Effect of occupational exposure to multiple pesticides on translocation yield and chromosomal aberrations in lymphocytes of plant workers

Environmental Science and Technology

Volumn 43, Issue 16, 2009, Pages 6370-6377

  Zeljezic, Davor ^a   Vrdoljak, A Lucic ^a   Lucas, Joe N ^b   Lasan, Ruzica ^c   Fucic, Aleksandra ^a   Kopjar, Nevenka ^a   Katic, Jelena ^a   Mladinic, Marin ^a   Radic, Bozica ^a  

^a INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^b ChromoTrax Inc   (United States)

^c UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SUBSTANCE; CARBOFURANS; CHEMICAL EXPOSURE; CHLORPYRIFOS; CHROMOSOMAL ABERRATION; CHROMOSOME ABERRATION; CONTROL SUBJECT; DNA CONTENT; DNA DAMAGES; FLUORESCENT IN SITU HYBRIDIZATION; GENOMIC FREQUENCY; METALAXYL; OCCUPATIONAL EXPOSURE; PESTICIDE EXPOSURE; PESTICIDE PRODUCTION; TRANSLOCATION FREQUENCY;

ABERRATIONS; DNA; GENES; HEALTH RISKS; NUCLEIC ACIDS; PROBES; RISK ASSESSMENT; RISK MANAGEMENT;

PESTICIDES;

ACETIC ACID DERIVATIVE; CARBOFURAN; CHLORPYRIFOS; DNA; DODINE; METALAXYL; UNCLASSIFIED DRUG;

AGE CLASS; BLOOD; CHROMOSOME; DNA; GENOMICS; HEALTH IMPACT; HEALTH RISK; OCCUPATIONAL EXPOSURE; PESTICIDE; RISK FACTOR; SMOKING; TRANSLOCATION;

ADULT; AGE DISTRIBUTION; ARTICLE; ASSAY; CHROMATID; CHROMOSOME 1; CHROMOSOME 2; CHROMOSOME 4; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FREQUENCY; HUMAN; HUMAN CELL; LYMPHOCYTE; MALE; OCCUPATIONAL EXPOSURE; OUTCOME ASSESSMENT; SEX RATIO; SMOKING; WORKER;

ADULT; CASE-CONTROL STUDIES; CHROMOSOME ABERRATIONS; CHROMOSOME PAINTING; FEMALE; HUMANS; INDUSTRY; LYMPHOCYTES; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; PESTICIDES; TRANSLOCATION, GENETIC;

EID: 68849111390     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es900824t     Document Type: Article

References (57)

