Gene expression in the lamellar dermis-epidermis during the developmental phase of carbohydrate overload-induced laminitis in the horse

Veterinary Immunology and Immunopathology

Volumn 131, Issue 1-2, 2009, Pages 86-96

  Budak, Murat T ^a   Orsini, James A ^b   Pollitt, Christopher C ^c   Rubinstein, Neal A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Carbohydrate overload; Gene; Horse; Laminitis; Microarray

Indexed keywords

AGGRECANASE; AUTACOID; BINDING PROTEIN; CARBOHYDRATE; CASEIN KINASE I; CHEMOKINE RECEPTOR; CHROMOGRANIN A; CYSTATIN C; CYTOCHROME B; FRUCTOSE OLIGOSACCHARIDE; I KAPPA B KINASE ALPHA; LIPOCORTIN 2; METALLOTHIONEIN II; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEASOME; PROTEIN V FOS; REGULATOR PROTEIN; RIBOSOME PROTEIN; RNA; SMAD2 PROTEIN; UBIQUITIN CONJUGATING ENZYME E2;

ANIMAL CELL; ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CELL ACTIVITY; CONTROLLED STUDY; CRYOPRESERVATION; DERMIS; DOWN REGULATION; EPIDERMIS; FOOT PAIN; GENE EXPRESSION; HOOF AND CLAW; HORSE DISEASE; LAMELLAR BODY; LAMINITIS; MICROARRAY ANALYSIS; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN DEGRADATION; RNA EXTRACTION; UPREGULATION;

ADAM PROTEINS; ANIMALS; DERMIS; DIETARY CARBOHYDRATES; EPIDERMIS; FOOT DISEASES; GENE EXPRESSION PROFILING; HOOF AND CLAW; HORSE DISEASES; HORSES; LIPOPOLYSACCHARIDES; PROCOLLAGEN N-ENDOPEPTIDASE;

ANIMALIA; BOVINAE; EQUIDAE;

EID: 68549140126     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2009.03.019     Document Type: Article

References (56)

