Gene expression studies reveal that DNA damage, vascular perturbation, and inflammation contribute to the pathogenesis of carbonyl sulfide neurotoxicity

Toxicologic Pathology

Volumn 37, Issue 4, 2009, Pages 502-511

  Morrison, James P ^a   Ton, Thai Vu ^b   Collins, Jennifer B ^b   Switzer, Robert C ^c   Little, Peter B ^a   Morgan, Daniel L ^b   Sills, Robert C ^b  

^a CHARLES RIVER LABORATORIES   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c Neuroscience Associates Inc   (United States)

Author keywords

Brain; Carbonyl sulfide; Gene expression; Neuropathology; Neurotoxicity; Posterior colliculus; Transcriptome

Indexed keywords

CARBONYL SULFIDE; CONNECTIVE TISSUE GROWTH FACTOR; CYSTEINE RICH PROTEIN 61; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; KRUPPEL LIKE FACTOR 4; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; SULFUR DERIVATIVE; TRANSCRIPTOME; UNCLASSIFIED DRUG; VASCULOTROPIN C; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

APOPTOSIS; ARTICLE; ASTROCYTE; CELL CYCLE G1 PHASE; CENTRAL NERVOUS SYSTEM; DNA DAMAGE; DRUG INDUCED DISEASE; ENVIRONMENTAL EXPOSURE; FISCHER 344 RAT; GENE EXPRESSION; HUMAN; INFERIOR COLLICULUS; INFLAMMATION; NEUROTOXICITY; NEUROTOXICOLOGY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RAT; UPREGULATION;

ADMINISTRATION, INHALATION; ANIMALS; APOPTOSIS; BRAIN; BRAIN DISEASES; DNA DAMAGE; FEMALE; GENE EXPRESSION; GLIAL FIBRILLARY ACIDIC PROTEIN; INFLAMMATION; MALE; NECROSIS; NERVE DEGENERATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SULFUR OXIDES;

RATTUS;

EID: 68649122367     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623309335631     Document Type: Article

References (48)

