Isolation and characterisation of a human monoclonal autoantibody to the islet cell autoantigen IA-2

Journal of Autoimmunity

Volumn 24, Issue 4, 2005, Pages 337-345

  Ananieva Jordanova, R ^a   Evans, M ^a   Nakamatsu, T ^a,b   Premawardhana, L D K E ^c   Sanders, J ^a   Powell, M ^a   Chen, S ^a   McGrath, V ^a   Belton, C ^a   Arnold, C ^a   Baker, S ^a   Betterle, C ^d   Zanchetta, R ^d   Smith, B Rees ^a,b   Furmaniak, J ^a,b  

^a RSR LTD   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c ANEURIN BEVAN UNIVERSITY HEALTH BOARD   (United Kingdom)

^d UNIVERSITY OF PADOVA   (Italy)

Author keywords

Autoantibodies; Autoimmunity; Diabetes mellitus; IA 2; Islet cell antibodies

Indexed keywords

AUTOANTIGEN; EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; INSULINOMA ASSOCIATED ANTIGEN 2; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY ISOLATION; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; CASE REPORT; CONTROLLED STUDY; EPSTEIN BARR VIRUS; EXPERIMENTAL INFECTION; FEMALE; GRAVES DISEASE; HUMAN; HUMAN CELL; HYBRID CELL; HYBRIDOMA CELL CULTURE; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; INDUCED MUTATION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; VIRUS INFECTION; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOANTIGENS; DIABETES MELLITUS, TYPE 1; EPITOPE MAPPING; HUMANS; HYBRIDOMAS; MEMBRANE PROTEINS; MICE; PROTEIN-TYROSINE-PHOSPHATASE;

EID: 20144371738     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaut.2005.03.003     Document Type: Article

References (38)

