Lung cancer and inflammation: interaction of chemokines and hnRNPs

Current Opinion in Pharmacology

Volumn 9, Issue 4, 2009, Pages 384-388

  Tauler, Jordi ^a   Mulshine, James L ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; CYCLOOXYGENASE 2; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; RNA BINDING PROTEIN; STROMAL CELL DERIVED FACTOR 1; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

CELL FUNCTION; CELL STIMULATION; GENETIC STABILITY; HUMAN; INFLAMMATION; LUNG CANCER; LUNG CARCINOGENESIS; MOLECULAR MECHANICS; NONHUMAN; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW;

ANIMALS; CHEMOKINES; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LUNG NEOPLASMS; PROTEIN BINDING;

EID: 68849124716     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2009.06.004     Document Type: Review

References (60)

1. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Murray T., and Thun M.J. Cancer statistics. CA Cancer J Clin 58 (2008) 71-96
2. Ballaz S., and Mulshine J.L. The potential contributions of chronic inflammation to lung carcinogenesis. Clin Lung Cancer 5 (2003) 46-62. Interesting review of main pathways involved in chronic inflammation and cancer development and their interactions.
3. de Torres J.P., Bastarrika G., Wisnivesky J.P., Alcaide A.B., Campo A., Seijo L.M., Pueyo J.C., Villanueva A., Lozano M.D., Montes U., et al. Assessing the relationship between lung cancer risk and emphysema detected on low-dose CT of the chest. Chest 132 (2007) 1932-1938. In this paper, they evaluate by low-radiation-dose CT the correlation between emphysema and lung cancer using a prospective cohort of 1166 former and current smokers participating in a lung cancer screening study.
4. Houghton A.M., Mouded M., and Shapiro S.D. Common origins of lung cancer and COPD. Nat Med 14 (2008) 1023-1024
5. Adair-Kirk T.L., Atkinson J.J., and Senior R.M. Smoke particulates stress lung cells. Nat Med 14 (2008) 1024-1025
6. Brody J.S., and Spira A. State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer. Proc Am Thorac Soc 3 (2006) 535-537
7. Rot A., and von Andrian U.H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 22 (2004) 891-928
8. Gerard C., and Rollins B.J. Chemokines and disease. Nat Immunol 2 (2001) 108-115
9. Zlotnik A., Yoshie O., and Nomiyama H. The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biol 7 (2006) 243
10. Singh S., Varney M., and Singh R.K. Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis. Cancer Res 69 (2009) 411-415
11. Wu Y., Li Y.Y., Matsushima K., Baba T., and Mukaida N. CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process. J Immunol 181 (2008) 6384-6393
12. Fan J., Heller N.M., Gorospe M., Atasoy U., and Stellato C. The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy. Eur Respir J 26 (2005) 933-947. Extensive review on post-transcriptional regulation in chemikines. Regulation of CXCL8 (IL-8), CCL11, GCs and IL-10 through ARE in their 3′UTR mRNA is discussed.
13. Zhai Y., Zhong Z., Chen C.Y., Xia Z., Song L., Blackburn M.R., and Shyu A.B. Coordinated changes in mRNA turnover, translation, and RNA processing bodies in bronchial epithelial cells following inflammatory stimulation. Mol Cell Biol 28 (2008) 7414-7426
14. van den Berg A., Freitas J., Keles F., Snoek M., van Marle J., Jansen H.M., and Lutter R. Cytoskeletal architecture differentially controls post-transcriptional processing of IL-6 and IL-8 mRNA in airway epithelial-like cells. Exp Cell Res 312 (2006) 1496-1506
