluorescence correlation spectroscopy
    • Weiss, M., H. Hashimoto, and T. Nilsson. 2003. Anomalous protein diffusion in living cells as seen by fluorescence correlation spectroscopy. Biophys. J. 84:4043-4052.
    • (2003) Biophys. J , vol.84 , pp. 4043-4052
    • Weiss, M.1    Hashimoto, H.2    Nilsson, T.3
  • 27
    • 14844331313 scopus 로고    scopus 로고
    • Anomalous subdiffusion is a measure for cytoplasmic crowding in living cells
    • Weiss, M., M. Elsner, F. Kartberg, and T. Nilsson. 2004. Anomalous subdiffusion is a measure for cytoplasmic crowding in living cells. Biophys. J. 87:3518-3524.
    • (2004) Biophys. J , vol.87 , pp. 3518-3524
    • Weiss, M.1    Elsner, M.2    Kartberg, F.3    Nilsson, T.4
  • 28
    • 0023770546 scopus 로고
    • The submicroscopic properties of cytoplasm as a determinant of cellular function
    • Luby-Phelps, K., F. Lanni, and D. L. Taylor. 1988. The submicroscopic properties of cytoplasm as a determinant of cellular function. Annu. Rev. Biophys. Biophys. Chem. 17:369-396.
    • (1988) Annu. Rev. Biophys. Biophys. Chem , vol.17 , pp. 369-396
    • Luby-Phelps, K.1    Lanni, F.2    Taylor, D.L.3
  • 29
    • 33751113261 scopus 로고    scopus 로고
    • Hybrid simulations of stochastic reaction-diffusion processes for modeling intracellular signaling pathways
    • Chiam, K.-H., C. M. Tan, V. Bhargava, and G. Rajagopal. 2006. Hybrid simulations of stochastic reaction-diffusion processes for modeling intracellular signaling pathways. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 74:051910.
    • (2006) Phys. Rev. E Stat. Nonlin. Soft Matter Phys , vol.74 , pp. 051910
    • Chiam, K.-H.1    Tan, C.M.2    Bhargava, V.3    Rajagopal, G.4
  • 30
  • 31
    • 33845470371 scopus 로고
    • Diffusion of Brownian spheres in semidilute polymer solutions
    • Cukier, R. I. 1984. Diffusion of Brownian spheres in semidilute polymer solutions. Macromolecules. 17:252-255.
    • (1984) Macromolecules , vol.17 , pp. 252-255
    • Cukier, R.I.1
  • 32
    • 0024006767 scopus 로고
    • Tracer diffusion of globular proteins in concentrated protein solutions
    • Muramatsu, N., and A. P. Minton. 1988. Tracer diffusion of globular proteins in concentrated protein solutions. Proc. Natl. Acad. Sci. USA. 85:2984-2988.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 2984-2988
    • Muramatsu, N.1    Minton, A.P.2
  • 33
    • 0037033754 scopus 로고    scopus 로고
    • Modeling solute diffusion in aqueous polymer solutions
    • Amsden, B. 2002. Modeling solute diffusion in aqueous polymer solutions. Polymer. 43:1623-1630.
    • (2002) Polymer , vol.43 , pp. 1623-1630
    • Amsden, B.1
  • 34
    • 0027293090 scopus 로고
    • Macromolecular diffusion in crowded solutions
    • Han, J., and J. Herzfeld. 1993. Macromolecular diffusion in crowded solutions. Biophys. J. 65:1155-1161.
    • (1993) Biophys. J , vol.65 , pp. 1155-1161
    • Han, J.1    Herzfeld, J.2
  • 36
    • 0034804337 scopus 로고    scopus 로고
    • Reduced protein diffusion rate by cytoskeleton in vegetative and polarized Dictyostelium cells
    • Potma, E., W. P. de Boeij, L. Bosgraaf, J. Roelofs, P. J. M. van Haastert, et al. 2001. Reduced protein diffusion rate by cytoskeleton in vegetative and polarized Dictyostelium cells. Biophys. J. 81:2010-2019.
    • (2001) Biophys. J , vol.81 , pp. 2010-2019
    • Potma, E.1    de Boeij, W.P.2    Bosgraaf, L.3    Roelofs, J.4    van Haastert, P.J.M.5
  • 37
    • 14844324003 scopus 로고    scopus 로고
    • Actin cytoskeleton as the principal determinant of size-dependent DNA mobility in cytoplasm
    • Dauty, E., and A. S. Verkman. 2005. Actin cytoskeleton as the principal determinant of size-dependent DNA mobility in cytoplasm. J. Biol. Chem. 280:7823-7828.