1. Ambrosini, E, and F Aloisi (2004). Chemokines and glial cells: a complex network in the central nervous system. Neurochem Res, 29, 1017-38.
2. Anderson, P, K Phillips, G Stoecklin, and N Kedersha (2004). Post-transcriptional regulation of proinflammatory proteins. J Leukoc Biol, 76, 42-47.
3. Banisor, I, TP Leist, and B Kalman (2005). Involvement of beta-chemokines in the development of inflammatory demyelination. J Neuroinflammation, 2, 7.
4. Brigstock, DR (2002). Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61). Angiogenesis, 5, 153-65.
5. Cardinaux, JR, I Allaman, and PJ Magistretti (2000). Pro-inflammatory cytokines induce the transcription factors C/EBPbeta and C/EBPdelta in astrocytes. Glia, 29, 91-97.
6. Conrad, S, HJ Schluesener, M Adibzahdeh, and JM Schwab (2005). Spinal cord injury induction of lesional expression of profibrotic and angiogenic connective tissue growth factor confined to reactive astrocytes, invading fibroblasts and endothelial cells. J Neurosurg Spine, 2, 319-26.
7. Corrente, G, D Guardavaccaro, and F Tirone (2002). PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis. Neuroreport, 13, 417-22.
8. Cross, AK, G Haddock, CJ Stock, S Allan, J Surr, RA Bunning, DJ Buttle, and MN Woodroofe (2006). ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. Brain Res, 1088, 19-30.
9. Cummings, CJ, Y Sun, P Opal, B Antalffy, R Mestril, HT Orr, WH Dill-mann, and HY Zoghbi (2001). Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Hum Mol Genet, 10, 1511-18.
10. Cummins, JM, and B Vogelstein (2004). HAUSP is required for p53 destabilization. Cell Cycle, 3, 689-92.
11. de Olmos, JS, CA Beltramino, and S de Olmos de Lorenzo (1994). Use of an amino-cupric-silver technique for the detection of early and semiacute neuronal degeneration caused by neurotoxicants, hypoxia, and physical trauma. Neurotoxicol Teratol, 16, 545-61.
12. Edgar, R, M Domrachev, and AE Lash (2002). Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res, 30, 207-10.
13. el-Ghissassi, F, S Valsesia-Wittmann, N Falette, C Duriez, PD Walden, and A Puisieux (2002). BTG2(TIS21/PC3) induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cells. Oncogene, 21, 6772-78.
14. Fesus, L, V Thomazy, and A Falus (1987). Induction and activation of tissue transglutaminase during programmed cell death. FEBS Lett, 224, 104-8.
15. Fix, AS, JF Ross, SR Stitzel, and RC Switzer (1996). Integrated evaluation of central nervous system lesions: stains for neurons, astrocytes, and microglia reveal the spatial and temporal features of MK-801-induced neuronal necrosis in the rat cerebral cortex. Toxicol Pathol, 24, 291-304.
16. Herr, DW, JE Graff, VC Moser, KM Crofton, PB Little, DL Morgan, and RC Sills (2007). Inhalational exposure to carbonyl sulfide (COS) produces altered brainstem auditory (BAER) and somatosensory (SEP) evoked potentials in F344 rats. Toxicological Sciences, 1, 118.
17. Joukov, V, K Pajusola, A Kaipainen, D Chilov, I Lahtinen, E Kukk, O Saksela, N Kalkkinen, and K Alitalo (1996). A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J, 15, 1751.
18. Jung, N, YW Yi, D Kim, M Shong, SS Hong, HS Lee, and I Bae (2000). Regulation of Gadd45gamma expression by C/EBP. Eur J Biochem, 267, 6180-87.
19. Kasof, GM, JC Prosser, D Liu, MV Lorenzi, and BC Gomes (2000). The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria. FEBS Lett, 473, 285-91.
20. Li, M, D Chen, A Shiloh, J Luo, AY Nikolaev, J Qin, and W Gu (2002). Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature, 416, 648-53.
21. Li, R, R Strohmeyer, Z Liang, LF Lue, and J Rogers (2004). CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease. Neurobiol Aging, 25, 991-99.
22. Martin, LJ (2001). Neuronal cell death in nervous system development, disease, and injury (Review). Int J Mol Med, 7, 455-78.
23. McDowell, EM, and BF Trump (1976). Histologic fixatives suitable for diagnostic light and electron microscopy. Arch Pathol Lab Med, 100, 405-14.
24. Meuer, K, C Pitzer, P Teismann, C Kruger, B Goricke, R Laage, P Lingor, K Peters, JC Schlachetzki, K Kobayashi, GP Dietz, D Weber, B Ferger, WR Schabitz, A Bach, JB Schulz, M Bahr, A Schneider, and JH Weishaupt (2006). Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease. J Neurochem, 97, 675-86.
