Role of multidrug-resistance protein 2 in coproporphyrin transport: Results from experimental studies in bile fistula rat models

Cellular and Molecular Biology

Volumn 55, Issue 2, 2009, Pages 70-78

  Moriondo, V ^a   Marchini, S ^a   Di Gangi, P ^a   Ferrari, M C ^a   Nascimbeni, F ^a   Rocchi, E ^a   Ventura, Paolo ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Cholestasis; Coproporphyins; Dubin Johnson; Isomers; Multidrug resistance proteins; Porphyrias; Transporters

Indexed keywords

BILIRUBIN; COPROPORPHYRIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT FISTULA; BILE LEVEL; BILIARY EXCRETION; BLOOD LEVEL; CHOLESTASIS; CONTROLLED STUDY; HISTOPATHOLOGY; MALE; NONHUMAN; PORPHYRIA; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; URINARY EXCRETION; URINE LEVEL;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE; BILIRUBIN; BIOLOGICAL TRANSPORT; CHOLESTASIS; COPROPORPHYRINS; DISEASE MODELS, ANIMAL; ISOMERISM; JAUNDICE, CHRONIC IDIOPATHIC; MALE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RATS; RATS, WISTAR;

ANIMALIA; FISTULA; RATTUS;

EID: 68549104491     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: 10.1170/T855     Document Type: Article

References (49)

