Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 23, 2008, Pages 6067-6070

  Zhang, Puwen ^a   Terefenko, Eugene A ^a   McComas, Casey C ^a   Mahaney, Paige E ^a   Vu, An ^a   Trybulski, Eugene ^a   Koury, Elizabeth ^a   Johnston, Grace ^a   Bray, Jenifer ^a   Deecher, Darlene ^a  

^a PFIZER INC   (United States)

Author keywords

3 (3 Amino 1 phenyl propyl) 1,3 dihydro 2H benzimidazol 2 ones; Dopamine reuptake inhibitor; Norepinephrine reuptake inhibitor; NRI; Serotonin reuptake inhibitor

Indexed keywords

1 (3 AMINO 1 PHENYL PROPYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 3 (3 AMINO 1 PHENYL PROPYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; ATOMOXETINE; BENZIMIDAZOLE DERIVATIVE; DESIPRAMINE; DOPAMINE TRANSPORTER; FLUOXETINE; MAZINDOL; NORADRENALIN TRANSPORTER; NORADRENALIN UPTAKE INHIBITOR; REBOXETINE; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

BENZIMIDAZOLES; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; NEUROTRANSMITTER UPTAKE INHIBITORS; NOREPINEPHRINE; STEREOISOMERISM;

EID: 55549090301     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.026     Document Type: Article

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