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Volumn 2, Issue 3, 2008, Pages 179-187

Review: Therapeutic perspectives in bronchial vascular remodeling in COPD

Author keywords

airway remodeling; angiogenesis; COPD; corticosteroids

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; 6 CHLORO 7 METHOXY 8 (2 METHYLNICOTINAMIDO) BETA CARBOLINE; 6 CHLORO 8 NICOTINAMIDO BETA CARBOLINE; AE 941; ANGIOGENESIS INHIBITOR; AZ 11557272; BECLOMETASONE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BEVACIZUMAB; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; FIBROBLAST GROWTH FACTOR; FIBRONECTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAMININ; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 14; ML 120 B; SORAFENIB; SR 2 F; SUNITINIB; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VITRONECTIN RECEPTOR;

EID: 68749102528     PISSN: 17534658     EISSN: None     Source Type: Journal    
DOI: 10.1177/1753465808092339     Document Type: Review
Times cited : (12)

References (58)
  • 2
    • 33747595955 scopus 로고    scopus 로고
    • Transcription factors in airway diseases
    • Barnes, P.J. (2006) Transcription factors in airway diseases. Lab Invest 86: 867-872.
    • (2006) Lab Invest , vol.86 , pp. 867-872
    • Barnes, P.J.1
  • 3
    • 4444280869 scopus 로고    scopus 로고
    • Prospects for new drugs for chronic obstructive pulmonary disease
    • Barnes, P.J. and Hansel, T.T. (2004) Prospects for new drugs for chronic obstructive pulmonary disease. Lancet 364: 985-996.
    • (2004) Lancet , vol.364 , pp. 985-996
    • Barnes, P.J.1    Hansel, T.T.2
  • 4
    • 0024996333 scopus 로고
    • Small airway dimensions in smokers with obstruction to airflow
    • Bosken, C.H., Wiggs, B.R., Paré, P.D., Hogg, J.C. (1990) Small airway dimensions in smokers with obstruction to airflow. Am Rev Respir Dis 142: 563-570.
    • (1990) Am Rev Respir Dis , vol.142 , pp. 563-570
    • Bosken, C.H.1    Wiggs, B.R.2    Paré, P.D.3    Hogg, J.C.4
  • 5
    • 33745368689 scopus 로고    scopus 로고
    • Evidence of angiogenesis in bronchial biopsies of smokers with and without airway obstruction
    • Calabrese, C., Bocchino, V., Vatrella, A., Marzo, C., Guarino, C., Mascitti, S. et al. (2006) Evidence of angiogenesis in bronchial biopsies of smokers with and without airway obstruction. Resp Med 100: 1415-1422.
    • (2006) Resp Med , vol.100 , pp. 1415-1422
    • Calabrese, C.1    Bocchino, V.2    Vatrella, A.3    Marzo, C.4    Guarino, C.5    Mascitti, S.6
  • 6
    • 0037425745 scopus 로고    scopus 로고
    • TRial of Inhaled STeroids ANd long-acting beta2 agonists study group. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial
    • Calverley, P., Pauwels, R., Vestbo, J., Jones, P., Pride, N., Gulsvik, A. et al. (2003) TRial of Inhaled STeroids ANd long-acting beta2 agonists study group. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 361: 449-456.
    • (2003) Lancet , vol.361 , pp. 449-456
    • Calverley, P.1    Pauwels, R.2    Vestbo, J.3    Jones, P.4    Pride, N.5    Gulsvik, A.6
  • 7
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet, P. (2003) Angiogenesis in health and disease. Nat Med 9: 653-660.
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 8
    • 4344689086 scopus 로고    scopus 로고
    • The transforming growth factor-beta1 gene is associated with chronic obstructive pulmonary disease
    • Celedòn, J.C., Lange, C., Raby, B.A., Litonjua, A.A., Palmer, L.J., DeMeo, D.L. et al. (2004) The transforming growth factor-beta1 gene is associated with chronic obstructive pulmonary disease. Hum Mol Genet 13: 1649-1656.
    • (2004) Hum Mol Genet , vol.13 , pp. 1649-1656
    • Celedòn, J.C.1    Lange, C.2    Raby, B.A.3    Litonjua, A.A.4    Palmer, L.J.5    DeMeo, D.L.6
  • 9
    • 33947646770 scopus 로고    scopus 로고
    • Vascular remodelling and angiogenesis in asthma: morphological aspects and pharmacological modulation
    • Chetta, A., Zanini, A., Torre, O. and Olivieri, D. (2007) Vascular remodelling and angiogenesis in asthma: morphological aspects and pharmacological modulation. Inflamm Allergy Drug Targets 1: 41-45.