1. Anderson, K.E., Sassa, S., Bishop, D.F. and Desnick, R.J., Disorders of heme biosynthesis: X-linked sideroblastic anemia and the porphyrias. In: The metabolic and molecular basis of inherited diseases,Scriver, C.R., Beaudet, A., Sly, W.S. and Valle, D. (eds.), McGraw-Hill, New York, 2001, 2991-3062.
2. Bakos, E., Evers, R., Sinko, E., Varadi, A., Borst, P. and Sarkadi, B., Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol 2000, 57: 760-768. (Pubitemid 30183717)
3. Bickers, D.R., Miller, L. and Kappas, A., Exacerbation of hereditary hepatic porphyria by surreptitious ingestion of an unusual provacative agent - a mouthwash preparation. N Engl J Med 1975, 292: 1115-1116.
4. Borst, P., Evers, R., Kool, M. and Wijnholds, J., A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 2000, 92: 1295-1302. (Pubitemid 30662093)
5. De Salamanca, R.E., Pena, M.L., Chinarro, S., Olmos, A., Mingo, D., Molina, C. and Munoz, J.J., Quantitative and qualitative porphyrin excretion in normal subjects. Int J Biochem 1982, 14: 251-254.
6. De Salamanca, R.E., Pena, M.L., Olmos, A., Molina, C. and Ladero, J.M., Follow-up studies of porphyrin excretion in porphyria cutanea tarda treated with p-aminobenzoic acid. Ann Clin Res 1980, 12: 279-281. (Pubitemid 11179068)
7. Dietrich, C.G., Geier, A. and Oude Elferink, R.P., ABC of oral bioavailability: transporters as gatekeepers in the gut. Gut 2003, 52: 1788-1795.
8. Fontanellas, A., Herrero, J.A., Moran, M.J., Coronel, F., Sepulveda, P., Barrientos, A. and De Salamanca, R.E., Efficiency of three different hemodialysis membranes for plasma porphyrin removal. Am J Kidney Dis 1995, 25: 30-33.
9. Frank, M., Doss, M. and de Carvalho, D.G., Diagnostic and pathogenetic implications of urinary coproporphyrin excretion in the Dubin-Johnson syndrome. Hepatogastroenterology 1990, 37: 147-151. (Pubitemid 20092226)
10. Gibson, P.R., Grant, J., Cronin, V., Blake, D. and Ratnaike, S., Effect of hepatobiliary disease, chronic hepatitis C and hepatitis B virus infections and interferon-alpha on porphyrin profiles in plasma, urine and faeces. J Gastroenterol Hepatol 2000, 15: 192-201. (Pubitemid 30154413)
11. Glavinas, H., Krajcsi, P., Cserepes, J. and Sarkadi, B., The role of ABC transporters in drug resistance, metabolism and toxicity. Curr Drug Deliv 2004, 1: 27-42.
12. Haimi-Cohen, Y., Merlob, P., Marcus-Eidlits, T. and Amir, J., Dubin-Johnson syndrome as a cause of neonatal jaundice: the importance of coproporphyrins investigation. Clin Pediatr (Phila) 1998, 37: 511-513. (Pubitemid 28378249)
13. Hardison, R.C., A brief history of hemoglobins: plant, animal, protist, and bacteria. Proc Natl Acad Sci U S A 1996, 93: 5675-5679.
14. Heme proteins. Adv Inorg Biochem 1988, 7: 1-271.
15. Homolya, L., Varadi, A. and Sarkadi, B., Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate. Biofactors 2003, 17: 103-114. (Pubitemid 37267146)
16. Kaplowitz, N., Javitt, N. and Kappas, A., Coproporphyrin I and 3 excretion in bile and urine. J Clin Invest 1972, 51: 2895-2899
17. Kauppinen, R., Porphyrias. Lancet 2005, 365: 241-252.
18. Kojima, H., Nies, A.T., Konig, J., Hagmann, W., Spring, H., Uemura, M., Fukui, H. and Keppler, D., Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. J Hepatol 2003, 39: 693-702. (Pubitemid 37372176)
19. Kondo, T., Kuchiba, K. and Shimizu, Y., Coproporphyrin isomers in Dubin-Johnson syndrome. Gastroenterology 1976, 70: 1117-1120.
20. Konig, J., Cui, Y., Nies, A.T. and Keppler, D., A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol Gastrointest Liver Physiol 2000, 278: G156-164. (Pubitemid 30108080)
21. Konig, J., Cui, Y., Nies, A.T. and Keppler, D., Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem 2000, 275: 23161-23168. (Pubitemid 30646210)
22. Konig, J., Rost, D., Cui, Y. and Keppler, D., Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology 1999, 29: 1156-1163. (Pubitemid 29168750)
23. Koopen, N.R., Muller, M., Vonk, R.J., Zimniak, P. and Kuipers, F., Molecular mechanisms of cholestasis: causes and consequences of impaired bile formation. Biochim Biophys Acta 1998, 1408: 1-17. (Pubitemid 28495640)
24. Koopen, N.R., Wolters, H., Havinga, R., Vonk, R.J., Jansen, P.L., Muller, M. and Kuipers, F., Impaired activity of the bile canalicular organic anion transporter (Mrp2/cmoat) is not the main cause of ethinylestradiolinduced cholestasis in the rat. Hepatology 1998, 27: 537-545. (Pubitemid 28081071)
25. Koskelo, P. and Mustajoki, P., Altered coproporhyrinisomer excretion in patients with the Dubin-Johnson syndrome. Int J Biochem 1980, 12: 975-978.
26. Koskelo, P. and Toivonen, I., Separation of urinary coproporphyrin isomers 1 and 3 by thin-layer chromatography. Studies in healthy subjects and patients with myocardial infarction. Scand J Clin Lab Invest 1966, 18: 543-549.