15. Kamma H., Fujimoto M., Fujiwara M., Matsui M., Horiguchi H., Hamasaki M., and Satoh H. Interaction of hnRNP A2/B1 isoforms with telomeric ssDNA and the in vitro function. Biochem Biophys Res Commun 280 (2001) 625-630
16. Zhu D., Xu G., Ghandhi S., and Hubbard K. Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: implications for cellular senescence. J Cell Physiol 193 (2002) 19-25
17. Smith R. Moving molecules: mRNA trafficking in Mammalian oligodendrocytes and neurons. Neuroscientist 10 (2004) 495-500
18. Moran-Jones K., Wayman L., Kennedy D.D., Reddel R.R., Sara S., Snee M.J., and Smith R. hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere. Nucleic Acids Res 33 (2005) 486-496
19. Landsberg M.J., Moran-Jones K., and Smith R. Molecular recognition of an RNA trafficking element by heterogeneous nuclear ribonucleoprotein A2. Biochemistry 45 (2006) 3943-3951
20. Guil S., Long J.C., and Caceres J.F. hnRNP A1 relocalization to the stress granules reflects a role in the stress response. Mol Cell Biol 26 (2006) 5744-5758
21. Martinez-Contreras R., Cloutier P., Shkreta L., Fisette J.F., Revil T., and Chabot B. hnRNP proteins and splicing control. Adv Exp Med Biol 623 (2007) 123-147
22. Cammas A., Pileur F., Bonnal S., Lewis S.M., Leveque N., Holcik M., and Vagner S. Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs. Mol Biol Cell 18 (2007) 5048-5059
23. Hossain M.N., Fuji M., Miki K., Endoh M., and Ayusawa D. Downregulation of hnRNP C1/C2 by siRNA sensitizes HeLa cells to various stresses. Mol Cell Biochem 296 (2007) 151-157
24. Fukuda T., Naiki T., Saito M., and Irie K. hnRNP K interacts with RNA binding motif protein 42 and functions in the maintenance of cellular ATP level during stress conditions. Genes Cells 14 (2009) 113-128
25. Carpenter B., MacKay C., Alnabulsi A., MacKay M., Telfer C., Melvin W.T., and Murray G.I. The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression. Biochim Biophys Acta 1765 (2006) 85-100
26. Velusamy T., Shetty P., Bhandary Y.P., Liu M.C., and Shetty S. Posttranscriptional regulation of urokinase receptor expression by heterogeneous nuclear ribonuclear protein C. Biochemistry 47 (2008) 6508-6517
27. Griffin M.E., Hamilton B.J., Roy K.M., Du M., Willson A.M., Keenan B.J., Wang X.W., and Nichols R.C. Post-transcriptional regulation of glucose transporter-1 by an AU-rich element in the 3′UTR and by hnRNP A2. Biochem Biophys Res Commun 318 (2004) 977-982
28. Fahling M., Mrowka R., Steege A., Martinka P., Persson P.B., and Thiele B.J. Heterogeneous nuclear ribonucleoprotein-A2/B1 modulate collagen prolyl 4-hydroxylase, alpha (I) mRNA stability. J Biol Chem 281 (2006) 9279-9286
29. Shanmugam N., Reddy M.A., and Natarajan R. Distinct roles of heterogeneous nuclear ribonuclear protein K and microRNA-16 in cyclooxygenase-2 RNA stability induced by S100b, a ligand of the receptor for advanced glycation end products. J Biol Chem 283 (2008) 36221-36233
30. Lu J.Y., Sadri N., and Schneider R.J. Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs. Genes Dev 20 (2006) 3174-3184. Interesting approach to study the effect of hnRNP D (AUF1) on TNF-α and IL-1β mRNA stability regulation using an AUF1 knockout mice and proposing a role for hnRNP D (AUF1) as attenuator of inflammatory response.
31. Soderberg M., Raffalli-Mathieu F., and Lang M.A. Inflammation modulates the interaction of heterogeneous nuclear ribonucleoprotein (hnRNP) I/polypyrimidine tract binding protein and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA. Mol Pharmacol 62 (2002) 423-431