    • (2005) J. Biol. Chem , vol.280 , pp. 7823-7828
    • Dauty, E.1    Verkman, A.S.2
  • 39
    • 0032978690 scopus 로고    scopus 로고
    • Diffusion of macromolecules in agarose gels: Comparison of linear and globular configurations
    • Pluen, A., P. A. Netti, R. K. Jain, and D. A. Berk. 1999. Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations. Biophys. J. 77:542-552.
    • (1999) Biophys. J , vol.77 , pp. 542-552
    • Pluen, A.1    Netti, P.A.2    Jain, R.K.3    Berk, D.A.4
  • 40
    • 0037044387 scopus 로고    scopus 로고
    • Diffusion of mesoscopic probes in aqueous polymer solutions measured by fluorescence recovery after photobleaching
    • Cheng, Y., R. K. Prud'homme, and J. L. Thomas. 2002. Diffusion of mesoscopic probes in aqueous polymer solutions measured by fluorescence recovery after photobleaching. Macromolecules. 35:8111-8121.
    • (2002) Macromolecules , vol.35 , pp. 8111-8121
    • Cheng, Y.1    Prud'homme, R.K.2    Thomas, J.L.3
  • 42
    • 0000728710 scopus 로고
    • The cytoplasmic matrix: Its volume and surface area and the diffusion of molecules through it
    • Gershon, N. D., K. R. Porter, and B. L. Trus. 1985. The cytoplasmic matrix: Its volume and surface area and the diffusion of molecules through it. Proc. Natl. Acad. Sci. USA. 82:5030-5034.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 5030-5034
    • Gershon, N.D.1    Porter, K.R.2    Trus, B.L.3
  • 43
    • 0025277334 scopus 로고
    • Tracer diffusion in F-actin and Ficoll mixtures: Toward a model for cytoplasm
    • Hou, L., F. Lanni, and K. Luby-Phelps. 1990. Tracer diffusion in F-actin and Ficoll mixtures: toward a model for cytoplasm. Biophys. J. 58:31-43.
    • (1990) Biophys. J , vol.58 , pp. 31-43
    • Hou, L.1    Lanni, F.2    Luby-Phelps, K.3
  • 45
    • 0033841764 scopus 로고    scopus 로고
    • Trafficking and signaling through the cytoskeleton: A specific mechanism
    • Shafrir, Y., D. Ben-Avraham, and G. Forgacs. 2000. Trafficking and signaling through the cytoskeleton: a specific mechanism. J. Cell Sci. 113:2747-2757.
    • (2000) J. Cell Sci , vol.113 , pp. 2747-2757
    • Shafrir, Y.1    Ben-Avraham, D.2    Forgacs, G.3
  • 47
    • 0035815743 scopus 로고    scopus 로고
    • The influence of macromolecular crowding and macromolecular confinement on biochemical reactions in physiological media
    • Minton, A. P. 2001. The influence of macromolecular crowding and macromolecular confinement on biochemical reactions in physiological media. J. Biol. Chem. 276:10577-10580.
    • (2001) J. Biol. Chem , vol.276 , pp. 10577-10580
    • Minton, A.P.1
  • 48
    • 38449108386 scopus 로고    scopus 로고
    • Toward realistic modeling of dynamic processes in cell signaling: Quantification of macromolecular crowding effects
    • Sun, J., and H. Weinstein. 2007. Toward realistic modeling of dynamic processes in cell signaling: Quantification of macromolecular crowding effects. J. Chem. Phys. 127:155105.
    • (2007) J. Chem. Phys , vol.127 , pp. 155105
    • Sun, J.1    Weinstein, H.2
  • 49
    • 43849103490 scopus 로고    scopus 로고
    • Coarse-grained molecular simulation of diffusion and reaction kinetics in a crowded virtual cytoplasm
    • Ridgway, D., G. Broderick, A. Lopez-Campistrous, M. Ru'aini, P. Winter, et al. 2008. Coarse-grained molecular simulation of diffusion and reaction kinetics in a crowded virtual cytoplasm. Biophys. J. 94:3748-3759.
