Induction of apoptosis in a macrophage cell line RAW 264.7 by acemannan, a β-(1,4)-acetylated mannan

Molecular Pharmacology

Volumn 53, Issue 3, 1998, Pages 415-421

  Ramamoorthy, Lalitha ^a   Tizard, Ian R ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACEMANNAN; GAMMA INTERFERON; N(G) NITROARGININE METHYL ESTER;

APOPTOSIS; ARTICLE; CHROMATIN CONDENSATION; DNA CLEAVAGE; DNA STRUCTURE; IMMUNOMODULATION; MACROPHAGE; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 0031967454     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.53.3.415     Document Type: Article

References (34)

1. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JD, and Struhl K (1987) Current Protocols in Molecular Biology. John Wiley and Sons, New York.
2. Boersma AWM, Nooter K, Burger H, Kortland CJ, and Stoter G (1997) Bax upregulation is an early event in Cisplatin-Induced apoptosis in Human testicular germcell tumor cell line NT2 as quantitated by flow cytometry. Cytometry 27:275-282.
3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. Damle NK, Leytze G, Klussman K, and Ledbetter JA (1993) Activation with superantigens induces programmed cell death in antigen-primed CD4+ class II+ major histocompatability complex T lymphocytes via a CD 11a/CD18-dependent mechanisms. Eur J Immunol 23:1513-1522.
5. Dive C and Wyllie AH (1993) Apoptosis and Cancer Chemotherapy, Blackwell Scientific, London.
6. Drapier JC, Wietzerbin J, and Hibbs Jr. JB (1988) Interferon-gamma and tumor necrosis factor induce L-arginine-dependent cytotoxic effector mechanism in murine macrophages. Eur J Immunol 18:1587-1592.
7. Gonzalez-Garcia M, Perez-Ballesttero D, Duan L, Boise LH, and Thompson CB (1994) bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development 120:3033-3042.
8. Hannun Y (1994) The sphingomyelin cycle and second messenger function of ceramide. J Biol Chem 269:3125-3128.
9. King GK, Yates KM, Greenlee PG, Pierce KR, Ford CR, McAnalley BH, and Tizard IR (1995) The effect of acemannan immunostimulant in combination with surgery and radiation therapy on spontaneous canine and feline fibrosarcoas. J Am Anim Hosp Assoc 31:439-447.
10. Kolesnick R and Golde DW (1994) The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signalling. Cell 77:325-328.
11. Kroemer G, Petit P, Zamzami N, Vayssiere JL, and Mignotte B (1995) The biochemistry of programmed cell death. FASEB J 9:1277-1287.
12. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond) 227:680-685.
13. Lewis JG, Adams DO, and Fan S (1995) Selective sensitivity of macrophages to cytotoxicity by inhibitors of macromolecular synthesis: induction of apoptosis. J Leukocyte Biol 57:635-642.
14. Manna SM and McAnalley BH (1993) Determination of the position of the O-acetyl group in a β-(1,4)-mannan (*acemannan*) from Aloe barbardensis Miller. Carbohydr Res 24:317-319.
15. Matzinger P (1991) The JAM test. A simple assay for DNA fragmentation and cell death. J Immunol Methods 145:185-192.
16. Meikrantz W, Gisselbrecht S, Tam SW, and Schlegel R (1994) Activation of cyclin A-dependent protein kinases during apoptosis. Proc Natl Acad Sci USA 91:3754-3758.
17. L and CD40 in WEHI-231 cells. Dissociation from cell cycle arrest and dependence on the avidity of the antibody-IgM receptor interaction. J Immunol 155:3830-3838.
18. Merriam EA, Campbell BD, Flood LP, Welsh CJR, McDaniel HR, and Busbee DL (1995) Enhancement of immune function in rodents using a complex plant carbohydrate which stimulates macrophage secretion of immunoreactive cytokines, in Advances in Anti-Aging Medicine, Vol. 1 (Klatz RM, ed), pp. 181-203. Mary Ann Liebert, Inc., Larchmont, New York.
19. Messmer UK, Lapetina EG, and Brune B (1995) Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds. Mol Pharmacol 47:757-765.
20. Negrini M, Silini E, Kozak C, Tsujimoto Y, and Croce CM (1987) Molecular analysis of mbcl-2: Structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell 49:455-463.
21. Oltvai ZNC, Milliman CL, and Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619.
22. Paquet P and Pierard GE (1996) Interleukin-6 and the skin, Int Arch Allergy Immunol 109:308-317.
23. Pelfrey CM, Tranquill LR, Boehme SA, McFarland HF, and Lenardo MJ (1995) Two mechanisms of antigen- specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from multiple sclerosis patients and normal individuals. J Immunol 154:6191-6202.
24. Ramamoorthy L, Kemp MC, and Tizard IR (1996) Acemannan, a β-(1,4)-acetylated mannan induces nitric oxide production in a macrophage cell line RAW 264.7. Mol Pharmacol 50:878-884.
25. Sabath DE, Broome HE, and Prytowsky MB (1990) Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin-2 induced transcript in a cloned T-helper lymphocyte. Gene 91:185-191.
26. Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, and Arnheim N (1985) Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (Washington DC) 250:1350-1354.
27. Searle J, Lawson TA, Abbott PJ, Harmon B, and Kerr JFR (1975) An electron-microscope study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferating normal and neoplastic cells. J Pathol 116: 129-138.
28. Sen S and D'Incalci M (1992) Apoptosis: biochemical events and relevance to cancer chemotherapy. FEBS Lett 307:122-127.
29. Skladanowski A and Konopa J (1993) Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumor cells. Biochem Pharmacol 46:375-382.
30. Stuehr DJ and Marietta MA (1987) Synthesis of nitrite and nitrate in murine macrophage cell lines. Cancer Res 47:5590-5594.
31. Tamura T, Ishihara M, Lampher MS, Tanaka N, Oishi I, Aizawa S, Matsuyama T, Mak TW, Taki S, and Taniguchi T (1995) An IRF-1 -dependent pathway of DNA damage-iduced apoptosis in mitogen activated T lymphocytes. Nature (Lond) 376: 596-599.
32. Tanaka N, Ishihara M, Kitagawa M, Harada H, Kimura T, Matsuyama T, Lampher MS, Aizawa S, Mak TW, and Taniguchi T (1994) Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell 77:829-839.
33. Vermes I, Haanen C, Steffens-Nakken H, and Reutelingsperger C (1995) A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 184:39-51.
34. Wang Z, Karras JG, Howard RG, and Rothstein TL (1995) Induction of bcl-x by CD40 engagement rescues slg-induced apoptosis in murine B cells. J Immunol 155: 3722-3725.