Disulfide-mediated apoptosis of human T-lymphotrophc virus type-I (HTLV-I)-infected cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis

Antiviral Therapy

Volumn 14, Issue 4, 2009, Pages 533-542

  Nishiura, Yoshihiro ^a   Nakamura, Tatsufumi ^a   Fukushima, Naomi ^a   Nakamura, Hideki ^a   Ida, Hiroaki ^a   Aramaki, Toshiyuki ^a   Eguchi, Katsumi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALLICIN; ALPHA INTERFERON; ANTIINFLAMMATORY AGENT; ASCORBIC ACID; CASPASE; PREDNISOLONE; PROSULTIAMINE; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DISULFIDE; DRUG DERIVATIVE; SULFINIC ACID DERIVATIVE; THIAMINE;

ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CELL VIABILITY; CLINICAL ARTICLE; CLINICAL TRIAL; CYTOTOXICITY; DRUG STRUCTURE; FEMALE; FLOW CYTOMETRY; GENE NUMBER; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS 1 ASSOCIATED MYELOPATHY; IN VITRO STUDY; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOTOR PERFORMANCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SPASTIC PARAPLEGIA; SPINAL CORD DISEASE; VIRUS LOAD; WESTERN BLOTTING; CELL LINE; CHEMISTRY; DRUG EFFECT; HUMAN T CELL LEUKEMIA VIRUS INFECTION; ISOLATION AND PURIFICATION; MIDDLE AGED;

AGED; ANTI-HIV AGENTS; APOPTOSIS; CELL LINE; DISULFIDES; FEMALE; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; MALE; MIDDLE AGED; PARAPARESIS, TROPICAL SPASTIC; SPINAL CORD DISEASES; SULFINIC ACIDS; THIAMINE;

EID: 68549122656     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Osame M, Matsumoto M, Usuku K, et al. Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type I and adult T-cell leukemia-like cells. Ann Neurol 1987; 21:117-122.
2. Iwasaki Y. Pathology of chronic myelopathy associated with HTLV-I infection (HAM/TSP). J Neurol Sci 1990; 96:103-123.
3. Nakamura T. Immunopathogenesis of HTLV-I-associated myelopathy/tropical spastic paaparesis. Ann Med 2000; 32:600-607.
4. Osame M. Pathological mechanisms of human T-cell lymphotropic virus type I-associated myelopathy (HAM/TSP). J Neurovirol 2002; 8:359-364.
5. Nakagawa M, Nakahara K, Maruyama Y, et al. Therapeutic trials in 200 patients with HTLV-associated myelopathy/tropical spastic paraparesis. J Neurovirol 1996; 2:345-355.
6. Shibayama K, Nakamura T, Nagasato K, Shirabe S, Tsujihata M, Nagataki S. Interferon-alpha treatment in HTLV-I-associated myelopathy: studies of clinical and immunological aspects. J Neurol Sci 1991; 106:186-192.
7. Izumo S, Goto I, Itoyama Y, et al. Interferon-alpha is effective in HTLV-I-associated myelopathy: a multicentercentre, randomized, double-blind, controlled trial. Neurology 1996; 46:1016-1021.
8. + T cells as activated Th1 cells in the immunopathogenesis of HTLV-I-associated myelopathy/tropical spastic paraparesis. In Broglio PV (Editor). Neuroimmunology Research Focus. New York: Nova Science Publishers 2007; pp. 43-84.
9. Ankri S, Mirelman D. Antimicrobial properties of allicin from garlic. Microbes Infect 1999; 1:125-129.
10. Hirsch K, Danilenko M, Giat J, et al. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr Cancer 2000; 38:245-254.
11. Wong WW, Macdonald S, Langler RF, Penn LZ. Novel synthetic organosulfur compounds induce apoptosis of human leukemic cells. Anticancer Res 2000; 20:1367-1374.
12. Lawson LD, Wang ZJ. Pre-hepatic fate of the organosulfur compounds derived from garlic (Allium sativum). Planta Med 1993; 59:A688-A689.
13. Freeman F, Kodera Y. Garlic chemistry-stability of S-(2-propenyl)-2-propene-1-sulfinothioate (allicin) in blood, solvents, and simulated physiological fluids. J Agric Food Chem 1995; 43:2332-2338.
14. Fujiwara M, Watanabe H, Matsui K. 'Allithiamine a newly found derivative of vitamine B1. I. discovery of allithiamine. J Biochem 1954; 41:29-39.
15. Matsukawa T, Yurugi S. On the structure of allithiamine. Proceedings of the Japan Academy 1951; 28:146-149.
16. Fukushima N, Nakamura T, Nishiura Y, Ida H, Aramaki T, Eguchi K HTLV-I production based on activation of infegrin/ligand signaling in HTLV-I-infected cell lines derived from HAM/TSP patients. Intervirology 2008; 51:123-129.
17. Fukushima N, Nishiura Y, Nakamura T, Yamada Y, Kohno S, Eguchi K. Involvement of p38 MAPK signaling pathway in IFN-γ and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. J Neuroimmunol 20O5; 159:196-202.
18. Shibatomi K; Ida H, Yamasaki S, et al. A novel role for interleukin-18 in human natural killer cell death: high serum levels and low naturat killer cell numbers in patients with systemic autoimmune diseases. Arthritis Rheum 2001; 44:884-892.
19. Nakamura H, Kawakami A, Ida H, Koji T, Eguchi K. EGF activates PI3K-Akt and NFκB via distinct pathways in salivary epithelial cells in Sjögren's syndrome. Rheumatol Int 2007; 28:127-136.
20. Osame M. Review of WHO-Kagoshima meeting and diagnostic guidelines for HAM/TSP. In Blattner WA (Editor). Human Retrovirology: HTLV. New York: Raven Press 1990; pp. 191-197.
21. Matsuo H, Tsujihata M, Satoh, A, et al. Plasmapheresis in treatment of human T-lymphotropic virus type-I associated myelopathy. Lancet 1988; 332:1109-1113.
22. Miron T, Wilchek M, Sharp A, et al. Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937. J Nutr Biochem 2008; 19:524-535.
23. Saitoh M, Nishitoh H, Fujii M, et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 1998; 17:2596-2606.
24. Hayakawa T, Matsuzawa A, Noguchi T, Takeda K, Ichijo H. The ASK1-MAP kinase pathways in immune and stress responses. Microbes Infect 2006; 8:1098-1107.
25. Masutani H, Ueda S, Yodoi J. The thioredoxin system in retroviral infection and apoptosis. Cell Death Differ 2005; 12:991-998.