    • (2007) Inflamm Allergy Drug Targets , vol.1 , pp. 41-45
    • Chetta, A.1    Zanini, A.2    Torre, O.3    Olivieri, D.4
  • 11
    • 34547815598 scopus 로고    scopus 로고
    • Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs
    • Churg, A., Wang, R., Wang, X., Onnervik, P.O., Thim, K. and Wright, J.L. (2007) Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs. Thorax 62: 706-713.
    • (2007) Thorax , vol.62 , pp. 706-713
    • Churg, A.1    Wang, R.2    Wang, X.3    Onnervik, P.O.4    Thim, K.5    Wright, J.L.6
  • 12
    • 34447130180 scopus 로고    scopus 로고
    • FDA drug approval summary: bevacizumab (Avastin) plus Carboplatin and Paclitaxel as first-line treatment of advanced/metastic recurrent nonsquamous non-small cell lung cancer
    • Cohen, M.H., Gootenberg, J., Keegan, P., Pazdur, R. (2007) FDA drug approval summary: bevacizumab (Avastin) plus Carboplatin and Paclitaxel as first-line treatment of advanced/metastic recurrent nonsquamous non-small cell lung cancer. Oncologist 12: 713-718.
    • (2007) Oncologist , vol.12 , pp. 713-718
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 13
    • 18744384999 scopus 로고    scopus 로고
    • Therapeutic inhibition of matrix metalloproteinases for the treatment of chronic pulmonary disease (COPD)
    • Daheshia, M. (2005) Therapeutic inhibition of matrix metalloproteinases for the treatment of chronic pulmonary disease (COPD). Curr Med Res Opin 21: 587-594.
    • (2005) Curr Med Res Opin , vol.21 , pp. 587-594
    • Daheshia, M.1
  • 14
    • 34147093566 scopus 로고    scopus 로고
    • Molecular mechanisms in chronic obstructive pulmonary disease: potential targets for therapy
    • de Boer, W.I., Alagappan, V.K.T. and Sharma, H.S. (2007) Molecular mechanisms in chronic obstructive pulmonary disease: potential targets for therapy. Cell Biochem Biophys 47: 131-148.
    • (2007) Cell Biochem Biophys , vol.47 , pp. 131-148
    • de Boer, W.I.1    Alagappan, V.K.T.2    Sharma, H.S.3
  • 15
    • 0032416948 scopus 로고    scopus 로고
    • Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease
    • de Boer, W.I., van Schadewijk, A., Sont, J.K., Sharma, H.S., Stolk, J., Hiemstra, P.S. and van Krieken, J.H. (1998) Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158: 1951-1957.
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 1951-1957
    • de Boer, W.I.1    van Schadewijk, A.2    Sont, J.K.3    Sharma, H.S.4    Stolk, J.5    Hiemstra, P.S.6    van Krieken, J.H.7
  • 16
    • 84975525035 scopus 로고
    • Clinical applications of research on angiogenesis
    • Folkman, J. (1995) Clinical applications of research on angiogenesis. New Engl J Med 333: 1757-1763.
    • (1995) New Engl J Med , vol.333 , pp. 1757-1763
    • Folkman, J.1
  • 17
    • 0032557564 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells
    • Gerber, H.P., Dixit, V. and Ferrara, N. (1998) Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J Biol Chem 273: 13313-13316.
    • (1998) J Biol Chem , vol.273 , pp. 13313-13316
    • Gerber, H.P.1    Dixit, V.2    Ferrara, N.3
  • 20
  • 21
    • 15844401603 scopus 로고    scopus 로고
    • Quantitative analysis of bronchial wall vascularity in the medium and small airways of patients with asthma and COPD
    • Hashimoto, M., Tanaka, H. and Abe, S. (2005) Quantitative analysis of bronchial wall vascularity in the medium and small airways of patients with asthma and COPD. Chest 127: 965-972.
    • (2005) Chest , vol.127 , pp. 965-972
    • Hashimoto, M.1    Tanaka, H.2    Abe, S.3
  • 22
    • 2942720573 scopus 로고    scopus 로고
    • The nature of small-airway obstruction in chronic obstructive pulmonary disease
    • Hogg, J.C., Chu, F., Utokaparch, S., Woods, R., Elliott, W.M., Buzatu, L. et al. (2004) The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350: 2645-2653.
