Corticosteroids in children with bacterial meningitis: Indications and administration;Corticothérapie chez l'enfant (indications, modalités d'administration)

Medecine et Maladies Infectieuses

Volumn 39, Issue 7-8, 2009, Pages 539-546

  Grimprel, E ^a,b  

^a Groupe de Pathologie Infectieuse Pédiatrique   (France)

^b ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

Bacterial meningitis; Children; Dexamethasone; Infants

Indexed keywords

ANTIBIOTIC AGENT; CEFOTAXIME; CEPHALOSPORIN; CORTICOSTEROID; DEXAMETHASONE; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; BACTERIAL MENINGITIS; CEREBROSPINAL FLUID; CHILD; CHILDHOOD MORTALITY; DRUG ANTAGONISM; DRUG EFFICACY; DRUG INDICATION; DRUG PENETRATION; EARLY INTERVENTION; HAEMOPHILUS INFLUENZAE TYPE B; HUMAN; NEUROLOGIC DISEASE; NONHUMAN; PNEUMOCOCCAL MENINGITIS; RECOMMENDED DRUG DOSE; REVIEW; STREPTOCOCCUS PNEUMONIAE;

ADOLESCENT; ADRENAL CORTEX HORMONES; ANTI-INFLAMMATORY AGENTS; CHILD; CHILD, PRESCHOOL; DEVELOPED COUNTRIES; DEXAMETHASONE; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; INFANT; MENINGITIS, BACTERIAL;

EID: 68249110109     PISSN: 0399077X     EISSN: 17696690     Source Type: Journal    
DOI: 10.1016/j.medmal.2009.02.024     Document Type: Review

References (57)

