Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 4924-4928

  Allen, John G ^a   Lee, Matthew R ^a   Han, Chun Ya E ^a   Scherrer, Jon ^a   Flynn, Shaun ^a   Boucher, Christy ^a   Zhao, Huilin ^a   O'Connor, Anne B ^a   Roveto, Philip ^a   Bauer, David ^a   Graceffa, Russell ^a   Richards, William G ^a   Babij, Philip ^a  

^a AMGEN INC   (United States)

Author keywords

Bone; Chemical screen; Kinase; Molecular model; Osteoblast; Pyk2; Small molecule

Indexed keywords

FOCAL ADHESION KINASE 1; PROLINE; PROTEIN TYROSINE KINASE INHIBITOR; PYRIDONE DERIVATIVE;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; BONE DEVELOPMENT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR LIBRARY; MOUSE; NONHUMAN; OSTEOBLAST; RAT;

ANIMALS; BINDING SITES; CELL LINE; COMPUTER SIMULATION; FOCAL ADHESION KINASE 2; HUMANS; MICE; OSTEOBLASTS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PYRIDONES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 68349154347     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.084     Document Type: Article

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