메뉴 건너뛰기




Volumn 1072, Issue , 2006, Pages 194-209

Immunomodulatory roles of the carcinoembryonic antigen family of glycoproteins

Author keywords

Carcinoembryonic antigen; Mucosal immunity; Regulatory T cells

Indexed keywords

CARCINOEMBRYONIC ANTIGEN;

EID: 33749000327     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1326.037     Document Type: Conference Paper
Times cited : (17)

References (45)
  • 1
    • 0017253248 scopus 로고
    • Human fecal flora: Variation in bacterial composition within individuals and a possible effect of emotional stress
    • HOLDEMAN, L.V., I.J. GOOD & W.E.C. MOORE. 1976. Human fecal flora: variation in bacterial composition within individuals and a possible effect of emotional stress. Appl. Environ. Microbiol. 31: 359-375.
    • (1976) Appl. Environ. Microbiol. , vol.31 , pp. 359-375
    • Holdeman, L.V.1    Good, I.J.2    Moore, W.E.C.3
  • 2
    • 0017341656 scopus 로고
    • Microbial ecology of the gastrointestinal tract
    • SAVAGE, D.C. 1977. Microbial ecology of the gastrointestinal tract. Annu. Rev. Microbiol. 31: 107-133.
    • (1977) Annu. Rev. Microbiol. , vol.31 , pp. 107-133
    • Savage, D.C.1
  • 4
    • 0022505159 scopus 로고
    • Gastrointestinal micro flora in mammalian nutrition
    • SAVAGE, D.C. 1986. Gastrointestinal micro flora in mammalian nutrition. Annu. Rev. Nutr. 6: 155-178.
    • (1986) Annu. Rev. Nutr. , vol.6 , pp. 155-178
    • Savage, D.C.1
  • 5
    • 0007681911 scopus 로고
    • The normal human microflora composition
    • Grubb, R., T. Midvedt & E. Norin Eds. Stockton. London
    • SAVAGE, D.C. 1989. The normal human microflora composition. In The regulatory and protective role of the normal microflora. Grubb, R., T. Midvedt & E. Norin Eds.: 3-18. Stockton. London.
    • (1989) The Regulatory and Protective Role of the Normal Microflora , pp. 3-18
    • Savage, D.C.1
  • 6
    • 0028207219 scopus 로고
    • Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding
    • HUSBY, S., J. MESTECKY, Z. MOLDOVEANU, et al. 1994. Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding. J. Immunol. 152: 4663-4670.
    • (1994) J. Immunol. , vol.152 , pp. 4663-4670
    • Husby, S.1    Mestecky, J.2    Moldoveanu, Z.3
  • 7
    • 2942529181 scopus 로고    scopus 로고
    • Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease
    • KRAUS, T.A., L. TOY, L. CHAN, et al. 2004. Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease. Gastroenterology. 126: 1771-1778.
    • (2004) Gastroenterology , vol.126 , pp. 1771-1778
    • Kraus, T.A.1    Toy, L.2    Chan, L.3
  • 9
    • 20744459116 scopus 로고    scopus 로고
    • Oral tolerance and regulation of mucosal immunity
    • DUBOIS, B., A. GOUBIER, G. JOUBERT, et al. 2005. Oral tolerance and regulation of mucosal immunity. Cell Mol. Life Sci. 62: 1322-1332.
    • (2005) Cell Mol. Life Sci. , vol.62 , pp. 1322-1332
    • Dubois, B.1    Goubier, A.2    Joubert, G.3
  • 10
    • 0036828289 scopus 로고    scopus 로고
    • Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells
    • ALLEZ, M., J. BRIMNES, I. DOTAN, et al. 2002. Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells. Gastroenterology. 123: 1516-1526.
    • (2002) Gastroenterology , vol.123 , pp. 1516-1526
    • Allez, M.1    Brimnes, J.2    Dotan, I.3
  • 11
    • 23344449248 scopus 로고    scopus 로고
    • Non-classical MHC class I molecules on intestinal epithelial cells: Mediators of mucosal crosstalk
    • SHAO, L., O. KAMALU & L. MAYER. 2005. Non-classical MHC class I molecules on intestinal epithelial cells: mediators of mucosal crosstalk. Immunol. Rev. 206: 160-176.
