Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5029-5032

  Kim, Callain Y ^a   Mahaney, Paige E ^a   McConnell, Oliver ^a   Zhang, Yingru ^a   Manas, Eric ^a   Ho, Douglas M ^b   Deecher, Darlene C ^a   Trybulski, Eugene J ^a  

^a PFIZER INC   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

5 HT; Monoamine reuptake inhibitor; NE; Norepiephrine reuptake inhibitor; NRI; Vasomotor symptoms

Indexed keywords

1 AMINO 3 (1H INDOL 1 YL) 3 PHENYLPROPAN 2 OL; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DESIPRAMINE; DOPAMINE TRANSPORTER; NISOXETINE; NORADRENALIN TRANSPORTER; NORADRENALIN UPTAKE INHIBITOR; REBOXETINE; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIASTEREOISOMER; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME; NONHUMAN; PSYCHOPHARMACOLOGY; RAT; STEREOCHEMISTRY;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ANTIDEPRESSIVE AGENTS; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; DOGS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DRUG DISCOVERY; HUMANS; MOLECULAR CONFORMATION; NOREPINEPHRINE; PROPANOLS; RECOMBINANT PROTEINS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 68349144413     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.053     Document Type: Article

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