A Robust Network of Double-Strand Break Repair Pathways Governs Genome Integrity during C. elegans Development

Current Biology

Volumn 19, Issue 16, 2009, Pages 1384-1388

  Pontier, Daphne B ^a   Tijsterman, Marcel ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

DEVBIO; DNA

Indexed keywords

BRC 1 PROTEIN, C ELEGANS; BRC-1 PROTEIN, C ELEGANS; CAENORHABDITIS ELEGANS PROTEIN; HELMINTH DNA; HYBRID PROTEIN;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CAENORHABDITIS ELEGANS; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENE DELETION; GENETICS; GENOME; GROWTH, DEVELOPMENT AND AGING; LARVA; METABOLISM; PHYSIOLOGY; POLYMERASE CHAIN REACTION; REPORTER GENE; TRANSGENE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA, HELMINTH; GENES, REPORTER; GENOME, HELMINTH; LARVA; MODELS, GENETIC; POLYMERASE CHAIN REACTION; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; TRANSGENES;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 68849100385     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2009.06.045     Document Type: Article

References (27)

1. Wyman C., and Kanaar R. DNA double-strand break repair: All's well that ends well. Annu. Rev. Genet. 40 (2006) 363-383
2. Pâques F., and Haber J.E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63 (1999) 349-404
3. Clejan I., Boerckel J., and Ahmed S. Developmental modulation of nonhomologous end joining in Caenorhabditis elegans. Genetics 173 (2006) 1301-1317
4. Rothkamm K., Krüger I., Thompson L.H., and Löbrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell. Biol. 23 (2003) 5706-5715
5. Saleh-Gohari N., and Helleday T. Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells. Nucleic Acids Res. 32 (2004) 3683-3688
6. Rathmell W.K., and Chu G. A DNA end-binding factor involved in double-strand break repair and V(D)J recombination. Mol. Cell. Biol. 14 (1994) 4741-4748
7. Wilson T., and Lieber M. Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature 388 (1997) 428-429
8. Morton J., Davis M.W., Jorgensen E.M., and Carroll D. Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells. Proc. Natl. Acad. Sci. USA 103 (2006) 16370-16375
9. Schulte-Uentrop L., El-Awady R.A., Schliecker L., Willers H., and Dahm-Daphi J. Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks. Nucleic Acids Res. 36 (2008) 2561-2569
10. Wang H., Perrault A.R., Takeda Y., Qin W., Wang H., and Iliakis G. Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res. 31 (2003) 5377-5388
11. Yan C.T., Boboila C., Souza E.K., Franco S., Hickernell T.R., Murphy M., Gumaste S., Geyer M., Zarrin A.A., Manis J.P., et al. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449 (2007) 478-482
12. Corneo B., Wendland R.L., Deriano L., Cui X., Klein I.A., Wong S.Y., Arnal S., Holub A.J., Weller G.R., Pancake B.A., et al. Rag mutations reveal robust alternative end joining. Nature 449 (2007) 483-486
13. Fishman-Lobell J., Rudin N., and Haber J.E. Two alternative pathways of double-strand break repair that are kinetically separable and independently modulated. Mol. Cell. Biol. 12 (1992) 1292-1303
14. Maryon E., and Carroll D. Characterization of recombination intermediates from DNA injected into Xenopus laevis oocytes: Evidence for a nonconservative mechanism of homologous recombination. Mol. Cell. Biol. 11 (1991) 3278-3287
15. Bennardo N., Cheng A., Huang N., and Stark J.M. Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genet. 4 (2008) e1000110
16. Rong Y.S., and Golic K.G. The homologous chromosome is an effective template for the repair of mitotic DNA double-strand breaks in Drosophila. Genetics 165 (2003) 1831-1842
17. Adamo A., Montemauri P., Silva N., Ward J.D., Boulton S.J., and La Volpe A. BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair. EMBO Rep. 9 (2008) 287-292
18. Stark J.M., Pierce A.J., Oh J., Pastink A., and Jasin M. Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol. Cell. Biol. 24 (2004) 9305-9316
19. Fanning E., Klimovich V., and Nager A.R. A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res. 34 (2006) 4126-4137
20. Umezu K., Sugawara N., Chen C., Haber J.E., and Kolodner R.D. Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism. Genetics 148 (1998) 989-1005
21. Sugawara N., Ira G., and Haber J.E. DNA length dependence of the single-strand annealing pathway and the role of Saccharomyces cerevisiae RAD59 in double-strand break repair. Mol. Cell. Biol. 20 (2000) 5300-5309
22. Ciccia A., McDonald N., and West S.C. Structural and functional relationships of the XPF/MUS81 family of proteins. Annu. Rev. Biochem. 77 (2008) 259-287
23. Al-Minawi A.Z., Saleh-Gohari N., and Helleday T. The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. Nucleic Acids Res. 36 (2008) 1-9
24. Li F., Dong J., Pan X., Oum J.H., Boeke J.D., and Lee S.E. Microarray-based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination intermediates. Mol. Cell 30 (2008) 325-335
25. Barlow J.H., Lisby M., and Rothstein R. Differential regulation of the cellular response to DNA double-strand breaks in G1. Mol. Cell 30 (2008) 73-85
26. Zierhut C., and Diffley J.F. Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J. 27 (2008) 1875-1885
27. Bennett C.B., Lewis A.L., Baldwin K.K., and Resnick M.A. Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid. Proc. Natl. Acad. Sci. USA 90 (1993) 5613-5617