Chking and executing cell division to prevent genomic instability

Cell Cycle

Volumn 8, Issue 15, 2009, Pages 2339-2342

  Peddibhotla, Sirisha ^a   Rosen, Jeffrey M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Aurora B; Binucleation; Chk1; Chromosome segregation; Cytokinesis; Lagging chromosomes

Indexed keywords

ATR PROTEIN; AURORA B KINASE; CHECKPOINT KINASE 1;

ANAPHASE; CELL CYCLE PROGRESSION; CELL DIVISION; CHROMOSOME ABERRATION; CHROMOSOME SEGREGATION; CYTOKINESIS; DNA DAMAGE; DNA REPAIR; ENZYME LOCALIZATION; GENOMIC INSTABILITY; METAPHASE; MITOSIS; NONHUMAN; REVIEW;

EUKARYOTA; MAMMALIA;

EID: 68449097078     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.15.9169     Document Type: Review

References (25)

1. Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003; 3:421-429 (Pubitemid 38340288)
2. Liu Q, Guntuku S, Cui XS, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000; 14:1448-1459
3. Puc J, Keniry M, Li HS, et al. Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell 2005; 7:193-204. (Pubitemid 40248344)
4. Groth A, Lukas J, Nigg EA, et al. Human Tousled like kinases are targeted by an ATM-and Chk1-dependent DNA damage checkpoint. EMBO J 2003; 22:1676-1687 (Pubitemid 36417415)
5. Kramer A, Mailand N, Lukas C, et al. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol 2004; 6:884-891 (Pubitemid 39207253)
6. Zachos G, Black EJ, Walker M, et al. Chk1 is required for spindle checkpoint function. Dev Cell 2007; 12:247-260 (Pubitemid 46193970)
7. Enders GH. Expanded roles for Chk1 in genome maintenance. J Biol Chem 2008; 283:17749-17752
8. 2 arrest in Fanconi anemia. Hum Mol Genet 2008; 17:679-689
9. Wang X, Kennedy RD, Ray K, Stuckert P, Ellenberger T, D'Andrea AD. Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway. Mol Cell Biol 2007; 27:3098-3108 (Pubitemid 46581321)
10. Shimada M, Nakanishi M. Checkpoints meet the transcription at a novel histone milestone (H3-T11). Cell Cycle 2008; 7:1555-1559
11. Shimada M, Niida H, Zineldeen DH, et al. Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell 2008; 132:221-232 (Pubitemid 351172429)
12. Peddibhotla S, Lam MH, Gonzalez-Rimbau M, Rosen JM. The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis. Proc Natl Acad Sci USA 2009.
13. Sorensen CS, Hansen LT, Dziegielewski J, et al. The cell cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol 2005; 7:195-201. (Pubitemid 40268135)
14. Van Hooser AA, Yuh P, Heald R. The perichromosomal layer. Chromosoma 2005; 1-12.
15. Hernandez-Verdun D, Gautier T. The chromosome periphery during mitosis. Bioessays 1994; 16:179-185
16. Wilsker D, Petermann E, Helleday T, Bunz F. Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control. Proc Natl Acad Sci USA 2008; 105:20752-20757
17. Wilsker D, Bunz F. Chk1 phosphorylation during mitosis: a new role for a master regulator. Cell Cycle 2009; 8:1161-1163
18. Tang J, Erikson RL, Liu X. Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1). Proc Natl Acad Sci USA 2006; 103:11964-11969
19. Zachos G, Gillespie DA. Exercising restraints: role of Chk1 in regulating the onset and progression of unperturbed mitosis in vertebrate cells. Cell Cycle 2007; 6:810-813 (Pubitemid 46572620)
20. Steigemann P, Wurzenberger C, Schmitz MH, et al. Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell 2009; 136:473-484
21. Chen CT, Doxsey S. A last-minute rescue of trapped chromatin. Cell 2009; 136:397-399
22. Reini K, Uitto L, Perera D, Moens PB, Freire R, Syvaoja JE. TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis. Chromosoma 2004; 112:323-330 (Pubitemid 38821141)
23. Daniels MJ, Wang Y, Lee M, Venkitaraman AR. Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science 2004; 306:876-879 (Pubitemid 39446997)
24. Ganem NJ, Storchova Z, Pellman D. Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev 2007; 17:157-162
25. Sidi S, Sanda T, Kennedy RD, et al. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2 and caspase-3. Cell 2008; 133:864-877