B cell activation regulates exosomal HLA production

European Journal of Immunology

Volumn 38, Issue 5, 2008, Pages 1423-1434

  Arita, Shuji ^a   Baba, Eishi ^a   Shibata, Yoshihiro ^a   Niiro, Hiroaki ^b   Shimoda, Shinji ^a   Isobe, Taichi ^a   Kusaba, Hitoshi ^a   Nakano, Shuji ^a   Harada, Mine ^a,c  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY HOSPITAL   (Japan)

^c Omuta National Hospital   (Japan)

Author keywords

B cells; Exosomes; HLA; NF B

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; HLA ANTIBODY; HLA ANTIGEN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; TOLL LIKE RECEPTOR 9; ANDROSTANE DERIVATIVE; ENZYME INHIBITOR; HLA ANTIGEN CLASS 1; HLA DR ANTIGEN; IL4 PROTEIN, HUMAN; IONOPHORE; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY; TLR9 PROTEIN, HUMAN; WORTMANNIN;

ARTICLE; B LYMPHOCYTE ACTIVATION; CD4+ T LYMPHOCYTE; CELL INTERACTION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOSOME; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; QUANTITATIVE STUDY; SIGNAL TRANSDUCTION; B LYMPHOCYTE; BLOOD; CELL LINE; CHEMISTRY; COCULTURE; CULTURE MEDIUM; CYTOPLASM VESICLE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; EXOCYTOSIS; IMMUNOLOGY; METABOLISM; METHODOLOGY; MONONUCLEAR CELL; PHYSIOLOGY; TUMOR CELL LINE;

ANDROSTADIENES; ANTIBODIES, MONOCLONAL; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; CYTOPLASMIC VESICLES; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXOCYTOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HLA-DR ANTIGENS; HUMANS; INTERLEUKIN-4; IONOPHORES; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; NF-KAPPA B; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9;

EID: 47049109897     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737694     Document Type: Article

References (53)