25. Morgan, DL, PB Little, DW Herr, VC Moser, B Collins, R Herbert, GA Johnson, RR Maronpot, GJ Harry, and RC Sills (2004). Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks. Toxicol Appl Pharmacol, 200, 131-45.
26. Nicotera, P, M Leist, E Fava, L Berliocchi, and C Volbracht (2000). Energy requirement for caspase activation and neuronal cell death. Brain Pathol, 10, 276-82.
27. Nicotera, P, M Leist, and E Ferrando-May (1998). Intracellular ATP, a switch in the decision between apoptosis and necrosis. Toxicol Lett, Vol. 102-103, 139-42.
28. Nutt, AW, JM Benson, EB Barr, DG Burt, FF Hahn, JL Lewis, and AR Dahl (1996). Acute inhalation toxicity of carbonyl sulfide. Soc Toxicol Proc, 18.
29. Ogilvie, RL, M Abelson, HH Hau, I Vlasova, PJ Blackshear, and PR Bohjanen (2005). Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay. J Immunol, 174, 953-61.
30. Okamura, S, H Arakawa, T Tanaka, H Nakanishi, CC Ng, Y Taya, M Monden, and Y Nakamura (2001). p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol Cell, 8, 85-94.
31. Piacentini, M, F Autuori, L Dini, MG Farrace, L Ghibelli, L Piredda, and L Fesus (1991). "Tissue" transglutaminase is specifically expressed in neonatal rat liver cells undergoing apoptosis upon epidermal growth factor-stimulation". Cell Tissue Res, 263, 227-35.
32. Qiu, Z, DK Strickland, BT Hyman, and GW Rebeck (2002). alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons. J Biol Chem, 277, 14458-66.
33. Rouault, JP, N Falette, F Guehenneux, C Guillot, R Rimokh, Q Wang, C Berthet, C Moyret-Lalle, P Savatier, B Pain, P Shaw, R Berger, J Samarut, JP Magaud, M Ozturk, C Samarut, and A Puisieux (1996). Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nat Genet, 14, 482-86.
34. Rowland, BD, and DS Peeper (2006). KLF4, p21 and context-dependent opposing forces in cancer. Nat Rev Cancer, 6, 11-23.
35. Schermer, C, and C Humpel (2002). Granulocyte macrophage-colony stimulating factor activates microglia in rat cortex organotypic brain slices. Neurosci Lett, 328, 180-84.
36. Schwab, JM, E Postler, TD Nguyen, M Mittelbronn, R Meyermann, and HJ Schluesener (2000). Connective tissue growth factor is expressed by a subset of reactive astrocytes in human cerebral infarction. Neuropathol Appl Neurobiol, 26, 434-40.
37. Shen, HY, JC He, Y Wang, QY Huang, and JF Chen (2005). Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice. J Biol Chem, 280, 39962-69.
38. Sills, RC, GJ Harry, WM Valentine, and DL Morgan (2005). Interdisciplinary neurotoxicity inhalation studies: Carbon disulfide and carbonyl sulfide research in F344 rats. Toxicol Appl Pharmacol, 207, 245-50.
39. Sills, RC, DL Morgan, DW Herr, PB Little, NM George, TV Ton, NE Love, RR Maronpot, and GA Johnson (2004). Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats. Toxicol Pathol, 32, 501-10.
40. Sun, X, J Lee, T Navas, DT Baldwin, TA Stewart, and VM Dixit (1999). RIP3, a novel apoptosis-inducing kinase. J Biol Chem, 274, 16871-75.
41. Tirone, F (2001). The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair? J Cell Physiol, 187, 155-65.
42. Ubogu, EE, MB Cossoy, and RM Ransohoff (2006). The expression and function of chemokines involved in CNS inflammation. Trends Pharmacol Sci, 27, 48-55.
43. The Clean Air Act Amendments of 1990 List of Hazardous Air Pollutants. Available at: http://www.epa.gov/ttn/atw/orig189.html. Accessed December10, 2008.
44. Van de Wouwer, M, and EM Conway (2004). Novel functions of thrombomodulin in inflammation. Crit Care Med, 32, S254-61.
45. Weng, L, H Dai, Y Zhan, Y He, SB Stepaniants, and DE Bassett (2006). Rosetta error model for gene expression analysis. Bioinformatics, 22, 1111-21.
46. Yoon, HS, X Chen, and VW Yang (2003). Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. J Biol Chem, 278, 2101-5.
47. Zhang, W, I Bae, K Krishnaraju, N Azam, W Fan, K Smith, B Hoffman, and DA Liebermann (1999). CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. Oncogene, 18, 4899-907.
48. Zhang, W, DE Geiman, JM Shields, DT Dang, CS Mahatan, KH Kaestner, JR Biggs, AS Kraft, and VW Yang (2000). The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. J Biol Chem, 275, 18391-98.