32. Zhang W., Wagner B.J., Ehrenman K., Schaefer A.W., DeMaria C.T., Crater D., DeHaven K., Long L., and Brewer G. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol Cell Biol 13 (1993) 7652-7665
33. Xu N., Chen C.Y., and Shyu A.B. Versatile role for hnRNP D isoforms in the differential regulation of cytoplasmic mRNA turnover. Mol Cell Biol 21 (2001) 6960-6971
34. He C., and Schneider R. 14-3-3sigma is a p37 AUF1-binding protein that facilitates AUF1 transport and AU-rich mRNA decay. EMBO J 25 (2006) 3823-3831
35. Neininger A., Kontoyiannis D., Kotlyarov A., Winzen R., Eckert R., Volk H.D., Holtmann H., Kollias G., and Gaestel M. MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. J Biol Chem 277 (2002) 3065-3068
36. Zhou J., Mulshine J.L., Unsworth E.J., Scott F.M., Avis I.M., Vos M.D., and Treston A.M. Purification and characterization of a protein that permits early detection of lung cancer. Identification of heterogeneous nuclear ribonucleoprotein-A2/B1 as the antigen for monoclonal antibody 703D4. J Biol Chem 271 (1996) 10760-10766
37. Tockman M.S., Mulshine J.L., Piantadosi S., Erozan Y.S., Gupta P.K., Ruckdeschel J.C., Taylor P.R., Zhukov T., Zhou W.H., Qiao Y.L., et al. Prospective detection of preclinical lung cancer: results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression [see comments]. Clin Cancer Res 3 (1997) 2237-2246
38. Montuenga L.M., Zhou J., Avis I., Vos M., Martinez A., Cuttitta F., Treston A.M., Sunday M., and Mulshine J.L. Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development. Am J Resp Cell Mol Biol 19 (1998) 554-562
39. Zhou J., Mulshine J.L., Ro J.Y., Avis I., Yu R., Lee J.J., Morice R., Lippman S.M., and Lee J.S. Expression of heterogeneous nuclear ribonucleoprotein A2/B1 in bronchial epithelium of chronic smokers. Clin Cancer Res 4 (1998) 1631-1640
40. Zhou J., Nong L., Wloch M., Cantor A., Mulshine J.L., and Tockman M.S. Expression of early lung cancer detection marker: hnRNP-A2/B1 and its relation to microsatellite alteration in non-small cell lung cancer. Lung Cancer 34 (2001) 341-350
41. Hutchison S., LeBel C., Blanchette M., and Chabot B. Distinct sets of adjacent heterogeneous nuclear ribonucleoprotein (hnRNP) A1/A2 binding sites control 5' splice site selection in the hnRNP A1 mRNA precursor. J Biol Chem 277 (2002) 29745-29752
42. Peebles K.A., Dwyer-Nield L.D., and Malkinson A.M. Altered expression of splicing factor, heterogeneous nuclear ribonucleoprotein A2/B1, in mouse lung neoplasia. Mol Carcinog 46 (2007) 887-900
43. Patry C., Bouchard L., Labrecque P., Gendron D., Lemieux B., Toutant J., Lapointe E., Wellinger R., and Chabot B. Small interfering RNA-mediated reduction in heterogeneous nuclear ribonucleoparticule A1/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines. Cancer Res 63 (2003) 7679-7688
44. He Y., Brown M.A., Rothnagel J.A., Saunders N.A., and Smith R. Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation. J Cell Sci 118 (2005) 3173-3183
45. He Y., Rothnagel J.A., Epis M.R., Leedman P.J., and Smith R. Downstream targets of heterogeneous nuclear ribonucleoprotein A2 mediate cell proliferation. Mol Carcinog 48 (2009) 167-179. In this paper, hnRNP A2 is silenced in Colo16 human squamous carcinoma cell line to analyze downstream targets of hnRNP A2 by microarray analysis.
46. Deng H., Liu R., Ellmeier W., Choe S., Unutmaz D., Burkhart M., Di Marzio P., Marmon S., Sutton R.E., Hill C.M., et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381 (1996) 661-666