    • (2005) Immunol. Rev. , vol.206 , pp. 160-176
    • Shao, L.1    Kamalu, O.2    Mayer, L.3
  • 12
    • 2142711024 scopus 로고    scopus 로고
    • The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells
    • NAKAZAWA, A., I. DOTAN, J. BRIMNES, et al. 2004. The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells. Gastroenterology. 126: 1347-1357.
    • (2004) Gastroenterology , vol.126 , pp. 1347-1357
    • Nakazawa, A.1    Dotan, I.2    Brimnes, J.3
  • 13
    • 0028127274 scopus 로고
    • Characteristics of carcinoembryonic antigen (CEA) expressed in different cell types: Evidence that CEA can function as an adhesion molecule and as a repulsion molecule
    • GRIMM, T., G. RIETHMULLER & J.P. JOHNSON. 1994. Characteristics of carcinoembryonic antigen (CEA) expressed in different cell types: evidence that CEA can function as an adhesion molecule and as a repulsion molecule. Biochem. Biophys. Res. Commun. 204: 1225-1234.
    • (1994) Biochem. Biophys. Res. Commun. , vol.204 , pp. 1225-1234
    • Grimm, T.1    Riethmuller, G.2    Johnson, J.P.3
  • 14
    • 0344443683 scopus 로고    scopus 로고
    • Tumor markers and colorectal cancer: Utility in management
    • CRAWFORD, N.P., D.W. COLLIVER & S. GALANDIUK. 2003. Tumor markers and colorectal cancer: utility in management. J. Surg. Oncol. 84: 239-248.
    • (2003) J. Surg. Oncol. , vol.84 , pp. 239-248
    • Crawford, N.P.1    Colliver, D.W.2    Galandiuk, S.3
  • 15
    • 0024558306 scopus 로고
    • Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule
    • BENCHIMOL, S., A. FUKS, S. JOTHY, et al. 1989. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 57: 327-334.
    • (1989) Cell , vol.57 , pp. 327-334
    • Benchimol, S.1    Fuks, A.2    Jothy, S.3
  • 16
    • 0024431956 scopus 로고
    • Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: Homophilic and heterophilic adhesion
    • OIKAWA, S., C. INUZUKA, M. KUROKI, et al. 1989. Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion. Biochem. Biophys. Res. Commun. 164: 39-45.
    • (1989) Biochem. Biophys. Res. Commun. , vol.164 , pp. 39-45
    • Oikawa, S.1    Inuzuka, C.2    Kuroki, M.3
  • 17
    • 0025518432 scopus 로고
    • Biliary glycoprotein, a member of the immunoglobulin supergene family, functions in vitro as a Ca2(+)-dependent intercellular adhesion molecule
    • ROJAS, M., A. FUKS & C.P. STANNERS. 1990. Biliary glycoprotein, a member of the immunoglobulin supergene family, functions in vitro as a Ca2(+)-dependent intercellular adhesion molecule. Cell Growth Differ. 1: 527-533.
    • (1990) Cell Growth Differ. , vol.1 , pp. 527-533
    • Rojas, M.1    Fuks, A.2    Stanners, C.P.3
  • 18
    • 0026758050 scopus 로고
    • Homotypic and heterotypic Ca(++)-independent cell adhesion activities of biliary glycoprotein, a member of carcinoembryonic antigen family, expressed on CHO cell surface
    • OIKAWA, S., M. KUROKI, Y. MATSUOKA, et al. 1992. Homotypic and heterotypic Ca(++)-independent cell adhesion activities of biliary glycoprotein, a member of carcinoembryonic antigen family, expressed on CHO cell surface. Biochem. Biophys. Res. Commun. 186: 881-887.
    • (1992) Biochem. Biophys. Res. Commun. , vol.186 , pp. 881-887
    • Oikawa, S.1    Kuroki, M.2    Matsuoka, Y.3
  • 19
    • 0034798725 scopus 로고    scopus 로고
    • Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8
    • KUROKI, M., H. ABE, T. IMAKIIREI, et al. 2001. Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8. J. Leukoc. Biol. 70: 543-550.