1. Fauci A.S. Infectious diseases: considerations for the 21st century. Clin Infect Dis 32 (2001) 675-685
2. Lebel M.H., and McCracken Jr. G.H. Delayed cerebrospinal fluid sterilization and adverse outcome of bacterial meningitis in infants and children. Pediatrics 83 (1989) 161-167
3. McCracken Jr. G.H. Management of bacterial meningitis: current status and future prospects. Am J Med (1984) 215-220
4. Bingen E., Levy C., de La Rocque F., Boucherat M., Varon E., Alonso J.M., et al. Bacterial meningitis in children: a french prospective study. Clin Infect Dis 41 (2005) 1059-1063
5. Sáez-Llorens X., and McCracken Jr. G.H. Bacterial meningitis in children. Lancet 361 (2003) 2139-2148
6. Peltola H., Anttila M., Renkonen O.V., and The Finnish study group. Randomised comparison of chloramphenicol, ampicillin, cefotaxime, and ceftriaxone for childhood bacterial meningitis. Lancet (1989) 1281-1287
7. Cohen R., de la Rocque F., Varon E., and Geslin P. Antibiothérapie de première intention des méningites communautaires. Pédiatrie 48 (1993) 37-49
8. Mustapha M.M., Mertsola J., Ramilo O., Sáez-Llorenz X., Risser R., and McCracken G.H. Increased endotoxin and interleukin-1b concentrations in cerebrospinal fluid of infants with coliform meningitis and ventriculitis associated with intraventricular gentamycin therapy. J Infect Dis 160 (1989) 891-895
9. Havens P.L. Meta-analysis redux-steroids and meningitis revisited. West J Med 156 (1992) 84-86
10. Pollard A.J., Nadel S., Ninis N., Faust S.N., and Levin M. Emergency management of meningoccal disease: eight years on. Arch Dis Child 92 (2007) 283-286
11. Pfister H.W., Feiden W., and Einhäupl K.M. Spectrum of complications during bacterial meningitis in adults. Results of a prospective clinical study. Arch Neurol 50 (1993) 575-581
12. Neuman H.B., and Wald E.R. Bacterial meningitis in childhood at the children's hospital of Pittsburgh: 1988-1998. Clin Pediatr 40 (2001) 595j-600j
13. Kornelisse R.F., Westerbeek C.M., Spoor A.B., van der Heijde B., Spanjaard L., Neijens H.J., and de Groot R. Pneumococcal meningitis in children: prognostic indicators and outcome. Clin Infect Dis 6 (1995) 1390-1397
14. Luster A.D. Chemokines-chemotactic cytokines that mediate inflammation. N Engl J Med 338 (1998) 436-445
15. Casado-Flores J., Aristegui J., Rodrigo de Liria C., Martinon J.M., and Fernandez C. Spanish pneumococcal meningitis study group. Clinical data and factors associated with poor outcome in pneumococcal meningitis. Eur J Pediatr 165 (2006) 285-289
16. van der Flier M., Geelen S.P.M., Kimpen J.L.L., Hoepelman I.M., and Tuomanen E.I. Reprogramming the host response in bacterial meningitis: how best to improve outcome?. Clin Microbiol Rev (2003) 415-429
17. McIntyre P.B., Berkey C.S., King S.M., Schaad U.B., Kilpi T., Kanra G., and Perez-Odio C.M. Dexamethasone as adjunctive therapy in bacterial meningitis: a meta-analysis of randomized clinical trials since 1988. JAMA 278 (1997) 925-931
18. Grimprel E., and Bégué P. Place de la dexaméthasone dans le traitement des méningites purulentes chez le nourrisson et l'enfant. Pédiatrie 48 (1993) 29-36
19. de Lemos R.A., and Haggerty R.J. Corticosteroids as an adjunct to treatment in bacterial meningitis. Pediatrics 44 (1969) 30-34
20. Belsey M.A., Hoffpauir C.W., and Smith M.H.D. Dexamethasone in the treatment of acute bacterial meningitis: the effect of study design on the interpretation of results. Pediatrics 44 (1969) 503-513
21. Odio C.M., Faingezicht I., Paris M., Nassar M., Baltodano A., Rogers J., et al. The beneficial effect of dexamethasone administration in infants and children with bacterial meningitis. N Engl J Med 324 (1991) 1525-1531
22. Lebel M.H., Freij B.J., Syrogiannopoulos G.A., Chrane D.F., Hoyt M.J., Stewart S.M., et al. Dexamethasone therapy for bacterial meningitis. N Engl J Med 319 (1988) 964-971
23. Schaad U.B., Lips U., Gnehm H.E., Blumberg A., Heilzer I., and Wedgwood J. Dexamethasone therapy for bacterial meningitis in children. Swiss meningitis study group. Lancet 342 (1993) 457-461
24. Wald E.R., Kaplan S.L., Mason Jr. E.O., Sabo D., Ross L., Arditi M., et al. Dexamethasone therapy for children with bacterial meningitis. Pediatrics 95 (1995) 21-28
25. Geiman B.J., and Smith A.L. Meta-analyses revisited. West J Med 156 (1992) 472-473
26. Geiman B.K., and Smith A.L. Dexamethasone and bacterial meningitis. A meta-analysis of randomized controlled trials. West J Med 157 (1992) 27-31
27. Tauber M.G., Khayam-Bashi H., and Sande M.A. Effects of ampicillin and corticosteroids on brain water content. CSF pressure and CSF lactate in experimental pneumococcal meningitis. J Infect Dis 151 (1985) 528-534
28. Jacqz-Aigrain E., and Guillonneau M. Place des corticoïdes dans les méningites purulentes de l'enfant : analyse des études de la littérature. Arch Pediatr 4 (1997) 52-60
29. Kennedy W.A., Hoyt M.J., and McCracken Jr. G.H. The role of corticosteroid therapy in children with pneumococcal meningitis. AJDC 145 (1991) 1374-1378
30. McIntyre P.B., MacIntyre C.R., Gilmour R., and Wang H. A population-based study of the impact of corticosteroid therapy and delayed diagnosis on the outcome of childhood pneumococcal meningitis. Arch Dis Child 90 (2005) 391-396