27. Koskelo, P. and Toivonen, I., Urinary excretion of coproporphyrin isomers 1 and 3 and delta-aminolaevulic acid in normal pregnancy and obstetric hepatosis. Acta Obstet Gynecol Scand 1968, 47: 292-299.
28. Kuroda, M., Kobayashi, Y., Tanaka, Y., Itani, T., Mifuji, R., Araki, J., Kaito, M. and Adachi, Y., Increased hepatic and renal expressions of multidrug resistanceassociated protein 3 in Eisai hyperbilirubinuria rats. J Gastroenterol Hepatol 2004, 19: 146-153. (Pubitemid 38253353)
29. Lim, C.K. and Peters, T.J., Urine and faecal porphyrin profiles by reversed-phase high-performance liquid chromatography in the porphyrias. Clin Chim Acta 1984, 139: 55-63. (Pubitemid 14145767)
30. Lim, C.K., Rideout, J.M. and Peters, T.J., High-performance liquid chromatography of dicarboxylic porphyrins and metalloporphyrins: retention behaviour and biomedical applications. J Chromatogr 1984, 317: 333-341.
31. Lockhart, A.C., Tirona, R.G. and Kim, R.B., Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy. Mol Cancer Ther 2003, 2: 685-698.
32. Meier, Y., Pauli-Magnus, C., Zanger, U.M., Klein, K., Schaeffeler, E., Nussler, A.K., Nussler, N., Eichelbaum, M., Meier, P.J. and Stieger, B., Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver. Hepatology 2006, 44: 62-74. (Pubitemid 44049139)
33. Moran, M.J., Fontanellas, A., Santos, J.L. and Enriquez de Salamanca, R., Correlation between levels of free and protein-bound plasma porphyrin and urinary porphyrins in porphyria cutanea tarda. Int J Biochem Cell Biol 1995, 27: 585-588.
34. Nomura, N., Zolla-Pazner, S., Simberkoff, M., Kim, M., Sassa, S. and Lim, H.W., Abnormal serum porphyrin levels in patients with the acquired immunodeficiency syndrome with or without hepatitis C virus infection. Arch Dermatol 1996, 132: 906-910. (Pubitemid 26266932)
35. O'Reilly, F.M., Darby, C., Fogarty, J., O'Moore, R., Courtney, M.G., O'Connor, J., Kay, E.W., Leader, M., Fielding, J.F. and Murphy, G.M., Porphyrin metabolism in hepatitis C infection. Photodermatol Photoimmunol Photomed 1996, 12: 31-33.
36. Ostrowski, J., Kosecki, P., Martynska, M. and Milewski, B., Urinary porphyrins in liver disease. Scand J Gastroenterol 1984, 19: 862-866.
37. Pauli-Magnus, C. and Meier, P.J., Hepatobiliary transporters and drug-induced cholestasis. Hepatology 2006, 44: 778-787.
38. Pinos, T., Constansa, J.M., Palacin, A. and Figueras, C., A new diagnostic approach to the Dubin-Johnson syndrome. Am J Gastroenterol 1990, 85: 91-93. (Pubitemid 20038990)
39. Ponka, P., Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells. Blood 1997, 89: 1-25. (Pubitemid 26428173)
40. Rocchi, E., Balli, F., Gibertini, P., Trenti, T., Pietrangelo, A., Cassanelli, M., Frigieri, G. and Ventura, E., Coproporphyrin excretion in healthy newborn babies. J Pediatr Gastroenterol Nutr 1984, 3: 402-407. (Pubitemid 14108914)
41. Rocchi, E., Gibertini, P., Santunione, V., Balli, F. and Ventura, E., Faecal and urinary coproporphyrin isomers in biliary atresia and neonatal hepatitis. Ric Clin Lab 1980, 10: 501-509.
42. Santos, J.L., Moran, M.J., Munoz, J.J., Fontanellas, A. and De Salamanca, R.E., Influence of pH on the porphyrin binding to plasma proteins. Horm Metab Res 1992, 24: 140.
43. Schaub, T.P., Kartenbeck, J., Konig, J., Spring, H., Dorsam, J., Staehler, G., Storkel, S., Thon, W.F. and Keppler, D., Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma. J Am Soc Nephrol 1999, 10: 1159-1169. (Pubitemid 29246980)
44. Scheffer, G.L., Kool, M., Heijn, M., de Haas, M., Pijnenborg, A.C., Wijnholds, J., van Helvoort, A., de Jong, M.C., Hooijberg, J.H., Mol, C.A., van der Linden, M., de Vree, J.M., van der Valk, P., Elferink, R.P., Borst, P. and Scheper, R.J., Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 Pglycoprotein with a panel of monoclonal antibodies. Cancer Res 2000, 60: 5269-5277. (Pubitemid 30739788)
45. Thunell, S., Porphyrins, porphyrin metabolism and porphyrias. I. Update. Scand J Clin Lab Invest 2000, 60: 509-540. (Pubitemid 32052515)
46. Toh, S., Wada, M., Uchiumi, T., Inokuchi, A., Makino, Y., Horie, Y., Adachi, Y., Sakisaka, S. and Kuwano, M., Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. Am J Hum Genet 1999, 64: 739-746. (Pubitemid 30460416)
47. Trauner, M., Arrese, M., Soroka, C.J., Ananthanarayanan, M., Koeppel, T.A., Schlosser, S.F., Suchy, F.J., Keppler, D. and Boyer, J.L., The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997, 113: 255-264. (Pubitemid 27281782)
48. Ventura, E. and Rocchi, E., Le Porfirie. In: Teodori 2000. Trattato di Medicina Interna, Guarini, G., Fiorelli, G., Malliani, A., Violi, E. and Volpe, M. (eds.), Società Editrice Universo, Roma, 2001, 2: 2301-2334.
49. Zimniak, P., Dubin-Johnson and Rotor syndromes: molecular basis and pathogenesis. Semin Liver Dis 1993, 13: 248-260. (Pubitemid 23294212)