1. Denzer, K, Kleijmeer, M. J., Heljnen, H. F., Stoorvogel, W. and Geuze, H. J., Exosome: From internal vesicle of the multivesicular body to intercellular signaling device. J. Cell. Sci. 2000. 113 Pt 19: 3365-3374.
2. Thery, C., ZitvogeJ, L. and Amigorena, S., Exosomes: Composition, biogenesis and function. Nat. Rev. Immunol. 2002. 2: 569-579.
3. Fevrier, B. and Raposo, G., Exosomes: Endosomal-derived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 2004. 16: 415-421.
4. van Niel, G., Porto-Carreiro, I., Simoes, S. and Raposo, G., Exosomes: A common pathway for a specialized function. J. Biochem. (Tokyo) 2006. 140: 13-21.
5. Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J. and Geuze, H. J., B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 1996. 183: 1161-1172.
6. Karlsson, M., Lundin, S., Dahlgren, U., Kahu, H., Pettersson, I. and Telemo, E., "Tolerosomes" are produced by intestinal epithelial cells. Eur. J. Immunol. 2001. 31: 2892-2900.
7. Ostman, S., Taube, M. and Telemo, E., Tolerosome-induced oral tolerance is MHC dependent. Immunology 2005. 116: 464-476.
8. van Lith, M., van Ham, M., Griekspoor, A., Tjin, E., Verwoerd, D., Calafat, J., Janssen, H. et al., Regulation of MEC class II antigen presentation by sorting of recycling HLA-DM/DO and class II within the multivesicular body. J. Immunol. 2001. 167: 884-892.
9. Segura, E., Niceo, C., Lombard, B., Veton, P., Raposo, G., Batteux, F., Amigorena, S. and Thery, C., ICAM-1 ori exosomes from mature dendritic cells is critical for efficient naive T-cell priming. Blood 2005. 106: 216-223.
10. Blanchard, N., Lankar D., Faure, F., Regnault, A., Dumont, C., Raposo, G. and Hivroz, C., TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. J. Immunol. 2002. 168: 3235-3241.
11. Wuhbolts, R., Leckie, R. S., Veenhuizen, P. T., Schwarzmann, G., Mobius, W., Hoernschemeyer, J., Slot, J. W. et al., Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J. Biol. Chem. 2003. 278: 10963-10972.
12. Clayton, A., Court, J., Navabi, H., Adams, M., Mason, M. D., Hobot, J. A., Newman, G. R. and Jasani, B., Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry. J. Immunol. Methods 2001. 247: 163-174.
13. Quezada, S. A., Jarvinett, L. Z., Lind, E. F. and Noelle, R. J., CD40/CD154 interactions at the interface of tolerance and immunity. Annu. Rev. Immunol. 2004. 22: 307-328.
14. Bishop, G. A. and Hostager, B. S., The:CD40-CD154 interaction in B cell-T cell liaisons. Cytokine Growth Factor Rev. 2003. 14: 297-309.
15. Siebenlist, U., Brown, K. and Claudio, E., Control of lymphocyte development by nuclear factor-kappaB. Nat. Rev. Immunol. 2005. 5: 435-445.
16. Thery, C., Regnault, A., Garin, J., Wolters, J., Zityogel, L., Ricciardi-Castagnoti, P., Raposo, G. and Amigorena, S., Molecular characterization of dendritic cell-derived exosornes. Selective accumulation of the heat shock protein Hsc73. J. Cell Biol. 1999. 147: 599-610.
17. Thery, C., Boussac, M., Veron, P., Ricciardi-Castagnoll, P., Raposo, G., Garin, J. and Amigorena, S., Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles. J. Immunol. 2001. 166: 7309-7318.
18. Kawano, A., Shimoda, S., Kamihira, T., Ishikawa, F., Niiro, H., Soejima, Y., Taketomi, A. et al., Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis. J. Immunol. 2007. 179: 3315-3324.
19. Shimoda, S., Ishikawa, F., Kamihira, T., Komori, A., Niiro, H., Baba, E., Harada, K. et al., Autoreactive T-cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory. Gastroenterology 2006. 131: 606-618.
20. Escola, J. M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O. and Geuze, H. J., Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J. Biol. Chem. 1998. 273: 20121-20127.
21. Savina, A., Furlan, M., Vidal, M. and Colombo, M. I., Exosome release is regulated by a calcium-dependent mechanism in K562 cells. J. Biol. Chem. 2003. 278: 20083-20090.
22. Thorley-Lawson, D. A., Epstein-Barr virus: Exploiting the immune system. Nat. Rev. Immunol. 2001. 1: 75-82.
23. Caby, M. P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G. and Bonnerot, C., Exosomal-like vesicles are present in human blood plasma. Int. Immunol. 2005. 17: 879-887.
24. Niiro, H. and Clark, E. A., Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2002. 2: 945-956.
25. Peng, S. L., Signaling in B cells via Toll-like receptors. Curr. Opin. Immunol. 2005. 17: 230-236.
26. Pierce, J. W., Schoenleber, R., Jesmok, G., Best, J., Moore, S. A., Collins, T. and Gerritsen, M. E., Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J. Biol. Chem. 1997. 272: 21096-21103.
27. Savina, A., Vidal, M. and Colombo, M. I., The exosome pathway in K562 cells is regulated by Rab11. J. Cell Sci. 2002. 115: 2505-2515.