1. Hicks, B. R. Agrow's report: Agrow's Complete Guide to Generic Pesticides. Products & Markets 2007 Edition (DS260); Agrow T&F Informa: United Kingdom, 2007.
2. Bhalli, J. A.; Khan, Q. M.; Haq, M. A.; Khalid, A. M.; Nasim, A. Cytogenetic analysis of Pakistani individuals occupationally exposed to pesticides in a pesticide production industry. Mutagenesis 2006, 21 (2), 143-148.
3. Bull, S.; Fletcher, K.; Boobis, A. R.; Battershill, J. M. Evidence for genotoxicity of pesticides in pesticide applicators: a review. Mutagenesis 2006, 21 (2), 93-103.
4. Hill, M. K. Understanding Environmental Pollution; Cambridge University Press: New York, 2004.
5. Roldan-Tapia, L.; Leyva, A.; Laynez, F.; Santed, F. S. Chronic neuropsychological sequelae of cholinesterase inhibitors in the absence of structural brain damage: two cases of acute poisoning. Environ. Health Perspect. 2005, 113, 762-766.
6. Baligar, P. N.; Kaliwal, B. B. Carbofuran induced block of compensatory ovarian growth in hemicastrated albino mice. Toxicology 2004, 204, 87-89.
7. McDufie, H. H.; Pahwa, P.; McLaughlin, J. R.; Spinelli, J. J.; Fincham, S.; Dosman, J. A.; Robson, D.; Skinnider, L. F.; Choi, N. W. Non Hodgkin's lymphoma and specific pesticides exposures in men: cross-Canada study of pesticides and health. Cancer Epidemiol. Biomarkers Prev. 2001, 10, 1155-1163.
8. Bonner, M. R.; Lee, W. J.; Sandler, D. P.; Hoppin, J. A.; Dosemeci, M.; Alavanja, M. C. R. Occupational exposure to carbofuran and the incidence of cancer in the agricultural health study. Environ. Health Perspect. 2005, 113, 285-289.
9. Lee, W. J.; Colt, J. S.; Heineman, E. F.; McCombm, R.; Weisenburger, D. D.; Lijinsky, W.; Ward, M. H. Agricultural pesticide use and risk of glioma in Nebraska, United States. Occupat. Environ. Med. 2005, 62, 786-792.
10. Lee, W. J.; Sandler, D. P.; Blair, A.; Samanic, C.; Cross, A. J.; Alavanja, M. C. R. Pesticide use and colorectal cancer risk in the agricultural health study. Int. J. Cancer 2007, 121, 339-346.
11. Meeker, J. D.; Ravi, S. R.; Barr, D. B.; Hauser, R. Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides. Reprod. Toxicol. 2008, 25, 184-191.
12. Vlastos, D.; Demsia, G.; Matthopoulos, D. Evaluation of genetic damage in tobacco-growing farmers occupationally exposed to a mixture of metalaxyl and imidacloprid. Int. J. Environ. Anal. Chem. 2004, 84, 183-191.
13. Puente, N. W.; Josephy, P. D. Technical note: analysis of the lidocaine metabolite 2,6-dimethylaniline in bovine and human milk. J. Anal. Toxicol. 2001, 5, 711-715.
14. U. S. Environmental Protection Agency Registration Eligibility Decision for Dodine: Case No. 0161; EPA: Washington, DC, 2005.
15. Lucas, J. N.; Deng, W. Views on issues in radiation biodosimetry basedonchromosometranslocations measured by FISH. Radiat. Protect. Dosimetry 2000, 88, 77-86.
16. International Atomic Energy Agency Cytogenetic analysis for radiation dose assessment: a manual; IAEA: Vienna, Austria, 2001.
17. U. S. Environmental Protection Agency Guidelines for Carcinogen Risk Assessment EPA/630/P-03/001B; EPA: Washington, DC, 2005.
18. Organization for Economic Cooperation and Development Guidelines for the testing of chemicals No. 473: In vitro mammalian chromosome aberration test; OECD: Paris, France, 1997.
19. Tucker, J. D.; Morgan, W. F.; Awa, A. A.; Bauchinger, M.; Blakei, D.; Cornfor, M. N.; Littlefield, L. G.; Natarajan, A. T.; Shasserre, C.Aproposed system for scoring structural aberrations detected by chromosome painting. Cytogenet. Cell Genet. 1995, 68, 211-221.
20. Lucas, J. N.; Sachs, R. K. Using three-color chromosome painting to test chromosome aberration models. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 1484-1487.