47. Ratajczak M.Z., Majka M., Kucia M., Drukala J., Pietrzkowski Z., Peiper S., and Janowska-Wieczorek A. Expression of functional CXCR4 by muscle satellite cells and secretion of SDF-1 by muscle-derived fibroblasts is associated with the presence of both muscle progenitors in bone marrow and hematopoietic stem/progenitor cells in muscles. Stem Cells 21 (2003) 363-371
48. Stumm R.K., Zhou C., Ara T., Lazarini F., Dubois-Dalcq M., Nagasawa T., Hollt V., and Schulz S. CXCR4 regulates interneuron migration in the developing neocortex. J Neurosci 23 (2003) 5123-5130
49. Lazarini F., Tham T.N., Casanova P., Arenzana-Seisdedos F., and Dubois-Dalcq M. Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system. GLIA 42 (2003) 139-148
50. Ratajczak M.Z., Kucia M., Reca R., Majka M., Janowska-Wieczorek A., and Ratajczak J. Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells 'hide out' in the bone marrow. Leukemia 18 (2004) 29-40
51. Helbig G., Christopherson II K.W., Bhat-Nakshatri P., Kumar S., Kishimoto H., Miller K.D., Broxmeyer H.E., and Nakshatri H. NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem 278 (2003) 21631-21638
52. Phillips R.J., Mestas J., Gharaee-Kermani M., Burdick M.D., Sica A., Belperio J.A., Keane M.P., and Strieter R.M. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. J Biol Chem 280 (2005) 22473-22481
53. Otsuka S., and Bebb G. The CXCR4/SDF-1 chemokine receptor axis: a new target therapeutic for non-small cell lung cancer. J Thorac Oncol 3 (2008) 1379-1383. Accurate review of role of the CXCR4/SDF1 axis in lung cancer and molecular pathways involved.
54. Spano J.P., Andre F., Morat L., Sabatier L., Besse B., Combadiere C., Deterre P., Martin A., Azorin J., Valeyre D., et al. Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome. Ann Oncol 15 (2004) 613-617
55. Su L., Zhang J., Xu H., Wang Y., Chu Y., Liu R., and Xiong S. Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells. Clin Cancer Res 11 (2005) 8273-8280
56. Pan H., Luo C., Li R., Qiao A., Zhang L., Mines M., Nyanda A.M., Zhang J., and Fan G.H. Cyclophilin A is required for CXCR4-mediated nuclear export of heterogeneous nuclear ribonucleoprotein A2, activation and nuclear translocation of ERK1/2, and chemotactic cell migration. J Biol Chem 283 (2008) 623-637. In this report, authors investigated the mechanim responsible of CXCR4-mediated effects in HEK293 cells. Stimulation of CXCR4 by its ligand, CXCL12 (SDF-1), induces hnRNP A2 nuclear export, ERK 1/2 activation and chemotactic cell migration. These effects are mediated by interaction of Cyclophilin A (CyPA) with internalized CXCR4 receptor. Silencing of CyPA inhibits or attenuates these CXCR4-mediated responses.
57. Yoo Y., Wu X., Egile C., Li R., and Guan J.L. Interaction of N-WASP with hnRNPK and its role in filopodia formation and cell spreading. J Biol Chem 281 (2006) 15352-15360
58. Inoue A., Watanabe T., Tominaga K., Tsugawa K., Nishio K., Takahashi K.P., and Kaneda K. Association of hnRNP S1 proteins with vimentin intermediate filaments in migrating cells. J Cell Sci 118 (2005) 2303-2311
59. Arai A., Aoki M., Weihua Y., Jin A., and Miura O. CrkL plays a role in SDF-1-induced activation of the Raf-1/MEK/Erk pathway through Ras and Rac to mediate chemotactic signaling in hematopoietic cells. Cell Signal 18 (2006) 2162-2171
60. Altraja S., Jaama J., Valk E., and Altraja A. Changes in the proteome of human bronchial epithelial cells following stimulation with leucotriene E4 and transforming growth factor-beta1. Respirology 14 (2009) 39-45