A susceptibility gene for type 2 diabetes confers substantial risk for diabetes complicating cystic fibrosis

Diabetologia

Volumn 52, Issue 9, 2009, Pages 1858-1865

  Blackman, S M ^a   Hsu, S ^a   Ritter, S E ^a   Naughton, K M ^a   Wright, F A ^b   Drumm, M L ^c   Knowles, M R ^d   Cutting, G R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b The University of North Carolina at Chapel Hill   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Association; CFRD; Corticosteroid; Cystic fibrosis; Diabetes; Genetics; Glucocorticoid; Modifier gene; TCF7L2

Indexed keywords

TRANSCRIPTION FACTOR 7 LIKE 2;

ADOLESCENT; ALLELE; ARTICLE; CASE CONTROL STUDY; CHILD; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CYSTIC FIBROSIS; FAMILY HISTORY; FAMILY STUDY; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAZARD RATIO; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POPULATION; PRIORITY JOURNAL; RISK FACTOR; SCHOOL CHILD; SIBLING; TCF7L2 GENE; TWINS;

ADOLESCENT; ADULT; CHILD, PRESCHOOL; CYSTIC FIBROSIS; DIABETES MELLITUS, TYPE 2; DNA; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GLUCOCORTICOIDS; HUMANS; INFANT; LUNG TRANSPLANTATION; MALE; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE; QUESTIONNAIRES; RESPIRATORY FUNCTION TESTS; RISK FACTORS; SIBLINGS; TCF TRANSCRIPTION FACTORS;

EID: 68449090520     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1436-2     Document Type: Article

References (39)