21. 0 human lymphocytes and their fate through mitotic divisions in culture. Environ. Mol. Mutagen. 1999, 33, 94-110.
22. Morton, N. E. Parameters of the human genome. Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 7474-7476.
23. Bonassi, S.; Norppa, H.; Ceppi, M.; Stromberg, U.; Vermeulen, R.; Znaor, A.; Cebulska-Wasilewska, A.; Fabianova, E.; Fucic, A. Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22,358 subjects in 11 countries. Carcinogenesis 2008, 29 (6), 1178-83.
24. Natarajan, A. T. Chromosome aberrations: past, present and future. Mutat. Res. 2002, 504, 3-16.
25. Hsieh, W. A.; Lucas, J. N.; Hwang, J. J.; Chan, C. C.; Chang, W. P. Biodosimetry using chromosomal translocations measured by FISH in the population chronically exposed to low dose rate 60Co gamma-irradiation. Int. J. Radiat. Biol. 2001, 77, 797-804.
26. Verdorfer, I.; Neubauer, S.; Letzer, S.; Angerer, J.; Arutyunyan, R.; Martus, P.; Wucherer, M.; Gebhart, E. Chromosome painting for cytogenetic monitoring of occupationally exposed and nonexposed groups of human individuals. Mutat. Res. 2001, 491, 97-109.
27. Tawn, E. J.; Whitehouse, C. A.; Tarrone, R. E. FISH chromosome aberrations analysis on retired radiationworkers from Sellafield nuclear facility. Radiat. Res. 2004, 162, 249-256.
28. Sram, R. J.; Beskid, O.; Binkova, B.; Rossner, P.; Smerhovsky, Z. Cytogenetic analysis using fluorescence in situ hybridization (FISH) to evaluate occupational exposure to carcinogens. Toxicol. Lett. 2004, 149, 335-344.
29. Beskid, O.; Dusek, Z.; Solansky, I.; Sram, R. J. The effects of exposure to different clastogens on the pattern of chromosomal aberrations detected by FISH whole chromosome painting in occupationally exposed individuals. Mutat. Res. 2006, 594, 20-29.
30. Tucker, J. D.; Moore, D. H.; Ramsey, M. J.; Kato, P.; Langlois, R. G.; Burroughs, B.; Long, L.; Garry, V. F. Multi-endpoint biological monitoring of phosphine workers. Mutat. Res. 2003, 536, 7-14.
31. Bolognesi, C.; Landini, E.; Perrone, E.; Roggieri, P. Cytogenetic biomonitoring of a floriculturist population in Italy: micronucleus analysis by fluorescence in situ hybridization (FISH) with an all-chromosome centromeric probe. Mutat. Res. 2004, 557, 109-117.
32. Gomez-Arroyo, S.; Diaz-Sanchez, Y.; Meneses-Perez, M. A.; Villalobos-Pietrini, R.; De Leon-Rodriguez, J. Cytogenetic biomonitoring in a Mexican floriculture worker group exposed to pesticides. Mutat. Res. 2000, 466, 117-124.
33. Kehdy, F. S. G.; Cerqueira, E. M. M.; Bonjardim, M. B.; Camelo, R. M.; Castro, M. C. L. Study of the cytogenetic effects of occupational exposure to pesticides on sanitation workers in Belo Horizonte, Brazil. Genet. Mol. Res. 2007, 6, 581-593.
34. De Ferrari, M.; Artuso, M.; Bonassi, A. M.; Bonatti, S.; Cavalieri, Z.; Pescatore, D.; Marchini, E.; Pisano, V.; Abbondandolo, A. Cytogenetic biomonitoring of an Italian population exposed to pesticides: chromosome aberration and sister-chromatid exchange analysis in peripheral blood lymphocytes. Mutat. Res. 1991, 260, 105-113.
35. Lander, B.; Knudsen, L.; Gamborg, M.; Jarventaus, H.; Norppa, H. Chromosome aberrations in pesticide-exposed greenhouse workers. Scand. J. Work Environ. Health 2000, 26, 436-442.
36. Shaham, J.; Kaufman, Z.; Gurvich, R.; Levi, Z. Frequency of sister-chromatid exchange among greenhouse farmers exposed to pesticides. Mutat. Res. 2001, 491, 71-80.
37. Gregio D'Arce, L. P.; Colus, I. M. Cytogenetic and molecular biomonitoring of agricultural workers exposed to pesticides in Brazil. Teratog. Carcinog. Mutagen. 2000, 20, 161-170.
38. Lucero, L.; Pastor, S.; Suarez, S.; Durban, R.; Gomez, C.; Parron, T.; Creus, A.; Marcos, R. Cytogenetic biomonitoring of Spanish greenhouse workers exposed to pesticides: micronuclei analysis in peripheral blood lymphocytes and buccal epithelial cells. Mutat. Res. 2000, 464, 255-262.