    • (2004) N Engl J Med , vol.350 , pp. 2645-2653
    • Hogg, J.C.1    Chu, F.2    Utokaparch, S.3    Woods, R.4    Elliott, W.M.5    Buzatu, L.6
  • 23
    • 30744443041 scopus 로고    scopus 로고
    • Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma
    • Horvath, G. and Wanner, A. (2006) Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma. Eur Respir J 27: 172-187.
    • (2006) Eur Respir J , vol.27 , pp. 172-187
    • Horvath, G.1    Wanner, A.2
  • 24
    • 0034846870 scopus 로고    scopus 로고
    • Inhaled corticosteroids decrease vascularity of the bronchial mucosa in patients with asthma
    • Hoshino, M., Takahashi, M., Takai, Y., Sim, J. and Aoike, N. (2001) Inhaled corticosteroids decrease vascularity of the bronchial mucosa in patients with asthma. Clin Exp Allergy 31: 722-730.
    • (2001) Clin Exp Allergy , vol.31 , pp. 722-730
    • Hoshino, M.1    Takahashi, M.2    Takai, Y.3    Sim, J.4    Aoike, N.5
  • 26
    • 36148988400 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease
    • Kanazawa, H. (2007) Role of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease. Med Sci Monit 13: RA189-195.
    • (2007) Med Sci Monit , vol.13 , pp. RA189-RA195
    • Kanazawa, H.1
  • 27
    • 0037398983 scopus 로고    scopus 로고
    • Possible effects of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease
    • Kanazawa, H., Asai, K., Hirata, K. and Yoshikawa, J. (2003) Possible effects of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease. Am J Med 114: 354-358.
    • (2003) Am J Med , vol.114 , pp. 354-358
    • Kanazawa, H.1    Asai, K.2    Hirata, K.3    Yoshikawa, J.4
  • 29
    • 13544275539 scopus 로고    scopus 로고
    • Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease
    • Kranenburg, A.R., de Boer, W.I., Alagappan, V.K.T., Sterk, P.J. and Sharma, H.S. (2005) Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease. Thorax 60: 106-113.
    • (2005) Thorax , vol.60 , pp. 106-113
    • Kranenburg, A.R.1    de Boer, W.I.2    Alagappan, V.K.T.3    Sterk, P.J.4    Sharma, H.S.5
  • 31
    • 0027365905 scopus 로고
    • Small airways dimensions in asthma and chronic obstructive pulmonary disease
    • Kuwano, K., Bosken, C.H., Paré, P.D., Bai, T.R., Wiggs, B.R. and Hogg, J.C. (1993) Small airways dimensions in asthma and chronic obstructive pulmonary disease. Am Rev Respir Dis 148: 1220-1225.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 1220-1225
    • Kuwano, K.1    Bosken, C.H.2    Paré, P.D.3    Bai, T.R.4    Wiggs, B.R.5    Hogg, J.C.6
  • 32
    • 0036242810 scopus 로고    scopus 로고
    • SU6668 inhibits Flk-1/KDR and PDGFRbeta in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice
    • Laird, A.D., Christensen, J.G., Li, G., Carver, J., Smith, K., Xin, X. et al. (2002) SU6668 inhibits Flk-1/KDR and PDGFRbeta in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice. FASEB J 16: 681-690.
    • (2002) FASEB J , vol.16 , pp. 681-690
    • Laird, A.D.1    Christensen, J.G.2    Li, G.3    Carver, J.4    Smith, K.5    Xin, X.6
  • 33
    • 8144230707 scopus 로고    scopus 로고
    • Endoglin promotes endothelial cell proliferation and TGF-β/ALK1 signal transduction
    • Lebrin, F., Goumans, M.J., Jonker, L., Carvalho, R.L.C., Valdimarsdottir, G., Thorikay, M. et al. (2004) Endoglin promotes endothelial cell proliferation and TGF-β/ALK1 signal transduction. Embo J 23: 4018-4028.
    • (2004) Embo J , vol.23 , pp. 4018-4028
    • Lebrin, F.1    Goumans, M.J.2    Jonker, L.3    Carvalho, R.L.C.4    Valdimarsdottir, G.5    Thorikay, M.6
  • 34
    • 35548940240 scopus 로고    scopus 로고
    • Neovastat (AE-941) inhibits the airway inflammation via VEGF and HIF-2alpha suppression
    • Lee, S.Y. and Chung, S.M. (2007) Neovastat (AE-941) inhibits the airway inflammation via VEGF and HIF-2alpha suppression. Vascul Pharmacol 47: 313-318.