1. Adair III H.S., Goble D.O., Schmidhammer J.L., et al. Laminar microvascular flow, measured by means of laser Doppler flowmetry, during the prodromal stages of black walnut-induced laminitis in horses. Am. J. Vet. Res. 61 (2000) 862-868
2. Anon. Lameness and laminitis in US horses. CEAH National Animal Health Monitoring System (2000), United States Department of Agriculture
3. Bailey S.R. The pathogenesis of acute laminitis: fitting more pieces into the puzzle. Equine Vet. J. 36 (2004) 199-203
4. Bailey S.R., Marr C.M., and Elliott J. Identification and quantification of amines in the equine caecum. Res. Vet. Sci. 74 (2003) 113-1118
5. Bailey S.R., Baillon M.L., Rycroft A.N., et al. Identification of equine cecal bacteria producing amines in an in vitro model of carbohydrate overload. Appl. Environ. Microbiol. 69 (2003) 2087-2093
6. Bailey S.R., Menzies-Gow N.J., Marr C.M., et al. The effects of vasoactive amines found in the equine hindgut on digital blood flow in the normal horse. Equine Vet. J. 36 (2004) 267-272
7. Barrey E., Mucher E., Robert C., et al. Gene expression profiling in blood cells of endurance horses completing competition or disqualified due to metabolic disorder. Equine Vet. J. Suppl. 36 (2006) 43-49
8. Behera A.K., Hildebrand E., Szafranski J., et al. Role of aggrecanase 1 in Lyme arthritis. Arthritis Rheum. 54 (2006) 3319-3329
9. Benjamini Y., and Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B. 57 (1995) 289-300
10. Calley J.N., Mattes W.B., and Ryan T.P. Microarray probe mapping and annotation in cross-species comparative toxicogenomics. Methods Mol. Biol. 460 (2008) 159-183 PMID: 18449487. [PubMed-indexed for MEDLINE]
11. Chowdhary B.P., and Raudsepp T. The horse genome derby: racing from map to whole genome sequence. Chromosome Res. 16 (2008) 109-127
12. Clark E.S., and Moore J.N. The effects of slow infusion of a low dosage of endotoxin in healthy horses. Equine Vet. J. Suppl. 7 (1989) 33-37
13. Cornelisse C.J., Robinson N.E., Berney C.A., et al. Thermographic study of in vivo modulation of vascular responses to phenylephrine and endothelin-1 by dexamethasone in the horse. Equine Vet. J. 38 (2006) 119-126
14. Elliott J., and Bailey S.R. Gastrointestinal derived factors are potential triggers for the development of acute equine laminitis. J. Nutr. 136 (2006) 2103S-2107S
15. French K.R., and Pollitt C.C. Equine laminitis: cleavage of laminin 5 associated with basement membrane dysadhesion. Equine Vet. J. 36 (2004) 242-247
16. French K.R., and Pollitt C.C. Equine laminitis: loss of hemidesmosomoes in hoof secondary epidermal lamellae correlates to dose in an oligofructose induction model: an ultrastructural study. Equine Vet. J. 36 (2004) 230-235
17. Garner H.E., Coffman J.R., Hahn A.W., et al. Equine laminitis of alimentary origin: an experimental model. Am. J. Vet. Res. 36 (1975) 441-444
18. Gu W., and Bertone A.L. Generation and performance of an equine-specific large-scale gene expression microarray. Am. J. Vet. Res. 65 (2004) 1664-1673
19. Hood D.M. Laminitis as a systemic disease. Vet. Clin. North Am. Equine Pract. 15 (1999) 81-494
20. Hood D.M. The pathophysiology of developmental and acute laminitis. Vet. Clin. North Am. Equine Pract. 15 (1999) 321-343
21. Hood D.M., Grosenbaugh D.A., Mostafa M.B., et al. The role of vascular mechanisms in the development of acute equine laminitis. J. Vet. Intern. Med. 7 (1993) 228-234
22. Hood D.M., Wagner I.P., and Brumbaugh G.W. Evaluation of hoof wall surface temperature as an index of digital vascular perfusion during the prodromal and acute phases of carbohydrate-induced laminitis in horses. Am. J. Vet. Res. 62 (2001) 1167-1172
23. Hood D.M., Brumbaugh G.W., and Wagner I.P. Effectiveness of a unique dihydropyridine (BAYTG 1000) for prevention of laminitis in horses. Am. J. Vet. Res. 63 (2002) 443-447
24. Kane J., Lackland H., Karakawa W.W., et al. Chemical studies on the structure of mucopeptide isolated from Streptococcus bovis. J. Bacteriol. 99 (1969) 175-179
25. Kashiwagi M., Tortorella M., Nagase H., et al. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J. Biol. Chem. 276 (2001) 12501-12504
26. Kyaw-Tanner M., and Pollitt C.C. Equine laminitis: increased transcription of matrix metalloproteinase-2 (MMP-2) occurs during the developmental phase. Equine Vet. J. 36 (2004) 221-225
27. Lauer-Fields J.L., Minond D., Sritharan T., et al. Substrate conformation modulates aggrecanase (ADAMTS4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases. J. Biol. Chem. 282 (2007) 142-150
28. Livak K.J., and Schmittegen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 December (2001) 402-408
29. Loftus J.P., Belknap J.K., and Black S.J. Matrix metalloproteinase-9 in laminae of black walnut extract treated horses correlates with neutrophil abundance. Vet. Immunol. Immunopathol. 113 (2006) 267-276
