FISH chromosome aberration analysis on retired radiation workers from the Sellafield nuclear facility

Radiation Research

Volumn 162, Issue 3, 2004, Pages 249-256

  Tawn, E Janet ^a   Whitehouse, Caroline A ^a   Tarone, Robert E ^b  

^a WESTLAKES RESEARCH INSTITUTE   (United Kingdom)

^b INTERNATIONAL EPIDEMIOLOGY INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; ATOMIC BOMB; CANCER RISK; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DOSE RESPONSE; DOSIMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; NUCLEAR POWER PLANT; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; SMOKING;

AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; BODY BURDEN; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; DOSE-RESPONSE RELATIONSHIP, RADIATION; GREAT BRITAIN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; POWER PLANTS; RADIATION DOSAGE; RADIOMETRY; RISK ASSESSMENT; RISK FACTORS; SMOKING;

EID: 4644239346     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3214     Document Type: Article

References (60)

1. J. N. Lucas, A. Awa, T. Straume, M. Poggensee, Y. Kodama, M. Nakano, K. Ohtaki, H. U. Weier, D. Pinkel and G. Littlefield, Rapid translocation frequency analysis in humans decades after exposure to ionizing radiation. Int. J. Radiat. Biol. 62, 53-63 (1992).
2. M. Nakano, Y. Kodama, K. Ohtaki, M. Itoh, R. Delongchamp, A. A. Awa and N. Nakamura, Detection of stable chromosome aberrations by FISH in A-bomb survivors: Comparison with previous solid Giemsa staining data on the same 230 individuals. Int. J. Radiat. Biol. 77, 971-977 (2001).
3. K. Salassidis, E. Schmid, R. U. Peter, H. Braselmann and M. Bauchinger, Dicentric and translocation analysis for retrospective dose estimation in humans exposed to ionising radiation during the Chernobyl nuclear power plant accident. Mutat. Res. 311, 39-48 (1994).
4. K. Salassidis, V. Georgiadou-Schumacher, H. Braselmann, P. Muller, R. U. Peter and M. Bauchinger, Chromosome painting in highly irradiated Chernobyl victims: A follow-up study to evaluate the stability of symmetrical translocations and the influence of clonal aberrations for retrospective dose estimation. Int. J. Radiat. Biol. 68, 257-262 (1995).
5. F. Granath, F. Darroudi, A. Auvinen, L. Ehrenberg, T. Hakulinen, A. T. Natarajan, M. Rahu, T. Rytomaa, M. Tekkel and T. Veidebaum, Retrospective dose estimates in Estonian Chernobyl clean-up workers by means of FISH. Mutat. Res. 369, 7-12 (1996).
6. D. H. Moore, 2nd, J. D. Tucker, I. M. Jones, R. G. Langlois, R Pleshanov, I. Vorobtsova and R. Jensen, A study of the effects of exposure on cleanup workers at the Chernobyl nuclear reactor accident using multiple end points. Radiat. Res. 148, 463-475 (1997).
7. G. Snigiryova, H. Braselmann, K. Salassidis, V. Shevchenko and M. Bauchinger, Retrospective biodosimetry of Chernobyl clean-up workers using chromosome painting and conventional chromosome analysis. Int. J. Radiat. Biol. 71, 119-127 (1997).
8. L. G. Littlefield, A. F. McFee, S. I. Salomaa, J. D. Tucker, P. D. Inskip, A. M. Sayer, C. Lindholm, S. Makinen, R. Mustonen and J. D. Boice, Jr., Do recorded doses overestimate true doses received by Chernobyl cleanup workers? Results of cytogenetic analyses of Estonian workers by fluorescence in situ hybridization. Radiat. Res. 150, 237-249 (1998).