39. Pastor, S.; Gutierrez, S.; Creus, A.; Cebulska-Wasilewska, A.; Marcos, R. Micronuclei in peripheral blood lymphocytes and buccal epithelial cells of Polish farmers exposed to pesticides. Mutat. Res. 2001, 495, 147-156.
40. Bolognesi, C. Genotoxicity of pesticides: a review of human biomonitoring studies. Mutat. Res. 2003, 543, 251-272.
41. Bolognesi, C.; Abbondandolo, A.; Barale, R.; Casalone, R.; Dalpra, L.; De Ferrari, M.; Degrassi, F.; Forni, A.; Lamberti, L.; Lando, C.; et al. Age-related increase of baseline frequencies of sister chromatid exchanges, chromosome aberrations and micronuclei inhumanlymphocytes. Cancer Epidemiol. Biomarkers Prev. 1997, 6, 249-256.
42. Stephan, G.; Pressl, S. Chromosomal aberration in peripheral lymphocytes from healthy subjects as detected in first cell division. Mutat. Res. 1999, 446, 231-237.
43. Meeker, J. D.; Ryan, L.; Bar, D. B.; Hauser, R. Exposure to nonpersistent insecticides and male reproductive hormones. Epidemiology 2006, 17, 61-68.
44. Abell, A.; Ernst, E.; Bonde, J. P. Semen quality and sexual hormones in greenhouse workers. Scand. J. Work. Environ. Health 2000, 26, 492-500.
45. Rawlings, N. C.; Cook, S. J.; Waldbillig, D. Effects of the pesticides carbofuran, chlorpyrifos, dimethoate, lindane, triallate, trifluralin, 2,4-D, and pentachlorophenol on the metabolic endocrine and reproductive endocrine system in ewes. J. Toxicol. Environ. Health A. 1998, 54, 21-36.
46. Timchenko, O. I. The effect of thyroid and gonadal hormones on the chromosomal integrity of liver cells. Tsitol. Genet 1995, 29, 41-45.
47. Djelic, N.; Spremo-Potparević, B.; Bajić, V.; Djelic, D. Sister chromatid exchangeandmicronuclei inhumanperipheral blood lymphocytes treated with thyroxine in vitro. Mutat. Res. 2006, 604, 1-7.
48. Hrelia, P.; Maffe, F.; Fimognari, C.; Vigagni, F.; Cantelli-Forti, G. Cytogenetic effects of metalaxyl on human and animal chromosomes. Mutat. Res. 1996, 369, 81-86.
49. Chauhan, L. K. S.; Pant, N.; Gupta, S. K.; Srivastava, S. P. Induction ofchromosomeaberrations, micronucleus formation and sperm abnormalities in mouse following carbofuran exposure. Mutat. Res. 2000, 465, 123-129.
50. Gollapudi, B. B.; Mendrala, A. L.; Linscombe, V. A. Evaluation of the genetic toxicity of the organophosphate insecticide chlorpyrifos. Mutat. Res. 1995, 342, 25-36.
51. Rahman, M. F.; Mahboob, M.; Danadevi, K.; Banu, B. S.; Grover, P. Assessment of genotoxic effects of chloropyriphos and acephate by the comet assay in mice leucocytes. Mutat. Res. 2002, 516, 139-147.
52. Cox, C.; Surgan, M. Unidentified inert ingredients in pesticides: implications for human and environmental health. Health Perspect. 2006, 114, 1803-1806.
53. Zheng, T.; Zahm, S. H.; Cantor, K. P.; Weisenburger, D. D.; Zhang, Y.; Blair, A. Agricultural exposure to carbamate pesticides and risk of non-Hodgkin lymphoma. J. Occup. Environ. Med. 2001, 43, 641-649.
54. Johnson, K. L.; Tucker, J. D.; Nath, J. Frequency, distribution and clonality of chromosome damage in human lymphocytes by multi-color FISH. Mutagenesis 1998, 13, 217-227.
55. Sigurdson, A. J.; Ha, M.; Hauptmannd, M.; Bhatti, P.; Sram, R. J.; Beskid, O.; Tawn, E. J.; Whitehouse, C. A.; Lindholm, C.; Nakano, M.; et al. International study of factors affecting human chromosome translocations. Mutat. Res. 2008, 652, 112-121.
56. Fomina, J.; Darroudi, F.; Boei, J.; Natarajan, A. Discrimination between complete and incomplete chromosome exchanges in X-irradiated human lymphocytes using FISH with pan-centromeric and chromosome specific DNA probes in combination with telomeric PNA probe. Int. J. Radiat. Biol. 2000, 76, 807-813.
57. Meaburn, K. J.; Misteli, T. Chromosome territories. Nature 2007, 445, 379-381.