28. Heijnen, H. F., Schiel, A. E., Fijnheer, R., Geuze, H. J. and Sixma, J. J., Activated platelets release two types of membrane vesicles: Microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood 1999. 94: 3791-3799.
29. Janiszewski, M., Do Carmo, A. O., Pedro, M. A., Silva, E., Knobel, E. and Laurindo, F. R., Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: A novel vascular redox pathway. Crit. Care Med. 2004. 32: 818-825.
30. Dal Porto, J.M., Gauld, S. B., Merrell, K. T.,Mills, D., Pugh-Bernard, A. E. and Cambier, J., B cell antigen receptor signaling 101. Mol. Immunol. 2004. 41: 599-613.
31. Schulze-Luehrmann, J. and Ghosh, S., Antigen-receptor signaling to nuclear factor kappa B. Immunity 2006. 25: 701-715.
32. Kaisho, T. and Akira, S., Toll-like receptor function and signaling. J. Allergy Clin. Immunol. 2006. 117: 979-987; quiz 988.
33. Park, J. H., Lee, H. W., Fleischhauer, K. L., Kim, C. G., Sheffery, M. and Yang, S. Y., DNA-binding proteins for transcription enhancing region of HLA class I gene. Tissue Antigens 1993. 42: 78-86.
34. Girdlestone, J., Isamat, M., Gewert, D. and Milstein, C., Transcriptional regulation of HLA-A and -B: Differential binding of members of the Rel and IRF families of transcription factors. Proc. Natl. Acad. Sci. USA 1993. 90: 11568-11572.
35. Savina, A., Fader, C. M., Damiani, M. T. and Colombo, M. I., Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner. Traffic 2005. 6: 131-143.
36. Yu, X., Harris, S. L. and Levine, A. J., The regulation of exosome secretion: A novel function of the p53 protein. Cancer Res. 2006. 66: 4795-4801.
37. Amzallag, N., Passer, B. J., Allanic, D., Segura, E., Thery, C., Goud, B., Amson, R. and Telerman, A., TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. J. Biol. Chem. 2004. 279: 46104-46112.
38. + T cells by dendritic cell-derived exosomes. Nat. Immunol. 2002. 3: 1156-1162.
39. Vincent-Schneider, H., Stumptner-Cuvelette, P., Lankar, D., Pain, S., Raposo, G., Benaroch, P. and Bonnerot, C., Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells. Int. Immunol. 2002. 14: 713-722.
40. Andre, F., Chaput, N., Schartz, N. E., Flament, C., Aubert, N., Bernard, J., Lemonnier, F. et al., Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells. J. Immunol. 2004. 172: 2126-2136.
41. Morelli, A. E., Larregina, A. T., Shufesky, W. J., Sullivan, M. L., Stolz, D. B., Papworth, G. D., Zahorchak, A. F. et al., Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood 2004. 104: 3257-3266.
42. Escudier, B., Dorval, T., Chaput, N., Andre, F., Caby, M. P., Novault, S., Flament, C. et al., Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: Results of the first phase I clinical trial. J. Transl. Med. 2005. 3: 10.
43. Morse, M. A., Garst, J., Osada, T., Khan, S., Hobeika, A., Clay, T. M., Valente, N. et al., A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J. Transl. Med. 2005. 3: 9.
44. Alonso, R., Rodriguez, M. C., Pindado, J., Merino, E., Merida, I. and Izquierdo, M., Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes. J. Biol. Chem. 2005. 280: 28439-28450.
45. + T-cell apoptosis. Blood Cells Mol. Dis. 2005. 35: 169-173.
46. Taylor, D. D. and Gercel-Taylor, C., Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br. J. Cancer 2005. 92: 305-311.
47. Frangsmyr, L., Baranov, V., Nagaeva, O., Stendahl, U., Kjellberg, L. and Mincheva-Nilsson, L., Cytoplasmic microvesicular form of Fas ligand in human early placenta: Switching the tissue immune privilege hypothesis from cellular to vesicular level. Mol. Hum. Reprod. 2005. 11: 35-41.
48. Mincheva-Nilsson, L., Nagaeva, O., Chen, T., Stendahl, U., Antsiferova, J., Mogren, I., Hernestal, J. and Baranov, V., Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: A possible novel immune escape mechanism for fetal survival. J. Immunol. 2006. 176: 3585-3592.
49. Sabapatha, A., Gercel-Taylor, C. and Taylor, D. D., Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences. Am. J. Reprod. Immunol. 2006. 56: 345-355.
50. Taylor, D. D., Akyol, S. and Gercel-Taylor, C., Pregnancy-associated exosomes and their modulation of T cell signaling. J. Immunol. 2006. 176: 1534-1542.
51. Kim, S. H., Lechman, E. R., Bianco, N., Menon, R., Keravala, A., Nash, J., Mi, Z. et al., Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J. Immunol. 2005. 174: 6440-6448.
52. Dukers, D. F., Meij, P., Vervoort, M. B., Vos, W., Scheper, R. J., Meijer, C. J., Bloemena, E. and Middeldorp, J. M., Direct immunosuppressive effects of EBV-encoded latent membrane protein 1. J. Immunol. 2000. 165: 663-670.
53. Flanagan, J., Middeldorp, J. and Sculley, T., Localization of the Epstein-Barr virus protein LMP 1 to exosomes. J. Gen. Virol. 2003. 84: 1871-1879.