1. Welsh MJ, Ramsey BW, Accurso FJ, Cutting GR (2001) Cystic fibrosis. In: Scriver CR, Beaudet AL, Valle D, Sly WS (eds) The metabolic and molecular bases of inherited disease, 8th edn. McGraw-Hill, New York, pp 5121-5188
2. A Moran D Hardin D Rodman 1999 Diagnosis, screening and management of cystic fibrosis related diabetes mellitus: a consensus conference report Diabetes Res Clin Pract 45 61 73
3. AD Mackie SJ Thornton FP Edenborough 2003 Cystic fibrosis-related diabetes Diabet Med 20 425 436
4. CE Milla WJ Warwick A Moran 2000 Trends in pulmonary function in patients with cystic fibrosis correlate with the degree of glucose intolerance at baseline Am J Respir Crit Care Med 162 891 895
5. K Mohan KL Israel H Miller R Grainger MJ Ledson MJ Walshaw 2008 Long-term effect of insulin treatment in cystic fibrosis-related diabetes Respiration 76 181 186
6. CC Cowie KF Rust DD Byrd-Holt 2006 Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health and Nutrition Examination Survey 1999-2002 Diabetes Care 29 1263 1268
7. N Ahmed M Corey G Forstner 2003 Molecular consequences of cystic fibrosis transmembrane regulator (CFTR) gene mutations in the exocrine pancreas Gut 52 1159 1164
8. SM Blackman S Hsu LL Vanscoy 2009 Genetic modifiers play a substantial role in diabetes complicating cystic fibrosis J Clin Endocrinol Metab 94 1302 1309
9. L Minicucci M Cotellessa L Pittaluga 2005 Beta-cell autoantibodies and diabetes mellitus family history in cystic fibrosis J Pediatr Endocrinol Metab 18 755 760
10. S Lanng B Thorsteinsson F Pociot 1993 Diabetes mellitus in cystic fibrosis: genetic and immunological markers Acta Paediatr 82 150 154
11. S Nousia-Arvanitakis A Galli-Tsinopoulou D Dracoulacos M Karamouzis A Demitriadou 2000 Islet autoantibodies and insulin dependent diabetes mellitus in cystic fibrosis J Pediatr Endocrinol Metab 13 319 324
12. SE Kahn 2001 Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes J Clin Endocrinol Metab 86 4047 4058
13. E Bismuth K Laborde P Taupin 2008 Glucose tolerance and insulin secretion, morbidity, and death in patients with cystic fibrosis J Pediatr 152 540-5 545
14. RL Hull GT Westermark P Westermark SE Kahn 2004 Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes J Clin Endocrinol Metab 89 3629 3643
15. M Couce TD O'Brien A Moran PC Roche PC Butler 1996 Diabetes mellitus in cystic fibrosis is characterized by islet amyloidosis J Clin Endocrinol Metab 81 1267 1272
16. SF Grant G Thorleifsson I Reynisdottir 2006 Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nat Genet 38 320 323
17. MN Weedon 2007 The importance of TCF7L2 Diabet Med 24 1062 1066
18. SM Blackman R Deering-Brose R McWilliams 2006 Relative contribution of genetic and nongenetic modifiers to intestinal obstruction in cystic fibrosis Gastroenterology 131 1030 1039
19. LL Vanscoy SM Blackman JM Collaco 2007 Heritability of lung disease severity in cystic fibrosis Am J Respir Crit Care Med 175 1036 1043
20. BJ Rosenstein GR Cutting 1998 The diagnosis of cystic fibrosis: a consensus statement J Pediatr 132 589 595
21. LB Kahn JA Marshall J Baxter SM Shetterly RF Hamman 1990 Accuracy of reported family history of diabetes mellitus. Results from San Luis Valley Diabetes Study Diabetes Care 13 796 798
22. P Zimmet KG Alberti J Shaw 2001 Global and societal implications of the diabetes epidemic Nature 414 782 787
23. JM Collaco L Vanscoy L Bremer 2008 Interactions between secondhand smoke and genes that affect cystic fibrosis lung disease JAMA 299 417 424
24. ML Drumm MW Konstan MD Schluchter 2005 Genetic modifiers of lung disease in cystic fibrosis N Engl J Med 353 1443 1453
25. NM Laird S Horvath X Xu 2000 Implementing a unified approach to family-based tests of association Genet Epidemiol 19 Suppl 1 S36 S42
26. KV Steen C Lange 2005 PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies Hum Genome 2 67 69
27. KL Lunetta SV Faraone J Biederman NM Laird 2000 Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions Am J Hum Genet 66 605 614
28. D Altshuler JN Hirschhorn M Klannemark 2000 The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes Nat Genet 26 76 80
29. KJ Gaulton CJ Willer Y Li 2008 Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes Diabetes 57 3136 3144
30. S Cauchi Y El Achhab H Choquet 2007 TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis J Mol Med 85 777 782
31. BC Marshall SM Butler M Stoddard AM Moran TG Liou WJ Morgan 2005 Epidemiology of cystic fibrosis-related diabetes J Pediatr 146 681 687
32. AI Adler E Gunn CS Haworth D Bilton 2007 Characteristics of adults with and without cystic fibrosis-related diabetes Diabet Med 24 1143 1148
33. CF Weijnen SS Rich JB Meigs AS Krolewski JH Warram 2002 Risk of diabetes in siblings of index cases with Type 2 diabetes: implications for genetic studies Diabet Med 19 41 50
34. A Helgason S Palsson G Thorleifsson 2007 Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution Nat Genet 39 218 225
35. Z Liu JF Habener 2008 Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta-cell proliferation J Biol Chem 283 13 8723 8735
36. L Wegner MS Hussain K Pilgaard 2008 Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins J Clin Endocrinol Metab 93 4013 4019
37. JC Florez KA Jablonski N Bayley 2006 TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program N Engl J Med 355 241 250
38. JB Meigs P Shrader LM Sullivan 2008 Genotype score in addition to common risk factors for prediction of type 2 diabetes N Engl J Med 359 2208 2219
39. V Lyssenko A Jonsson P Almgren 2008 Clinical risk factors, DNA variants, and the development of type 2 diabetes N Engl J Med 359 2220 2232