30. Lohmander L.S., Neame P.J., and Sandy J.D. The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis. Arthritis Rheum. 36 (1993) 1214-1222
31. Matthews R.T., Gary S.C., Zerillo C., et al. Brain-enriched Hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member. J. Biol. Chem. 275 (2000) 22695-22703
32. Milinovich G.H., Trott D.J., Burrell P.C., et al. Changes in equine hindgut bacterial populations during oligofructose-induced laminitis. Environ. Microbiol. 8 (2006) 885-898
33. Moore R.M., Eades S.C., and Stokes A.M. Evidence for vascular and enzymatic events in the pathophysiology of acute laminitis: which pathway is responsible for initiation of this process in horses?. Equine Vet. J. 36 (2004) 204-209
34. Morgan S.J., Hood D.M., Wagner I.P., et al. Submural histopathologic changes attributable to peracute laminitis in horses. Am. J. Vet. Res. 64 (2003) 829-834
35. Mungall B.A., Kyaw-Tanner M., and Pollitt C.C. In vitro evidence for a bacterial pathogenesis of equine laminitis. Vet. Microbiol. 79 (2001) 209-223
36. NCBI database. NCBI Reference Sequences (http://www.ncbi.nlm.nih.gov/RefSeq/) http://www.ncbi.nlm.nih.gov/ (Accessed 2007).
37. Pollitt C.C. Basement membrane pathology: a feature of acute equine laminitis. Equine Vet. J. 28 (1996) 38-46
38. Pollitt C.C. Equine laminitis. Clin. Tech. Equine Pract. 3 (2004) 34-44
39. Pollitt C.C. New scientific developments in managing laminitis. The Third International Equine Conference on Laminitis and Diseases of the Foot. Palm Beach, FL (2005) 52-61
40. Pollitt C.C., and Davies C.T. Equine laminitis: its development coincides with increased sublamellar blood flow. Equine Vet. J. Suppl. 26 (1998) 125-132
41. Ramery E., Closset R., Bureau F., et al. Relevance of using a human microarray to study gene expression in heaves-affected horses. Vet. J. 177 (2008) 216-221
42. Rodgerson D.H., Belknap J.K., Moore J.N., et al. Investigation of mRNA expression of tumor necrosis factor-alpha, interleukin-1beta, and cyclooxygenase-2 in cultured equine digital artery smooth muscle cells after exposure to endotoxin. Am. J. Vet. Res. 62 (2001) 1957-1963
43. Schönig B., Brown D.W., Oeser B., et al. Cross-species hybridization with Fusarium verticillioides microarrays reveals new insights in Fusarium fujikuroi nitrogen regulation and the role of AreA and NMR. Eukaryot. Cell (2008) [Epub ahead of print, August 8], PMID: 18689524, [PubMed-as supplied by publisher]
44. Shao L., Allez M., Park M.S., et al. Immunomodulatory roles of the carcinoembryonic antigen family of glycoproteins. Ann. N. Y. Acad. Sci. 1072 (2006) 194-209
45. Sher I., Zisman-Rozen S., Eliahu L., et al. Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation. J. Biol. Chem. 281 (2006) 5178-5187
46. Sprouse R.F., Garner H.E., and Green E.M. Plasma endotoxin levels in horses subjected to carbohydrate induced laminitis. Equine Vet. J. 19 (1987) 25-28
47. Tang B.L. ADAMTS: a novel family of extracellular matrix proteases. Int. J. Biochem. Cell Biol. 33 (2001) 33-44
48. Trummer E., Ernst W., Hesse F., et al. Transcriptional profiling of phenotypically different Epo-Fc expressing CHO clones by cross-species microarray analysis. Biotechnol. J. 3 (2008) 924-937 PMID: 18481264, [PubMed-indexed for MEDLINE]
49. Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 5116-5121
50. Universal Protein Knowledgebase. http://www.ebi.uniprot.org/ (accessed on March 20, 2007).
51. Vallée M., Aiba K., Piao Y., et al. Comparative analysis of oocyte transcript profiles reveals a high degree of conservation among species. Reproduction 135 (2008) 439-448 PMID: 18367505, [PubMed-indexed for MEDLINE]
52. Waguespack R.W., Cochran A., and Belknap J.K. Expression of the cyclooxygenase isoforms in the prodromal stage of black walnut-induced laminitis in horses. Am. J. Vet. Res. 65 (2004) 1724-1729
53. Waguespack R.W., Kemppainen R.J., Cochran A., et al. Increased expression of MAIL, a cytokine-associated nuclear protein, in the prodromal stage of black walnut-induced laminitis. Equine Vet. J. 36 (2004) 285-291
54. Weiss D.J., Evanson O.A., MacLeay J., et al. Transient alteration in intestinal permeability to technetium Tc99m diethylenetriaminopentaacetate during the prodromal stages of alimentary laminitis in ponies. Am. J. Vet. Res. 59 (1998) 1431-1434
55. Wight T.N. The ADAMTS proteases, extracellular matrix and vascular disease; waking the sleeping giant(s)!. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 12-14
56. Worster A.A., Gaughan E.M., Hoskinson J.J., et al. Effects of external thermal manipulation on laminar temperature and perfusion scintigraphy of the equine digit. N. Z. Vet. J. 48 (2000) 111-116