    • (2007) Vascul Pharmacol , vol.47 , pp. 313-318
    • Lee, S.Y.1    Chung, S.M.2
  • 35
    • 34748863572 scopus 로고    scopus 로고
    • Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis
    • Mahabeleshwar, G.H., Feng, W., Reddy, K., Plow, E.F. and Byzova, T.V. (2007) Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis. Circ Res 101: 570-580.
    • (2007) Circ Res , vol.101 , pp. 570-580
    • Mahabeleshwar, G.H.1    Feng, W.2    Reddy, K.3    Plow, E.F.4    Byzova, T.V.5
  • 36
    • 2442528995 scopus 로고    scopus 로고
    • Effect of montelukast and fluticasone propionate on airway mucosal blood flow in asthma
    • Mendes, E.S., Campos, M.A., Hurtado, A. and Wanner, A. (2004) Effect of montelukast and fluticasone propionate on airway mucosal blood flow in asthma. Am J Respir Crit Care Med 169: 1131-1134.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 1131-1134
    • Mendes, E.S.1    Campos, M.A.2    Hurtado, A.3    Wanner, A.4
  • 37
    • 34247222126 scopus 로고    scopus 로고
    • Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors
    • Newton, R., Holden, N.S., Catley, M.C., Oyelusi, W., Leigh, R., Proud, D. et al. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. J Pharmacol Exp Ther 321: 734-742.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 734-742
    • Newton, R.1    Holden, N.S.2    Catley, M.C.3    Oyelusi, W.4    Leigh, R.5    Proud, D.6
  • 38
    • 0035402361 scopus 로고    scopus 로고
    • Effect of a long-acting β2-agonist over three months on airway wall vascular remodeling in asthma
    • Orsida, B.E., Ward, C., Li, X., Bish, R., Wilson, J.W., Thien, F. et al. (2001) Effect of a long-acting β2-agonist over three months on airway wall vascular remodeling in asthma. Am J Respir Crit Care Med 164: 117-121.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 117-121
    • Orsida, B.E.1    Ward, C.2    Li, X.3    Bish, R.4    Wilson, J.W.5    Thien, F.6
  • 39
    • 0033024225 scopus 로고    scopus 로고
    • Vascularity in asthmatic airways: relation to inhaled steroid dose
    • Orsida, B.E., Li, X., Hickey, B., Thien, F., Wilson, J.W. and Walters, E.H. (1999) Vascularity in asthmatic airways: relation to inhaled steroid dose. Thorax 54: 289-295.
    • (1999) Thorax , vol.54 , pp. 289-295
    • Orsida, B.E.1    Li, X.2    Hickey, B.3    Thien, F.4    Wilson, J.W.5    Walters, E.H.6
  • 40
    • 0035035768 scopus 로고    scopus 로고
    • Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) workshop summary
    • Pauwels, R.A., Buist, A.S., Calverley, P.M., Jenkins, C.R. and Hurd, S.S. (2001) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) workshop summary. Am J Respir Crit Care Med 163: 1256-1276.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1256-1276
    • Pauwels, R.A.1    Buist, A.S.2    Calverley, P.M.3    Jenkins, C.R.4    Hurd, S.S.5
  • 42
    • 34547657584 scopus 로고    scopus 로고
    • Vascular endothelial growth factor trap in non-small cell lung cancer
    • Riely, G.J. and Miller, V.A. (2007) Vascular endothelial growth factor trap in non-small cell lung cancer. Clin Cancer Res 13: 4623s-4627s.
    • (2007) Clin Cancer Res , vol.13 , pp. 4623s-4627s
    • Riely, G.J.1    Miller, V.A.2
  • 45
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler, A., Gray, R., Perry, M.C., Brahmer, J., Schiller, J.H., Dowlati, A. et al. (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 55: 2542-2550.
    • (2006) N Engl J Med , vol.55 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3    Brahmer, J.4    Schiller, J.H.5    Dowlati, A.6
  • 46
    • 30544448281 scopus 로고    scopus 로고
    • Phase I clinical and pharmacological evaluation of the multi-tyrosine kinase inhibitor SU006668 by chronic oral dosing
    • Sessa, C., Viganò, L., Grasselli, G., Trigo, J., Marimon, I., Lladò, A. et al. (2006) Phase I clinical and pharmacological evaluation of the multi-tyrosine kinase inhibitor SU006668 by chronic oral dosing. Eur J Cancer 42: 171-178.
    • (2006) Eur J Cancer , vol.42 , pp. 171-178
    • Sessa, C.1    Viganò, L.2    Grasselli, G.3    Trigo, J.4    Marimon, I.5    Lladò, A.6
  • 47
    • 0033558087 scopus 로고    scopus 로고
    • Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2
    • Soldi, R., Mitola, S., Strasly, M., Defilippi, P., Tarone, G. and Bussolino, F. (1999) Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J 18: 882-892.