9. I. M. Jones, H. Galick, P. Kato, R. G. Langlois, M. L. Mendelsohn, G. A. Murphy, P. Pleshanov, M. J. Ramsey, C. B. Thomas and D. O. Nelson, Three somatic genetic biomarkers and covariates in radiation-exposed Russian cleanup workers of the Chernobyl nuclear reactor 6-13 years after exposure. Radiat. Res. 158, 424-442 (2002).
10. A. T. Natarajan, R. C. Vyas, J. Wiegant and M. P. Curado, A cytogenetic follow-up study of the victims of a radiation accident in Goiania (Brazil). Mutat. Res. 247, 103-111 (1991).
11. 137Cesium-induced chromosome aberrations analyzed by fluorescence in situ hybridization: Eight years follow up of the Goiania radiation accident victims. Mutat. Res. 400, 299-312 (1998).
12. E. T. Sakamoto-Hojo, A. T. Natarajan and M. P. Curado, Chromosome translocations in lymphocytes from individuals exposed to Cs-137 7.5 years after the accident in Goiania (Brazil). Radiat. Prot. Dosim. 86, 25-32 (1999).
13. K. Salassidis, H. Braselmann, N. D. Okladnikova, S. Pressl, G. Stephan, G. Snigiryova and M. Bauchinger, Analysis of symmetrical translocations for retrospective biodosimetry in radiation workers of the Mayak nuclear-industrial complex (Southern Urals) using FISH-chromosome painting. Int. J. Radiat. Biol. 74, 431-439 (1998).
14. M. Bauchinger, H. Braselmann, J. R. Savage, A. T. Natarajan, G. I. Terzoudi, G. E. Pantelias, F. Darroudi, M. Figgitt, C. S. Griffin and G. Snigiryova, Collaborative exercise on the use of FISH chromosome painting for retrospective biodosimetry of Mayak nuclear-industrial personnel. Int. J. Radiat. Biol. 77, 259-267 (2001).
15. L. E. Burak, Y. Kodama, M. Nakano, K. Ohtaki, M. Itoh, N. D. Okladnikova, E. K. Vasilenko, J. B. Cologne and N. Nakamura, FISH examination of lymphocytes from Mayak workers for assessment of translocation induction rate under chronic radiation exposures. Int. J. Radiat. Biol. 77, 901-908 (2001).
16. M. Bauchinger, K. Salassidis, H. Braselmann, A. Vozilova, S. Pressl, G. Stephan, G. Snigiryova, V. P. Kozheurov and A. Akleyev, FISH-based analysis of stable translocations in a Techa River population. Int. J. Radiat. Biol. 73, 605-612 (1998).
17. 60Co γ-irradiation. Int. J. Radiat. Biol. 77, 797-804 (2001).
18. J. D. Tucker, E. J. Tawn, D. Holdsworth, S. Morris, R. Langlois, M. J. Ramsey, P. Kato, J. D. Boice, Jr., R. E. Tarone and R. H. Jensen, Biological dosimetry of radiation workers at the Sellafield nuclear facility. Radiat. Res. 148, 216-226 (1997).
19. E. J. Tawn, C. A. Whitehouse, D. Holdsworth, S. Morris and R. E. Tarone, Chromosome analysis of workers occupationally exposed to radiation at the Sellafield nuclear facility. Int. J. Radiat. Biol. 76, 355-365 (2000).
20. C. Lindholm, Stable and unstable chromosomal aberrations among Finnish nuclear power plant workers. Radiat. Prot. Dosim. 93, 143-150 (2001).
21. K. George, M. Durante, H. Wu, V. Willingham, G. Badhwar and F. A. Cucinotta, Chromosome aberrations in the blood lymphocytes of astronauts after space flight. Radiat. Res. 156, 731-738 (2001).
22. S. Heim and F. Mitelman, Cancer Cytogenetics. Wiley-Liss, New York, 1995.
23. E. J. Tawn, Chromosome changes in human cancer-are they pointers to mechanisms of initiation? Radiat. Oncol. Investig. 5, 97-102 (1997).
24. S. Bonassi and W. W. Au, Biomarkers in molecular epidemiology studies for health risk prediction. Mutat. Res. 511, 73-86 (2002).