31. Molyneux E.M., Walsh A.L., Forsyth H., et al. Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomized controlled trial. Lancet 360 (2002) 211-218
32. Grimwood K., Nolan T.M., Bond L., et al. Risk factors for adverse outcomes of bacterial meningitis. J Paediatr Child Health 32 (1996) 457-462
33. Radetsky M. Duration of symptoms and outcome in bacterial meningitis: an analysis of causation and implications of a delay in diagnosis. Pediatr Infect Dis J 11 (1992) 694-701
34. Pomeroy S.L., Holmes S.J., Dodge P.R., and Feigin R.D. Seizures and other neurologic sequelae of bacterial meningitis in children. N Engl J Med 323 (1990) 1651-1657
35. Kanra G.Y., Ozen H., Seçmeer G., Ceyhan M., Ecevit Z., and Belgin E. Beneficial effect of dexamethasone in children with pneumococcal meningitis. Pediatr Infect Dis J 14 (1995) 490-494
36. Havens P.L., Wendelberger K.J., Hoffman G.M., Lee M.B., and Chusid M.J. Corticosteroids as adjunctive therapy in bacterial meningitis. A meta-analysis of clinical trials. AJDC 143 (1989) 1051-1055
37. van de Beek D, de Gans J, McIntyre P, Prasad K. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev 2003;3:CD004405 (review).
38. Paris M.M., Hickey S.M., Uscher M.I., Shelton S., Olsen K.D., and McCracken Jr. G.H. Effect of dexamethasone on therapy of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. Antimicrob Agents Chemother 38 (1994) 1320-1324
39. American Academy of Pediatrics. Dexamethasone therapy for bacterial meningitis in infants and children. In: Peter G, editor. 1994 Red book report of the Committee on Infectious Diseases. 23rd ed. Elk Grove Village, IL: Am Acad Pediatr; 1994. p. 558-9.
40. Conférence de consensus sur le traitement des méningites purulentes du nourrisson et de l'enfant. Nancy, 23 avril 1992. Pédiatrie 1993;48:3-8.
41. American Academy of Pediatrics. Pneumococcal infections. In: Pickering LK, Baker CJ, Long SS, McMillan JA, editors. Red Book: 2006 Report of the Committee on Infectious Diseases. 27th ed. Elk Grove Village, IL: Ame Acad Pediatr; 530.
42. van de Beek D, de Gans J, McIntyre P, Prasad K. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev 2007;1:CD004405 (review).
43. van de Beek D., and de Gans J. Dexamethasone and pneumococcal meningitis. Ann Intern Med 141 (2004) 327
44. Scarborough M., Gordon S.B., Whitty C.J.M., French N., Njalale Y., Chitani A., et al. Corticosteroids for bacterial meningitis in adults in sub-Saharan Africa. N Engl J Med 357 (2007) 2441-2450
45. Nguyen T.H., Tran T.H., Thwaites G., Ly V.C., Dinh X.S., Ho Dang T.N., et al. Dexamethasone in vietnamese adolescents and adults with bacterial meningitis. N Engl J Med 357 (2007) 2431-2440
46. Doit C., Barre J., Cohen R., Bonacorsi S., Bourrillon A., and Bingen E.H. Bactericidal activity against intermediately cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with bacterial meningitis treated with high doses of cefotaxime and vancomycin. Antimicrob Agents Chemother 41 (1997) 2050-2052
47. Friedland I.R., and Klugman K.P. Cerebrospinal fluid bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in children with meningitis treated with high-dosage cefotaxime. Antimicrob Agents Chemother 41 (1997) 1888-1891
48. Gaillard J.L., Abadie V., Cheron G., Lacaille F., Mahut B., Silly C., et al. Concentrations of ceftriaxone in cerebrospinal fluid of children with meningitis receiving dexamethasone therapy. Antimicrob Agents Chemother 38 (1994) 1209-1210
49. Klugman K., Friedland I.R., and Bradley J.S. Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis. Antimicrob Agents Chemother 39 (1995) 1988-1992
50. Varon E, Gutmann L. Rapport d'activité 2006 du Centre national de référence du pneumocoque. Épidémiologie 2006, www.invs.sante.fr/display/?doc=surveillance/cnr/index.htm. (Consulté le 10 septembre 2008).
51. Bingen E, Levy C, Varon E, de la Rocque F, Boucherat M, d'Athis P, et al. Eur J Microbiol Infect Dis 2008;27:191-9.
52. Hees L, Gillet Y, Floret D. Analyse des échecs bactériologiques des méningites à pneumocoque de l'enfant de 2001 à 2005 : caractéristiques et hypothèses étiologiques. Arch Ped 2008;15:S119-25.
53. Spreer A., Gerber J., Hanssen M., Schindler S., Hermann C., Lange P., et al. Dexamethasone increases hippocampal neuronal apoptosis in a rabbit model of Escherichia coli meningitis. Pediatr Res 60 (2006) 210-215
54. Leib S.L., Heimgartner C., Bifrafe Y.D., Loeffler U.M., and Täuber M.G. Dexamethasone aggravates hippocampal apoptosis and learning deficiency in pneumococcal meningitis in infant rats. Pediatr Res 54 (2003) 353-357
55. Nau R., Soto A., and Bruck W. Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis. J Neuropathol Exp Neurol 58 (1999) 265-274
56. Lutsar I., Friedland I.R., Jafri H.S., Wubbel L., Ahmed A., Trujillo M., et al. Factors influencing the anti-inflammatory effect of dexamethasone therapy in experimental pneumococcal meningitis. J Antimicrob Chemother 52 (2003) 651-655
57. Peltola H., Roine I., Fernandez J., Zavala I., Gonzalea Ayala S., Gonzalez Mata A., et al. Adjuvant glycerol and/or dexamethasone to improve the outcomes of childhood bacterial meningitis: a prospective, randomized, double-blind, placebo-controlled trial. Clin Infect Dis 45 (2007) 1277-1286