    • (1999) EMBO J , vol.18 , pp. 882-892
    • Soldi, R.1    Mitola, S.2    Strasly, M.3    Defilippi, P.4    Tarone, G.5    Bussolino, F.6
  • 48
    • 2942729608 scopus 로고    scopus 로고
    • Management of chronic obstructive pulmonary disease
    • Sutherland, E.R. and Cherniack, R.M. (2004) Management of chronic obstructive pulmonary disease. N Engl J Med 350: 2689-2697.
    • (2004) N Engl J Med , vol.350 , pp. 2689-2697
    • Sutherland, E.R.1    Cherniack, R.M.2
  • 49
    • 17044453955 scopus 로고    scopus 로고
    • Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease
    • Takizawa, H., Tanaka, M., Takami, K., Ohtoshi, T., Ito, K., Satoh, M. et al. (2001) Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 163: 1476-1483.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1476-1483
    • Takizawa, H.1    Tanaka, M.2    Takami, K.3    Ohtoshi, T.4    Ito, K.5    Satoh, M.6
  • 50
    • 0347992806 scopus 로고    scopus 로고
    • Increased airway vascularity in newly diagnosed asthma using a high-magnification bronchovideoscope
    • Tanaka, H., Yamada, G., Saikai, T., Hashimoto, M., Tanaka, S., Suzuki, K. et al. (2003) Increased airway vascularity in newly diagnosed asthma using a high-magnification bronchovideoscope. Am J Respir Crit Care Med 168: 1495-1499.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 1495-1499
    • Tanaka, H.1    Yamada, G.2    Saikai, T.3    Hashimoto, M.4    Tanaka, S.5    Suzuki, K.6
  • 51
    • 42349114587 scopus 로고    scopus 로고
    • Endothelial sprouting and angiogenesis: metalloproteinases in the lead
    • (Epub ahead of print)
    • van Hinsbergh,V.W. and Koolwijk, P. (2008) Endothelial sprouting and angiogenesis: metalloproteinases in the lead. Cardiovasc Res (Epub ahead of print).
    • (2008) Cardiovasc Res
    • van HinsberghV.W.1    Koolwijk, P.2
  • 52
    • 10444274041 scopus 로고    scopus 로고
    • Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD
    • Vernooy, J.H., Lindeman, J.H., Jacobs, J.A., Hanemaaijer, R. and Wouters, E.F. et al. (2004) Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD. Chest 126: 1802-1810.
    • (2004) Chest , vol.126 , pp. 1802-1810
    • Vernooy, J.H.1    Lindeman, J.H.2    Jacobs, J.A.3    Hanemaaijer, R.4    Wouters, E.F.5
  • 54
    • 10444273257 scopus 로고    scopus 로고
    • and high-resolution computed tomography in asthma and COPD
    • and high-resolution computed tomography in asthma and COPD. Eur Respir J 24: 910-917.
    • Eur Respir J , vol.24 , pp. 910-917
  • 55
    • 0027563926 scopus 로고
    • New perspectives on basic mechanisms in lung disease. Why are the airways so vascular?
    • Widdicombe, J. (1993) New perspectives on basic mechanisms in lung disease. Why are the airways so vascular? Thorax 48: 290-295.
    • (1993) Thorax , vol.48 , pp. 290-295
    • Widdicombe, J.1
  • 57
    • 0036087521 scopus 로고    scopus 로고
    • Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects
    • Yang,Y.A., Dukhanina, O., Tang, B., Mamura, M., Letterio, J.J., MacGregor, J. et al. (2002) Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects. J Clin Invest 109: 1607-1615.
    • (2002) J Clin Invest , vol.109 , pp. 1607-1615
    • YangY.A.1    Dukhanina, O.2    Tang, B.3    Mamura, M.4    Letterio, J.J.5    MacGregor, J.6
  • 58
    • 84992776439 scopus 로고    scopus 로고
    • Vascular remodeling and inhaled beclomethasone dipropionate in copd
    • D’, Ippolito R., Neri M., ERS Annual Congress, 598s
    • Zanini, A., Chetta, A., Nicolini, G., Castagnetti, C., D’ Ippolito, R., Neri, M. et al. (2007) Vascular remodeling and inhaled beclomethasone dipropionate in copd. ERS Annual Congress 598s.
    • (2007)
    • Zanini, A.1    Chetta, A.2    Nicolini, G.3    Castagnetti, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.