    • (2001) J. Leukoc. Biol. , vol.70 , pp. 543-550
    • Kuroki, M.1    Abe, H.2    Imakiirei, T.3
  • 20
    • 0035002762 scopus 로고    scopus 로고
    • Adhesion of neutrophils to fibronectin: Role of the cd66 antigens
    • NAIR, K.S. & S.M. ZINGDE. 2001. Adhesion of neutrophils to fibronectin: role of the cd66 antigens. Cell Immunol. 208: 96-106.
    • (2001) Cell Immunol. , vol.208 , pp. 96-106
    • Nair, K.S.1    Zingde, S.M.2
  • 21
    • 0028859572 scopus 로고
    • CD66 family members are associated with tyrosine kinase activity in human neutrophils
    • SKUBITZ, K.M., K.D. CAMPBELL, K. AHMED, et al. 1995. CD66 family members are associated with tyrosine kinase activity in human neutrophils. J. Immunol. 155: 5382-5390.
    • (1995) J. Immunol. , vol.155 , pp. 5382-5390
    • Skubitz, K.M.1    Campbell, K.D.2    Ahmed, K.3
  • 22
    • 0027493938 scopus 로고
    • Cross-linking of the carcinoembryonic antigen-like glycoproteins CD66 and CD67 induces neutrophil aggregation
    • KUIJPERS, T.W., C.E. VAN DER SCHOOT, M. HOOGERWERF, et al. 1993. Cross-linking of the carcinoembryonic antigen-like glycoproteins CD66 and CD67 induces neutrophil aggregation. J. Immunol. 151: 4934-4940.
    • (1993) J. Immunol. , vol.151 , pp. 4934-4940
    • Kuijpers, T.W.1    Van Der Schoot, C.E.2    Hoogerwerf, M.3
  • 23
    • 0029957169 scopus 로고    scopus 로고
    • Role of nonspecific cross-reacting antigen, a CD66 cluster antigen, in activation of human granulocytes
    • KLEIN, M.L., S.A. MCGHEE, J. BARANIAN, et al. 1996. Role of nonspecific cross-reacting antigen, a CD66 cluster antigen, in activation of human granulocytes. Infect. Immun. 64: 4574-4579.
    • (1996) Infect. Immun. , vol.64 , pp. 4574-4579
    • Klein, M.L.1    Mcghee, S.A.2    Baranian, J.3
  • 24
    • 0034234257 scopus 로고    scopus 로고
    • Human carcinoembryonic antigen functions as a general inhibitor of anoikis
    • ORDONEZ, C., R. A. SCREATON, C. ILANTZIS, et al. 2000. Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Res. 60: 3419-3424.
    • (2000) Cancer Res. , vol.60 , pp. 3419-3424
    • Ordonez, C.1    Screaton, R.A.2    Ilantzis, C.3
  • 25
    • 0034715889 scopus 로고    scopus 로고
    • Angiogenic properties of the carcinoembryonic antigen-related cell adhesion molecule 1
    • WAGENER, C. & S. ERGUN. 2000. Angiogenic properties of the carcinoembryonic antigen-related cell adhesion molecule 1. Exp. Cell Res. 261: 19-24.
    • (2000) Exp. Cell Res. , vol.261 , pp. 19-24
    • Wagener, C.1    Ergun, S.2
  • 26
    • 0029905022 scopus 로고    scopus 로고
    • CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins
    • CHEN, T. & E.G. GOTSCHLICH. 1996. CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins. Proc. Natl. Acad. Sci. USA. 93: 14851-14856.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14851-14856
    • Chen, T.1    Gotschlich, E.G.2
  • 27
    • 0029848536 scopus 로고    scopus 로고
    • Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae
    • VIRJI, M., K. MAKEPEACE, D.J. FERGUSON, et al. 1996. Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae. Mol. Microbiol. 22: 941-950.
    • (1996) Mol. Microbiol. , vol.22 , pp. 941-950
    • Virji, M.1    Makepeace, K.2    Ferguson, D.J.3
  • 28
    • 0030924679 scopus 로고    scopus 로고
    • Several carcinoembryonic antigens (CD66) serve as receptors for gonococcal opacity proteins
    • CHEN, T., F. GRUNERT, A. MEDINA-MARINO, et al. 1997. Several carcinoembryonic antigens (CD66) serve as receptors for gonococcal opacity proteins. J. Exp. Med. 185: 1557-1564.
