Cardiac and CNS toxicity of levobupivacaine strength of evidence for advantage over bupivacaine: Strength of evidence for advantage over bupivacaine

Drug Safety

Volumn 25, Issue 3, 2002, Pages 153-163

  Gristwood, Robert W ^a  

^a ST JOHN S COLLEGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; DEXBUPIVACAINE; EPHEDRINE; LEVOBUPIVACAINE; LOCAL ANESTHETIC AGENT; LONG ACTING DRUG; OXYGEN; POTASSIUM CHANNEL; PROPOFOL; SODIUM CHANNEL; THIOPENTAL; UNCLASSIFIED DRUG;

BLOOD PRESSURE REGULATION; CARDIOTOXICITY; CLINICAL TRIAL; CONVULSION; COST BENEFIT ANALYSIS; DOG; DRUG CHOICE; DRUG COST; DRUG MARKETING; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG WITHDRAWAL; ELECTROCARDIOGRAM; ELECTROENCEPHALOGRAM; FOOD AND DRUG ADMINISTRATION; HEART MUSCLE CONTRACTILE FORCE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HEMODYNAMIC MONITORING; HUMAN; LETHAL DOSE; LOCAL ANESTHESIA; NEUROTOXICITY; NONHUMAN; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; QT INTERVAL; REVIEW; SHEEP; TINNITUS; VERTIGO;

EID: 0036251841     PISSN: 01145916     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002018-200225030-00002     Document Type: Review

References (41)

1. Cardiac arrest following regional anesthesia with etidocaine or bupivacaine
2. Deaths after intravenous regional anaesthesia
3. Local anesthetics
4. Levobupivacaine: A new safer long acting local anaesthetic agent
5. Are the new local anesthetics worth their cost?
6. Levobuvacaine
7. Functional interaction between local anaesthetics and calcium antagonists in guinea-pig myocardium. II. Electrophysiological studies with bupivacaine and nifedipine
8. Toxic systemic reactions of bupivacaine and etidocaine
9. Toxicity of local anesthetic agents
10. Stereoselective block of cardiac sodium channels by bupivacaine in guinea-pig ventricular myocytes
11. Stereoselective effects of the enantiomers of bupivacaine on the electrophysiological properties of the guinea-pig papillary muscle
12. Block of human heart hH 1 sodium channels by the enantiomers of bupivacaine
13. Effects of bupivacaine on membrane currents of guinea-pig ventricular myocytes
14. Bupivacaine and lidocaine blockade of calcium-mediated slow action potentials in guinea-pig ventricular muscle
15. Is comparative cardiotoxicity of S(-) and R(+) bupivacaine related to enantiomer-selective inhibition of L-type Ca(2+) channels?
16. Comparison of the cardiotoxic effects of bupivacaine, levobupivacaine and ropivacaine: An in vitro study in guinea-pig and human cardiac muscle
17. Stereoselective block of a human cardiac potassium channel [Kv1.5] by bupivacaine enantiomers
18. HERG, a human inward rectifier in the voltage-gated potassium channel family
19. 2-adrenergic receptor
20. Absence of stereospecific effects of bupivacaine isomers on heart mitochondrial bioenergetics
21. Myocardial uptake of bupivacaine II. Pharmacokinetics and pharmacodynamics of bupivacaine enantiomers in the isolated perfused rabbit heart
22. Comparative ventricular electrophysiologic effect of racemic bupivacaine, levobupivacaine, and ropivacaine on the isolated rabbit heart
23. Stereospecific effect of bupivacaine isomers on atrioventricular conduction in the isolated perfused guinea-pig heart
24. Toxicological and local anesthetic effects of optically active isomers of two local anesthetic compounds
25. Optical isomers of mepivacaine and bupivacaine
26. Enantiomer-specific effects of an intravenously administered arrhythmogenic dose of bupivacaine on neurones of the nucleus tractus solitarius and the cardiovascular system in the anesthetized rat
27. A comparison of the electrocardiographic cardiotoxic effects of racemic bupivacaine, levobupivacaine and ropivacaine in anesthetized swine
28. Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep
29. Tolerability of large dose intravenous levobupivacaine in sheep
30. Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep
31. Ventricular arrhythmias with or without programmed electrical stimulation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine and ropivacaine
32. Reduced cardiotoxicity of levobupivacaine compared with racemic bupivacaine (Marcain): New clinical evidence
33. A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers
34. Differential effects of levo- and racemic bupivacaine on the EEG in volunteers
35. Accidental intravenous levobupivacaine
36. Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine and ropivacaine in anesthetized dogs
37. Levobupivacaine a stereoselective amide local anesthetic