1. M.A. Atkinson, and G.S. Eisenbarth Type 1 diabetes: new perspectives on disease pathogenesis and treatment Lancet 358 2001 221 229
2. A.L. Notkins, and å. Lernmark Autoimmune type 1 diabetes: resolved and unresolved issues Journal of Clinical Investigation 108 2001 1247 1252 10.1172/JCI200114257
3. J.M. LaGasse, M.S. Brantley, N.J. Leech, R.E. Rowe, S. Monks, and J.P. Palmer Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies Diabetes Care 25 2002 505 511
4. M. Schlosser, M. Strebelow, R. Wassmuth, M.-L. Arnold, I. Breunig, and I. Rjasanowski The Karlsburg type 1 diabetes risk study of a normal schoolchild population: association of β-cell autoantibodies and human leukocyte antigen-DQB1 alleles in antibody-positive individuals Journal of Clinical Endocrinology and Metabolism 87 2002 2254 2261
5. J.P. Krischer, D.D. Cuthbertson, L. Yu, T. Orban, N. Maclaren, and R. Jackson Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes Journal of Clinical Endocrinology and Metabolism 88 2003 103 108
6. V. Lampasona, M. Bearzatto, S. Genovese, E. Bosi, M. Ferrari, and E. Bonifacio Autoantibodies in insulin-dependent diabetes recognize distinct cytoplasmic domains of the protein tyrosine phosphatase-like IA-2 autoantigen Journal of Immunology 157 1996 2707 2711
7. H. Xie, B. Zhang, Y. Matsumoto, Q. Li, A.L. Notkins, and M.S. Lan Autoantibodies to IA-2 and IA-2β in insulin-dependent diabetes mellitus recognize conformational epitopes Journal of Immunology 159 1997 3662 3667
8. E. Bonifacio, V. Lampasona, and P.J. Bingley IA-2 (islet cell antigen 512) is the primary target of humoral autoimmunity against type 1 diabetes-associated tyrosine phosphatase autoantigens Journal of Immunology 161 1998 2648 2654
9. J. Seissler, M. Schott, N.G. Morgenthaler, and W.A. Scherbaum Mapping of novel autoreactive epitopes of the diabetes-associated autoantigen IA-2 Clinical and Experimental Immunology 122 2000 157 163
10. M. Bearzatto, H. Naserke, S. Piquer, K. Koczwara, V. Lampasona, and A. Williams Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens Journal of Immunology 168 2002 4202 4208
11. V. Kolm-Litty, S. Berlo, E. Bonifacio, M. Bearzatto, A.M. Engel, and M. Christie Human monoclonal antibodies isolated from type 1 diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen Journal of Immunology 165 2000 4676 4684
12. N. Hayakawa, L.D.K.E. Premawardhana, M. Powell, M. Masuda, C. Arnold, and J. Sanders Isolation and characterization of human monoclonal autoantibodies to glutamic acid decarboxylase Autoimmunity 35 2002 343 355
13. J. Sanders, M. Evans, L.D.K.E. Premawardhana, H. Depraetere, J. Jeffreys, and T. Richards Human monoclonal thyroid stimulating autoantibody Lancet 362 2003 126 128
14. C. Betterle, F. Presotto, L. Magrin, B. Pedini, L. Moro, and A. Caretto The natural history of pre-Type 1 (insulin-dependent) diabetes mellitus in patients with autoimmune endocrine diseases Diabetologia 37 1994 95 103
15. 65 produced in yeast Clinica Chimica Acta 256 1996 175 188
16. M. Masuda, M. Powell, S. Chen, C. Beer, P. Fichna, and B. Rees Smith Autoantibodies to IA-2 in IDDM. Measurements with a new immunoprecipitation assay Clinica Chimica Acta 291 2000 53 66
17. 125I-labeled TSH receptor Journal of Clinical Endocrinology and Metabolism 84 1999 3797 3802
18. K. Beever, J. Bradbury, D. Phillips, S.M. McLachlan, C. Pegg, and A. Goral Highly sensitive assays of autoantibodies to thyroglobulin and to thyroid peroxidase Clinical Chemistry 35 1989 1949 1954
19. B.J. Bolton, and N.K. Spurr B-lymphocytes R.I. Freshney N.G. Freshney Culture of immortalized cells 1996 Wiley-Liss New York 283 297
20. W.L. Carroll, K. Thielemans, J. Dilley, and R. Levy Mouse x human heterohybridomas as fusion partners with human B cell tumors Journal of Immunological Methods 89 1986 61 72
21. P. Chomczynski, and N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Analytical Biochemistry 162 1987 156 159
22. F. Sanger, S. Nicklen, and A.R. Coulson DNA sequencing with chain terminating inhibitors Proceedings of the National Academy of Sciences of the USA 74 1977 5463 5467
23. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 684
24. H.-W. Birk, and H. Koepsell Reaction of monoclonal antibodies with plasma membrane proteins after binding on nitrocellulose: renaturation of antigenic sites and reduction of nonspecific antibody binding Analytical Biochemistry 164 1987 12 22
25. E. Kabat, H. Perry, T. Wu, K. Gottesman, and C. Foeller Sequences of proteins of immunological interest 5th ed. 1991 US Public Health Service Bethesda, MD
26. J. Sanders, J. Jeffreys, H. Depraetere, M. Evans, T. Richards, and A. Kiddie Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function Thyroid 14 2004 560 570
27. T. Chardès, N. Chapal, D. Bresson, C. Bès, V. Giudicelli, and M.-P. Lefranc The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's thyroid diseases Immunogenetics 54 2002 141 157
28. H. Dersimonian, R.S. Schwartz, K.J. Barrett, and B.D. Stollar Relationship of human variable region heavy chain germ-line genes to genes encoding anti-DNA autoantibodies Journal of Immunology 139 1987 2496 2501
29. J. Davies, and W.H. Ouwehand Primary structure of the variable domains of anti-FVIII antibodies isolated from inhibitor patient B cell RNA by phage display Genbank accession: AF078944 1999
30. T.H. Jukes, and J.L. King Evolutionary nucleotide replacements in DNA Nature 281 1979 605 606
31. W. Richter, W. Northemann, M. Müller, and B. Böhm Mapping of an autoreactive epitope within glutamate decarboxylase using a diabetes-associated human monoclonal autoantibody and an epitope cDNA library Hybridoma 15 1996 103 108
32. F. Grennan Jones, K. Ziemnicka, J. Sanders, A. Wolstenholme, R. Fiera, and J. Furmaniak Analysis of autoantibody epitopes on human thyroid peroxidase Autoimmunity 30 1999 157 169
33. J. Furmaniak, J. Sanders, and B. Rees Smith Autoantigens in the autoimmune endocrinopathies R. Volpe Contemporary endocrinology: autoimmune endocrinopathies 1999 Humana Press Totowa, NJ 183 216
34. Q. Li, A.E. Borovitskaya, M.G. DeSilva, C. Wasserfall, N.K. Maclaren, and A.L. Notkins Autoantigens in insulin-dependent diabetes mellitus: molecular cloning and characterization of human IA-2β Proceedings of the Association of American Physicians 109 1997 429 439
35. M. Bearzatto, V. Lampasona, C. Belloni, and E. Bonifacio Fine mapping of diabetes-associated IA-2 specific autoantibodies Journal of Autoimmunity 21 2003 377 382
36. J.A. Dromey, S.M. Weenink, G.H. Peters, J. Endl, P.J. Tighe, and I. Todd Mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen IA-2 by peptide phage display and molecular modeling: overlap of antibody and T cell determinants Journal of Immunology 172 2004 4084 4090
37. E.C.I. Hatfield, C.J. Hawkes, M.A. Payton, and M.R. Christie Cross reactivity between IA-2 and phogrin/IA-2β in binding of autoantibodies in IDDM Diabetologia 40 1997 1327 1333
38. H.E. Naserke, A.-G. Ziegler, V. Lampasona, and E. Bonifacio Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes Journal of Immunology 161 1998 6963 6969