Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 24, 2006, Pages 8455-8466

  Mahaney, Paige E ^a   Vu, An T ^a   McComas, Casey C ^a   Zhang, Puwen ^a   Nogle, Lisa M ^a   Watts, William L ^a   Sarkahian, Ani ^a   Leventhal, Liza ^a   Sullivan, Nicole R ^a   Uveges, Albert J ^a   Trybulski, Eugene J ^a  

^a PFIZER INC   (United States)

Author keywords

Aryloxypropanamines; Monoamine reuptake inhibitors; Norepinephrine reuptake inhibitors; Serotonin reuptake inhibitors

Indexed keywords

3 (1H INDOL 1 YL) N METHYL 3 PHENYLPROPAN 1 AMINE; 3 (1H INDOL 1 YL) N,N DIMETHYL 3 PHENYLPROPAN 1 AMINE; 3 (2,3 DIHYDRO 1H INDOL 1 YL) 3 (3 FLUOROPHENYL) N,N DIMETHYLPROPAN 1 AMINE; 3 (2,3 DIHYDRO 1H INDOL 1 YL) N,N DIMETHYL 3 PHENYLPROPAN 1 AMINE; 3 (3 FLUOROPHENYL) 3 (1H INDOL 1 YL) N METHYLPROPAN 1 AMINE; 3 (3 FLUOROPHENYL) 3 (1H INDOL 1 YL) N,N DIMETHYLPROPAN 1 AMINE; 3 (4 FLUORO 1H INDOL 1 YL) 3 (3 FLUOROPHENYL) N METHYLPROPAN 1 AMINE; 3 (4 FLUORO 1H INDOL 1 YL) 3 (3 FLUOROPHENYL) N,N DIMETHYLPROPAN 1 AMINE; 3 (4 FLUORO 1H INDOL 1 YL) N METHYL 3 PHENYLPROPAN 1 AMINE; 3 (4 FLUORO 1H INDOL 1 YL) N,N DIMETHYL 3 PHENYLPROPAN 1 AMINE; 3 (4 FLUORO 2,3 DIHYDRO 1H INDOL 1 YL) 3 (3 FLUOROPHENYL) N,N DIMETHYLPROPAN 1 AMINE; 3 (4 FLUORO 2,3 DIHYDRO 1H INDOL 1 YL) N,N DIMETHYL 3 PHENYLPROPAN 1 AMINE; 3 (5 FLUORO 1H INDOL 1 YL) 3 (3 FLUOROPHENYL) N,N DIMETHYLPROPAN 1 AMINE; 3 (5 FLUORO 1H INDOL 1 YL) N METHYL 3 PHENYLPROPAN 1 AMINE; 3 (5 FLUORO 1H INDOL 1 YL) N,N DIMETHYL 3 PHENYLPROPAN 1 AMINE; 3 (5 FLUORO 2,3 DIHYDRO 1H INDOL 1 YL) 3 (3 FLUOROPHENYL) N,N DIMETHYLPROPAN 1 AMINE; 3 (5 FLUORO 2,3 DIHYDRO 1H INDOL 1 YL) N,N DIMETHYL 3 PHENYLPROPAN 1 AMINE; 3 (6 FLUORO 1H INDOL 1 YL) 3 (3 FLUOROPHENYL) N,N DIMETHYLPROPAN 1 AMINE; 3 (6 FLUORO 1H INDOL 1 YL) N METHYL 3 PHENYLPROPAN 1 AMINE; 3 (6 FLUORO 1H INDOL 1 YL) N,N DIMETHYL 3 PHENYLPROPAN 1 AMINE; 3 (6 FLUORO 2,3 DIHYDRO 1H INDOL 1 YL) 3 (3 FLUOROPHENYL) N,N DIMETHYLPROPAN 1 AMINE; 3 (6 FLUORO 2,3 DIHYDRO 1H INDOL 1 YL) N,N DIMETHYL 3 PHENYLPROPAN 1 AMINE; 3 (7 FLUORO 1H INDOL 1 YL) 3 (3 FLUOROPHENYL) N,N DIMETHYLPROPAN 1 AMINE; 3 (7 FLUORO 1H INDOL 1 YL) N METHYL 3 PHENYLPROPAN 1 AMINE; 3 (7 FLUORO 1H INDOL 1 YL) N,N DIMETHYL 3 PHENYLPROPAN 1 AMINE; 3 (7 FLUORO 2,3 DIHYDRO 1H INDOL 1 YL) 3 (3 FLUOROPHENYL) N,N DIMETHYLPROPAN 1 AMINE; 3 (7 FLUORO 2,3 DIHYDRO 1H INDOL 1 YL) N,N DIMETHYL 3 PHENYLPROPAN 1 AMINE; NORADRENALIN UPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN;

ADRENERGIC UPTAKE INHIBITORS; BIOGENIC AMINES; CELL LINE, TUMOR; CHORIOCARCINOMA; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; INDOLES; NOREPINEPHRINE; PLACENTA; PROPYLAMINES; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33750521157     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.08.039     Document Type: Article

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