    • (1997) J. Exp. Med. , vol.185 , pp. 1557-1564
    • Chen, T.1    Grunert, F.2    Medina-Marino, A.3
  • 29
    • 0032518818 scopus 로고    scopus 로고
    • CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway
    • HAUCK, C.R., T.F. MEYER, F. LANG, et al. 1998. CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway. EMBO J. 17: 443-454.
    • (1998) EMBO J. , vol.17 , pp. 443-454
    • Hauck, C.R.1    Meyer, T.F.2    Lang, F.3
  • 30
    • 0032859115 scopus 로고    scopus 로고
    • Tyrosine phosphatase SHP-1 is involved in CD66-mediated phagocytosis of Opa52-expressing Neisseria gonorrhoeae
    • HAUCK, C.R., E. GULBINS, F. LANG, et al. 1999. Tyrosine phosphatase SHP-1 is involved in CD66-mediated phagocytosis of Opa52-expressing Neisseria gonorrhoeae. Infect. Immun. 67: 5490-5494.
    • (1999) Infect. Immun. , vol.67 , pp. 5490-5494
    • Hauck, C.R.1    Gulbins, E.2    Lang, F.3
  • 31
    • 0035968308 scopus 로고    scopus 로고
    • Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM 1; previously CD66a) receptor on primary endothelial cells by activating the immediate early response transcription factor, nuclear factor-kappaB
    • MUENZNER, P., M. NAUMANN, T.F. MEYER, et al. 2001. Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM 1; previously CD66a) receptor on primary endothelial cells by activating the immediate early response transcription factor, nuclear factor-kappaB. J. Biol. Chem. 276: 24331-24340.
    • (2001) J. Biol. Chem. , vol.276 , pp. 24331-24340
    • Muenzner, P.1    Naumann, M.2    Meyer, T.F.3
  • 32
    • 0037083747 scopus 로고    scopus 로고
    • Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways
    • BILLKER, O., A. POPP, V. BRINKMANN, et al. 2002. Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways. EMBO J. 21: 560-571.
    • (2002) EMBO J. , vol.21 , pp. 560-571
    • Billker, O.1    Popp, A.2    Brinkmann, V.3
  • 33
    • 3142721456 scopus 로고    scopus 로고
    • Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC)
    • BERGER, C.N., O. BILLKER, T.F. MEYER, et al. 2004. Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC). Mol. Microbiol. 52: 963-983.
    • (2004) Mol. Microbiol. , vol.52 , pp. 963-983
    • Berger, C.N.1    Billker, O.2    Meyer, T.F.3
  • 34
    • 24144490843 scopus 로고    scopus 로고
    • CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells
    • MUENZNER, P., M. ROHDE, S. KNEITZ, et al. 2005. CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells. J. Cell Biol. 170: 825-836.
    • (2005) J. Cell Biol. , vol.170 , pp. 825-836
    • Muenzner, P.1    Rohde, M.2    Kneitz, S.3
  • 35
    • 21544462006 scopus 로고    scopus 로고
    • Neisseria gonorrhoeae kills carcinoembryonic antigen-related cellular adhesion molecule 1 (CD66a)-expressing human B cells and inhibits antibody production
    • PANTELIC, M., Y.J. KIM, S. BOLLAND, et al. 2005. Neisseria gonorrhoeae kills carcinoembryonic antigen-related cellular adhesion molecule 1 (CD66a)-expressing human B cells and inhibits antibody production. Infect. Immun. 73: 4171-4179.
    • (2005) Infect. Immun. , vol.73 , pp. 4171-4179
    • Pantelic, M.1    Kim, Y.J.2    Bolland, S.3
  • 36
    • 0035337109 scopus 로고    scopus 로고
    • Carcinoembryonic antigen-related cell adhesion molecule 1 on murine dendritic cells is a potent regulator of T cell stimulation
    • KAMMERER, R., D. STOBER, B.B. SINGER, et al. 2001. Carcinoembryonic antigen-related cell adhesion molecule 1 on murine dendritic cells is a potent regulator of T cell stimulation. J. Immunol. 166: 6537-6544.