25. A. V. Kite and A. R. Britcher, Uncertainties in recorded photon radiation doses at Sellafield. Radiat. Prot. Dosim. 67, 23-32 (1996).
26. R. W. Anderson and A. V. Kite, A dose reconstruction case study - the retrospective assessment of neutron dose for workers on the Windscale Piles at Sellafield. Radiation dose management. BNES 6, 5-70 (1995).
27. A. M. Bothwell, C. A. Whitehouse and E. J. Tawn, The application of FISH for chromosome aberration analysis in relation to radiation exposure. Radiat. Prot. Dosim. 88, 7-14 (2000).
28. I. Sorokine-Durm, C. A. Whitehouse and A. Edwards, The variability of translocations yields amongst control populations. Radiat. Prot. Dosim. 88, 93-99 (2000).
29. E. Tawn and C. A. Whitehouse, Stable chromosome aberration frequencies in men occupationally exposed to radiation. J. Radiat. Prot. 23, 269-278 (2003).
30. J. D. Tucker, W. F. Morgan, A. A. Awa, M. Bauchinger, D. Blakey, M. N. Cornforth, L. G. Littlefield, A. T. Natarajan and C. Shasserre, PAINT: a proposed nomenclature for structural aberrations detected by whole chromosome painting. Mutat. Res. 347, 21-24 (1995).
31. J. Fomina, F. Darroudi, J. J. Boei and A. T. Natarajan, Discrimination between complete and incomplete chromosome exchanges in X-irradiated human lymphocytes using FISH with pan-centromeric and chromosome specific DNA probes in combination with telomeric PNA probe. Int. J. Radiat. Biol. 76, 807-813 (2000).
32. P. McCullagh and J. A. Neider, Generalized Linear Models. Chapman and Hall, Norwell, MA, 1989.
33. M. J. Ramsey, D. H. Moore, 2nd, J. F. Briner, D. A. Lee, L. Olsen, J. R. Senft and J. D. Tucker, The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutat. Res. 338, 95-106 (1995).
34. J. D. Tucker and D. H. Moore, 2nd, The importance of age and smoking in evaluating adverse cytogenetic effects of exposure to environmental agents. Environ. Health Perspect. 104 (Suppl. 3), 489-492 (1996).
35. J. N. Lucas, W. Deng, D. Moore, F. Hill, M. Wade, A. Lewis, F. Sailes, C. Kramer, A. Hsieh and N. Galvan, Background ionizing radiation plays a minor role in the production of chromosome translocations in a control population. Int. J. Radiat. Biol. 75, 819-827 (1999).
36. S. Pressl, A. Edwards and G. Stephan, The influence of age, sex and smoking habits on the background level of FISH-detected translocations. Mutat. Res. 442, 89-95 (1999).
37. E. J. Tawn and C. A. Whitehouse, Frequencies of chromosome aberrations in a control population determined by G banding. Mutat. Res. 490, 171-177 (2001).
38. P. C. van Diemen, D. Maasdam, S. Vermeulen, F. Darroudi and A. T. Natarajan, Influence of smoking habits on the frequencies of structural and numerical chromosomal aberrations in human peripheral blood lymphocytes using the fluorescence in situ hybridization (FISH) technique. Mutagenesis 10, 487-495 (1995).
39. IAEA, Cytogenetic Analysis for Radiation Dose Assessment. Technical Report Series No. 405, International Atomic Energy Agency, Vienna, 2001.
40. E. J. Tawn and C. A. Whitehouse, Persistence of translocation frequencies in blood lymphocytes following radiotherapy: Implications for retrospective radiation biodosimetry. J. Radiol. Prot. 23, 423-430 (2003).
41. A. Edwards, A critique of 'Collaborative exercise on the use of FISH chromosome painting for retrospective biodosimetry of Mayak nuclear-industrial personnel'. Int. J. Radiat. Biol. 78, 867-871 (2002).