    • (2008) Biophys. J , vol.94 , pp. 3748-3759
    • Ridgway, D.1    Broderick, G.2    Lopez-Campistrous, A.3    Ru'aini, M.4    Winter, P.5
  • 51
    • 0037044862 scopus 로고    scopus 로고
    • Macromolecular architecture in eukaryotic cells visualized by cryoelectron tomography
    • Medalia, O., I. Weber, A. S. Frangakis, D. Nicastro, G. Gerisch, et al. 2002. Macromolecular architecture in eukaryotic cells visualized by cryoelectron tomography. Science. 298:1209-1213.
    • (2002) Science , vol.298 , pp. 1209-1213
    • Medalia, O.1    Weber, I.2    Frangakis, A.S.3    Nicastro, D.4    Gerisch, G.5
  • 52
    • 0030462603 scopus 로고    scopus 로고
    • Role of cytoarchitecture in cytoplasmic transport
    • Luby-Phelps, K., and R. Weisiger. 1996. Role of cytoarchitecture in cytoplasmic transport. Comp. Biochem. Physiol. 115B:295-306.
    • (1996) Comp. Biochem. Physiol , vol.115 B , pp. 295-306
    • Luby-Phelps, K.1    Weisiger, R.2
  • 54
    • 36849126470 scopus 로고
    • Effective diffusion coefficient in porous media
    • Weissberg, H. L. 1963. Effective diffusion coefficient in porous media. J. Appl. Phys. 34:2636-2639.
    • (1963) J. Appl. Phys , vol.34 , pp. 2636-2639
    • Weissberg, H.L.1
  • 55
    • 0034114310 scopus 로고    scopus 로고
    • Effective diffusivities of point-like molecules in isotropic porous media by Monte Carlo simulation
    • Trinh, S., P. Arce, and B. R. Locke. 2000. Effective diffusivities of point-like molecules in isotropic porous media by Monte Carlo simulation. Transp. Porous Media. 38:241-259.
    • (2000) Transp. Porous Media , vol.38 , pp. 241-259
    • Trinh, S.1    Arce, P.2    Locke, B.R.3
  • 56
    • 2142643217 scopus 로고    scopus 로고
    • Size effects on diffusion processes within agarose gels
    • Fatin-Rouge, N., K. Starchev, and J. Buffle. 2004. Size effects on diffusion processes within agarose gels. Biophys. J. 86:2710-2719.
    • (2004) Biophys. J , vol.86 , pp. 2710-2719
    • Fatin-Rouge, N.1    Starchev, K.2    Buffle, J.3
  • 57
    • 27744475701 scopus 로고    scopus 로고
    • Anomalous diffusion of proteins due to molecular crowding
    • Banks, D. S., and C. Fradin. 2005. Anomalous diffusion of proteins due to molecular crowding. Biophys. J. 89:2960-2971.
    • (2005) Biophys. J , vol.89 , pp. 2960-2971
    • Banks, D.S.1    Fradin, C.2
  • 58
    • 0001516161 scopus 로고
    • Computer simulation studies of anomalous diffusion in gels: Structural properties and probe-size dependence
    • Netz, P., and T. Dorfmüller. 1995. Computer simulation studies of anomalous diffusion in gels: structural properties and probe-size dependence. J. Chem. Phys. 103:9074-9082.
    • (1995) J. Chem. Phys , vol.103 , pp. 9074-9082
    • Netz, P.1    Dorfmüller, T.2
  • 59
    • 33846844797 scopus 로고    scopus 로고
    • A biological interpretation of transient anomalous subdiffusion. I. Qualitative model
    • Saxton, M. 2007. A biological interpretation of transient anomalous subdiffusion. I. Qualitative model. Biophys. J. 92:1178-1191.
    • (2007) Biophys. J , vol.92 , pp. 1178-1191
    • Saxton, M.1
  • 60
    • 42749103490 scopus 로고    scopus 로고
    • Diffusion of hard sphere fluids in disordered media: A molecular dynamics simulation study
    • Chang, R., K. Jagannathan, and A. Yethiraj. 2004. Diffusion of hard sphere fluids in disordered media: a molecular dynamics simulation study. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 69:051101.
    • (2004) Phys. Rev. E Stat. Nonlin. Soft Matter Phys , vol.69 , pp. 051101
    • Chang, R.1    Jagannathan, K.2    Yethiraj, A.3
  • 62
    • 0027533269 scopus 로고
    • Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape
    • Gittes, F., B. Mickey, J. Nettleton, and J. Howard. 1993. Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape. J. Cell Biol. 120:923-934.
    • (1993) J. Cell Biol , vol.120 , pp. 923-934
    • Gittes, F.1    Mickey, B.2    Nettleton, J.3    Howard, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.