    • (2001) J. Immunol. , vol.166 , pp. 6537-6544
    • Kammerer, R.1    Stober, D.2    Singer, B.B.3
  • 37
    • 0037087297 scopus 로고    scopus 로고
    • CD66a interactions between human melanoma and NK cells: A novel class I MHC-independent inhibitory mechanism of cytotoxicity
    • MARKEL, G., N. LIEBERMAN, G. KATZ, et al. 2002. CD66a interactions between human melanoma and NK cells: a novel class I MHC-independent inhibitory mechanism of cytotoxicity. J. Immunol. 168: 2803-2810.
    • (2002) J. Immunol. , vol.168 , pp. 2803-2810
    • Markel, G.1    Lieberman, N.2    Katz, G.3
  • 38
    • 18944379881 scopus 로고    scopus 로고
    • Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1
    • STERN, N., G. MARKEL, T.I. ARNON, et al. 2005. Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. J. Immunol. 174: 6692-6701.
    • (2005) J. Immunol. , vol.174 , pp. 6692-6701
    • Stern, N.1    Markel, G.2    Arnon, T.I.3
  • 39
    • 0036467540 scopus 로고    scopus 로고
    • Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte function
    • NAKAJIMA, A., H. IIJIMA, M.F. NEURATH, et al. 2002. Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte function. J. Immunol. 168: 1028-1035.
    • (2002) J. Immunol. , vol.168 , pp. 1028-1035
    • Nakajima, A.1    Iijima, H.2    Neurath, M.F.3
  • 40
    • 12144287697 scopus 로고    scopus 로고
    • Carcinoembryonic antigen-related cellular adhesion molecule 1 isoforms alternatively inhibit and costimulate human T cell function
    • CHEN, D., H. IIJIMA, T. NAGAISHI, et al. 2004. Carcinoembryonic antigen-related cellular adhesion molecule 1 isoforms alternatively inhibit and costimulate human T cell function. J. Immunol. 172: 3535-3543.
    • (2004) J. Immunol. , vol.172 , pp. 3535-3543
    • Chen, D.1    Iijima, H.2    Nagaishi, T.3
  • 41
    • 1542514774 scopus 로고    scopus 로고
    • The cell-cell adhesion molecule carcinoembryonic antigen-related cellular adhesion molecule 1 inhibits IL-2 production and proliferation in human T cells by association with Src homology protein-1 and down-regulates IL-2 receptor
    • CHEN, C.J. & J.E. SHIVELY. 2004. The cell-cell adhesion molecule carcinoembryonic antigen-related cellular adhesion molecule 1 inhibits IL-2 production and proliferation in human T cells by association with Src homology protein-1 and down-regulates IL-2 receptor. J. Immunol. 172: 3544-3552.
    • (2004) J. Immunol. , vol.172 , pp. 3544-3552
    • Chen, C.J.1    Shively, J.E.2
  • 42
    • 14244257721 scopus 로고    scopus 로고
    • Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells
    • IDEO, H., A. SEKO, & K. YAMASHITA. 2005. Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells. J. Biol. Chem. 280: 4730-4737.
    • (2005) J. Biol. Chem. , vol.280 , pp. 4730-4737
    • Ideo, H.1    Seko, A.2    Yamashita, K.3
  • 43
    • 2942617342 scopus 로고    scopus 로고
    • Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation
    • HOKAMA, A., E. MIZOGUCHI, K. SUGIMOTO, et al. 2004. Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Immunity 20: 681-693.
    • (2004) Immunity , vol.20 , pp. 681-693
    • Hokama, A.1    Mizoguchi, E.2    Sugimoto, K.3
  • 44
    • 20444401235 scopus 로고    scopus 로고
    • Activation of CD8+ regulatory T cells by human placental trophoblasts
    • SHAO, L., A.R. JACOBS, V.V. JOHNSON, et al. 2005. Activation of CD8+ regulatory T cells by human placental trophoblasts. J. Immunol. 174: 7539-7547.
    • (2005) J. Immunol. , vol.174 , pp. 7539-7547
    • Shao, L.1    Jacobs, A.R.2    Johnson, V.V.3
  • 45
    • 0023612719 scopus 로고
    • Evidence for function of Ia molecules on gut epithelial cells in man
    • MAYER, L. & R. SHLIEN. 1987. Evidence for function of Ia molecules on gut epithelial cells in man. J. Exp. Med. 166: 1471-1483.
    • (1987) J. Exp. Med. , vol.166 , pp. 1471-1483
    • Mayer, L.1    Shlien, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.