Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions

American Journal of Human Genetics

Volumn 66, Issue 2, 2000, Pages 605-614

  Lunetta, Kathryn L ^a,b,d   Faraone, Stephen V ^a,c   Biederman, Joseph ^a,c   Laird, Nan M ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ATTENTION DEFICIT DISORDER; GENETIC ASSOCIATION; GENETIC LINKAGE; HUMAN; PRIORITY JOURNAL; SCORING SYSTEM; SIBLING;

EID: 0033913218     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302782     Document Type: Article

References (36)

1. Allison, DB (1997) Transmission-disequilibrium tests for quantitative traits. Am J Hum Genet 60:676-690
2. Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HH (1995) Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 65:1157-1165
3. Asherson P, Virdee V, Curran S, Ebersole S, Freeman B, Craig I, Simonoff E, et al (1998) Association of DSM-IV attention deficit hyperacrivity disorder and monoamine pathway genes. Am J Med Genet 81:549
4. Castellanos FX, Lau E, Tayebi N, Lee P, Long RE, Giedd JN, Sharp W, et al (1998) Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/ hyperactivity disorder: genetic and brain morphometric analyses. Mol Psychiatry 3:431-434
5. Clayton D, Jones H (1999) Transmission/disequilibrium tests for extended marker haplotypes. Am J Hum Genet 65: 1161-1169
6. Comings DE, Comings BG, Muhleman D, Dietz G, Shahbahrami B, Tast D, Knell E, et al (1991) The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA 266:1793-1800
7. Comings DE, Gonzalez N, Wu S, Gade R, Muhleman D, Saucier G, Johnson P, et al (1999) Studies of the 48 bp repeat polymorphism of the DRD4 gene in impulsive, compulsive, addictive behaviors: Tourette syndrome, ADHD, pathological gambling, and substance abuse. Am J Med Genet 88: 358-368
8. Cook EH Jr, Stein MA, Krasowski MD, Cox NJ, Olkon DM, Kieffer JE, Leventhal BL (1995) Association of attention-deficit disorder and the dopamine transporter gene. Am J Hum Genet 56:993-998
9. Daly G, Hawi Z, Fitzgerald M, Gill M (1998) Attention deficit hyperactivity disorder: association with the dopamine transporter (DAT1) but not with the dopamine D4 receptor (DRD4). Am J Med Genet 81:501
10. -(1999) Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol Psychiatry 4:192-196
11. Davies RB (1977) Hypothesis testing when a nuisance parameter is present only under the alternative. Biometrika 64: 247-254
12. Falk CT, Rubinstein P (1987) Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet 51:227-233
13. Faraone SV, Biederman J (1998) Neurobiology of attention deficit hyperactivity disorder. Biol Psychiatry 44:951-958
14. Faraone S, Biederman J, Weiffenbach B, Keith T, Chu M, Weaver A, Spencer T, et al (1999) Dopamine D4 gene 7-repeat allele and attention-deficit hyperactivity disorder. Am J Psychiatry 156:768-770
15. Fulker DW, Cherny SS, Sham PC, Hewitt JK (1999) Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet 64:259-267
16. Gill M, Daly G, Heron S, Hawi Z, Fitzgerald M (1997) Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry 2:311-313
17. Kaplan NE, Martin ER, Weir BS (1997) Power studies for the transmission/disequilibrium tests with multiple alleles. Am J Hum Genet 60:691-702
18. LaHoste GJ, Swanson JM, Wigal SB, Glabe C, Wigal T, King N, Kennedy JL (1996) Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol Psychiatry 1:121-124
19. Martin ER, Kaplan NL, Weir BS (1997) Tests for linkage and association in nuclear families. Am J Hum Genet 61:439-448
20. McCullagh P and Nelder JA (1989) Generalized linear models, 2d ed. Chapman & Hall, New York
21. Poulton K, Holmes J, Hever T, Trumper A, Fitzpatrick H, McGuffin P, Owen M, et al (1998) A molecular genetic study of hyperkinetic disorder/attention deficit hyperactivity disorder. Am J Med Genet 81:458
22. Rabinowitz D (1997) A transmission disequilibrium test for quantitative trait loci. Hum Hered 47:342-350
23. Rabinowitz D, Laird NM. Adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered (in press)
24. Rowe DC, Stever C, Giedinghagen LN, Gard JM, Cleveland HH, Terris ST, Mohr JH, et al (1998) Dopamine DRD4 receptor polymorphism and attention deficit hyperactivity disorder. Mol Psychiatry 3:419-426
25. Rubinstein P, Walker M, Carpenter C, Carrier C, Krassner J, Falk C, Ginsberg F (1981) Genetics of HLA disease associations: the use of haplotype relative risk (HRR) and the "haplo-delta" (Dh) estimates in juvenile diabetes from the three racial groups. Hum Immunol 3:384
26. Schaid DJ (1996) General score tests for association of genetic markers with disease using cases and their parents. Genet Epidemiol 13:423-449
27. Schaid DJ, Sommer SS (1994) Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet 55:402-409
28. Self SG, Longton G, Kopecky KJ, Liang K-Y (1991) On estimating HLA/disease association with application to a study of aplastic anemia. Biometrics 47:53-62
29. Sham PC, Curtis D (1995) An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet 59:323-336
30. Smalley SL, Bailey JN, Palmer CG, Cantwell DP, McGough JJ, Del'Homme MA, Asarnow JR, et al (1998) Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder. Mol Psychiatry 3:427-430
31. Spielman RS, Ewens WJ (1998) A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. Am J Hum Genet 62:450-458
32. Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516
33. Swanson JM, Sunohara GA, Kennedy JL, Regino R, Fineberg E, Wigal T, Lerner M, et al (1998) Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): a family-based approach. Mol Psychiatry 3:38-41
34. Terwilliger JD, Ott J (1992) A haplotype-based "haplotype relative risk" approach to detecting allelic associations. Hum Hered 42:337-346
35. Waldman ID, Rowe DC, Abramowitz A, Kozel ST, Mohr JH, Sherman SL, Cleveland HH, et al (1998) Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. Am J Hum Genet 63: 1767-1776
36. Whittaker JC Lewis CM (1998) The effect of family structure on linkage tests using allelic association. Am J Hum Genet 63:889-897