42. C. Lindholm, S. Luomahaara, A. Koivistoinen, T. Ilus, A. A. Edwards and S. Salomaa, Comparison of dose-response curves for chromosomal aberrations established by chromosome painting and conventional analysis. Int. J. Radiat. Biol. 74, 27-34 (1998).
43. 60Co gamma ray dose-response for chromosomal aberrations in human lymphocytes analysed by FISH; Applicability to biological dosimetry. Int. J. Radiat. Biol. 75, 1215-1222 (1999).
44. 60Co gamma rays. Health Phys. 68, 761-765 (1995).
45. 60Co gamma rays at body temperature. Int. J. Radiat. Biol. 75, 435-439 (1999).
46. M. N. Cornforth, S. M. Bailey and E. H. Goodwin, Dose responses for chromosome aberrations produced in noncycling primary human fibroblasts by alpha particles, and by gamma rays delivered at sub-limiting low dose rates. Radiat. Res. 158, 43-53 (2002).
47. D. J. Brenner, J. B. Little and R. K. Sachs, The bystander effect in radiation oncogenesis: II. A quantitative model. Radiat. Res. 155, 402-408 (2001).
48. A. T. Natarajan, F. Darroudi, L. H. Mullenders and M. Meijers, The nature and repair of DNA lesions that lead to chromosomal aberrations induced by ionizing radiations. Mutat. Res. 160, 231-236 (1986).
49. R. C. Vyas, F. Darroudi and A. T. Natarajan, Radiation-induced chromosomal breakage and rejoining in interphase-metaphase chromosomes of human lymphocytes. Mutat. Res. 249, 29-35 (1991).
50. F. Darroudi, J. Fomina, M. Meijers and A. T. Natarajan, Kinetics of the formation of chromosome aberrations in X-irradiated human lymphocytes, using PCC and FISH. Mutat. Res. 404, 55-65 (1998).
51. C. Mothersill and C. Seymour, Radiation-induced bystander effects: Past history and future directions. Radiat. Res. 155, 759-767 (2001).
52. Z. Goldberg and B. E. Lehnert, Radiation-induced effects in unirradiated cells: A review and implications in cancer. Int. J. Oncol. 21, 337-349 (2002).
53. E. S. Hall, Genomic instability, bystander effect, cytoplasmic irradiation and other phenomena that may achieve fame without fortune. Phys. Med. 17 (Suppl. 1), 21-25 (2001).
54. K. M. Prise, O. V. Belyakov, H. C. Newman, S. Patel, G. Schettino, M. Folkard and B. D. Michael, Non-targeted effects of radiation: Bystander responses in cell and tissue models. Radiat. Prot. Dosim. 99, 223-226 (2002).
55. W. F. Morgan, Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159, 567-580 (2003).
56. C. B. Seymour and C. Mothersill, Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat. Res. 153, 508-511 (2000).
57. UNSCEAR, Sources and Effects of Ionizing Radiation, Vol. 2. United Nations, New York, 2000.
58. S. Bonassi, L. Hagmar, U. Stromberg, A. H. Montagud, H. Tinnerberg, A. Forni, P. Heikkila, S. Wanders, P. Wilhardt and H. Norppa, Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens. European Study Group on cytogenetic biomarkers and health. Cancer Res. 60, 1619-1625 (2000).
59. Y. Kodama, D. Pawel, N. Nakamura, D. Preston, T. Honda, M. Itoh, M. Nakano, K. Ohtaki, S. Funamoto and A. A. Awa, Stable chromosome aberrations in atomic bomb survivors: Results from 25 years of investigation. Radiat. Res. 156, 337-346 (2001).
60. D. A. Pierce and D. L. Preston, Radiation-related cancer risks at low doses among atomic bomb survivors. Radiat. Res. 154, 178-186 (2000).