Encapsulation of local anesthetic bupivacaine in biodegradable poly(DL-lactide-co-glycolide) nanospheres: Factorial design, characterization and cytotoxicity studies

Macromolecular Symposia

Volumn 281, Issue 1, 2009, Pages 106-112

  Moraes, Carolina Morales ^a   De Lima, Renata ^b   Rosa, André Henrique ^c   De Paula, Eneida ^a   Fraceto, Leonardo Fernandes ^a,c  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SOROCABA   (Brazil)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Bupivacaine; Local anesthetic; Poly(DL lactide coglycolide) nanospheres; Polymeric nanoparticle

Indexed keywords

CELL CULTURE; COLLOIDS; CONTROLLED DRUG DELIVERY; FUNCTIONAL POLYMERS; LIGHT SCATTERING; NANOPARTICLES; NANOSPHERES; PARTICLE SIZE; SIZE DISTRIBUTION; TOXICITY; ZETA POTENTIAL;

BUPIVACAINE; CENTRIFUGATION TECHNIQUE; DL-LACTIDE; FACTORIAL EXPERIMENTAL DESIGN; LOCAL ANESTHETICS; NARROW SIZE DISTRIBUTIONS; POLY(DL-LACTIDE-COGLYCOLIDE); POLYMERIC NANOPARTICLES;

ANESTHETICS;

EID: 68349122568     PISSN: 10221360     EISSN: 15213900     Source Type: Journal    
DOI: 10.1002/masy.200950714     Document Type: Article

References (30)

1. D. R. De Araújo, E. De Paula, L. F. Fraceto, Quim. Nova 2008, 31, 1775.
2. R. H. de Jong, Local anesthetics, C.C. Thomas, Springfield 1994.
3. J. M. Ritchie, G. R. Strichartz, Local Anesthetics-Handbook of Experimental Pharmacology, Springer- Verlag, Berlin 1987.
4. L. E. Mather, P. McCall, P. L. McNicol, Anesth. Analg. 1995, 80, 328.
5. R. W. Gristwood, Drug Saf. 2002, 25, 153.
6. Y. F. Huang, M. E. Pryor, L. E. Mather, B. T. Veering, Anesth. Analg. 1998, 86, 797.
7. R. H. Foster, A. Markham, Drugs 2000, 59, 551.
8. L. E. Mather, P. McCall, P. L. McNicol, Anesth. Analg. 1995, 80, 328.
9. D. R. de Araújo, L. F. Fraceto, A. F. A. Braga, E. De Paula, Rev. Bras. Anestesiol. 2005, 55, 316.
10. L. M. A. Pinto, D. K. Yokaichiya, L. F. Fraceto, E. De Paula, Biophys. Chem. 2000, 87, 213.
11. L. M. A. Pinto, L. F. Fraceto, M. H. A. Santana, T. A. Pertinhez, S. Oyama-Junior, E. De Paula, J. Pharm. Biomed. Anal. 2005, 39, 956.
12. M. Polakovic, T. Gorner, R. Gref, E. Dellacherie, J. Controlled Release 1999, 60, 169.
13. M. D. Blanco, M. V. Bernardo, R. L. Sastre, R. Olmo, E. Muniz, J. M. Teijón, Eur. J. Pharm. Biopharm. 2003, 55, 229.
14. C. M. Moraes, A. P. De Matos, R. Lima, A. H. Rosa, E. De Paula, L. F. Fraceto, J. Biol. Phys. 2007, 33, 455.
15. T. Govender, S. Stolnik, M. C. Garnett, L. I. Stanley, S. Davis, J. Controlled Release 1999, 57, 171.
16. T. Gorner, R. Gref, D. Michenor, F. Sommer, M. N. Tran, E. Dellacherie, J. Controlled Release 1999, 57, 259.
17. S. P. Schwendeman, M. Cardamone, A. Klibanov, R. Langer, S. Chen, H. Bernstein, Microparticulate Systems for the Delivery of Proteins and Vaccines, Marcel Dekker, New York 1996.
18. A. Shenderova, T. G. Burke, S. P. Schwendeman, Pharm. Res. 1997, 14, 1406.
19. A. Shenderova, T. G. Burke, S. P. Schwendeman, Pharm. Res. 1999, 16, 241.
20. S. R. Mallery, A. Shenderova, P. Pei, S. Begum, J. R. Ciminieri, Anticancer Res. 2001, 21, 1713.
21. D. Quintanar-Guerrero, E. Allemann, H. Fessi, E. Doelker, Drug Dev. Ind. Pharm. 1998, 24, 1113.
22. H. Fessi, F. Puisieux, J. P. Devissaguet, N. Ammoury, S. Benita, Int. J. Pharm. 1989, R1.
23. J. M. Barichello, M. Morishita, K. Takayama, T. Nagai, J. Drug Dev. Ind. Pharm. 1999, 25, 471.
24. S. C. Yang, J. B. Zhu, Drug. Dev. Ind. Pharm. 2002, 28, 265.
25. G. A. Lewis, Encyclopedia Pharm. Technol. 2002, 2, 1922.
26. A. K.Seth, A.Misra, J. Pharm. Pharm.Sci. 2002, 5, 285.
27. C. M. Moraes, A. H. Rosa, E. De Paula, L. F. Fraceto, Quim. Nova 2008, 31, (in press).
28. K. Avgoustakis, A. Beletsi, Z. Panagi, P. Kleptsanis, E. Livaniou, G. Evangelatos, D. S. Ithakissios, Int. J. Pharm. 2003, 259, 115.
29. C. B. Michalowski, S. S. Guterres, T. Dalla Costa, J. Pharm. Biomed. Anal. 2004, 35, 1093.
30. T. Govender, T. Riley, T. Ehtezazi, M. C. Garnett, S. Solnik, L. Illum, S. S. Davis, Int. J. Pharm. 2000, 199, 95.